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P42026

- NDUS7_BOVIN

UniProt

P42026 - NDUS7_BOVIN

Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Gene

NDUFS7

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    Cofactori

    Binds 1 4Fe-4S cluster.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi91 – 911Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi92 – 921Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi156 – 1561Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi186 – 1861Iron-sulfur (4Fe-4S)Sequence Analysis

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    4. quinone binding Source: InterPro

    GO - Biological processi

    1. mitochondrial respiratory chain complex I assembly Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

    Enzyme and pathway databases

    ReactomeiREACT_223064. Respiratory electron transport.

    Protein family/group databases

    TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    Complex I-20kD
    Short name:
    CI-20kD
    NADH-ubiquinone oxidoreductase 20 kDa subunit
    PSST subunit
    Gene namesi
    Name:NDUFS7
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 7

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex I Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3737MitochondrionAdd
    BLAST
    Chaini38 – 216179NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialPRO_0000020026Add
    BLAST

    Proteomic databases

    PaxDbiP42026.
    PRIDEiP42026.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.

    Protein-protein interaction databases

    IntActiP42026. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP42026.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 20 kDa subunit family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0377.
    GeneTreeiENSGT00390000006565.
    HOGENOMiHOG000228249.
    HOVERGENiHBG001576.
    InParanoidiP42026.
    KOiK03940.
    OMAiQVRGVHS.
    TreeFamiTF312859.

    Family and domain databases

    Gene3Di3.40.50.700. 1 hit.
    HAMAPiMF_01356. NDH1_NuoB.
    InterProiIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
    IPR006138. NADH_UQ_OxRdtase_20Kd_su.
    [Graphical view]
    PfamiPF01058. Oxidored_q6. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01957. nuoB_fam. 1 hit.
    PROSITEiPS01150. COMPLEX1_20K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P42026-1 [UniParc]FASTAAdd to Basket

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    MAALAALRLL HPILAVRSGV GAALQVRGVH SSMAADSPSS TQPAVSQARA    50
    VVPKPAALPS SRGEYVVAKL DDLINWARRS SLWPMTFGLA CCAVEMMHMA 100
    APRYDMDRFG VVFRASPRQS DVMIVAGTLT NKMAPALRKV YDQMPEPRYV 150
    VSMGSCANGG GYYHYSYSVV RGCDRIVPVD IYVPGCPPTA EALLYGILQL 200
    QKKIKREKRL RIWYRR 216
    Length:216
    Mass (Da):23,771
    Last modified:November 1, 1995 - v1
    Checksum:i514B8A63C59BE641
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65020 mRNA. Translation: CAA46154.1.
    BC109716 mRNA. Translation: AAI09717.1.
    PIRiS22371.
    RefSeqiNP_001033111.1. NM_001038022.1.
    XP_005209312.1. XM_005209255.1.
    XP_005209313.1. XM_005209256.1.
    UniGeneiBt.315.

    Genome annotation databases

    EnsembliENSBTAT00000025870; ENSBTAP00000025870; ENSBTAG00000019419.
    GeneIDi338079.
    KEGGibta:338079.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65020 mRNA. Translation: CAA46154.1 .
    BC109716 mRNA. Translation: AAI09717.1 .
    PIRi S22371.
    RefSeqi NP_001033111.1. NM_001038022.1.
    XP_005209312.1. XM_005209255.1.
    XP_005209313.1. XM_005209256.1.
    UniGenei Bt.315.

    3D structure databases

    ProteinModelPortali P42026.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P42026. 2 interactions.

    Protein family/group databases

    TCDBi 3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

    Proteomic databases

    PaxDbi P42026.
    PRIDEi P42026.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000025870 ; ENSBTAP00000025870 ; ENSBTAG00000019419 .
    GeneIDi 338079.
    KEGGi bta:338079.

    Organism-specific databases

    CTDi 374291.

    Phylogenomic databases

    eggNOGi COG0377.
    GeneTreei ENSGT00390000006565.
    HOGENOMi HOG000228249.
    HOVERGENi HBG001576.
    InParanoidi P42026.
    KOi K03940.
    OMAi QVRGVHS.
    TreeFami TF312859.

    Enzyme and pathway databases

    Reactomei REACT_223064. Respiratory electron transport.

    Miscellaneous databases

    NextBioi 20812528.

    Family and domain databases

    Gene3Di 3.40.50.700. 1 hit.
    HAMAPi MF_01356. NDH1_NuoB.
    InterProi IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
    IPR006138. NADH_UQ_OxRdtase_20Kd_su.
    [Graphical view ]
    Pfami PF01058. Oxidored_q6. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01957. nuoB_fam. 1 hit.
    PROSITEi PS01150. COMPLEX1_20K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NADH: ubiquinone oxidoreductase from bovine heart mitochondria. A fourth nuclear encoded subunit with a homologue encoded in chloroplast genomes."
      Arizmendi J.M., Runswick M.J., Skehel J.M., Walker J.E.
      FEBS Lett. 301:237-242(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Heart.
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.

    Entry informationi

    Entry nameiNDUS7_BOVIN
    AccessioniPrimary (citable) accession number: P42026
    Secondary accession number(s): Q2TBS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3