Reviewed, UniProtKB/Swiss-Prot P42037 (RLA2_ALTAL)

Names and origin

Protein names

Recommended name:
    60S acidic ribosomal protein P2
Alternative name(s):
    Minor allergen Alt a 5
    Allergen Alt a 6
    Allergen Alt a VI
    Allergen=Alt a 5

Gene names

Name:	ALTA5
Synonyms:	ALTA6

Organism

Alternaria alternata (Alternaria rot fungus)

Taxonomic identifier

5599 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporaceae › mitosporic Pleosporaceae › Alternaria › Alternaria alternata group

Protein attributes

Sequence length	113 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Plays an important role in the elongation step of protein synthesis.
Subunit structure	P1 and P2 exist as dimers at the large ribosomal subunit.
Allergenic properties	Causes an allergic reaction in human. Ref.1
Sequence similarities	Belongs to the ribosomal protein L12P family.

Ontologies

Keywords
Disease	Allergen
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	translational elongation Inferred from electronic annotation. Source: InterPro
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 113	113	60S acidic ribosomal protein P2		PRO_0000157672
Amino acid modifications
	Modified residue	103	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	59	1	S → P in AAB48041. Ref.2
	Sequence conflict	87	1	Q → E in AAB48041. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P42037-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 3A4B199E512D8099	FASTA	113	11,134
	10 20 30 40 50 60 MKHLAAYLLL GLGGNTSPSA ADVKAVLESV GIEADSDRLD KLISELEGKD INELIASGSE 70 80 90 100 110 KLASVPSGGA GGAAASGGAA AAGGSAQAEA APEAAKEEEK EESDEDMGFG LFD

References

[1]	"Molecular cloning of major and minor allergens of Alternaria alternata and Cladosporium herbarum." Achatz G., Oberkofler H., Lechenauer E., Simon-Nobbe B., Unger A., Kandler D., Ebner C., Prillinger H., Kraft D., Breitenbach M. Mol. Immunol. 32:213-227(1995) [PubMed: 7898496] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGENICITY. Strain: 08-0203-Berlin.
[2]	"Molecular cloning of IgE-binding fragments of Alternaria alternata allergens." De Vouge M.W., Thaker A.J., Zhang L., Muradia G., Rode H., Vijay H.M. Int. Arch. Allergy Immunol. 116:261-268(1998) [PubMed: 9693275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X78222 mRNA. Translation: CAA55066.1. U87806 mRNA. Translation: AAB48041.1.
PIR	S43109.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR001813. Ribosomal_60S. [Graphical view]
Pfam	PF00428. Ribosomal_60s. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RLA2_ALTAL

Accession

Primary (citable) accession number: P42037
Secondary accession number(s): P78982

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)