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P41970

- ELK3_HUMAN

UniProt

P41970 - ELK3_HUMAN

Protein

ETS domain-containing protein Elk-3

Gene

ELK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi5 – 8581ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. purine-rich negative regulatory element binding Source: HGNC
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    5. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    6. sequence-specific DNA binding transcription factor activity Source: ProtInc
    7. transcription corepressor activity Source: HGNC

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. cell differentiation Source: RefGenome
    3. negative regulation of transcription, DNA-templated Source: HGNC
    4. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    5. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    6. signal transduction Source: ProtInc
    7. transcription from RNA polymerase II promoter Source: GOC
    8. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiP41970.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ETS domain-containing protein Elk-3
    Alternative name(s):
    ETS-related protein ERP
    ETS-related protein NET
    Serum response factor accessory protein 2
    Short name:
    SAP-2
    Short name:
    SRF accessory protein 2
    Gene namesi
    Name:ELK3
    Synonyms:NET, SAP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:3325. ELK3.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular membrane-bounded organelle Source: HPA
    2. mitochondrion Source: HPA
    3. nucleus Source: HGNC

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27752.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 407407ETS domain-containing protein Elk-3PRO_0000204097Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei115 – 1151Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP41970.
    PaxDbiP41970.
    PRIDEiP41970.

    PTM databases

    PhosphoSiteiP41970.

    Expressioni

    Gene expression databases

    ArrayExpressiP41970.
    BgeeiP41970.
    CleanExiHS_ELK3.
    GenevestigatoriP41970.

    Organism-specific databases

    HPAiHPA001600.

    Interactioni

    Subunit structurei

    Interacts with CTBP1.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NCK1P163333EBI-1758534,EBI-389883

    Protein-protein interaction databases

    BioGridi108319. 4 interactions.
    IntActiP41970. 4 interactions.
    MINTiMINT-7242082.
    STRINGi9606.ENSP00000228741.

    Structurei

    3D structure databases

    ProteinModelPortaliP41970.
    SMRiP41970. Positions 2-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi273 – 2775CTBP-binding motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi207 – 2126Poly-Ala

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG288109.
    HOGENOMiHOG000237332.
    HOVERGENiHBG004344.
    InParanoidiP41970.
    KOiK09430.
    OMAiTNKTDKH.
    OrthoDBiEOG7NPFTD.
    PhylomeDBiP41970.
    TreeFamiTF317732.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    [Graphical view]
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41970-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESAITLWQF LLQLLLDQKH EHLICWTSND GEFKLLKAEE VAKLWGLRKN    50
    KTNMNYDKLS RALRYYYDKN IIKKVIGQKF VYKFVSFPEI LKMDPHAVEI 100
    SRESLLLQDS DCKASPEGRE AHKHGLAALR STSRNEYIHS GLYSSFTINS 150
    LQNPPDAFKA IKTEKLEEPP EDSPPVEEVR TVIRFVTNKT DKHVTRPVVS 200
    LPSTSEAAAA SAFLASSVSA KISSLMLPNA ASISSASPFS SRSPSLSPNS 250
    PLPSEHRSLF LEAACHDSDS LEPLNLSSGS KTKSPSLPPK AKKPKGLEIS 300
    APPLVLSGTD IGSIALNSPA LPSGSLTPAF FTAQTPNGLL LTPSPLLSSI 350
    HFWSSLSPVA PLSPARLQGP STLFQFPTLL NGHMPVPIPS LDRAASPVLL 400
    SSNSQKS 407
    Length:407
    Mass (Da):44,240
    Last modified:October 17, 2006 - v2
    Checksum:iDD4515270ECED1E3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1141A → V in CAA85309. (PubMed:7958835)Curated
    Sequence conflicti117 – 1171E → G in CAG47047. 1 PublicationCurated
    Sequence conflicti128 – 1281A → V in CAA85309. (PubMed:7958835)Curated
    Sequence conflicti152 – 1521Q → E in CAA85309. (PubMed:7958835)Curated
    Sequence conflicti163 – 1631T → R in CAA85309. (PubMed:7958835)Curated
    Sequence conflicti249 – 2491N → K in CAA85309. (PubMed:7958835)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti169 – 1691P → L.
    Corresponds to variant rs35332676 [ dbSNP | Ensembl ].
    VAR_048946

