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P41992

- GGTB2_CAEEL

UniProt

P41992 - GGTB2_CAEEL

Protein

Probable geranylgeranyl transferase type-2 subunit beta

Gene

ggtb-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (06 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal.By similarity

    Catalytic activityi

    Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi244 – 2441ZincBy similarity
    Metal bindingi244 – 2441Zinc; catalyticBy similarity
    Metal bindingi246 – 2461ZincBy similarity
    Metal bindingi246 – 2461Zinc; catalyticBy similarity
    Metal bindingi296 – 2961ZincBy similarity
    Metal bindingi296 – 2961Zinc; via tele nitrogen; catalyticBy similarity

    GO - Molecular functioni

    1. Rab geranylgeranyltransferase activity Source: UniProtKB
    2. Rab GTPase binding Source: UniProtKB
    3. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. protein geranylgeranylation Source: UniProtKB

    Keywords - Molecular functioni

    Prenyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable geranylgeranyl transferase type-2 subunit beta (EC:2.5.1.60)
    Alternative name(s):
    Geranylgeranyl transferase type II subunit beta
    Short name:
    GGTase-II-beta
    Rab geranyl-geranyltransferase subunit beta
    Short name:
    Rab GG transferase beta
    Short name:
    Rab GGTase beta
    Rab geranylgeranyltransferase subunit beta
    Type II protein geranyl-geranyltransferase subunit beta
    Gene namesi
    Name:ggtb-1
    ORF Names:B0280.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiB0280.1a; CE24762; WBGene00015099; ggtb-1.
    B0280.1b; CE00735; WBGene00015099; ggtb-1.

    Subcellular locationi

    GO - Cellular componenti

    1. Rab-protein geranylgeranyltransferase complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Probable geranylgeranyl transferase type-2 subunit betaPRO_0000119766Add
    BLAST

    Proteomic databases

    PaxDbiP41992.
    PRIDEiP41992.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit.By similarity

    Protein-protein interaction databases

    STRINGi6239.B0280.1a.

    Structurei

    3D structure databases

    ProteinModelPortaliP41992.
    SMRiP41992. Positions 11-326.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati74 – 11542PFTB 1Add
    BLAST
    Repeati122 – 16342PFTB 2Add
    BLAST
    Repeati170 – 21142PFTB 3Add
    BLAST
    Repeati218 – 25942PFTB 4Add
    BLAST
    Repeati266 – 31247PFTB 5Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni196 – 1983Geranylgeranyl diphosphate bindingBy similarity
    Regioni238 – 25013Geranylgeranyl diphosphate bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 5 PFTB repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5029.
    GeneTreeiENSGT00530000063392.
    HOGENOMiHOG000180334.
    InParanoidiP41992.
    KOiK05956.
    OMAiSWSTHAH.
    OrthoDBiEOG7XSTDZ.
    PhylomeDBiP41992.

    Family and domain databases

    Gene3Di1.50.10.20. 1 hit.
    InterProiIPR001330. Prenyltrans.
    IPR026873. Ptb1.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PANTHERiPTHR11774:SF9. PTHR11774:SF9. 1 hit.
    PfamiPF00432. Prenyltrans. 5 hits.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: P41992-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSFAGLLDFA RKDVDLPQNS PNELLKDLHA NFINQYEKNK NSYHYIMAEH    50
    LRVSGIYWCV NAMDLSKQLE RMSTEEIVNY VLGCRNTDGG YGPAPGHDSH 100
    LLHTLCAVQT LIIFNSIEKA DADTISEYVK GLQQEDGSFC GDLSGEVDTR 150
    FTLCSLATCH LLGRLSTLNI DSAVRFLMRC YNTDGGFGTR PGSESHSGQI 200
    YCCVGALAIA GRLDEIDRDR TAEWLAFRQC DSGGLNGRPE KLPDVCYSWW 250
    VLASLAILGR LNFIDSDAMK KFIYACQDDE TGGFADRPGD CADPFHTVFG 300
    IAALSLFGDD TLESVDPIFC MTKRCLGDKQ VEMYY 335

    Note: No experimental confirmation available.

    Length:335
    Mass (Da):37,226
    Last modified:June 6, 2002 - v2
    Checksum:iF54AB54E58F9A67E
    GO
    Isoform b (identifier: P41992-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         292-335: ADPFHTVFGI...LGDKQVEMYY → VSFLNNIQKFIFVLQSNNVLATTKQLFECSFNNS

    Note: No experimental confirmation available.

    Show »
    Length:325
    Mass (Da):36,190
    Checksum:iAF4EF82E0FC729E8
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei292 – 33544ADPFH…VEMYY → VSFLNNIQKFIFVLQSNNVL ATTKQLFECSFNNS in isoform b. CuratedVSP_018160Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080148 Genomic DNA. Translation: CCD61597.1.
    FO080148 Genomic DNA. Translation: CCD61598.1.
    RefSeqiNP_498559.1. NM_066158.6. [P41992-1]
    NP_741214.2. NM_171183.3. [P41992-2]
    UniGeneiCel.10970.

    Genome annotation databases

    EnsemblMetazoaiB0280.1a; B0280.1a; WBGene00015099. [P41992-1]
    GeneIDi175998.
    KEGGicel:CELE_B0280.1.
    UCSCiB0280.1a. c. elegans. [P41992-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080148 Genomic DNA. Translation: CCD61597.1 .
    FO080148 Genomic DNA. Translation: CCD61598.1 .
    RefSeqi NP_498559.1. NM_066158.6. [P41992-1 ]
    NP_741214.2. NM_171183.3. [P41992-2 ]
    UniGenei Cel.10970.

    3D structure databases

    ProteinModelPortali P41992.
    SMRi P41992. Positions 11-326.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.B0280.1a.

    Proteomic databases

    PaxDbi P41992.
    PRIDEi P41992.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai B0280.1a ; B0280.1a ; WBGene00015099 . [P41992-1 ]
    GeneIDi 175998.
    KEGGi cel:CELE_B0280.1.
    UCSCi B0280.1a. c. elegans. [P41992-1 ]

    Organism-specific databases

    CTDi 175998.
    WormBasei B0280.1a ; CE24762 ; WBGene00015099 ; ggtb-1.
    B0280.1b ; CE00735 ; WBGene00015099 ; ggtb-1.

    Phylogenomic databases

    eggNOGi COG5029.
    GeneTreei ENSGT00530000063392.
    HOGENOMi HOG000180334.
    InParanoidi P41992.
    KOi K05956.
    OMAi SWSTHAH.
    OrthoDBi EOG7XSTDZ.
    PhylomeDBi P41992.

    Miscellaneous databases

    NextBioi 890666.
    PROi P41992.

    Family and domain databases

    Gene3Di 1.50.10.20. 1 hit.
    InterProi IPR001330. Prenyltrans.
    IPR026873. Ptb1.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    PANTHERi PTHR11774:SF9. PTHR11774:SF9. 1 hit.
    Pfami PF00432. Prenyltrans. 5 hits.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGGTB2_CAEEL
    AccessioniPrimary (citable) accession number: P41992
    Secondary accession number(s): Q2V4X4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: June 6, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3