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P41971

- ELK3_MOUSE

UniProt

P41971 - ELK3_MOUSE

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Protein

ETS domain-containing protein Elk-3

Gene

Elk3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi5 – 8581ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. purine-rich negative regulatory element binding Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  5. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
  6. sequence-specific DNA binding transcription factor activity Source: MGI
  7. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. angiogenesis Source: MGI
  2. cell differentiation Source: RefGenome
  3. negative regulation of transcription, DNA-templated Source: Ensembl
  4. regulation of transcription, DNA-templated Source: MGI
  5. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  6. transcription from RNA polymerase II promoter Source: GOC
  7. wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS domain-containing protein Elk-3
Alternative name(s):
ETS-related protein ERP
ETS-related protein NET
Gene namesi
Name:Elk3
Synonyms:Erp, Net
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:101762. Elk3.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409ETS domain-containing protein Elk-3PRO_0000204098Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei115 – 1151PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP41971.
PRIDEiP41971.

PTM databases

PhosphoSiteiP41971.

Expressioni

Tissue specificityi

Heart, liver, lung, kidney and muscle.

Gene expression databases

BgeeiP41971.
CleanExiMM_ELK3.
ExpressionAtlasiP41971. baseline and differential.
GenevestigatoriP41971.

Interactioni

Subunit structurei

Interacts with CTBP1.

Structurei

3D structure databases

ProteinModelPortaliP41971.
SMRiP41971. Positions 2-151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi275 – 2795CTBP-binding motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi208 – 2125Poly-Ala

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG288109.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000237332.
HOVERGENiHBG004344.
InParanoidiP41971.
KOiK09430.
OMAiTNKTDKH.
OrthoDBiEOG7NPFTD.
TreeFamiTF317732.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41971-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESAITLWQF LLHLLLDQKH EHLICWTSND GEFKLLKAEE VAKLWGLRKN
60 70 80 90 100
KTNMNYDKLS RALRYYYDKN IIKKVIGQKF VYKFVSFPDI LKMDPHAVEI
110 120 130 140 150
SRESLLLQDG DCKVSPEGRE VHRHGLSSLK SASRNEYLHS GLYSSFTINS
160 170 180 190 200
LQNAPEAFKA IKTEKLEEPC DDSPPVEEVR TVIRFVTNKT DKHITRPVVS
210 220 230 240 250
LPSTSETAAA AASAFLASSV SAKISSLMLP NAASISSASP SSSRSPSLSP
260 270 280 290 300
DSPLPSEHRS LFLEAACHDS DSLEPLNLSS GSKTKSPSLP PKGKKPKGLE
310 320 330 340 350
ISAPQLLLSG TDIGSIALNS PALPSGSLTP AFFTAQTPSG LFLASSPLLP
360 370 380 390 400
SIHFWSSLSP VAPLSPARLQ GPNTLFQFPT LLNGHMPVPL PSLDRAPSPV

LLSPSSQKS
Length:409
Mass (Da):44,414
Last modified:July 27, 2011 - v3
Checksum:i7F6B5D1626C62ABA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521Q → E in CAA83676. (PubMed:7958835)Curated
Sequence conflicti199 – 1991V → M in CAA83676. (PubMed:7958835)Curated
Sequence conflicti199 – 1991V → M in AAA19872. (PubMed:7909357)Curated
Sequence conflicti235 – 2351I → V in CAA83676. (PubMed:7958835)Curated
Sequence conflicti235 – 2351I → V in AAA19872. (PubMed:7909357)Curated
Sequence conflicti235 – 2351I → V in AAB46893. (PubMed:8892757)Curated
Sequence conflicti238 – 2381A → V in CAA83676. (PubMed:7958835)Curated
Sequence conflicti269 – 2691D → E in CAA83676. (PubMed:7958835)Curated
Sequence conflicti269 – 2691D → E in AAA19872. (PubMed:7909357)Curated
Sequence conflicti269 – 2691D → E in AAB46893. (PubMed:8892757)Curated
Sequence conflicti331 – 3311A → T in AAB46893. (PubMed:8892757)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32815 mRNA. Translation: CAA83676.1.
L19953 mRNA. Translation: AAA19872.1.
S82864 mRNA. Translation: AAB46893.1.
AK052546 mRNA. Translation: BAC35034.1.
CCDSiCCDS24124.1.
PIRiI48680.
RefSeqiNP_038536.2. NM_013508.2.
UniGeneiMm.4454.

Genome annotation databases

EnsembliENSMUST00000008542; ENSMUSP00000008542; ENSMUSG00000008398.
GeneIDi13713.
KEGGimmu:13713.
UCSCiuc011xlt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32815 mRNA. Translation: CAA83676.1 .
L19953 mRNA. Translation: AAA19872.1 .
S82864 mRNA. Translation: AAB46893.1 .
AK052546 mRNA. Translation: BAC35034.1 .
CCDSi CCDS24124.1.
PIRi I48680.
RefSeqi NP_038536.2. NM_013508.2.
UniGenei Mm.4454.

3D structure databases

ProteinModelPortali P41971.
SMRi P41971. Positions 2-151.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P41971.

Proteomic databases

MaxQBi P41971.
PRIDEi P41971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000008542 ; ENSMUSP00000008542 ; ENSMUSG00000008398 .
GeneIDi 13713.
KEGGi mmu:13713.
UCSCi uc011xlt.1. mouse.

Organism-specific databases

CTDi 2004.
MGIi MGI:101762. Elk3.

Phylogenomic databases

eggNOGi NOG288109.
GeneTreei ENSGT00760000118996.
HOGENOMi HOG000237332.
HOVERGENi HBG004344.
InParanoidi P41971.
KOi K09430.
OMAi TNKTDKH.
OrthoDBi EOG7NPFTD.
TreeFami TF317732.

Miscellaneous databases

NextBioi 284486.
PROi P41971.
SOURCEi Search...

Gene expression databases

Bgeei P41971.
CleanExi MM_ELK3.
ExpressionAtlasi P41971. baseline and differential.
Genevestigatori P41971.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
[Graphical view ]
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Net, a new ets transcription factor that is activated by Ras."
    Giovane A., Pintzas A., Maira S.-M., Sobieszczuk P., Wasylyk B.
    Genes Dev. 8:1502-1513(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development."
    Lopez M., Oettgen P., Akbarali Y., Dendorfer U., Libermann T.A.
    Mol. Cell. Biol. 14:3292-3309(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Lung.
  3. "Molecular cloning of Elk-3, a new member of the Ets family expressed during mouse embryogenesis and analysis of its transcriptional repression activity."
    Nozaki M., Onishi Y., Kanno N., Ono Y., Fujimura Y.
    DNA Cell Biol. 15:855-862(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.

Entry informationi

Entry nameiELK3_MOUSE
AccessioniPrimary (citable) accession number: P41971
Secondary accession number(s): P97747, Q62346, Q8BWH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3