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36715 mRNA. Translation: CAA85309.1.
    CR542251 mRNA. Translation: CAG47047.1.
    AK312694 mRNA. Translation: BAG35573.1.
    CH471054 Genomic DNA. Translation: EAW97561.1.
    BC017371 mRNA. Translation: AAH17371.1.
    CCDSiCCDS9060.1.
    PIRiI38062.
    RefSeqiNP_005221.2. NM_005230.2.
    XP_006719338.1. XM_006719275.1.
    UniGeneiHs.46523.

    Genome annotation databases

    EnsembliENST00000228741; ENSP00000228741; ENSG00000111145.
    GeneIDi2004.
    KEGGihsa:2004.
    UCSCiuc001teo.1. human.

    Polymorphism databases

    DMDMi116241349.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36715 mRNA. Translation: CAA85309.1 .
    CR542251 mRNA. Translation: CAG47047.1 .
    AK312694 mRNA. Translation: BAG35573.1 .
    CH471054 Genomic DNA. Translation: EAW97561.1 .
    BC017371 mRNA. Translation: AAH17371.1 .
    CCDSi CCDS9060.1.
    PIRi I38062.
    RefSeqi NP_005221.2. NM_005230.2.
    XP_006719338.1. XM_006719275.1.
    UniGenei Hs.46523.

    3D structure databases

    ProteinModelPortali P41970.
    SMRi P41970. Positions 2-151.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108319. 4 interactions.
    IntActi P41970. 4 interactions.
    MINTi MINT-7242082.
    STRINGi 9606.ENSP00000228741.

    PTM databases

    PhosphoSitei P41970.

    Polymorphism databases

    DMDMi 116241349.

    Proteomic databases

    MaxQBi P41970.
    PaxDbi P41970.
    PRIDEi P41970.

    Protocols and materials databases

    DNASUi 2004.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000228741 ; ENSP00000228741 ; ENSG00000111145 .
    GeneIDi 2004.
    KEGGi hsa:2004.
    UCSCi uc001teo.1. human.

    Organism-specific databases

    CTDi 2004.
    GeneCardsi GC12P096521.
    HGNCi HGNC:3325. ELK3.
    HPAi HPA001600.
    MIMi 600247. gene.
    neXtProti NX_P41970.
    PharmGKBi PA27752.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288109.
    HOGENOMi HOG000237332.
    HOVERGENi HBG004344.
    InParanoidi P41970.
    KOi K09430.
    OMAi TNKTDKH.
    OrthoDBi EOG7NPFTD.
    PhylomeDBi P41970.
    TreeFami TF317732.

    Enzyme and pathway databases

    SignaLinki P41970.

    Miscellaneous databases

    GeneWikii ELK3.
    GenomeRNAii 2004.
    NextBioi 8109.
    PROi P41970.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41970.
    Bgeei P41970.
    CleanExi HS_ELK3.
    Genevestigatori P41970.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    [Graphical view ]
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Net, a new ets transcription factor that is activated by Ras."
      Giovane A., Pintzas A., Maira S.-M., Sobieszczuk P., Wasylyk B.
      Genes Dev. 8:1502-1513(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)."
      Price M.A., Rogers A.E., Treisman R.
      EMBO J. 14:2589-2601(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiELK3_HUMAN
    AccessioniPrimary (citable) accession number: P41970
    Secondary accession number(s): B2R6S6
    , Q6FG57, Q6GU29, Q9UD17
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3