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P41971 (ELK3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ETS domain-containing protein Elk-3
Alternative name(s):
ETS-related protein ERP
ETS-related protein NET
Gene names
Name:Elk3
Synonyms:Erp, Net
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

Subunit structure

Interacts with CTBP1.

Subcellular location

Nucleus.

Tissue specificity

Heart, liver, lung, kidney and muscle.

Sequence similarities

Belongs to the ETS family.

Contains 1 ETS DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionActivator
Repressor
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from mutant phenotype PubMed 12975317. Source: MGI

cell differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of transcription, DNA-templated

Inferred from direct assay PubMed 12975317. Source: MGI

transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: GOC

wound healing

Inferred from mutant phenotype PubMed 12975317. Source: MGI

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay PubMed 12975317. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 12975317. Source: MGI

purine-rich negative regulatory element binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 12975317. Source: MGI

transcription corepressor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 409409ETS domain-containing protein Elk-3
PRO_0000204098

Regions

DNA binding5 – 8581ETS
Motif275 – 2795CTBP-binding motif
Compositional bias208 – 2125Poly-Ala

Amino acid modifications

Modified residue1151Phosphoserine By similarity

Experimental info

Sequence conflict1521Q → E in CAA83676. Ref.1
Sequence conflict1991V → M in CAA83676. Ref.1
Sequence conflict1991V → M in AAA19872. Ref.2
Sequence conflict2351I → V in CAA83676. Ref.1
Sequence conflict2351I → V in AAA19872. Ref.2
Sequence conflict2351I → V in AAB46893. Ref.3
Sequence conflict2381A → V in CAA83676. Ref.1
Sequence conflict2691D → E in CAA83676. Ref.1
Sequence conflict2691D → E in AAA19872. Ref.2
Sequence conflict2691D → E in AAB46893. Ref.3
Sequence conflict3311A → T in AAB46893. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P41971 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 7F6B5D1626C62ABA

FASTA40944,414
        10         20         30         40         50         60 
MESAITLWQF LLHLLLDQKH EHLICWTSND GEFKLLKAEE VAKLWGLRKN KTNMNYDKLS 

        70         80         90        100        110        120 
RALRYYYDKN IIKKVIGQKF VYKFVSFPDI LKMDPHAVEI SRESLLLQDG DCKVSPEGRE 

       130        140        150        160        170        180 
VHRHGLSSLK SASRNEYLHS GLYSSFTINS LQNAPEAFKA IKTEKLEEPC DDSPPVEEVR 

       190        200        210        220        230        240 
TVIRFVTNKT DKHITRPVVS LPSTSETAAA AASAFLASSV SAKISSLMLP NAASISSASP 

       250        260        270        280        290        300 
SSSRSPSLSP DSPLPSEHRS LFLEAACHDS DSLEPLNLSS GSKTKSPSLP PKGKKPKGLE 

       310        320        330        340        350        360 
ISAPQLLLSG TDIGSIALNS PALPSGSLTP AFFTAQTPSG LFLASSPLLP SIHFWSSLSP 

       370        380        390        400 
VAPLSPARLQ GPNTLFQFPT LLNGHMPVPL PSLDRAPSPV LLSPSSQKS 

« Hide

References

« Hide 'large scale' references
[1]"Net, a new ets transcription factor that is activated by Ras."
Giovane A., Pintzas A., Maira S.-M., Sobieszczuk P., Wasylyk B.
Genes Dev. 8:1502-1513(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
[2]"ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development."
Lopez M., Oettgen P., Akbarali Y., Dendorfer U., Libermann T.A.
Mol. Cell. Biol. 14:3292-3309(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Lung.
[3]"Molecular cloning of Elk-3, a new member of the Ets family expressed during mouse embryogenesis and analysis of its transcriptional repression activity."
Nozaki M., Onishi Y., Kanno N., Ono Y., Fujimura Y.
DNA Cell Biol. 15:855-862(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z32815 mRNA. Translation: CAA83676.1.
L19953 mRNA. Translation: AAA19872.1.
S82864 mRNA. Translation: AAB46893.1.
AK052546 mRNA. Translation: BAC35034.1.
CCDSCCDS24124.1.
PIRI48680.
RefSeqNP_038536.2. NM_013508.2.
UniGeneMm.4454.

3D structure databases

ProteinModelPortalP41971.
SMRP41971. Positions 2-151.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP41971.

Proteomic databases

PRIDEP41971.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000008542; ENSMUSP00000008542; ENSMUSG00000008398.
GeneID13713.
KEGGmmu:13713.
UCSCuc011xlt.1. mouse.

Organism-specific databases

CTD2004.
MGIMGI:101762. Elk3.

Phylogenomic databases

eggNOGNOG288109.
GeneTreeENSGT00750000117271.
HOGENOMHOG000237332.
HOVERGENHBG004344.
InParanoidQ8BWH1.
KOK09430.
OMATNKTDKH.
OrthoDBEOG7NPFTD.
TreeFamTF317732.

Gene expression databases

ArrayExpressP41971.
BgeeP41971.
CleanExMM_ELK3.
GenevestigatorP41971.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00178. Ets. 1 hit.
[Graphical view]
PRINTSPR00454. ETSDOMAIN.
SMARTSM00413. ETS. 1 hit.
[Graphical view]
PROSITEPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio284486.
PROP41971.
SOURCESearch...

Entry information

Entry nameELK3_MOUSE
AccessionPrimary (citable) accession number: P41971
Secondary accession number(s): P97747, Q62346, Q8BWH1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot