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Protein

ETS domain-containing protein Elk-3

Gene

ELK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi5 – 8581ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: Ensembl
  • cell differentiation Source: GO_Central
  • negative regulation of transcription, DNA-templated Source: HGNC
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • signal transduction Source: ProtInc
  • transcription from RNA polymerase II promoter Source: GOC
  • wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP41970.

Names & Taxonomyi

Protein namesi
Recommended name:
ETS domain-containing protein Elk-3
Alternative name(s):
ETS-related protein ERP
ETS-related protein NET
Serum response factor accessory protein 2
Short name:
SAP-2
Short name:
SRF accessory protein 2
Gene namesi
Name:ELK3
Synonyms:NET, SAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:3325. ELK3.

Subcellular locationi

GO - Cellular componenti

  • intracellular membrane-bounded organelle Source: HPA
  • mitochondrion Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27752.

Polymorphism and mutation databases

BioMutaiELK3.
DMDMi116241349.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407ETS domain-containing protein Elk-3PRO_0000204097Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei115 – 1151Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP41970.
PaxDbiP41970.
PRIDEiP41970.

PTM databases

PhosphoSiteiP41970.

Expressioni

Gene expression databases

BgeeiP41970.
CleanExiHS_ELK3.
ExpressionAtlasiP41970. baseline and differential.
GenevisibleiP41970. HS.

Organism-specific databases

HPAiHPA001600.

Interactioni

Subunit structurei

Interacts with CTBP1.

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163333EBI-1758534,EBI-389883
PIK3R1P279862EBI-1758534,EBI-79464

Protein-protein interaction databases

BioGridi108319. 3 interactions.
IntActiP41970. 4 interactions.
MINTiMINT-7242082.
STRINGi9606.ENSP00000228741.

Structurei

3D structure databases

ProteinModelPortaliP41970.
SMRiP41970. Positions 2-151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi273 – 2775CTBP-binding motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi207 – 2126Poly-Ala

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG288109.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000237332.
HOVERGENiHBG004344.
InParanoidiP41970.
KOiK09430.
OMAiEISAPPM.
OrthoDBiEOG7NPFTD.
PhylomeDBiP41970.
TreeFamiTF317732.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESAITLWQF LLQLLLDQKH EHLICWTSND GEFKLLKAEE VAKLWGLRKN
60 70 80 90 100
KTNMNYDKLS RALRYYYDKN IIKKVIGQKF VYKFVSFPEI LKMDPHAVEI
110 120 130 140 150
SRESLLLQDS DCKASPEGRE AHKHGLAALR STSRNEYIHS GLYSSFTINS
160 170 180 190 200
LQNPPDAFKA IKTEKLEEPP EDSPPVEEVR TVIRFVTNKT DKHVTRPVVS
210 220 230 240 250
LPSTSEAAAA SAFLASSVSA KISSLMLPNA ASISSASPFS SRSPSLSPNS
260 270 280 290 300
PLPSEHRSLF LEAACHDSDS LEPLNLSSGS KTKSPSLPPK AKKPKGLEIS
310 320 330 340 350
APPLVLSGTD IGSIALNSPA LPSGSLTPAF FTAQTPNGLL LTPSPLLSSI
360 370 380 390 400
HFWSSLSPVA PLSPARLQGP STLFQFPTLL NGHMPVPIPS LDRAASPVLL

SSNSQKS
Length:407
Mass (Da):44,240
Last modified:October 17, 2006 - v2
Checksum:iDD4515270ECED1E3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141A → V in CAA85309 (PubMed:7958835).Curated
Sequence conflicti117 – 1171E → G in CAG47047 (Ref. 3) Curated
Sequence conflicti128 – 1281A → V in CAA85309 (PubMed:7958835).Curated
Sequence conflicti152 – 1521Q → E in CAA85309 (PubMed:7958835).Curated
Sequence conflicti163 – 1631T → R in CAA85309 (PubMed:7958835).Curated
Sequence conflicti249 – 2491N → K in CAA85309 (PubMed:7958835).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti169 – 1691P → L.
Corresponds to variant rs35332676 [ dbSNP | Ensembl ].
VAR_048946

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36715 mRNA. Translation: CAA85309.1.
CR542251 mRNA. Translation: CAG47047.1.
AK312694 mRNA. Translation: BAG35573.1.
CH471054 Genomic DNA. Translation: EAW97561.1.
BC017371 mRNA. Translation: AAH17371.1.
CCDSiCCDS9060.1.
PIRiI38062.
RefSeqiNP_005221.2. NM_005230.3.
XP_006719338.1. XM_006719275.2.
UniGeneiHs.46523.
Hs.718709.

Genome annotation databases

EnsembliENST00000228741; ENSP00000228741; ENSG00000111145.
GeneIDi2004.
KEGGihsa:2004.
UCSCiuc001teo.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36715 mRNA. Translation: CAA85309.1.
CR542251 mRNA. Translation: CAG47047.1.
AK312694 mRNA. Translation: BAG35573.1.
CH471054 Genomic DNA. Translation: EAW97561.1.
BC017371 mRNA. Translation: AAH17371.1.
CCDSiCCDS9060.1.
PIRiI38062.
RefSeqiNP_005221.2. NM_005230.3.
XP_006719338.1. XM_006719275.2.
UniGeneiHs.46523.
Hs.718709.

3D structure databases

ProteinModelPortaliP41970.
SMRiP41970. Positions 2-151.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108319. 3 interactions.
IntActiP41970. 4 interactions.
MINTiMINT-7242082.
STRINGi9606.ENSP00000228741.

PTM databases

PhosphoSiteiP41970.

Polymorphism and mutation databases

BioMutaiELK3.
DMDMi116241349.

Proteomic databases

MaxQBiP41970.
PaxDbiP41970.
PRIDEiP41970.

Protocols and materials databases

DNASUi2004.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228741; ENSP00000228741; ENSG00000111145.
GeneIDi2004.
KEGGihsa:2004.
UCSCiuc001teo.1. human.

Organism-specific databases

CTDi2004.
GeneCardsiGC12P096521.
HGNCiHGNC:3325. ELK3.
HPAiHPA001600.
MIMi600247. gene.
neXtProtiNX_P41970.
PharmGKBiPA27752.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG288109.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000237332.
HOVERGENiHBG004344.
InParanoidiP41970.
KOiK09430.
OMAiEISAPPM.
OrthoDBiEOG7NPFTD.
PhylomeDBiP41970.
TreeFamiTF317732.

Enzyme and pathway databases

SignaLinkiP41970.

Miscellaneous databases

GeneWikiiELK3.
GenomeRNAii2004.
NextBioi8109.
PROiP41970.
SOURCEiSearch...

Gene expression databases

BgeeiP41970.
CleanExiHS_ELK3.
ExpressionAtlasiP41970. baseline and differential.
GenevisibleiP41970. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Net, a new ets transcription factor that is activated by Ras."
    Giovane A., Pintzas A., Maira S.-M., Sobieszczuk P., Wasylyk B.
    Genes Dev. 8:1502-1513(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)."
    Price M.A., Rogers A.E., Treisman R.
    EMBO J. 14:2589-2601(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiELK3_HUMAN
AccessioniPrimary (citable) accession number: P41970
Secondary accession number(s): B2R6S6
, Q6FG57, Q6GU29, Q9UD17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 17, 2006
Last modified: July 22, 2015
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.