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Protein

Beta-centractin

Gene

ACTR1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2132295. MHC class II antigen presentation.
SignaLinkiP42025.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-centractin
Alternative name(s):
Actin-related protein 1B
Short name:
ARP1B
Gene namesi
Name:ACTR1B
Synonyms:CTRN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:168. ACTR1B.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: LIFEdb
  • cytosol Source: Reactome
  • dynactin complex Source: ProtInc
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • microtubule cytoskeleton Source: HPA
  • microtubule end Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24487.

Polymorphism and mutation databases

BioMutaiACTR1B.
DMDMi1168333.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Beta-centractinPRO_0000089060Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei4 – 41Nitrated tyrosineBy similarity

Keywords - PTMi

Acetylation, Nitration

Proteomic databases

EPDiP42025.
MaxQBiP42025.
PaxDbiP42025.
PeptideAtlasiP42025.
PRIDEiP42025.

2D gel databases

OGPiP42025.
REPRODUCTION-2DPAGEIPI00029469.

PTM databases

iPTMnetiP42025.
PhosphoSiteiP42025.

Expressioni

Gene expression databases

BgeeiP42025.
CleanExiHS_ACTR1B.
GenevisibleiP42025. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Actr10Q9QZB72EBI-367493,EBI-367600From a different organism.
DCTN1Q142033EBI-367493,EBI-724352

Protein-protein interaction databases

BioGridi115424. 57 interactions.
IntActiP42025. 16 interactions.
MINTiMINT-1374548.
STRINGi9606.ENSP00000289228.

Structurei

3D structure databases

ProteinModelPortaliP42025.
SMRiP42025. Positions 7-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00840000129754.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiP42025.
KOiK16575.
OMAiDEWHENP.
OrthoDBiEOG72G17C.
PhylomeDBiP42025.
TreeFamiTF300420.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR029909. Arp1.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF195. PTHR11937:SF195. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESYDIIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHMRVMAG
60 70 80 90 100
ALEGDLFIGP KAEEHRGLLT IRYPMEHGVV RDWNDMERIW QYVYSKDQLQ
110 120 130 140 150
TFSEEHPVLL TEAPLNPSKN REKAAEVFFE TFNVPALFIS MQAVLSLYAT
160 170 180 190 200
GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI MRVDIAGRDV SRYLRLLLRK
210 220 230 240 250
EGVDFHTSAE FEVVRTIKER ACYLSINPQK DEALETEKVQ YTLPDGSTLD
260 270 280 290 300
VGPARFRAPE LLFQPDLVGD ESEGLHEVVA FAIHKSDMDL RRTLFANIVL
310 320 330 340 350
SGGSTLFKGF GDRLLSEVKK LAPKDIKIKI SAPQERLYST WIGGSILASL
360 370
DTFKKMWVSK KEYEEDGSRA IHRKTF
Length:376
Mass (Da):42,293
Last modified:November 1, 1995 - v1
Checksum:i24C24ECEE18B83BD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti93 – 931V → A.1 Publication
Corresponds to variant rs11547231 [ dbSNP | Ensembl ].
VAR_025315
Natural varianti143 – 1431A → V.
Corresponds to variant rs11692435 [ dbSNP | Ensembl ].
VAR_048187

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82207 mRNA. Translation: CAA57691.1.
AC017099 Genomic DNA. Translation: AAY24280.1.
CH471127 Genomic DNA. Translation: EAX01924.1.
CH471127 Genomic DNA. Translation: EAX01927.1.
BC004374 mRNA. Translation: AAH04374.1.
BC006372 mRNA. Translation: AAH06372.1.
BC010090 mRNA. Translation: AAH10090.1.
CCDSiCCDS2033.1.
RefSeqiNP_005726.1. NM_005735.3.
UniGeneiHs.98791.

Genome annotation databases

EnsembliENST00000289228; ENSP00000289228; ENSG00000115073.
GeneIDi10120.
KEGGihsa:10120.
UCSCiuc002syb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82207 mRNA. Translation: CAA57691.1.
AC017099 Genomic DNA. Translation: AAY24280.1.
CH471127 Genomic DNA. Translation: EAX01924.1.
CH471127 Genomic DNA. Translation: EAX01927.1.
BC004374 mRNA. Translation: AAH04374.1.
BC006372 mRNA. Translation: AAH06372.1.
BC010090 mRNA. Translation: AAH10090.1.
CCDSiCCDS2033.1.
RefSeqiNP_005726.1. NM_005735.3.
UniGeneiHs.98791.

3D structure databases

ProteinModelPortaliP42025.
SMRiP42025. Positions 7-376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115424. 57 interactions.
IntActiP42025. 16 interactions.
MINTiMINT-1374548.
STRINGi9606.ENSP00000289228.

PTM databases

iPTMnetiP42025.
PhosphoSiteiP42025.

Polymorphism and mutation databases

BioMutaiACTR1B.
DMDMi1168333.

2D gel databases

OGPiP42025.
REPRODUCTION-2DPAGEIPI00029469.

Proteomic databases

EPDiP42025.
MaxQBiP42025.
PaxDbiP42025.
PeptideAtlasiP42025.
PRIDEiP42025.

Protocols and materials databases

DNASUi10120.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289228; ENSP00000289228; ENSG00000115073.
GeneIDi10120.
KEGGihsa:10120.
UCSCiuc002syb.3. human.

Organism-specific databases

CTDi10120.
GeneCardsiACTR1B.
HGNCiHGNC:168. ACTR1B.
MIMi605144. gene.
neXtProtiNX_P42025.
PharmGKBiPA24487.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00840000129754.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiP42025.
KOiK16575.
OMAiDEWHENP.
OrthoDBiEOG72G17C.
PhylomeDBiP42025.
TreeFamiTF300420.

Enzyme and pathway databases

ReactomeiR-HSA-2132295. MHC class II antigen presentation.
SignaLinkiP42025.

Miscellaneous databases

ChiTaRSiACTR1B. human.
GeneWikiiACTR1B.
GenomeRNAii10120.
NextBioi38279.
PROiP42025.
SOURCEiSearch...

Gene expression databases

BgeeiP42025.
CleanExiHS_ACTR1B.
GenevisibleiP42025. HS.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR029909. Arp1.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF195. PTHR11937:SF195. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins."
    Clark S.W., Staub O., Holzbaur E.L.F., Paschal B.M., Vallee R.B., Meyer D.I., Clark I.B.
    Mol. Biol. Cell 5:1301-1310(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-93.
    Tissue: Lymph and Placenta.
  5. Lubec G., Afjehi-Sadat L.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 239-255, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain and Cajal-Retzius cell.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiACTY_HUMAN
AccessioniPrimary (citable) accession number: P42025
Secondary accession number(s): D3DVH2, Q53SK5, Q9BRB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.