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P41977 (SODM2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Superoxide dismutase [Mn] 2, mitochondrial

EC=1.15.1.1
Gene names
Name:sod-3
ORF Names:C08A9.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activity

2 superoxide + 2 H+ = O2 + H2O2.

Cofactor

Binds 1 manganese ion per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion matrix.

Sequence similarities

Belongs to the iron/manganese superoxide dismutase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2424Mitochondrion By similarity
Chain25 – 218194Superoxide dismutase [Mn] 2, mitochondrial
PRO_0000032877

Sites

Metal binding501Manganese By similarity
Metal binding981Manganese By similarity
Metal binding1791Manganese By similarity
Metal binding1831Manganese By similarity

Secondary structure

.............................. 218
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P41977 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: F35375C9E63BCDC7

FASTA21824,661
        10         20         30         40         50         60 
MLQSTARTAS KLVQPVAGVL AVRSKHTLPD LPFDYADLEP VISHEIMQLH HQKHHATYVN 

        70         80         90        100        110        120 
NLNQIEEKLH EAVSKGNLKE AIALQPALKF NGGGHINHSI FWTNLAKDGG EPSKELMDTI 

       130        140        150        160        170        180 
KRDFGSLDNL QKRLSDITIA VQGSGWGWLG YCKKDKILKI ATCANQDPLE GMVPLFGIDV 

       190        200        210 
WEHAYYLQYK NVRPDYVHAI WKIANWKNIS ERFANARQ 

« Hide

References

« Hide 'large scale' references
[1]"The manganese superoxide dismutase gene of Caenorhabditis elegans."
Giglio M.P., Hunter T., Bannister J.V., Bannister W.H., Hunter G.J.
Biochem. Mol. Biol. Int. 33:37-40(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X77021 Genomic DNA. Translation: CAA54319.1.
X85790 mRNA. Translation: CAA59790.1.
FO080426 Genomic DNA. Translation: CCD63614.1.
PIRS52721.
RefSeqNP_510764.1. NM_078363.6.
UniGeneCel.17915.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3DC5X-ray1.70A/C25-218[»]
ProteinModelPortalP41977.
SMRP41977. Positions 25-218.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.C08A9.1.1.

Proteomic databases

PaxDbP41977.
PRIDEP41977.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC08A9.1; C08A9.1; C08A9.1.
GeneID181748.
KEGGcel:CELE_C08A9.1.
UCSCC08A9.1.1. c. elegans.

Organism-specific databases

CTD181748.
WormBaseC08A9.1; CE08002; WBGene00004932; sod-3.

Phylogenomic databases

eggNOGCOG0605.
HOGENOMHOG000013583.
InParanoidP41977.
KOK04564.
OMAYVEERFE.
OrthoDBEOG7FV3R5.
PhylomeDBP41977.

Family and domain databases

InterProIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERPTHR11404. PTHR11404. 1 hit.
PfamPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFPIRSF000349. SODismutase. 1 hit.
PRINTSPR01703. MNSODISMTASE.
SUPFAMSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP41977.
NextBio915182.

Entry information

Entry nameSODM2_CAEEL
AccessionPrimary (citable) accession number: P41977
Secondary accession number(s): Q27469
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase