Reviewed, UniProtKB/Swiss-Prot P42025 (ACTY_HUMAN)

Names and origin

Protein names

Recommended name:
    Beta-centractin
Alternative name(s):
    Actin-related protein 1B
      Short name=ARP1B

Gene names

Name:	ACTR1B
Synonyms:	CTRN2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.
Subcellular location	Cytoplasm › cytoskeleton. Cytoplasm › cytoskeleton › centrosome.
Sequence similarities	Belongs to the actin family. ARP1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Cellular component	centrosome Inferred from electronic annotation. Source: UniProtKB-SubCell dynactin complex Ref.1 Traceable author statement. Source: ProtInc
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Actr10	Q9QZB7	1	EBI-367493,EBI-367600	From a different organism.
DCTN1	Q14203	1	EBI-367493,EBI-724352

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Beta-centractin		PRO_0000089060
Natural variations
	Natural variant	93	1	V → A: dbSNP rs11547231. Ref.3		VAR_025315
	Natural variant	143	1	A → V: dbSNP rs11692435.		VAR_048187

Sequences

	Sequence		Length	Mass (Da)
	P42025-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 24C24ECEE18B83BD	FASTA	376	42,293
	10 20 30 40 50 60 MESYDIIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHMRVMAG ALEGDLFIGP 70 80 90 100 110 120 KAEEHRGLLT IRYPMEHGVV RDWNDMERIW QYVYSKDQLQ TFSEEHPVLL TEAPLNPSKN 130 140 150 160 170 180 REKAAEVFFE TFNVPALFIS MQAVLSLYAT GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI 190 200 210 220 230 240 MRVDIAGRDV SRYLRLLLRK EGVDFHTSAE FEVVRTIKER ACYLSINPQK DEALETEKVQ 250 260 270 280 290 300 YTLPDGSTLD VGPARFRAPE LLFQPDLVGD ESEGLHEVVA FAIHKSDMDL RRTLFANIVL 310 320 330 340 350 360 SGGSTLFKGF GDRLLSEVKK LAPKDIKIKI SAPQERLYST WIGGSILASL DTFKKMWVSK 370 KEYEEDGSRA IHRKTF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins." Clark S.W., Staub O., Holzbaur E.L.F., Paschal B.M., Vallee R.B., Meyer D.I., Clark I.B. Mol. Biol. Cell 5:1301-1310(1994) [PubMed: 7696711] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-93. Tissue: Lymph and Placenta.
[4]	Lubec G., Afjehi-Sadat L. Submitted (MAR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 239-255, MASS SPECTROMETRY. Tissue: Brain and Cajal-Retzius cell.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X82207 mRNA. Translation: CAA57691.1. AC017099 Genomic DNA. Translation: AAY24280.1. BC004374 mRNA. Translation: AAH04374.1. BC006372 mRNA. Translation: AAH06372.1. BC010090 mRNA. Translation: AAH10090.1.
IPI	IPI00029469.
RefSeq	NP_005726.1.
UniGene	Hs.98791
3D structure databases
HSSP	HSSP built from PDB template 1NM1 based on UniProtKB P02577.
ModBase	Search...
Protein-protein interaction databases
IntAct	P42025. 4 interactions.
STRING	P42025.
PTM databases
PhosphoSite	P42025.
2-D gel databases
OGP	P42025.
REPRODUCTION-2DPAGE	IPI00029469.
Proteomic databases
PeptideAtlas	P42025.
PRIDE	P42025.
Genome annotation databases
Ensembl	ENST00000289228; ENSP00000289228; ENSG00000115073; Homo sapiens. [Genome view] ENST00000451664; ENSP00000408202; ENSG00000115073; Homo sapiens. [Genome view]
GeneID	10120.
KEGG	hsa:10120.
UCSC	uc002syb.1. human.
Organism-specific databases
CTD	10120.
GeneCards	GC02M097730.
H-InvDB	HIX0002291.
HGNC	HGNC:168. ACTR1B.
MIM	605144. gene.
PharmGKB	PA24487.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P42025.
HOVERGEN	P42025.
OMA	XFGDRLL.
Gene expression databases
ArrayExpress	P42025.
Bgee	P42025.
CleanEx	HS_ACTR1B.
Genevestigator	P42025.
GermOnline	ENSG00000115073. Homo sapiens.
Family and domain databases
InterPro	IPR004000. Actin-like. IPR004001. Actin_CS. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00432. ACTINS_2. 1 hit. PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	38279.
SOURCE	Search...

Entry information

Entry name

ACTY_HUMAN

Accession

Primary (citable) accession number: P42025
Secondary accession number(s): Q53SK5, Q9BRB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 3, 2009
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.