P41974 (SODE_DIRIM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Extracellular superoxide dismutase [Cu-Zn] Short name=EC-SOD EC=1.15.1.1
Organism	Dirofilaria immitis (Canine heartworm)
Taxonomic identifier	6287 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Spirurida › Filarioidea › Onchocercidae › Dirofilaria

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May act in the parasite defense by neutralizing superoxide generated by activated leukocytes, thus acting as both an antioxidant and an anti-inflammatory factor.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Subcellular location	Secreted › extracellular space.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 38	38	Potential
	Chain	39 – 195	157	Extracellular superoxide dismutase [Cu-Zn]		PRO_0000032862
Sites
	Metal binding	83	1	Copper; catalytic By similarity
	Metal binding	85	1	Copper; catalytic By similarity
	Metal binding	100	1	Copper; catalytic By similarity
	Metal binding	100	1	Zinc; structural By similarity
	Metal binding	108	1	Zinc; structural By similarity
	Metal binding	117	1	Zinc; structural By similarity
	Metal binding	120	1	Zinc; structural By similarity
	Metal binding	157	1	Copper; catalytic By similarity
Amino acid modifications
	Disulfide bond	94 ↔ 186		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P41974 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: A49FC6605837C44B	FASTA	195	20,794
	10 20 30 40 50 60 MMGSFIFLLS IIISINYINS LHTVHRSNIH RNMHNGGMPK KAVAVLKSDT VNGIIYFQQN 70 80 90 100 110 120 NRASATTIYG TINGLTPGLH GFHIHQYGIK ANGCTSAAAH YNPFEKTHGR PTNNIKHIGD 130 140 150 160 170 180 LRNIKAGADG VANVNIISNH IQLSGPLSVI GRSLVVHANP DDLGKGNGDA REESLKTGNA 190 GSRIVCSIIG IAPST

References

[1]	James E.R., McLean D.C. Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U14994 mRNA. Translation: AAA50247.1.
3D structure databases
ProteinModelPortal	P41974.
SMR	P41974. Positions 40-192.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.60.40.200. 1 hit.
InterPro	IPR024134. SOD_Cu/Zn_/chaperones. IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn_dom. [Graphical view]
PANTHER	PTHR10003. PTHR10003. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
PRINTS	PR00068. CUZNDISMTASE.
SUPFAM	SSF49329. SOD_Cu_Zn. 1 hit.
PROSITE	PS00087. SOD_CU_ZN_1. False negative. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODE_DIRIM

Accession

Primary (citable) accession number: P41974

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	March 6, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)