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P41970 (ELK3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ETS domain-containing protein Elk-3
Alternative name(s):
ETS-related protein ERP
ETS-related protein NET
Serum response factor accessory protein 2
Short name=SAP-2
Short name=SRF accessory protein 2
Gene names
Name:ELK3
Synonyms:NET, SAP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

Subunit structure

Interacts with CTBP1.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the ETS family.

Contains 1 ETS DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Molecular functionActivator
Repressor
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from electronic annotation. Source: Ensembl

cell differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 12933792. Source: HGNC

regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

signal transduction

Traceable author statement Ref.1. Source: ProtInc

transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: GOC

wound healing

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintracellular membrane-bounded organelle

Inferred from direct assay. Source: HPA

mitochondrion

Inferred from direct assay. Source: HPA

nucleus

Inferred by curator PubMed 12933792. Source: HGNC

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 17474147. Source: IntAct

purine-rich negative regulatory element binding

Inferred from direct assay PubMed 12933792. Source: HGNC

sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding transcription factor activity

Non-traceable author statement PubMed 7851904. Source: ProtInc

transcription corepressor activity

Inferred from direct assay PubMed 12933792. Source: HGNC

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NCK1P163333EBI-1758534,EBI-389883

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407ETS domain-containing protein Elk-3
PRO_0000204097

Regions

DNA binding5 – 8581ETS
Motif273 – 2775CTBP-binding motif
Compositional bias207 – 2126Poly-Ala

Amino acid modifications

Modified residue1151Phosphoserine Ref.7

Natural variations

Natural variant1691P → L.
Corresponds to variant rs35332676 [ dbSNP | Ensembl ].
VAR_048946

Experimental info

Sequence conflict1141A → V in CAA85309. Ref.1
Sequence conflict1171E → G in CAG47047. Ref.3
Sequence conflict1281A → V in CAA85309. Ref.1
Sequence conflict1521Q → E in CAA85309. Ref.1
Sequence conflict1631T → R in CAA85309. Ref.1
Sequence conflict2491N → K in CAA85309. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P41970 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: DD4515270ECED1E3

FASTA40744,240
        10         20         30         40         50         60 
MESAITLWQF LLQLLLDQKH EHLICWTSND GEFKLLKAEE VAKLWGLRKN KTNMNYDKLS 

        70         80         90        100        110        120 
RALRYYYDKN IIKKVIGQKF VYKFVSFPEI LKMDPHAVEI SRESLLLQDS DCKASPEGRE 

       130        140        150        160        170        180 
AHKHGLAALR STSRNEYIHS GLYSSFTINS LQNPPDAFKA IKTEKLEEPP EDSPPVEEVR 

       190        200        210        220        230        240 
TVIRFVTNKT DKHVTRPVVS LPSTSEAAAA SAFLASSVSA KISSLMLPNA ASISSASPFS 

       250        260        270        280        290        300 
SRSPSLSPNS PLPSEHRSLF LEAACHDSDS LEPLNLSSGS KTKSPSLPPK AKKPKGLEIS 

       310        320        330        340        350        360 
APPLVLSGTD IGSIALNSPA LPSGSLTPAF FTAQTPNGLL LTPSPLLSSI HFWSSLSPVA 

       370        380        390        400 
PLSPARLQGP STLFQFPTLL NGHMPVPIPS LDRAASPVLL SSNSQKS 

« Hide

References

« Hide 'large scale' references
[1]"Net, a new ets transcription factor that is activated by Ras."
Giovane A., Pintzas A., Maira S.-M., Sobieszczuk P., Wasylyk B.
Genes Dev. 8:1502-1513(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)."
Price M.A., Rogers A.E., Treisman R.
EMBO J. 14:2589-2601(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[7]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z36715 mRNA. Translation: CAA85309.1.
CR542251 mRNA. Translation: CAG47047.1.
AK312694 mRNA. Translation: BAG35573.1.
CH471054 Genomic DNA. Translation: EAW97561.1.
BC017371 mRNA. Translation: AAH17371.1.
CCDSCCDS9060.1.
PIRI38062.
RefSeqNP_005221.2. NM_005230.2.
XP_006719338.1. XM_006719275.1.
UniGeneHs.46523.

3D structure databases

ProteinModelPortalP41970.
SMRP41970. Positions 2-151.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108319. 4 interactions.
IntActP41970. 4 interactions.
MINTMINT-7242082.
STRING9606.ENSP00000228741.

PTM databases

PhosphoSiteP41970.

Polymorphism databases

DMDM116241349.

Proteomic databases

MaxQBP41970.
PaxDbP41970.
PRIDEP41970.

Protocols and materials databases

DNASU2004.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000228741; ENSP00000228741; ENSG00000111145.
GeneID2004.
KEGGhsa:2004.
UCSCuc001teo.1. human.

Organism-specific databases

CTD2004.
GeneCardsGC12P096521.
HGNCHGNC:3325. ELK3.
HPAHPA001600.
MIM600247. gene.
neXtProtNX_P41970.
PharmGKBPA27752.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG288109.
HOGENOMHOG000237332.
HOVERGENHBG004344.
InParanoidP41970.
KOK09430.
OMATNKTDKH.
OrthoDBEOG7NPFTD.
PhylomeDBP41970.
TreeFamTF317732.

Enzyme and pathway databases

SignaLinkP41970.

Gene expression databases

ArrayExpressP41970.
BgeeP41970.
CleanExHS_ELK3.
GenevestigatorP41970.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00178. Ets. 1 hit.
[Graphical view]
PRINTSPR00454. ETSDOMAIN.
SMARTSM00413. ETS. 1 hit.
[Graphical view]
PROSITEPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiELK3.
GenomeRNAi2004.
NextBio8109.
PROP41970.
SOURCESearch...

Entry information

Entry nameELK3_HUMAN
AccessionPrimary (citable) accession number: P41970
Secondary accession number(s): B2R6S6 expand/collapse secondary AC list , Q6FG57, Q6GU29, Q9UD17
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM