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P41996

- CPG2_CAEEL

UniProt

P41996 - CPG2_CAEEL

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Protein

Chondroitin proteoglycan-2

Gene
cpg-2, B0280.5
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin.4 Publications

GO - Molecular functioni

  1. chitin binding Source: UniProtKB

GO - Biological processi

  1. chitin metabolic process Source: InterPro
  2. eggshell formation Source: UniProtKB
  3. embryo development Source: UniProtKB
  4. mitotic cytokinesis Source: UniProtKB
  5. regulation of cytokinesis Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

Chitin-binding

Protein family/group databases

CAZyiCBM14. Carbohydrate-Binding Module Family 14.

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroitin proteoglycan-2
Alternative name(s):
Cytokinesis protein B0280.5
Gene namesi
Name:cpg-2
ORF Names:B0280.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiB0280.5; CE31868; WBGene00015102; cpg-2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Worms lacking cpg-2 and cpg-1 exhibit defects in cytokinesis during embryo development more specifically meiotic chromosome segregation, polar-body extrusion, osmotic barrier function and polarization. Embryos lacking cpg-2 and cpg-1 proteins have multiple nuclei lacking plasma membranes and may also have weak egg shells. Oocytes lacking cpg-2 and cpg-1 show cortical granules that are reduced in size.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 524506Chondroitin proteoglycan-2PRO_0000023617Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 67 By similarity
Glycosylationi103 – 1031O-linked (Xyl...) (chondroitin sulfate)1 Publication
Glycosylationi119 – 1191O-linked (Xyl...) (chondroitin sulfate)1 Publication
Disulfide bondi168 ↔ 181 By similarity
Glycosylationi208 – 2081O-linked (Xyl...) (chondroitin sulfate)1 Publication
Glycosylationi212 – 2121O-linked (Xyl...) (chondroitin sulfate)1 Publication
Disulfide bondi277 ↔ 290 By similarity
Disulfide bondi337 ↔ 350 By similarity
Glycosylationi355 – 3551N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi432 ↔ 445 By similarity
Glycosylationi497 – 4971N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi500 ↔ 514 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiP41996.

Expressioni

Tissue specificityi

Expressed in the germline.1 Publication

Developmental stagei

Expressed throughout development but appears to be up-regulated in adults.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi41203. 1 interaction.
MINTiMINT-1061878.
STRINGi6239.B0280.5.

Structurei

3D structure databases

ProteinModelPortaliP41996.
SMRiP41996. Positions 27-80, 138-192, 251-295, 309-358, 415-451.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 7858Chitin-binding type-2 1Add
BLAST
Domaini135 – 19258Chitin-binding type-2 2Add
BLAST
Domaini244 – 30158Chitin-binding type-2 3Add
BLAST
Domaini306 – 36156Chitin-binding type-2 4Add
BLAST
Domaini400 – 45657Chitin-binding type-2 5Add
BLAST
Domaini469 – 52456Chitin-binding type-2 6Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi75 – 258184Gly-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG241358.
GeneTreeiENSGT00650000093766.
HOGENOMiHOG000017714.
InParanoidiP41996.
OMAiFDCSTDG.
PhylomeDBiP41996.

Family and domain databases

Gene3Di2.170.140.10. 5 hits.
InterProiIPR002557. Chitin-bd_dom.
[Graphical view]
PfamiPF01607. CBM_14. 6 hits.
[Graphical view]
SMARTiSM00494. ChtBD2. 6 hits.
[Graphical view]
SUPFAMiSSF57625. SSF57625. 6 hits.
PROSITEiPS50940. CHIT_BIND_II. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41996-1 [UniParc]FASTAAdd to Basket

