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Protein

Superoxide dismutase [Mn] 2, mitochondrial

Gene

sod-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi50ManganeseBy similarity1
Metal bindingi98ManganeseBy similarity1
Metal bindingi179ManganeseBy similarity1
Metal bindingi183ManganeseBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein homodimerization activity Source: WormBase
  • superoxide dismutase activity Source: WormBase

GO - Biological processi

  • removal of superoxide radicals Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] 2, mitochondrial (EC:1.15.1.1)
Gene namesi
Name:sod-3
ORF Names:C08A9.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC08A9.1; CE08002; WBGene00004932; sod-3.

Subcellular locationi

  • Mitochondrion 1 Publication

GO - Cellular componenti

  • mitochondrial respiratory chain supercomplex Source: WormBase
  • mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionBy similarityAdd BLAST24
ChainiPRO_000003287725 – 218Superoxide dismutase [Mn] 2, mitochondrialAdd BLAST194

Proteomic databases

EPDiP41977.
PaxDbiP41977.
PeptideAtlasiP41977.
PRIDEiP41977.

PTM databases

iPTMnetiP41977.

Expressioni

Tissue specificityi

Expressed in pharynx and rectum. Upon thermal stress, expressed in vulva, body wall muscles and hypodermis.1 Publication

Inductioni

By heat.1 Publication

Gene expression databases

BgeeiWBGene00004932.

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: WormBase

Protein-protein interaction databases

STRINGi6239.C08A9.1.

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni35 – 41Combined sources7
Helixi44 – 52Combined sources9
Helixi54 – 75Combined sources22
Helixi78 – 83Combined sources6
Helixi85 – 103Combined sources19
Helixi114 – 124Combined sources11
Helixi127 – 139Combined sources13
Beta strandi143 – 152Combined sources10
Turni153 – 156Combined sources4
Beta strandi157 – 164Combined sources8
Beta strandi171 – 179Combined sources9
Helixi182 – 184Combined sources3
Helixi186 – 189Combined sources4
Helixi193 – 200Combined sources8
Helixi201 – 203Combined sources3
Helixi206 – 217Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DC5X-ray1.70A/C25-218[»]
4X9QX-ray1.77A/C25-218[»]
5AG2X-ray1.77A/C25-218[»]
ProteinModelPortaliP41977.
SMRiP41977.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41977.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0876. Eukaryota.
COG0605. LUCA.
GeneTreeiENSGT00390000011877.
HOGENOMiHOG000013583.
InParanoidiP41977.
KOiK04564.
OMAiANNAVEP.
OrthoDBiEOG091G0MVL.
PhylomeDBiP41977.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQSTARTAS KLVQPVAGVL AVRSKHTLPD LPFDYADLEP VISHEIMQLH
60 70 80 90 100
HQKHHATYVN NLNQIEEKLH EAVSKGNLKE AIALQPALKF NGGGHINHSI
110 120 130 140 150
FWTNLAKDGG EPSKELMDTI KRDFGSLDNL QKRLSDITIA VQGSGWGWLG
160 170 180 190 200
YCKKDKILKI ATCANQDPLE GMVPLFGIDV WEHAYYLQYK NVRPDYVHAI
210
WKIANWKNIS ERFANARQ
Length:218
Mass (Da):24,661
Last modified:February 1, 1996 - v2
Checksum:iF35375C9E63BCDC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77021 Genomic DNA. Translation: CAA54319.1.
X85790 mRNA. Translation: CAA59790.1.
FO080426 Genomic DNA. Translation: CCD63614.1.
PIRiS52721.
RefSeqiNP_510764.1. NM_078363.6.
UniGeneiCel.17915.

Genome annotation databases

EnsemblMetazoaiC08A9.1; C08A9.1; WBGene00004932.
GeneIDi181748.
KEGGicel:CELE_C08A9.1.
UCSCiC08A9.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77021 Genomic DNA. Translation: CAA54319.1.
X85790 mRNA. Translation: CAA59790.1.
FO080426 Genomic DNA. Translation: CCD63614.1.
PIRiS52721.
RefSeqiNP_510764.1. NM_078363.6.
UniGeneiCel.17915.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DC5X-ray1.70A/C25-218[»]
4X9QX-ray1.77A/C25-218[»]
5AG2X-ray1.77A/C25-218[»]
ProteinModelPortaliP41977.
SMRiP41977.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C08A9.1.

PTM databases

iPTMnetiP41977.

Proteomic databases

EPDiP41977.
PaxDbiP41977.
PeptideAtlasiP41977.
PRIDEiP41977.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC08A9.1; C08A9.1; WBGene00004932.
GeneIDi181748.
KEGGicel:CELE_C08A9.1.
UCSCiC08A9.1.1. c. elegans.

Organism-specific databases

CTDi181748.
WormBaseiC08A9.1; CE08002; WBGene00004932; sod-3.

Phylogenomic databases

eggNOGiKOG0876. Eukaryota.
COG0605. LUCA.
GeneTreeiENSGT00390000011877.
HOGENOMiHOG000013583.
InParanoidiP41977.
KOiK04564.
OMAiANNAVEP.
OrthoDBiEOG091G0MVL.
PhylomeDBiP41977.

Enzyme and pathway databases

ReactomeiR-CEL-3299685. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

EvolutionaryTraceiP41977.
PROiP41977.

Gene expression databases

BgeeiWBGene00004932.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSODM2_CAEEL
AccessioniPrimary (citable) accession number: P41977
Secondary accession number(s): Q27469
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.