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P41971

- ELK3_MOUSE

UniProt

P41971 - ELK3_MOUSE

Protein

ETS domain-containing protein Elk-3

Gene

Elk3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi5 – 8581ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. purine-rich negative regulatory element binding Source: Ensembl
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    4. sequence-specific DNA binding transcription factor activity Source: MGI
    5. transcription corepressor activity Source: Ensembl

    GO - Biological processi

    1. angiogenesis Source: MGI
    2. cell differentiation Source: RefGenome
    3. negative regulation of transcription, DNA-templated Source: Ensembl
    4. regulation of transcription, DNA-templated Source: MGI
    5. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    6. transcription from RNA polymerase II promoter Source: GOC
    7. wound healing Source: MGI

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ETS domain-containing protein Elk-3
    Alternative name(s):
    ETS-related protein ERP
    ETS-related protein NET
    Gene namesi
    Name:Elk3
    Synonyms:Erp, Net
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:101762. Elk3.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 409409ETS domain-containing protein Elk-3PRO_0000204098Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei115 – 1151PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP41971.

    PTM databases

    PhosphoSiteiP41971.

    Expressioni

    Tissue specificityi

    Heart, liver, lung, kidney and muscle.

    Gene expression databases

    ArrayExpressiP41971.
    BgeeiP41971.
    CleanExiMM_ELK3.
    GenevestigatoriP41971.

    Interactioni

    Subunit structurei

    Interacts with CTBP1.

    Structurei

    3D structure databases

    ProteinModelPortaliP41971.
    SMRiP41971. Positions 2-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi275 – 2795CTBP-binding motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi208 – 2125Poly-Ala

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG288109.
    GeneTreeiENSGT00750000117271.
    HOGENOMiHOG000237332.
    HOVERGENiHBG004344.
    InParanoidiQ8BWH1.
    KOiK09430.
    OMAiTNKTDKH.
    OrthoDBiEOG7NPFTD.
    TreeFamiTF317732.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    [Graphical view]
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41971-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESAITLWQF LLHLLLDQKH EHLICWTSND GEFKLLKAEE VAKLWGLRKN    50
    KTNMNYDKLS RALRYYYDKN IIKKVIGQKF VYKFVSFPDI LKMDPHAVEI 100
    SRESLLLQDG DCKVSPEGRE VHRHGLSSLK SASRNEYLHS GLYSSFTINS 150
    LQNAPEAFKA IKTEKLEEPC DDSPPVEEVR TVIRFVTNKT DKHITRPVVS 200
    LPSTSETAAA AASAFLASSV SAKISSLMLP NAASISSASP SSSRSPSLSP 250
    DSPLPSEHRS LFLEAACHDS DSLEPLNLSS GSKTKSPSLP PKGKKPKGLE 300
    ISAPQLLLSG TDIGSIALNS PALPSGSLTP AFFTAQTPSG LFLASSPLLP 350
    SIHFWSSLSP VAPLSPARLQ GPNTLFQFPT LLNGHMPVPL PSLDRAPSPV 400
    LLSPSSQKS 409
    Length:409
    Mass (Da):44,414
    Last modified:July 27, 2011 - v3
    Checksum:i7F6B5D1626C62ABA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti152 – 1521Q → E in CAA83676. (PubMed:7958835)Curated
    Sequence conflicti199 – 1991V → M in CAA83676. (PubMed:7958835)Curated
    Sequence conflicti199 – 1991V → M in AAA19872. (PubMed:7909357)Curated
    Sequence conflicti235 – 2351I → V in CAA83676. (PubMed:7958835)Curated
    Sequence conflicti235 – 2351I → V in AAA19872. (PubMed:7909357)Curated
    Sequence conflicti235 – 2351I → V in AAB46893. (PubMed:8892757)Curated
    Sequence conflicti238 – 2381A → V in CAA83676. (PubMed:7958835)Curated
    Sequence conflicti269 – 2691D → E in CAA83676. (PubMed:7958835)Curated
    Sequence conflicti269 – 2691D → E in AAA19872. (PubMed:7909357)Curated
    Sequence conflicti269 – 2691D → E in AAB46893. (PubMed:8892757)Curated
    Sequence conflicti331 – 3311A → T in AAB46893. (PubMed:8892757)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z32815 mRNA. Translation: CAA83676.1.
    L19953 mRNA. Translation: AAA19872.1.
    S82864 mRNA. Translation: AAB46893.1.
    AK052546 mRNA. Translation: BAC35034.1.
    CCDSiCCDS24124.1.
    PIRiI48680.
    RefSeqiNP_038536.2. NM_013508.2.
    UniGeneiMm.4454.

    Genome annotation databases

    EnsembliENSMUST00000008542; ENSMUSP00000008542; ENSMUSG00000008398.
    GeneIDi13713.
    KEGGimmu:13713.
    UCSCiuc011xlt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z32815 mRNA. Translation: CAA83676.1 .
    L19953 mRNA. Translation: AAA19872.1 .
    S82864 mRNA. Translation: AAB46893.1 .
    AK052546 mRNA. Translation: BAC35034.1 .
    CCDSi CCDS24124.1.
    PIRi I48680.
    RefSeqi NP_038536.2. NM_013508.2.
    UniGenei Mm.4454.

    3D structure databases

    ProteinModelPortali P41971.
    SMRi P41971. Positions 2-151.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P41971.

    Proteomic databases

    PRIDEi P41971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000008542 ; ENSMUSP00000008542 ; ENSMUSG00000008398 .
    GeneIDi 13713.
    KEGGi mmu:13713.
    UCSCi uc011xlt.1. mouse.

    Organism-specific databases

    CTDi 2004.
    MGIi MGI:101762. Elk3.

    Phylogenomic databases

    eggNOGi NOG288109.
    GeneTreei ENSGT00750000117271.
    HOGENOMi HOG000237332.
    HOVERGENi HBG004344.
    InParanoidi Q8BWH1.
    KOi K09430.
    OMAi TNKTDKH.
    OrthoDBi EOG7NPFTD.
    TreeFami TF317732.

    Miscellaneous databases

    NextBioi 284486.
    PROi P41971.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41971.
    Bgeei P41971.
    CleanExi MM_ELK3.
    Genevestigatori P41971.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    [Graphical view ]
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Net, a new ets transcription factor that is activated by Ras."
      Giovane A., Pintzas A., Maira S.-M., Sobieszczuk P., Wasylyk B.
      Genes Dev. 8:1502-1513(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. "ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development."
      Lopez M., Oettgen P., Akbarali Y., Dendorfer U., Libermann T.A.
      Mol. Cell. Biol. 14:3292-3309(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Lung.
    3. "Molecular cloning of Elk-3, a new member of the Ets family expressed during mouse embryogenesis and analysis of its transcriptional repression activity."
      Nozaki M., Onishi Y., Kanno N., Ono Y., Fujimura Y.
      DNA Cell Biol. 15:855-862(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Lung.

    Entry informationi

    Entry nameiELK3_MOUSE
    AccessioniPrimary (citable) accession number: P41971
    Secondary accession number(s): P97747, Q62346, Q8BWH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 111 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3