P41977 (SODM2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Mn] 2, mitochondrial
EC=1.15.1.1

Gene names

Name:	sod-3
ORF Names:	C08A9.1

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 manganese ion per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Mitochondrion matrix.
Sequence similarities	Belongs to the iron/manganese superoxide dismutase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Manganese Metal-binding
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from direct assay PubMed 17894411. Source: WormBase
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 24

24

Mitochondrion By similarity

Chain

25 – 218

194

Superoxide dismutase [Mn] 2, mitochondrial

PRO_0000032877

Sites

Metal binding

50

1

Manganese By similarity

Metal binding

98

1

Manganese By similarity

Metal binding

179

1

Manganese By similarity

Metal binding

183

1

Manganese By similarity

Secondary structure

1

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218

Helix Strand Turn

Details...

Turn

35 – 41

7

Helix

44 – 52

9

Helix

54 – 75

22

Helix

78 – 83

6

Helix

85 – 103

19

Helix

114 – 124

11

Helix

127 – 139

13

Beta strand

143 – 152

10

Turn

153 – 156

4

Beta strand

157 – 164

8

Beta strand

171 – 179

9

Helix

182 – 184

3

Helix

186 – 189

4

Helix

193 – 200

8

Helix

201 – 203

3

Helix

206 – 217

12

Sequences

	Sequence		Length	Mass (Da)
	P41977 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: F35375C9E63BCDC7	FASTA	218	24,661
	10 20 30 40 50 60 MLQSTARTAS KLVQPVAGVL AVRSKHTLPD LPFDYADLEP VISHEIMQLH HQKHHATYVN 70 80 90 100 110 120 NLNQIEEKLH EAVSKGNLKE AIALQPALKF NGGGHINHSI FWTNLAKDGG EPSKELMDTI 130 140 150 160 170 180 KRDFGSLDNL QKRLSDITIA VQGSGWGWLG YCKKDKILKI ATCANQDPLE GMVPLFGIDV 190 200 210 WEHAYYLQYK NVRPDYVHAI WKIANWKNIS ERFANARQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The manganese superoxide dismutase gene of Caenorhabditis elegans." Giglio M.P., Hunter T., Bannister J.V., Bannister W.H., Hunter G.J. Biochem. Mol. Biol. Int. 33:37-40(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X77021 Genomic DNA. Translation: CAA54319.1.
X85790 mRNA. Translation: CAA59790.1.
FO080426 Genomic DNA. Translation: CCD63614.1.

PIR

S52721.

RefSeq

NP_510764.1. NM_078363.6.

UniGene

Cel.17915.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3DC5	X-ray	1.70	A/C	25-218	[»]

ProteinModelPortal

P41977.

SMR

P41977. Positions 25-218.

ModBase

Search...

Protein-protein interaction databases

STRING

6239.C08A9.1.1.

Proteomic databases

PaxDb

P41977.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

C08A9.1; C08A9.1; C08A9.1.

GeneID

181748.

KEGG

cel:CELE_C08A9.1.

UCSC

C08A9.1.1. c. elegans.

Organism-specific databases

CTD

181748.

WormBase

C08A9.1; CE08002; WBGene00004932; sod-3.

Phylogenomic databases

eggNOG

COG0605.

GeneTree

ENSGT00390000011877.

HOGENOM

HOG000013583.

InParanoid

P41977.

KO

K04564.

OMA

YIKAFWF.

Family and domain databases

InterPro

IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]

PANTHER

PTHR11404. PTHR11404. 1 hit.

Pfam

PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]

PIRSF

PIRSF000349. SODismutase. 1 hit.

PRINTS

PR01703. MNSODISMTASE.

SUPFAM

SSF46609. SODismutase. 1 hit.
SSF54719. SODismutase. 1 hit.

PROSITE

PS00088. SOD_MN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P41977.

NextBio

915182.

Entry information

Entry name

SODM2_CAEEL

Accession

Primary (citable) accession number: P41977
Secondary accession number(s): Q27469

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project