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P41992 (GGTB2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable geranylgeranyl transferase type-2 subunit beta

EC=2.5.1.60
Alternative name(s):
Geranylgeranyl transferase type II subunit beta
Short name=GGTase-II-beta
Rab geranyl-geranyltransferase subunit beta
Short name=Rab GG transferase beta
Short name=Rab GGTase beta
Rab geranylgeranyltransferase subunit beta
Type II protein geranyl-geranyltransferase subunit beta
Gene names
Name:ggtb-1
ORF Names:B0280.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal By similarity.

Catalytic activity

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Heterodimer of an alpha and a beta subunit By similarity.

Sequence similarities

Belongs to the protein prenyltransferase subunit beta family.

Contains 5 PFTB repeats.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: P41992-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform b (identifier: P41992-2)

The sequence of this isoform differs from the canonical sequence as follows:
     292-335: ADPFHTVFGI...LGDKQVEMYY → VSFLNNIQKFIFVLQSNNVLATTKQLFECSFNNS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Probable geranylgeranyl transferase type-2 subunit beta
PRO_0000119766

Regions

Repeat74 – 11542PFTB 1
Repeat122 – 16342PFTB 2
Repeat170 – 21142PFTB 3
Repeat218 – 25942PFTB 4
Repeat266 – 31247PFTB 5
Region196 – 1983Geranylgeranyl diphosphate binding By similarity
Region238 – 25013Geranylgeranyl diphosphate binding By similarity

Sites

Metal binding2441Zinc By similarity
Metal binding2441Zinc; catalytic By similarity
Metal binding2461Zinc By similarity
Metal binding2461Zinc; catalytic By similarity
Metal binding2961Zinc By similarity
Metal binding2961Zinc; via tele nitrogen; catalytic By similarity

Natural variations

Alternative sequence292 – 33544ADPFH…VEMYY → VSFLNNIQKFIFVLQSNNVL ATTKQLFECSFNNS in isoform b.
VSP_018160

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified June 6, 2002. Version 2.
Checksum: F54AB54E58F9A67E

FASTA33537,226
        10         20         30         40         50         60 
MSFAGLLDFA RKDVDLPQNS PNELLKDLHA NFINQYEKNK NSYHYIMAEH LRVSGIYWCV 

        70         80         90        100        110        120 
NAMDLSKQLE RMSTEEIVNY VLGCRNTDGG YGPAPGHDSH LLHTLCAVQT LIIFNSIEKA 

       130        140        150        160        170        180 
DADTISEYVK GLQQEDGSFC GDLSGEVDTR FTLCSLATCH LLGRLSTLNI DSAVRFLMRC 

       190        200        210        220        230        240 
YNTDGGFGTR PGSESHSGQI YCCVGALAIA GRLDEIDRDR TAEWLAFRQC DSGGLNGRPE 

       250        260        270        280        290        300 
KLPDVCYSWW VLASLAILGR LNFIDSDAMK KFIYACQDDE TGGFADRPGD CADPFHTVFG 

       310        320        330 
IAALSLFGDD TLESVDPIFC MTKRCLGDKQ VEMYY 

« Hide

Isoform b [UniParc].

Checksum: AF4EF82E0FC729E8
Show »

FASTA32536,190

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080148 Genomic DNA. Translation: CCD61597.1.
FO080148 Genomic DNA. Translation: CCD61598.1.
RefSeqNP_498559.1. NM_066158.6. [P41992-1]
NP_741214.2. NM_171183.3. [P41992-2]
UniGeneCel.10970.

3D structure databases

ProteinModelPortalP41992.
SMRP41992. Positions 11-326.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.B0280.1a.

Proteomic databases

PaxDbP41992.
PRIDEP41992.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaB0280.1a; B0280.1a; WBGene00015099. [P41992-1]
GeneID175998.
KEGGcel:CELE_B0280.1.
UCSCB0280.1a. c. elegans. [P41992-1]

Organism-specific databases

CTD175998.
WormBaseB0280.1a; CE24762; WBGene00015099; ggtb-1.
B0280.1b; CE00735; WBGene00015099; ggtb-1.

Phylogenomic databases

eggNOGCOG5029.
GeneTreeENSGT00530000063392.
HOGENOMHOG000180334.
InParanoidP41992.
KOK05956.
OMASWSTHAH.
OrthoDBEOG7XSTDZ.
PhylomeDBP41992.

Family and domain databases

Gene3D1.50.10.20. 1 hit.
InterProIPR001330. Prenyltrans.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERPTHR11774:SF9. PTHR11774:SF9. 1 hit.
PfamPF00432. Prenyltrans. 5 hits.
[Graphical view]
SUPFAMSSF48239. SSF48239. 1 hit.
ProtoNetSearch...

Other

NextBio890666.
PROP41992.

Entry information

Entry nameGGTB2_CAEEL
AccessionPrimary (citable) accession number: P41992
Secondary accession number(s): Q2V4X4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 6, 2002
Last modified: June 11, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase