P42041 (ALDH_ALTAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aldehyde dehydrogenase
Short name=ALDDH
Short name=ALDH
EC=1.2.1.3

Alternative name(s):
Allergen Alt a X
Allergen=Alt a 10

Gene names

Name:

ALTA10

Organism

Alternaria alternata (Alternaria rot fungus) (Torula alternata)

Taxonomic identifier

5599 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › dothideomyceta › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporineae › Pleosporaceae › mitosporic Pleosporaceae › Alternaria › Alternaria alternata group

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = a carboxylate + NADH.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Subcellular location	Cytoplasm Probable.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Disease	Allergen
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	ethanol catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Aldehyde dehydrogenase		PRO_0000056434
Regions
	Nucleotide binding	241 – 246	6	NAD By similarity
Sites
	Active site	264	1	Proton acceptor By similarity
	Active site	298	1	Nucleophile By similarity
	Site	148	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	P42041 [UniParc]. Last modified June 13, 2006. Version 2. Checksum: 75DB63C621DFFB5C	FASTA	497	53,916
	10 20 30 40 50 60 MTSVKLSTPQ TGEFEQPTGL FINNEFVKAV DGKTFDVINP STEEVICSVQ EATEKDVDIA 70 80 90 100 110 120 VAAARKAFNG PWRKETPENR GKLLNKLADL FEKNADLIAA VEALDNGKAF SMAKNVDVPA 130 140 150 160 170 180 AAGCLRYYGG WADKIEGKVV DTAPDSFNYI RKEPIGVCGQ IIPWNFPILM WSWKIGPAIA 190 200 210 220 230 240 TGNTVVLKTA EQTPLSAYIA CKLIQEAGFP PGVINVITGF GKIAGAAMSA HMDIDKIAFT 250 260 270 280 290 300 GSTVVGRQIM KSAAGSNLKK VTLELGGKSP NIVFADADLD EAIHWVNFGI YFNHGQACCA 310 320 330 340 350 360 GSRIYVQEEI YDKFIQRFKE RAAQNAVGDP FAADTFQGPQ VSQLQFDRIM GYIEEGKKSG 370 380 390 400 410 420 ATIETGGNRK GDKGYFIEPT IFSNVTEDMK IQQEEIFGPV CTISKFKTKA DVIKIGNNTT 430 440 450 460 470 480 YGLAAAVHTS NLTTAIEVAN ALRAGTVWVN SYNTLHWQLP FGGYKESGIG RELGEAALDN 490 YIQTKTVSIR LGDVLFG

References

[1]	"Molecular cloning of major and minor allergens of Alternaria alternata and Cladosporium herbarum." Achatz G., Oberkofler H., Lechenauer E., Simon-Nobbe B., Unger A., Kandler D., Ebner C., Prillinger H., Kraft D., Breitenbach M. Mol. Immunol. 32:213-227(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 08-0203-Berlin.
[2]	Simon-Nobbe B. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 73; 153-166; 334-336 AND 424.
[3]	"The spectrum of fungal allergy." Simon-Nobbe B., Denk U., Poell V., Rid R., Breitenbach M. Int. Arch. Allergy Immunol. 145:58-86(2008) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X78227 mRNA. Translation: CAA55071.2.
PIR	S43108.
3D structure databases
ProteinModelPortal	P42041.
ModBase	Search...
Protein family/group databases
Allergome	13. Alt a 10. 3057. Alt a 10.0101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00780; UER00768.
Family and domain databases
Gene3D	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH_ALTAL

Accession

Primary (citable) accession number: P42041

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	June 13, 2006
Last modified:	April 3, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program