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Protein

Beta-centractin

Gene

ACTR1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2132295. MHC class II antigen presentation.
R-HSA-6798695. Neutrophil degranulation.
SignaLinkiP42025.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-centractin
Alternative name(s):
Actin-related protein 1B
Short name:
ARP1B
Gene namesi
Name:ACTR1B
Synonyms:CTRN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115073.7.
HGNCiHGNC:168. ACTR1B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi10120.
MalaCardsiACTR1B.
OpenTargetsiENSG00000115073.
PharmGKBiPA24487.

Polymorphism and mutation databases

BioMutaiACTR1B.
DMDMi1168333.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000890601 – 376Beta-centractinAdd BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei4Nitrated tyrosineBy similarity1

Keywords - PTMi

Acetylation, Nitration

Proteomic databases

EPDiP42025.
MaxQBiP42025.
PaxDbiP42025.
PeptideAtlasiP42025.
PRIDEiP42025.

2D gel databases

OGPiP42025.
REPRODUCTION-2DPAGEiIPI00029469.

PTM databases

iPTMnetiP42025.
PhosphoSitePlusiP42025.

Expressioni

Gene expression databases

BgeeiENSG00000115073.
CleanExiHS_ACTR1B.
GenevisibleiP42025. HS.

Organism-specific databases

HPAiHPA047443.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115424. 60 interactors.
IntActiP42025. 17 interactors.
MINTiMINT-1374548.
STRINGi9606.ENSP00000289228.

Structurei

3D structure databases

ProteinModelPortaliP42025.
SMRiP42025.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00840000129754.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiP42025.
KOiK16575.
OMAiVFAIHKS.
OrthoDBiEOG091G08LD.
PhylomeDBiP42025.
TreeFamiTF300420.

Family and domain databases

InterProiView protein in InterPro
IPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR029909. Arp1.
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF273. PTHR11937:SF273. 1 hit.
PfamiView protein in Pfam
PF00022. Actin. 1 hit.
PRINTSiPR00190. ACTIN.
SMARTiView protein in SMART
SM00268. ACTIN. 1 hit.
PROSITEiView protein in PROSITE
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

P42025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESYDIIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHMRVMAG
60 70 80 90 100
ALEGDLFIGP KAEEHRGLLT IRYPMEHGVV RDWNDMERIW QYVYSKDQLQ
110 120 130 140 150
TFSEEHPVLL TEAPLNPSKN REKAAEVFFE TFNVPALFIS MQAVLSLYAT
160 170 180 190 200
GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI MRVDIAGRDV SRYLRLLLRK
210 220 230 240 250
EGVDFHTSAE FEVVRTIKER ACYLSINPQK DEALETEKVQ YTLPDGSTLD
260 270 280 290 300
VGPARFRAPE LLFQPDLVGD ESEGLHEVVA FAIHKSDMDL RRTLFANIVL
310 320 330 340 350
SGGSTLFKGF GDRLLSEVKK LAPKDIKIKI SAPQERLYST WIGGSILASL
360 370
DTFKKMWVSK KEYEEDGSRA IHRKTF
Length:376
Mass (Da):42,293
Last modified:November 1, 1995 - v1
Checksum:i24C24ECEE18B83BD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02531593V → A1 PublicationCorresponds to variant dbSNP:rs11547231Ensembl.1
Natural variantiVAR_048187143A → V. Corresponds to variant dbSNP:rs11692435Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82207 mRNA. Translation: CAA57691.1.
AC017099 Genomic DNA. Translation: AAY24280.1.
CH471127 Genomic DNA. Translation: EAX01924.1.
CH471127 Genomic DNA. Translation: EAX01927.1.
BC004374 mRNA. Translation: AAH04374.1.
BC006372 mRNA. Translation: AAH06372.1.
BC010090 mRNA. Translation: AAH10090.1.
CCDSiCCDS2033.1.
RefSeqiNP_005726.1. NM_005735.3.
UniGeneiHs.98791.

Genome annotation databases

EnsembliENST00000289228; ENSP00000289228; ENSG00000115073.
GeneIDi10120.
KEGGihsa:10120.
UCSCiuc002syb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiACTY_HUMAN
AccessioniPrimary (citable) accession number: P42025
Secondary accession number(s): D3DVH2, Q53SK5, Q9BRB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 27, 2017
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families