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P41992

- GGTB2_CAEEL

UniProt

P41992 - GGTB2_CAEEL

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Protein

Probable geranylgeranyl transferase type-2 subunit beta

Gene
ggtb-1, B0280.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal By similarity.

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi244 – 2441Zinc By similarity
Metal bindingi244 – 2441Zinc; catalytic By similarity
Metal bindingi246 – 2461Zinc By similarity
Metal bindingi246 – 2461Zinc; catalytic By similarity
Metal bindingi296 – 2961Zinc By similarity
Metal bindingi296 – 2961Zinc; via tele nitrogen; catalytic By similarity

GO - Molecular functioni

  1. Rab geranylgeranyltransferase activity Source: UniProtKB
  2. Rab GTPase binding Source: UniProtKB
  3. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. protein geranylgeranylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable geranylgeranyl transferase type-2 subunit beta (EC:2.5.1.60)
Alternative name(s):
Geranylgeranyl transferase type II subunit beta
Short name:
GGTase-II-beta
Rab geranyl-geranyltransferase subunit beta
Short name:
Rab GG transferase beta
Short name:
Rab GGTase beta
Rab geranylgeranyltransferase subunit beta
Type II protein geranyl-geranyltransferase subunit beta
Gene namesi
Name:ggtb-1
ORF Names:B0280.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiB0280.1a; CE24762; WBGene00015099; ggtb-1.
B0280.1b; CE00735; WBGene00015099; ggtb-1.

Subcellular locationi

GO - Cellular componenti

  1. Rab-protein geranylgeranyltransferase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Probable geranylgeranyl transferase type-2 subunit betaPRO_0000119766Add
BLAST

Proteomic databases

PaxDbiP41992.
PRIDEiP41992.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit By similarity.

Protein-protein interaction databases

STRINGi6239.B0280.1a.

Structurei

3D structure databases

ProteinModelPortaliP41992.
SMRiP41992. Positions 11-326.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati74 – 11542PFTB 1Add
BLAST
Repeati122 – 16342PFTB 2Add
BLAST
Repeati170 – 21142PFTB 3Add
BLAST
Repeati218 – 25942PFTB 4Add
BLAST
Repeati266 – 31247PFTB 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni196 – 1983Geranylgeranyl diphosphate binding By similarity
Regioni238 – 25013Geranylgeranyl diphosphate binding By similarityAdd
BLAST

Sequence similaritiesi

Contains 5 PFTB repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5029.
GeneTreeiENSGT00530000063392.
HOGENOMiHOG000180334.
InParanoidiP41992.
KOiK05956.
OMAiSWSTHAH.
OrthoDBiEOG7XSTDZ.
PhylomeDBiP41992.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. Prenyltrans.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF9. PTHR11774:SF9. 1 hit.
PfamiPF00432. Prenyltrans. 5 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: P41992-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSFAGLLDFA RKDVDLPQNS PNELLKDLHA NFINQYEKNK NSYHYIMAEH    50
LRVSGIYWCV NAMDLSKQLE RMSTEEIVNY VLGCRNTDGG YGPAPGHDSH 100
LLHTLCAVQT LIIFNSIEKA DADTISEYVK GLQQEDGSFC GDLSGEVDTR 150
FTLCSLATCH LLGRLSTLNI DSAVRFLMRC YNTDGGFGTR PGSESHSGQI 200
YCCVGALAIA GRLDEIDRDR TAEWLAFRQC DSGGLNGRPE KLPDVCYSWW 250
VLASLAILGR LNFIDSDAMK KFIYACQDDE TGGFADRPGD CADPFHTVFG 300
IAALSLFGDD TLESVDPIFC MTKRCLGDKQ VEMYY 335

Note: No experimental confirmation available.

Length:335
Mass (Da):37,226
Last modified:June 6, 2002 - v2
Checksum:iF54AB54E58F9A67E
GO
Isoform b (identifier: P41992-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     292-335: ADPFHTVFGI...LGDKQVEMYY → VSFLNNIQKFIFVLQSNNVLATTKQLFECSFNNS

Note: No experimental confirmation available.

Show »
Length:325
Mass (Da):36,190
Checksum:iAF4EF82E0FC729E8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei292 – 33544ADPFH…VEMYY → VSFLNNIQKFIFVLQSNNVL ATTKQLFECSFNNS in isoform b. VSP_018160Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080148 Genomic DNA. Translation: CCD61597.1.
FO080148 Genomic DNA. Translation: CCD61598.1.
RefSeqiNP_498559.1. NM_066158.6. [P41992-1]
NP_741214.2. NM_171183.3. [P41992-2]
UniGeneiCel.10970.

Genome annotation databases

EnsemblMetazoaiB0280.1a; B0280.1a; WBGene00015099. [P41992-1]
GeneIDi175998.
KEGGicel:CELE_B0280.1.
UCSCiB0280.1a. c. elegans. [P41992-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080148 Genomic DNA. Translation: CCD61597.1 .
FO080148 Genomic DNA. Translation: CCD61598.1 .
RefSeqi NP_498559.1. NM_066158.6. [P41992-1 ]
NP_741214.2. NM_171183.3. [P41992-2 ]
UniGenei Cel.10970.

3D structure databases

ProteinModelPortali P41992.
SMRi P41992. Positions 11-326.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.B0280.1a.

Proteomic databases

PaxDbi P41992.
PRIDEi P41992.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai B0280.1a ; B0280.1a ; WBGene00015099 . [P41992-1 ]
GeneIDi 175998.
KEGGi cel:CELE_B0280.1.
UCSCi B0280.1a. c. elegans. [P41992-1 ]

Organism-specific databases

CTDi 175998.
WormBasei B0280.1a ; CE24762 ; WBGene00015099 ; ggtb-1.
B0280.1b ; CE00735 ; WBGene00015099 ; ggtb-1.

Phylogenomic databases

eggNOGi COG5029.
GeneTreei ENSGT00530000063392.
HOGENOMi HOG000180334.
InParanoidi P41992.
KOi K05956.
OMAi SWSTHAH.
OrthoDBi EOG7XSTDZ.
PhylomeDBi P41992.

Miscellaneous databases

NextBioi 890666.
PROi P41992.

Family and domain databases

Gene3Di 1.50.10.20. 1 hit.
InterProi IPR001330. Prenyltrans.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
PANTHERi PTHR11774:SF9. PTHR11774:SF9. 1 hit.
Pfami PF00432. Prenyltrans. 5 hits.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiGGTB2_CAEEL
AccessioniPrimary (citable) accession number: P41992
Secondary accession number(s): Q2V4X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 6, 2002
Last modified: June 11, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi