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P42026 (NDUS7_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
Complex I-20kD
Short name=CI-20kD
NADH-ubiquinone oxidoreductase 20 kDa subunit
PSST subunit
Gene names
Name:NDUFS7
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. HAMAP-Rule MF_01356

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out). HAMAP-Rule MF_01356

NADH + acceptor = NAD+ + reduced acceptor. HAMAP-Rule MF_01356

Cofactor

Binds 1 4Fe-4S cluster Potential.

Subunit structure

Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.

Subcellular location

Mitochondrion HAMAP-Rule MF_01356.

Sequence similarities

Belongs to the complex I 20 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3737Mitochondrion HAMAP-Rule MF_01356
Chain38 – 216179NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial HAMAP-Rule MF_01356
PRO_0000020026

Sites

Metal binding911Iron-sulfur (4Fe-4S) Potential
Metal binding921Iron-sulfur (4Fe-4S) Potential
Metal binding1561Iron-sulfur (4Fe-4S) Potential
Metal binding1861Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
P42026 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 514B8A63C59BE641

FASTA21623,771
        10         20         30         40         50         60 
MAALAALRLL HPILAVRSGV GAALQVRGVH SSMAADSPSS TQPAVSQARA VVPKPAALPS 

        70         80         90        100        110        120 
SRGEYVVAKL DDLINWARRS SLWPMTFGLA CCAVEMMHMA APRYDMDRFG VVFRASPRQS 

       130        140        150        160        170        180 
DVMIVAGTLT NKMAPALRKV YDQMPEPRYV VSMGSCANGG GYYHYSYSVV RGCDRIVPVD 

       190        200        210 
IYVPGCPPTA EALLYGILQL QKKIKREKRL RIWYRR 

« Hide

References

« Hide 'large scale' references
[1]"NADH: ubiquinone oxidoreductase from bovine heart mitochondria. A fourth nuclear encoded subunit with a homologue encoded in chloroplast genomes."
Arizmendi J.M., Runswick M.J., Skehel J.M., Walker J.E.
FEBS Lett. 301:237-242(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Heart.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X65020 mRNA. Translation: CAA46154.1.
BC109716 mRNA. Translation: AAI09717.1.
PIRS22371.
RefSeqNP_001033111.1. NM_001038022.1.
XP_005209312.1. XM_005209255.1.
XP_005209313.1. XM_005209256.1.
UniGeneBt.315.

3D structure databases

ProteinModelPortalP42026.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP42026. 2 interactions.

Protein family/group databases

TCDB3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbP42026.
PRIDEP42026.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000025870; ENSBTAP00000025870; ENSBTAG00000019419.
GeneID338079.
KEGGbta:338079.

Organism-specific databases

CTD374291.

Phylogenomic databases

eggNOGCOG0377.
GeneTreeENSGT00390000006565.
HOGENOMHOG000228249.
HOVERGENHBG001576.
InParanoidP42026.
KOK03940.
OMAKLRIWYR.
TreeFamTF312859.

Family and domain databases

Gene3D3.40.50.700. 1 hit.
HAMAPMF_01356. NDH1_NuoB.
InterProIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view]
PfamPF01058. Oxidored_q6. 1 hit.
[Graphical view]
TIGRFAMsTIGR01957. nuoB_fam. 1 hit.
PROSITEPS01150. COMPLEX1_20K. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20812528.

Entry information

Entry nameNDUS7_BOVIN
AccessionPrimary (citable) accession number: P42026
Secondary accession number(s): Q2TBS6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families