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P42041 (ALDH_ALTAL) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase

Short name=ALDDH
Short name=ALDH
EC=1.2.1.3
Alternative name(s):
Allergen Alt a X
Allergen=Alt a 10
Gene names
Name:ALTA10
OrganismAlternaria alternata (Alternaria rot fungus) (Torula alternata)
Taxonomic identifier5599 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeAlternariaAlternaria alternata group

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Subcellular location

Cytoplasm Probable.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   DiseaseAllergen
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processethanol catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Aldehyde dehydrogenase
PRO_0000056434

Regions

Nucleotide binding241 – 2466NAD By similarity

Sites

Active site2641Proton acceptor By similarity
Active site2981Nucleophile By similarity
Site1481Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
P42041 [UniParc].

Last modified June 13, 2006. Version 2.
Checksum: 75DB63C621DFFB5C

FASTA49753,916
        10         20         30         40         50         60 
MTSVKLSTPQ TGEFEQPTGL FINNEFVKAV DGKTFDVINP STEEVICSVQ EATEKDVDIA 

        70         80         90        100        110        120 
VAAARKAFNG PWRKETPENR GKLLNKLADL FEKNADLIAA VEALDNGKAF SMAKNVDVPA 

       130        140        150        160        170        180 
AAGCLRYYGG WADKIEGKVV DTAPDSFNYI RKEPIGVCGQ IIPWNFPILM WSWKIGPAIA 

       190        200        210        220        230        240 
TGNTVVLKTA EQTPLSAYIA CKLIQEAGFP PGVINVITGF GKIAGAAMSA HMDIDKIAFT 

       250        260        270        280        290        300 
GSTVVGRQIM KSAAGSNLKK VTLELGGKSP NIVFADADLD EAIHWVNFGI YFNHGQACCA 

       310        320        330        340        350        360 
GSRIYVQEEI YDKFIQRFKE RAAQNAVGDP FAADTFQGPQ VSQLQFDRIM GYIEEGKKSG 

       370        380        390        400        410        420 
ATIETGGNRK GDKGYFIEPT IFSNVTEDMK IQQEEIFGPV CTISKFKTKA DVIKIGNNTT 

       430        440        450        460        470        480 
YGLAAAVHTS NLTTAIEVAN ALRAGTVWVN SYNTLHWQLP FGGYKESGIG RELGEAALDN 

       490 
YIQTKTVSIR LGDVLFG 

« Hide

References

[1]"Molecular cloning of major and minor allergens of Alternaria alternata and Cladosporium herbarum."
Achatz G., Oberkofler H., Lechenauer E., Simon-Nobbe B., Unger A., Kandler D., Ebner C., Prillinger H., Kraft D., Breitenbach M.
Mol. Immunol. 32:213-227(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 08-0203-Berlin.
[2]Simon-Nobbe B.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 73; 153-166; 334-336 AND 424.
[3]"The spectrum of fungal allergy."
Simon-Nobbe B., Denk U., Poell V., Rid R., Breitenbach M.
Int. Arch. Allergy Immunol. 145:58-86(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78227 mRNA. Translation: CAA55071.2.
PIRS43108.

3D structure databases

ProteinModelPortalP42041.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome13. Alt a 10.
3057. Alt a 10.0101.

Proteomic databases

PRIDEP42041.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00780; UER00768.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH_ALTAL
AccessionPrimary (citable) accession number: P42041
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 13, 2006
Last modified: October 16, 2013
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Allergens

Nomenclature of allergens and list of entries