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P41977

- SODM2_CAEEL

UniProt

P41977 - SODM2_CAEEL

Protein

Superoxide dismutase [Mn] 2, mitochondrial

Gene

sod-3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Binds 1 manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi50 – 501ManganeseBy similarity
    Metal bindingi98 – 981ManganeseBy similarity
    Metal bindingi179 – 1791ManganeseBy similarity
    Metal bindingi183 – 1831ManganeseBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. superoxide dismutase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_184548. Detoxification of Reactive Oxygen Species.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Mn] 2, mitochondrial (EC:1.15.1.1)
    Gene namesi
    Name:sod-3
    ORF Names:C08A9.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiC08A9.1; CE08002; WBGene00004932; sod-3.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrial respiratory chain supercomplex Source: WormBase
    3. mitochondrion Source: WormBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2424MitochondrionBy similarityAdd
    BLAST
    Chaini25 – 218194Superoxide dismutase [Mn] 2, mitochondrialPRO_0000032877Add
    BLAST

    Proteomic databases

    PaxDbiP41977.
    PRIDEiP41977.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi6239.C08A9.1.1.

    Structurei

    Secondary structure

    1
    218
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni35 – 417
    Helixi44 – 529
    Helixi54 – 7522
    Helixi78 – 836
    Helixi85 – 10319
    Helixi114 – 12411
    Helixi127 – 13913
    Beta strandi143 – 15210
    Turni153 – 1564
    Beta strandi157 – 1648
    Beta strandi171 – 1799
    Helixi182 – 1843
    Helixi186 – 1894
    Helixi193 – 2008
    Helixi201 – 2033
    Helixi206 – 21712

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3DC5X-ray1.70A/C25-218[»]
    ProteinModelPortaliP41977.
    SMRiP41977. Positions 25-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP41977.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0605.
    GeneTreeiENSGT00390000011877.
    HOGENOMiHOG000013583.
    InParanoidiP41977.
    KOiK04564.
    OMAiFGSWDAC.
    OrthoDBiEOG7FV3R5.
    PhylomeDBiP41977.

    Family and domain databases

    InterProiIPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view]
    PANTHERiPTHR11404. PTHR11404. 1 hit.
    PfamiPF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000349. SODismutase. 1 hit.
    PRINTSiPR01703. MNSODISMTASE.
    SUPFAMiSSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEiPS00088. SOD_MN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P41977-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQSTARTAS KLVQPVAGVL AVRSKHTLPD LPFDYADLEP VISHEIMQLH    50
    HQKHHATYVN NLNQIEEKLH EAVSKGNLKE AIALQPALKF NGGGHINHSI 100
    FWTNLAKDGG EPSKELMDTI KRDFGSLDNL QKRLSDITIA VQGSGWGWLG 150
    YCKKDKILKI ATCANQDPLE GMVPLFGIDV WEHAYYLQYK NVRPDYVHAI 200
    WKIANWKNIS ERFANARQ 218
    Length:218
    Mass (Da):24,661
    Last modified:February 1, 1996 - v2
    Checksum:iF35375C9E63BCDC7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77021 Genomic DNA. Translation: CAA54319.1.
    X85790 mRNA. Translation: CAA59790.1.
    FO080426 Genomic DNA. Translation: CCD63614.1.
    PIRiS52721.
    RefSeqiNP_510764.1. NM_078363.6.
    UniGeneiCel.17915.

    Genome annotation databases

    EnsemblMetazoaiC08A9.1; C08A9.1; WBGene00004932.
    GeneIDi181748.
    KEGGicel:CELE_C08A9.1.
    UCSCiC08A9.1.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77021 Genomic DNA. Translation: CAA54319.1 .
    X85790 mRNA. Translation: CAA59790.1 .
    FO080426 Genomic DNA. Translation: CCD63614.1 .
    PIRi S52721.
    RefSeqi NP_510764.1. NM_078363.6.
    UniGenei Cel.17915.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3DC5 X-ray 1.70 A/C 25-218 [» ]
    ProteinModelPortali P41977.
    SMRi P41977. Positions 25-218.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.C08A9.1.1.

    Proteomic databases

    PaxDbi P41977.
    PRIDEi P41977.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C08A9.1 ; C08A9.1 ; WBGene00004932 .
    GeneIDi 181748.
    KEGGi cel:CELE_C08A9.1.
    UCSCi C08A9.1.1. c. elegans.

    Organism-specific databases

    CTDi 181748.
    WormBasei C08A9.1 ; CE08002 ; WBGene00004932 ; sod-3.

    Phylogenomic databases

    eggNOGi COG0605.
    GeneTreei ENSGT00390000011877.
    HOGENOMi HOG000013583.
    InParanoidi P41977.
    KOi K04564.
    OMAi FGSWDAC.
    OrthoDBi EOG7FV3R5.
    PhylomeDBi P41977.

    Enzyme and pathway databases

    Reactomei REACT_184548. Detoxification of Reactive Oxygen Species.

    Miscellaneous databases

    EvolutionaryTracei P41977.
    NextBioi 915182.

    Family and domain databases

    InterProi IPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view ]
    PANTHERi PTHR11404. PTHR11404. 1 hit.
    Pfami PF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000349. SODismutase. 1 hit.
    PRINTSi PR01703. MNSODISMTASE.
    SUPFAMi SSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEi PS00088. SOD_MN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The manganese superoxide dismutase gene of Caenorhabditis elegans."
      Giglio M.P., Hunter T., Bannister J.V., Bannister W.H., Hunter G.J.
      Biochem. Mol. Biol. Int. 33:37-40(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiSODM2_CAEEL
    AccessioniPrimary (citable) accession number: P41977
    Secondary accession number(s): Q27469
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3