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Protein

ETS domain-containing protein Elk-3

Gene

Elk3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 85ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: MGI
  • cell differentiation Source: GO_Central
  • negative regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • wound healing Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
ETS domain-containing protein Elk-3
Alternative name(s):
ETS-related protein ERP
ETS-related protein NET
Gene namesi
Name:Elk3
Synonyms:Erp, Net
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:101762. Elk3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002040981 – 409ETS domain-containing protein Elk-3Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei115PhosphoserineBy similarity1
Cross-linki165Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei398PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP41971.
MaxQBiP41971.
PaxDbiP41971.
PRIDEiP41971.

PTM databases

iPTMnetiP41971.
PhosphoSitePlusiP41971.

Expressioni

Tissue specificityi

Heart, liver, lung, kidney and muscle.

Gene expression databases

BgeeiENSMUSG00000008398.
CleanExiMM_ELK3.
ExpressionAtlasiP41971. baseline and differential.
GenevisibleiP41971. MM.

Interactioni

Subunit structurei

Interacts with CTBP1.

Protein-protein interaction databases

ELMiP41971.
STRINGi10090.ENSMUSP00000008542.

Structurei

3D structure databases

ProteinModelPortaliP41971.
SMRiP41971.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi275 – 279CTBP-binding motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi208 – 212Poly-Ala5

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000237332.
HOVERGENiHBG004344.
InParanoidiP41971.
KOiK09430.
OMAiEISAPPM.
OrthoDBiEOG091G0D25.
TreeFamiTF317732.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00178. Ets. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiView protein in SMART
SM00413. ETS. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.

Sequencei

Sequence statusi: Complete.

P41971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESAITLWQF LLHLLLDQKH EHLICWTSND GEFKLLKAEE VAKLWGLRKN
60 70 80 90 100
KTNMNYDKLS RALRYYYDKN IIKKVIGQKF VYKFVSFPDI LKMDPHAVEI
110 120 130 140 150
SRESLLLQDG DCKVSPEGRE VHRHGLSSLK SASRNEYLHS GLYSSFTINS
160 170 180 190 200
LQNAPEAFKA IKTEKLEEPC DDSPPVEEVR TVIRFVTNKT DKHITRPVVS
210 220 230 240 250
LPSTSETAAA AASAFLASSV SAKISSLMLP NAASISSASP SSSRSPSLSP
260 270 280 290 300
DSPLPSEHRS LFLEAACHDS DSLEPLNLSS GSKTKSPSLP PKGKKPKGLE
310 320 330 340 350
ISAPQLLLSG TDIGSIALNS PALPSGSLTP AFFTAQTPSG LFLASSPLLP
360 370 380 390 400
SIHFWSSLSP VAPLSPARLQ GPNTLFQFPT LLNGHMPVPL PSLDRAPSPV

LLSPSSQKS
Length:409
Mass (Da):44,414
Last modified:July 27, 2011 - v3
Checksum:i7F6B5D1626C62ABA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152Q → E in CAA83676 (PubMed:7958835).Curated1
Sequence conflicti199V → M in CAA83676 (PubMed:7958835).Curated1
Sequence conflicti199V → M in AAA19872 (PubMed:7909357).Curated1
Sequence conflicti235I → V in CAA83676 (PubMed:7958835).Curated1
Sequence conflicti235I → V in AAA19872 (PubMed:7909357).Curated1
Sequence conflicti235I → V in AAB46893 (PubMed:8892757).Curated1
Sequence conflicti238A → V in CAA83676 (PubMed:7958835).Curated1
Sequence conflicti269D → E in CAA83676 (PubMed:7958835).Curated1
Sequence conflicti269D → E in AAA19872 (PubMed:7909357).Curated1
Sequence conflicti269D → E in AAB46893 (PubMed:8892757).Curated1
Sequence conflicti331A → T in AAB46893 (PubMed:8892757).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32815 mRNA. Translation: CAA83676.1.
L19953 mRNA. Translation: AAA19872.1.
S82864 mRNA. Translation: AAB46893.1.
AK052546 mRNA. Translation: BAC35034.1.
CCDSiCCDS24124.1.
PIRiI48680.
RefSeqiNP_001309194.1. NM_001322265.1.
NP_001309197.1. NM_001322268.1.
NP_038536.2. NM_013508.2.
UniGeneiMm.4454.

Genome annotation databases

EnsembliENSMUST00000008542; ENSMUSP00000008542; ENSMUSG00000008398.
GeneIDi13713.
KEGGimmu:13713.
UCSCiuc011xlt.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiELK3_MOUSE
AccessioniPrimary (citable) accession number: P41971
Secondary accession number(s): P97747, Q62346, Q8BWH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: August 30, 2017
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families