P41975 (SODE_RABIT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Extracellular superoxide dismutase [Cu-Zn]
Short name=EC-SOD
EC=1.15.1.1

Gene names

Name:

SOD3

Organism

Oryctolagus cuniculus (Rabbit) [Reference proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen By similarity.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Secreted › extracellular space.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to hypoxia Inferred from electronic annotation. Source: Compara superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular matrix Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell trans-Golgi network Inferred from electronic annotation. Source: Compara
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	By similarity
	Chain	19 – 244	226	Extracellular superoxide dismutase [Cu-Zn]		PRO_0000032858
Sites
	Metal binding	118	1	Copper; catalytic By similarity
	Metal binding	120	1	Copper; catalytic By similarity
	Metal binding	135	1	Copper; catalytic By similarity
	Metal binding	135	1	Zinc; structural By similarity
	Metal binding	143	1	Zinc; structural By similarity
	Metal binding	146	1	Zinc; structural By similarity
	Metal binding	149	1	Zinc; structural By similarity
	Metal binding	185	1	Copper; catalytic By similarity
Amino acid modifications
	Glycosylation	111	1	N-linked (GlcNAc...) Potential
	Disulfide bond	67 ↔ 212		By similarity
	Disulfide bond	129 ↔ 211		By similarity
Experimental info
	Sequence conflict	53	1	R → W in CAA55018. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P41975 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: 7C9B1C59F942F2C5	FASTA	244	25,688
	10 20 30 40 50 60 MLALVCSCLL LAALPADTWS GPAAVELGSD TVEQIRDTHA KVTEIWQALT QQRAAQGEPA 70 80 90 100 110 120 GALHAVCRVQ PSATLDAAQP RVSGLVVFRQ LGPGAQLEAF FDLEGFPVEA NLSSRAIHVH 130 140 150 160 170 180 QFGDLSQGCD STGAHYNPLA VQHPQHPGDF GNFAVRDGRL WKYRSGLAAS LAGPHSIVGR 190 200 210 220 230 240 AVVVHAGEDD LGRGGNAASV ENGNAGPRLA CCVVGASGPA PWARQAQEHA ERKKRRRESE CKAA

References

[1]	Laukkanen M.O., Aittomaki S.J., Hiltunen T.P., Yla-Herttuala S. Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: New Zealand white.
[2]	Laukkanen M.O., Hiltunen M.O., Aittomaki S., Janne J., Yla-Herttuala S. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: New Zealand white. Tissue: Heart.
[3]	"Cloning and characterization of rabbit extracellular superoxide dismutase." Laukkanen M.O., Aittomaeki S., Mannermaa S., Hiltunen M.O., Yla-Herttuala S. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Hiltunen T.P., Nikkari T., Yla-Herttuala S. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 43-155. Strain: New Zealand white. Tissue: Aorta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z67878 mRNA. Translation: CAA91785.1. Y13339 Genomic DNA. Translation: CAA73783.1. AJ007044 Genomic DNA. Translation: CAA07431.1. X78139 mRNA. Translation: CAA55018.1.
RefSeq	NP_001076101.1. NM_001082632.1.
UniGene	Ocu.3290.
3D structure databases
ProteinModelPortal	P41975.
ModBase	Search...
Protein-protein interaction databases
STRING	9986.ENSOCUP00000006450.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSOCUT00000007456; ENSOCUP00000006450; ENSOCUG00000007460.
GeneID	100009320.
Organism-specific databases
CTD	6649.
Phylogenomic databases
eggNOG	COG2032.
GeneTree	ENSGT00530000063226.
HOGENOM	HOG000263447.
HOVERGEN	HBG000062.
OMA	CCVIGIC.
OrthoDB	EOG4MCX1S.
Family and domain databases
Gene3D	2.60.40.200. 1 hit.
InterPro	IPR024134. SOD_Cu/Zn_/chaperones. IPR018152. SOD_Cu/Zn_BS. IPR024141. SOD_Cu/Zn_extracel. IPR001424. SOD_Cu_Zn_dom. [Graphical view]
PANTHER	PTHR10003. PTHR10003. 1 hit. PTHR10003:SF10. PTHR10003:SF10. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
PRINTS	PR00068. CUZNDISMTASE.
SUPFAM	SSF49329. SOD_Cu_Zn. 1 hit.
PROSITE	PS00087. SOD_CU_ZN_1. 1 hit. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODE_RABIT

Accession

Primary (citable) accession number: P41975

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program