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P42064

- APPD_BACSU

UniProt

P42064 - APPD_BACSU

Protein

Oligopeptide transport ATP-binding protein AppD

Gene

appD

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transporting tripeptides. Probably responsible for energy coupling to the transport system.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi41 – 488ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. peptide transporter activity Source: InterPro

    GO - Biological processi

    1. establishment of competence for transformation Source: UniProtKB-KW
    2. protein transport Source: UniProtKB-KW
    3. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW

    Keywords - Biological processi

    Competence, Peptide transport, Protein transport, Sporulation, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBSUB:BSU11360-MONOMER.

    Protein family/group databases

    TCDBi3.A.1.5.20. the atp-binding cassette (abc) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oligopeptide transport ATP-binding protein AppD
    Gene namesi
    Name:appD
    Ordered Locus Names:BSU11360
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU11360. [Micado]

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328Oligopeptide transport ATP-binding protein AppDPRO_0000091931Add
    BLAST

    Proteomic databases

    PaxDbiP42064.

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU11360.

    Structurei

    3D structure databases

    ProteinModelPortaliP42064.
    SMRiP42064. Positions 1-299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 256252ABC transporterPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily.Curated
    Contains 1 ABC transporter domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0444.
    KOiK02031.
    OMAiKEYPHRL.
    OrthoDBiEOG6T7N3V.
    PhylomeDBiP42064.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR010066. Oligo_ATP-bd_C.
    IPR013563. Oligopep_ABC_C.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00005. ABC_tran. 1 hit.
    PF08352. oligo_HPY. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01727. oligo_HPY. 1 hit.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42064-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTLLEVNNL KTYFFRKKEP IPAVDGVDFH ISKGETVALV GESGSGKSIT    50
    SLSIMGLVQS SGGKIMDGSI KLEDKDLTSF TENDYCKIRG NEVSMIFQEP 100
    MTSLNPVLTI GEQITEVLIY HKNMKKKEAR QRAVELLQMV GFSRAEQIMK 150
    EYPHRLSGGM RQRVMIAIAL SCNPKLLIAD EPTTALDVTI QAQVLELMKD 200
    LCQKFNTSIL LITHDLGVVS EAADRVIVMY CGQVVENATV DDLFLEPLHP 250
    YTEGLLTSIP VIDGEIDKLN AIKGSVPTPD NLPPGCRFAP RCPKAMDKCW 300
    TNQPSLLTHK SGRTVRCFLY EEEGAEQS 328
    Length:328
    Mass (Da):36,311
    Last modified:November 1, 1995 - v1
    Checksum:iE4B87CD2B9D27F25
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20909 Genomic DNA. Translation: AAA62356.1.
    AL009126 Genomic DNA. Translation: CAB12993.1.
    PIRiI40543.
    RefSeqiNP_389018.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB12993; CAB12993; BSU11360.
    GeneIDi936391.
    KEGGibsu:BSU11360.
    PATRICi18973984. VBIBacSub10457_1186.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20909 Genomic DNA. Translation: AAA62356.1 .
    AL009126 Genomic DNA. Translation: CAB12993.1 .
    PIRi I40543.
    RefSeqi NP_389018.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali P42064.
    SMRi P42064. Positions 1-299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU11360.

    Protein family/group databases

    TCDBi 3.A.1.5.20. the atp-binding cassette (abc) superfamily.

    Proteomic databases

    PaxDbi P42064.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB12993 ; CAB12993 ; BSU11360 .
    GeneIDi 936391.
    KEGGi bsu:BSU11360.
    PATRICi 18973984. VBIBacSub10457_1186.

    Organism-specific databases

    GenoListi BSU11360. [Micado ]

    Phylogenomic databases

    eggNOGi COG0444.
    KOi K02031.
    OMAi KEYPHRL.
    OrthoDBi EOG6T7N3V.
    PhylomeDBi P42064.

    Enzyme and pathway databases

    BioCyci BSUB:BSU11360-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR010066. Oligo_ATP-bd_C.
    IPR013563. Oligopep_ABC_C.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00005. ABC_tran. 1 hit.
    PF08352. oligo_HPY. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01727. oligo_HPY. 1 hit.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a second oligopeptide transport system in Bacillus subtilis and determination of its role in sporulation."
      Koide A., Hoch J.A.
      Mol. Microbiol. 13:417-426(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.

    Entry informationi

    Entry nameiAPPD_BACSU
    AccessioniPrimary (citable) accession number: P42064
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3