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P42069 (CD28_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
T-cell-specific surface glycoprotein CD28
Alternative name(s):
CD_antigen=CD28
Gene names
Name:CD28
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Possibly involved in T-cell activation By similarity.

Subunit structure

Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 221202T-cell-specific surface glycoprotein CD28
PRO_0000014655

Regions

Topological domain20 – 150131Extracellular Potential
Transmembrane151 – 17727Helical; Potential
Topological domain178 – 22144Cytoplasmic Potential
Domain29 – 138110Ig-like V-type

Amino acid modifications

Modified residue1901Phosphoserine By similarity
Modified residue1921Phosphotyrosine By similarity
Modified residue2101Phosphotyrosine By similarity
Modified residue2191Phosphotyrosine By similarity
Glycosylation381N-linked (GlcNAc...) Potential
Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation931N-linked (GlcNAc...) Potential
Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Disulfide bond41 ↔ 113 By similarity
Disulfide bond67 ↔ 87 By similarity

Sequences

Sequence LengthMass (Da)Tools
P42069 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 3DF652C9CFC14F13

FASTA22125,307
        10         20         30         40         50         60 
MILRLLLAFN FFPSIQGTEN KILVKQSPML VVNNNEVNLS CKYTYNLFSK EFRASLYKGA 

        70         80         90        100        110        120 
DSAVEVCVVN GNFSHPHQFH STTGFNCDGK LGNETVTFYL KNLYVNQTDI YFCKIEVMYP 

       130        140        150        160        170        180 
PPYLDNEKSN GTIIHVKEQH FCPAHPSPKS STLFWVLVVV GAVLAFYSML VTVALFSCWM 

       190        200        210        220 
KSKKNRLLQS DYMNMTPRRP GPTRKHYQPY APARDFAAYR S

« Hide

References

[1]"Cloning and sequencing of the rabbit gene encoding T-cell costimulatory molecules."
Isono T., Seto A.
Immunogenetics 42:217-220(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: B/J X Chbb:HM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D49841 mRNA. Translation: BAA08641.1.
PIRI46689.
RefSeqNP_001075676.1. NM_001082207.1.
UniGeneOcu.3056.

3D structure databases

ProteinModelPortalP42069.
SMRP42069. Positions 20-137.
ModBaseSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000025050.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100008998.

Organism-specific databases

CTD940.

Phylogenomic databases

eggNOGNOG48152.
HOGENOMHOG000276892.
HOVERGENHBG004094.
OrthoDBEOG498V1S.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR008093. CD28.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
PRINTSPR01717. CD28ANTIGEN.
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCD28_RABIT
AccessionPrimary (citable) accession number: P42069
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 3, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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