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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Gene
N/A
Organism
Brassica oleracea (Wild cabbage)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi91Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi155Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi185Iron-sulfur (4Fe-4S)Sequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
OrganismiBrassica oleracea (Wild cabbage)
Taxonomic identifieri3712 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeBrassiceaeBrassica

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000020034? – 215NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Transit peptidei1 – ?Mitochondrion

Proteomic databases

PRIDEiP42027

Interactioni

Subunit structurei

Complex I is composed of about 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP42027
SMRiP42027
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 20 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

HAMAPiMF_01356 NDH1_NuoB, 1 hit
InterProiView protein in InterPro
IPR006137 NADH_UbQ_OxRdtase-like_20kDa
IPR006138 NADH_UQ_OxRdtase_20Kd_su
PfamiView protein in Pfam
PF01058 Oxidored_q6, 1 hit
TIGRFAMsiTIGR01957 nuoB_fam, 1 hit
PROSITEiView protein in PROSITE
PS01150 COMPLEX1_20K, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMITRNTAT RLPLVLQSHR AAAVSHLHTS LPALSPATTP TSYTRPGPPS
60 70 80 90 100
TSAPPPGLSK TAEFVISKVD DLMNWARRGS IWPMTFGLAC CAVEMMHTGA
110 120 130 140 150
ARYDLDRFGI IFRPSPRQSD CMIVAGTLTN KMAPALRKVY DQMPEPRWVI
160 170 180 190 200
SMGSCANGGG YYHYSYSVVR GCDRIVPVDI YVPGCPPTAE ALLYGLLQLQ
210
KKINRRKDFL HWWNK
Length:215
Mass (Da):23,839
Last modified:November 1, 1995 - v1
Checksum:iE39E62D038C11FC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82274 mRNA Translation: CAA57725.1
PIRiS48826
UniGeneiBol.682

Similar proteinsi

Entry informationi

Entry nameiNDUS7_BRAOL
AccessioniPrimary (citable) accession number: P42027
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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