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Protein

Superoxide dismutase [Mn], mitochondrial

Gene

SOD2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi50ManganeseBy similarity1
Metal bindingi98ManganeseBy similarity1
Metal bindingi183ManganeseBy similarity1
Metal bindingi187ManganeseBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn], mitochondrial (EC:1.15.1.1)
Gene namesi
Name:SOD2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionBy similarityAdd BLAST24
ChainiPRO_000003286625 – 222Superoxide dismutase [Mn], mitochondrialAdd BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58Nitrated tyrosineBy similarity1
Modified residuei68N6-acetyllysine; alternateBy similarity1
Modified residuei68N6-succinyllysine; alternateBy similarity1
Modified residuei75N6-acetyllysine; alternateBy similarity1
Modified residuei75N6-succinyllysine; alternateBy similarity1
Modified residuei122N6-acetyllysine; alternateBy similarity1
Modified residuei122N6-succinyllysine; alternateBy similarity1
Modified residuei130N6-acetyllysine; alternateBy similarity1
Modified residuei130N6-succinyllysine; alternateBy similarity1
Modified residuei202N6-acetyllysineBy similarity1

Post-translational modificationi

Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.By similarity
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).By similarity
Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.By similarity

Keywords - PTMi

Acetylation, Nitration, Ubl conjugation

Proteomic databases

PaxDbiP41976
PeptideAtlasiP41976
PRIDEiP41976

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi158821, 2 interactors
STRINGi9913.ENSBTAP00000008569

Structurei

3D structure databases

ProteinModelPortaliP41976
SMRiP41976
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0876 Eukaryota
COG0605 LUCA
HOVERGENiHBG004451
InParanoidiP41976
KOiK04564

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41976-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRAACSTS RRLVPALSVL GSRQKHSLPD LPYDYGALEP HINAQIMQLH
60 70 80 90 100
HSKHHAAYVN NLNVAEEKYR EALEKGDVTA QIALQPALKF NGGGHINHSI
110 120 130 140 150
FWTNLSPNGG GEPQGELLEA IKRDFGSFAK FKEKLTAVSV GVQGSGWGWL
160 170 180 190 200
GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY
210 220
LKAIWNVINW ENVTARYTAC SK
Length:222
Mass (Da):24,638
Last modified:November 1, 1995 - v1
Checksum:i806CC3FCB1A74413
GO

Sequence cautioni

The sequence AAA30655 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8S → R in AAD14001 (PubMed:8292376).Curated1
Sequence conflicti14V → A in AAX09005 (PubMed:16305752).Curated1
Sequence conflicti90F → V in AAC60522 (PubMed:8292376).Curated1
Sequence conflicti94 – 95GH → AI in BAC56526 (PubMed:12658628).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22092 mRNA Translation: AAA30655.1 Different initiation.
L22093 Genomic DNA Translation: AAA30656.1
S67818 mRNA Translation: AAC60522.2
S67819 Genomic DNA Translation: AAD14001.1
BT020988 mRNA Translation: AAX09005.1
BC105378 mRNA Translation: AAI05379.1
AB099036 mRNA Translation: BAC56526.1
PIRiI51918
RefSeqiNP_963285.2, NM_201527.2
XP_010807032.1, XM_010808730.1
UniGeneiBt.4748

Genome annotation databases

GeneIDi104973000
281496
KEGGibta:104973000
bta:281496

Similar proteinsi

Entry informationi

Entry nameiSODM_BOVIN
AccessioniPrimary (citable) accession number: P41976
Secondary accession number(s): Q2KJE8, Q5E9D2, Q862F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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