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Protein

ETS domain-containing protein Elk-3

Gene

ELK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 85ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: Ensembl
  • cell differentiation Source: GO_Central
  • negative regulation of transcription, DNA-templated Source: HGNC
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • signal transduction Source: ProtInc
  • wound healing Source: Ensembl

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP41970
SIGNORiP41970

Names & Taxonomyi

Protein namesi
Recommended name:
ETS domain-containing protein Elk-3
Alternative name(s):
ETS-related protein ERP
ETS-related protein NET
Serum response factor accessory protein 2
Short name:
SAP-2
Short name:
SRF accessory protein 2
Gene namesi
Name:ELK3
Synonyms:NET, SAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111145.7
HGNCiHGNC:3325 ELK3
MIMi600247 gene
neXtProtiNX_P41970

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2004
OpenTargetsiENSG00000111145
PharmGKBiPA27752

Polymorphism and mutation databases

BioMutaiELK3
DMDMi116241349

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002040971 – 407ETS domain-containing protein Elk-3Add BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei115PhosphoserineCombined sources1
Cross-linki165Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei396PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP41970
PaxDbiP41970
PeptideAtlasiP41970
PRIDEiP41970

PTM databases

iPTMnetiP41970
PhosphoSitePlusiP41970

Expressioni

Gene expression databases

BgeeiENSG00000111145
CleanExiHS_ELK3
ExpressionAtlasiP41970 baseline and differential
GenevisibleiP41970 HS

Organism-specific databases

HPAiHPA001600

Interactioni

Subunit structurei

Interacts with CTBP1.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi108319, 3 interactors
CORUMiP41970
ELMiP41970
IntActiP41970, 8 interactors
STRINGi9606.ENSP00000228741

Structurei

3D structure databases

ProteinModelPortaliP41970
SMRiP41970
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi273 – 277CTBP-binding motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi207 – 212Poly-Ala6

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000237332
HOVERGENiHBG004344
InParanoidiP41970
KOiK09430
OMAiEISAPPM
OrthoDBiEOG091G0D25
PhylomeDBiP41970
TreeFamiTF317732

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequencei

Sequence statusi: Complete.

P41970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESAITLWQF LLQLLLDQKH EHLICWTSND GEFKLLKAEE VAKLWGLRKN
60 70 80 90 100
KTNMNYDKLS RALRYYYDKN IIKKVIGQKF VYKFVSFPEI LKMDPHAVEI
110 120 130 140 150
SRESLLLQDS DCKASPEGRE AHKHGLAALR STSRNEYIHS GLYSSFTINS
160 170 180 190 200
LQNPPDAFKA IKTEKLEEPP EDSPPVEEVR TVIRFVTNKT DKHVTRPVVS
210 220 230 240 250
LPSTSEAAAA SAFLASSVSA KISSLMLPNA ASISSASPFS SRSPSLSPNS
260 270 280 290 300
PLPSEHRSLF LEAACHDSDS LEPLNLSSGS KTKSPSLPPK AKKPKGLEIS
310 320 330 340 350
APPLVLSGTD IGSIALNSPA LPSGSLTPAF FTAQTPNGLL LTPSPLLSSI
360 370 380 390 400
HFWSSLSPVA PLSPARLQGP STLFQFPTLL NGHMPVPIPS LDRAASPVLL

SSNSQKS
Length:407
Mass (Da):44,240
Last modified:October 17, 2006 - v2
Checksum:iDD4515270ECED1E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114A → V in CAA85309 (PubMed:7958835).Curated1
Sequence conflicti117E → G in CAG47047 (Ref. 3) Curated1
Sequence conflicti128A → V in CAA85309 (PubMed:7958835).Curated1
Sequence conflicti152Q → E in CAA85309 (PubMed:7958835).Curated1
Sequence conflicti163T → R in CAA85309 (PubMed:7958835).Curated1
Sequence conflicti249N → K in CAA85309 (PubMed:7958835).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048946169P → L. Corresponds to variant dbSNP:rs35332676Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36715 mRNA Translation: CAA85309.1
CR542251 mRNA Translation: CAG47047.1
AK312694 mRNA Translation: BAG35573.1
CH471054 Genomic DNA Translation: EAW97561.1
BC017371 mRNA Translation: AAH17371.1
CCDSiCCDS9060.1
PIRiI38062
RefSeqiNP_005221.2, NM_005230.3
XP_006719338.1, XM_006719275.3
UniGeneiHs.46523
Hs.718709

Genome annotation databases

EnsembliENST00000228741; ENSP00000228741; ENSG00000111145
GeneIDi2004
KEGGihsa:2004
UCSCiuc001teo.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiELK3_HUMAN
AccessioniPrimary (citable) accession number: P41970
Secondary accession number(s): B2R6S6
, Q6FG57, Q6GU29, Q9UD17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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