« Hide

MKTVAALTLL AFATAANGQF LQDCTNALDG LYALGECEPQ FLTCSGGIAR    50
IMDCPADLIY NEPLLICDWR HNVIGCEGSG ESSGETSGEG SGESSGEASG 100
EGSGEASGEG SGEASGEGSG EASGEGSGSG EETVENVCEN LEDGAYSSGG 150
CTTYYFFCTT NTARFLSCPT PLFYDADSQK CIWKSLVEEC KEDLTITDGS 200
GETSGEGSGE ASGEASGEGS GEASGESSGQ GSGEASGEGS GELEPTCEGK 250
ADGIHPNGVC STNFLTCSGG IARIMDCPAS LVFNPTILVC DWPRDVAECA 300
GLPTPQPTCE EDGYFSFGQC SSSFTACTNG RAIVMFCPAG LKFSESTVRC 350
DYESNVSECQ ETSGEESGEA SGEQSGEGSG EASGEASGES SGEGSGVEEQ 400
NQCVGLDNGL HAIGCSPRVL SCQNGHVDIF ECPSSLVFND QSLICDYPQT 450
SLKCLIEDTI LIDETPIAAF DCSTDGLFSD GLCSATYHQC TAGQLINFTC 500
AASNAVFSAA NTECVDSSTL LQCH 524
Length:524
Mass (Da):53,652
Last modified:August 15, 2003 - v3
Checksum:iFFCB9A750385FB34
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ340624 mRNA. Translation: ABC65812.1.
FO080148 Genomic DNA. Translation: CCD61602.1.
PIRiT15299.
RefSeqiNP_498551.3. NM_066150.10.
UniGeneiCel.17405.

Genome annotation databases

EnsemblMetazoaiB0280.5; B0280.5; WBGene00015102.
GeneIDi175991.
KEGGicel:CELE_B0280.5.
UCSCiB0280.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ340624 mRNA. Translation: ABC65812.1 .
FO080148 Genomic DNA. Translation: CCD61602.1 .
PIRi T15299.
RefSeqi NP_498551.3. NM_066150.10.
UniGenei Cel.17405.

3D structure databases

ProteinModelPortali P41996.
SMRi P41996. Positions 27-80, 138-192, 251-295, 309-358, 415-451.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 41203. 1 interaction.
MINTi MINT-1061878.
STRINGi 6239.B0280.5.

Protein family/group databases

CAZyi CBM14. Carbohydrate-Binding Module Family 14.

Proteomic databases

PaxDbi P41996.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai B0280.5 ; B0280.5 ; WBGene00015102 .
GeneIDi 175991.
KEGGi cel:CELE_B0280.5.
UCSCi B0280.5. c. elegans.

Organism-specific databases

CTDi 175991.
WormBasei B0280.5 ; CE31868 ; WBGene00015102 ; cpg-2.

Phylogenomic databases

eggNOGi NOG241358.
GeneTreei ENSGT00650000093766.
HOGENOMi HOG000017714.
InParanoidi P41996.
OMAi FDCSTDG.
PhylomeDBi P41996.

Miscellaneous databases

NextBioi 890638.

Family and domain databases

Gene3Di 2.170.140.10. 5 hits.
InterProi IPR002557. Chitin-bd_dom.
[Graphical view ]
Pfami PF01607. CBM_14. 6 hits.
[Graphical view ]
SMARTi SM00494. ChtBD2. 6 hits.
[Graphical view ]
SUPFAMi SSF57625. SSF57625. 6 hits.
PROSITEi PS50940. CHIT_BIND_II. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2."
    Olson S.K., Bishop J.R., Yates J.R., Oegema K., Esko J.D.
    J. Cell Biol. 173:985-994(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, GLYCOSYLATION AT SER-103; SER-119; SER-208 AND SER-212, FUNCTION, DISRUPTION PHENOTYPE.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  4. "Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell development."
    Lee M.-H., Schedl T.
    Genes Dev. 15:2408-2420(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "The eggshell is required for meiotic fidelity, polar-body extrusion and polarization of the C. elegans embryo."
    Johnston W.L., Krizus A., Dennis J.W.
    BMC Biol. 4:35-35(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Cortical granule exocytosis in C. elegans is regulated by cell cycle components including separase."
    Bembenek J.N., Richie C.T., Squirrell J.M., Campbell J.M., Eliceiri K.W., Poteryaev D., Spang A., Golden A., White J.G.
    Development 134:3837-3848(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCPG2_CAEEL
AccessioniPrimary (citable) accession number: P41996
Secondary accession number(s): Q1A3T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 15, 2003
Last modified: June 11, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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