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P42026

- NDUS7_BOVIN

UniProt

P42026 - NDUS7_BOVIN

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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Gene

NDUFS7

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

Binds 1 4Fe-4S cluster.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi91 – 911Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi92 – 921Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi156 – 1561Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi186 – 1861Iron-sulfur (4Fe-4S)Sequence Analysis

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  4. quinone binding Source: InterPro

GO - Biological processi

  1. mitochondrial respiratory chain complex I assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiREACT_223064. Respiratory electron transport.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-20kD
Short name:
CI-20kD
NADH-ubiquinone oxidoreductase 20 kDa subunit
PSST subunit
Gene namesi
Name:NDUFS7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 7

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3737MitochondrionAdd
BLAST
Chaini38 – 216179NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialPRO_0000020026Add
BLAST

Proteomic databases

PaxDbiP42026.
PRIDEiP42026.

Expressioni

Gene expression databases

ExpressionAtlasiP42026. baseline.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.

Protein-protein interaction databases

IntActiP42026. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP42026.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 20 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0377.
GeneTreeiENSGT00390000006565.
HOGENOMiHOG000228249.
HOVERGENiHBG001576.
InParanoidiP42026.
KOiK03940.
OMAiQVRGVHS.
TreeFamiTF312859.

Family and domain databases

Gene3Di3.40.50.700. 1 hit.
HAMAPiMF_01356. NDH1_NuoB.
InterProiIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view]
PfamiPF01058. Oxidored_q6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01957. nuoB_fam. 1 hit.
PROSITEiPS01150. COMPLEX1_20K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42026-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAALAALRLL HPILAVRSGV GAALQVRGVH SSMAADSPSS TQPAVSQARA
60 70 80 90 100
VVPKPAALPS SRGEYVVAKL DDLINWARRS SLWPMTFGLA CCAVEMMHMA
110 120 130 140 150
APRYDMDRFG VVFRASPRQS DVMIVAGTLT NKMAPALRKV YDQMPEPRYV
160 170 180 190 200
VSMGSCANGG GYYHYSYSVV RGCDRIVPVD IYVPGCPPTA EALLYGILQL
210
QKKIKREKRL RIWYRR
Length:216
Mass (Da):23,771
Last modified:November 1, 1995 - v1
Checksum:i514B8A63C59BE641
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65020 mRNA. Translation: CAA46154.1.
BC109716 mRNA. Translation: AAI09717.1.
PIRiS22371.
RefSeqiNP_001033111.1. NM_001038022.1.
XP_005209312.1. XM_005209255.1.
XP_005209313.1. XM_005209256.1.
UniGeneiBt.315.

Genome annotation databases

EnsembliENSBTAT00000025870; ENSBTAP00000025870; ENSBTAG00000019419.
GeneIDi338079.
KEGGibta:338079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65020 mRNA. Translation: CAA46154.1 .
BC109716 mRNA. Translation: AAI09717.1 .
PIRi S22371.
RefSeqi NP_001033111.1. NM_001038022.1.
XP_005209312.1. XM_005209255.1.
XP_005209313.1. XM_005209256.1.
UniGenei Bt.315.

3D structure databases

ProteinModelPortali P42026.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P42026. 2 interactions.

Protein family/group databases

TCDBi 3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbi P42026.
PRIDEi P42026.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000025870 ; ENSBTAP00000025870 ; ENSBTAG00000019419 .
GeneIDi 338079.
KEGGi bta:338079.

Organism-specific databases

CTDi 374291.

Phylogenomic databases

eggNOGi COG0377.
GeneTreei ENSGT00390000006565.
HOGENOMi HOG000228249.
HOVERGENi HBG001576.
InParanoidi P42026.
KOi K03940.
OMAi QVRGVHS.
TreeFami TF312859.

Enzyme and pathway databases

Reactomei REACT_223064. Respiratory electron transport.

Miscellaneous databases

NextBioi 20812528.

Gene expression databases

ExpressionAtlasi P42026. baseline.

Family and domain databases

Gene3Di 3.40.50.700. 1 hit.
HAMAPi MF_01356. NDH1_NuoB.
InterProi IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view ]
Pfami PF01058. Oxidored_q6. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01957. nuoB_fam. 1 hit.
PROSITEi PS01150. COMPLEX1_20K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NADH: ubiquinone oxidoreductase from bovine heart mitochondria. A fourth nuclear encoded subunit with a homologue encoded in chloroplast genomes."
    Arizmendi J.M., Runswick M.J., Skehel J.M., Walker J.E.
    FEBS Lett. 301:237-242(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Heart.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiNDUS7_BOVIN
AccessioniPrimary (citable) accession number: P42026
Secondary accession number(s): Q2TBS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3