Reviewed, UniProtKB/Swiss-Prot P41992 (PGTB2_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable geranylgeranyl transferase type-2 subunit beta
    EC=2.5.1.60
Alternative name(s):
    Geranylgeranyl transferase type II subunit beta
      Short name=GGTase-II-beta
    Type II protein geranyl-geranyltransferase subunit beta
    Rab geranylgeranyltransferase subunit beta
    Rab geranyl-geranyltransferase subunit beta
      Short name=Rab GG transferase beta
      Short name=Rab GGTase beta

Gene names

ORF Names:

B0280.1

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal By similarity.
Catalytic activity	Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Heterodimer of an alpha and a beta subunit By similarity.
Sequence similarities	Belongs to the protein prenyltransferase subunit beta family. Contains 5 PFTB repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	Metal-binding Zinc
Molecular function	Prenyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell death Inferred from mutant phenotype. Source: WormBase embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase reproduction Inferred from mutant phenotype. Source: WormBase
Molecular function	Rab geranylgeranyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform a (identifier: P41992-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform b (identifier: P41992-2)

The sequence of this isoform differs from the canonical sequence as follows:
     292-330: ADPFHTVFGIAALSLFGDDTLESVDPIFCMTKRCLGDKQ → VSFLNNIQKFIFVLQSNNVLATTKQLFECSFNNS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	Probable geranylgeranyl transferase type-2 subunit beta		PRO_0000119766
Regions
	Repeat	74 – 115	42	PFTB 1
	Repeat	122 – 163	42	PFTB 2
	Repeat	170 – 211	42	PFTB 3
	Repeat	218 – 259	42	PFTB 4
	Repeat	266 – 312	47	PFTB 5
Sites
	Metal binding	244	1	Zinc By similarity
	Metal binding	246	1	Zinc By similarity
	Metal binding	296	1	Zinc By similarity
Natural variations
	Alternative sequence	292 – 330	39	ADPFH…LGDKQ → VSFLNNIQKFIFVLQSNNVL ATTKQLFECSFNNS in isoform b.		VSP_018160

Sequences

	Sequence		Length	Mass (Da)
	Isoform a [UniParc]. Last modified June 6, 2002. Version 2. Checksum: F54AB54E58F9A67E	FASTA	335	37,226
	10 20 30 40 50 60 MSFAGLLDFA RKDVDLPQNS PNELLKDLHA NFINQYEKNK NSYHYIMAEH LRVSGIYWCV 70 80 90 100 110 120 NAMDLSKQLE RMSTEEIVNY VLGCRNTDGG YGPAPGHDSH LLHTLCAVQT LIIFNSIEKA 130 140 150 160 170 180 DADTISEYVK GLQQEDGSFC GDLSGEVDTR FTLCSLATCH LLGRLSTLNI DSAVRFLMRC 190 200 210 220 230 240 YNTDGGFGTR PGSESHSGQI YCCVGALAIA GRLDEIDRDR TAEWLAFRQC DSGGLNGRPE 250 260 270 280 290 300 KLPDVCYSWW VLASLAILGR LNFIDSDAMK KFIYACQDDE TGGFADRPGD CADPFHTVFG 310 320 330 IAALSLFGDD TLESVDPIFC MTKRCLGDKQ VEMYY
	Isoform b. Checksum: 456276B1BD8F4EF8	FASTA	330	36,876
	10 20 30 40 50 60 MSFAGLLDFA RKDVDLPQNS PNELLKDLHA NFINQYEKNK NSYHYIMAEH LRVSGIYWCV 70 80 90 100 110 120 NAMDLSKQLE RMSTEEIVNY VLGCRNTDGG YGPAPGHDSH LLHTLCAVQT LIIFNSIEKA 130 140 150 160 170 180 DADTISEYVK GLQQEDGSFC GDLSGEVDTR FTLCSLATCH LLGRLSTLNI DSAVRFLMRC 190 200 210 220 230 240 YNTDGGFGTR PGSESHSGQI YCCVGALAIA GRLDEIDRDR TAEWLAFRQC DSGGLNGRPE 250 260 270 280 290 300 KLPDVCYSWW VLASLAILGR LNFIDSDAMK KFIYACQDDE TGGFADRPGD CVSFLNNIQK 310 320 330 FIFVLQSNNV LATTKQLFEC SFNNSVEMYY

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U10438 Genomic DNA. Translation: AAL50321.1. U10438 Genomic DNA. Translation: ABB88244.1.
RefSeq	NP_498559.1. NP_741214.2.
UniGene	Cel.10970
3D structure databases
HSSP	HSSP built from PDB template 1LTX based on UniProtKB Q08603.
ModBase	Search...
Protein-protein interaction databases
STRING	P41992.
Proteomic databases
PRIDE	P41992.
Genome annotation databases
Ensembl	B0280.1a; B0280.1a; B0280.1; Caenorhabditis elegans. [Genome view] B0280.1b; B0280.1b; B0280.1; Caenorhabditis elegans. [Genome view]
GeneID	175998.
KEGG	cel:B0280.1.
UCSC	B0280.1a. c. elegans.
Organism-specific databases
CTD	175998.
WormBase	WBGene00015099. B0280.1.
WormPep	B0280.1a. CE24762. [WorfDB] B0280.1b. CE00735. [WorfDB]
Phylogenomic databases
OMA	YWGLTAL.
Enzyme and pathway databases
BRENDA	2.5.1.58. 672.
Gene expression databases
ArrayExpress	P41992.
Family and domain databases
InterPro	IPR001330. Prenyltrans. [Graphical view]
Pfam	PF00432. Prenyltrans. 5 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	890666.

Entry information

Entry name

PGTB2_CAEEL

Accession

Primary (citable) accession number: P41992
Secondary accession number(s): Q2V4X4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	June 6, 2002
Last modified:	November 3, 2009
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project