Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P42041

- ALDH_ALTAL

UniProt

P42041 - ALDH_ALTAL

Protein

Aldehyde dehydrogenase

Gene

ALTA10

Organism
Alternaria alternata (Alternaria rot fungus) (Torula alternata)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (13 Jun 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei148 – 1481Transition state stabilizerBy similarity
    Active sitei264 – 2641Proton acceptorPROSITE-ProRule annotation
    Active sitei298 – 2981NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi241 – 2466NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase (EC:1.2.1.3)
    Short name:
    ALDDH
    Short name:
    ALDH
    Alternative name(s):
    Allergen Alt a X
    Allergen: Alt a 10
    Gene namesi
    Name:ALTA10
    OrganismiAlternaria alternata (Alternaria rot fungus) (Torula alternata)
    Taxonomic identifieri5599 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeAlternariaAlternaria alternata group

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei13. Alt a 10.
    3057. Alt a 10.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Aldehyde dehydrogenasePRO_0000056434Add
    BLAST

    Proteomic databases

    PRIDEiP42041.

    Structurei

    3D structure databases

    ProteinModelPortaliP42041.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR015657. Aminobutyraldehyde_DH.
    [Graphical view]
    PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42041-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSVKLSTPQ TGEFEQPTGL FINNEFVKAV DGKTFDVINP STEEVICSVQ    50
    EATEKDVDIA VAAARKAFNG PWRKETPENR GKLLNKLADL FEKNADLIAA 100
    VEALDNGKAF SMAKNVDVPA AAGCLRYYGG WADKIEGKVV DTAPDSFNYI 150
    RKEPIGVCGQ IIPWNFPILM WSWKIGPAIA TGNTVVLKTA EQTPLSAYIA 200
    CKLIQEAGFP PGVINVITGF GKIAGAAMSA HMDIDKIAFT GSTVVGRQIM 250
    KSAAGSNLKK VTLELGGKSP NIVFADADLD EAIHWVNFGI YFNHGQACCA 300
    GSRIYVQEEI YDKFIQRFKE RAAQNAVGDP FAADTFQGPQ VSQLQFDRIM 350
    GYIEEGKKSG ATIETGGNRK GDKGYFIEPT IFSNVTEDMK IQQEEIFGPV 400
    CTISKFKTKA DVIKIGNNTT YGLAAAVHTS NLTTAIEVAN ALRAGTVWVN 450
    SYNTLHWQLP FGGYKESGIG RELGEAALDN YIQTKTVSIR LGDVLFG 497
    Length:497
    Mass (Da):53,916
    Last modified:June 13, 2006 - v2
    Checksum:i75DB63C621DFFB5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78227 mRNA. Translation: CAA55071.2.
    PIRiS43108.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78227 mRNA. Translation: CAA55071.2 .
    PIRi S43108.

    3D structure databases

    ProteinModelPortali P42041.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 13. Alt a 10.
    3057. Alt a 10.0101.

    Proteomic databases

    PRIDEi P42041.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR015657. Aminobutyraldehyde_DH.
    [Graphical view ]
    PANTHERi PTHR11699:SF46. PTHR11699:SF46. 1 hit.
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of major and minor allergens of Alternaria alternata and Cladosporium herbarum."
      Achatz G., Oberkofler H., Lechenauer E., Simon-Nobbe B., Unger A., Kandler D., Ebner C., Prillinger H., Kraft D., Breitenbach M.
      Mol. Immunol. 32:213-227(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 08-0203-Berlin.
    2. Simon-Nobbe B.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 73; 153-166; 334-336 AND 424.
    3. Cited for: REVIEW.

    Entry informationi

    Entry nameiALDH_ALTAL
    AccessioniPrimary (citable) accession number: P42041
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3