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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

Gene

NDUFA8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
Alternative name(s):
Complex I-19kD
Short name:
CI-19kD
Complex I-PGIV
Short name:
CI-PGIV
NADH-ubiquinone oxidoreductase 19 kDa subunit
Gene namesi
Name:NDUFA8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity
  • Mitochondrion intermembrane space By similarity

GO - Cellular componenti

  • mitochondrial intermembrane space Source: UniProtKB-SubCell
  • mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 172171NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8PRO_0000118733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 66Sequence analysis
Disulfide bondi46 ↔ 56Sequence analysis
Disulfide bondi78 ↔ 110Sequence analysis
Disulfide bondi88 ↔ 100Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP42029.
PeptideAtlasiP42029.
PRIDEiP42029.

Expressioni

Gene expression databases

BgeeiENSBTAG00000004295.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

IntActiP42029. 1 interaction.
STRINGi9913.ENSBTAP00000005628.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 6941CHCH 1Add
BLAST
Domaini71 – 11343CHCH 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611C-X9-C motif 1Add
BLAST
Motifi56 – 6611C-X9-C motif 2Add
BLAST
Motifi78 – 8811C-X9-C motif 3Add
BLAST
Motifi100 – 11011C-X9-C motif 4Add
BLAST

Domaini

Contains four C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the complex I NDUFA8 subunit family.Curated
Contains 2 CHCH domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3458. Eukaryota.
ENOG4111IST. LUCA.
GeneTreeiENSGT00390000008938.
HOGENOMiHOG000090856.
HOVERGENiHBG001244.
InParanoidiP42029.
KOiK03952.
OMAiYWTCLDY.
OrthoDBiEOG091G0M0S.
TreeFamiTF105633.

Family and domain databases

InterProiIPR010625. CHCH.
IPR016680. NADH_Ub_cplx-1_asu_su-8.
[Graphical view]
PfamiPF06747. CHCH. 1 hit.
[Graphical view]
PIRSFiPIRSF017016. NDUA8. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGIVELPSL EDLKVQEVKV SSSVLKAAAH HYGAQCDKPN KEFMLCRWEE
60 70 80 90 100
KDPRRCLEEG KLVNQCALEF FRQIKRHCAE PFTEYWTCID YSGLQLFRRC
110 120 130 140 150
RKQQAQFDEC VLDKLGWVRP DLGDLSKVTK VKTDRPLPEN PYHSRARPEP
160 170
NPEVEGDLKP ARHGSRLFFW TM
Length:172
Mass (Da):20,091
Last modified:January 23, 2007 - v2
Checksum:iC5EEB86E73BF22AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59697 mRNA. Translation: CAA42218.1.
BC105365 mRNA. Translation: AAI05366.1.
PIRiS16208.
RefSeqiNP_787020.1. NM_175826.4.
UniGeneiBt.59.

Genome annotation databases

EnsembliENSBTAT00000005628; ENSBTAP00000005628; ENSBTAG00000004295.
GeneIDi327710.
KEGGibta:327710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59697 mRNA. Translation: CAA42218.1.
BC105365 mRNA. Translation: AAI05366.1.
PIRiS16208.
RefSeqiNP_787020.1. NM_175826.4.
UniGeneiBt.59.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP42029. 1 interaction.
STRINGi9913.ENSBTAP00000005628.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiP42029.
PeptideAtlasiP42029.
PRIDEiP42029.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005628; ENSBTAP00000005628; ENSBTAG00000004295.
GeneIDi327710.
KEGGibta:327710.

Organism-specific databases

CTDi4702.

Phylogenomic databases

eggNOGiKOG3458. Eukaryota.
ENOG4111IST. LUCA.
GeneTreeiENSGT00390000008938.
HOGENOMiHOG000090856.
HOVERGENiHBG001244.
InParanoidiP42029.
KOiK03952.
OMAiYWTCLDY.
OrthoDBiEOG091G0M0S.
TreeFamiTF105633.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Gene expression databases

BgeeiENSBTAG00000004295.

Family and domain databases

InterProiIPR010625. CHCH.
IPR016680. NADH_Ub_cplx-1_asu_su-8.
[Graphical view]
PfamiPF06747. CHCH. 1 hit.
[Graphical view]
PIRSFiPIRSF017016. NDUA8. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUA8_BOVIN
AccessioniPrimary (citable) accession number: P42029
Secondary accession number(s): Q2KJF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.