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P41969

- ELK1_MOUSE

UniProt

P41969 - ELK1_MOUSE

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Protein
ETS domain-containing protein Elk-1
Gene
Elk1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi5 – 8682ETS
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: RefGenome
  2. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. positive regulation of transcription, DNA-templated Source: MGI
  4. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  5. regulation of transcription, DNA-templated Source: MGI
  6. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_215063. ERK/MAPK targets.

Names & Taxonomyi

Protein namesi
Recommended name:
ETS domain-containing protein Elk-1
Gene namesi
Name:Elk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:101833. Elk1.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
  2. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429ETS domain-containing protein Elk-1
PRO_0000204096Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki231 – 231Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Cross-linki250 – 250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Cross-linki255 – 255Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Modified residuei325 – 3251Phosphoserine; by MAPK1 By similarity
Modified residuei337 – 3371Phosphothreonine; by MAPK1 By similarity
Modified residuei354 – 3541Phosphothreonine; by MAPK1 By similarity
Modified residuei364 – 3641Phosphothreonine; by MAPK1 By similarity
Modified residuei369 – 3691Phosphothreonine; by MAPK1 By similarity
Modified residuei384 – 3841Phosphoserine; by MAPK1 and MAPK8 By similarity
Modified residuei390 – 3901Phosphoserine; by MAPK1 By similarity
Modified residuei418 – 4181Phosphothreonine; by MAPK1 By similarity
Modified residuei423 – 4231Phosphoserine; by MAPK1 By similarity

Post-translational modificationi

Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention By similarity.
On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1 but also MAPK8 and/or MAPK9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CaMK4, MAPK11, MAPK12 and MAPK14 By similarity.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiP41969.

PTM databases

PhosphoSiteiP41969.

Expressioni

Tissue specificityi

Predominantly expressed in the brain, and to a lesser extent in the heart, liver and muscle.

Gene expression databases

ArrayExpressiP41969.
BgeeiP41969.
CleanExiMM_ELK1.
GenevestigatoriP41969.

Interactioni

Subunit structurei

Interacts in its sumoylated form with PIAS2 which enhances its transcriptional activator activity. Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9 By similarity.

Protein-protein interaction databases

BioGridi199429. 2 interactions.
STRINGi10090.ENSMUSP00000009550.

Structurei

3D structure databases

ProteinModelPortaliP41969.
SMRiP41969. Positions 5-90.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni350 – 40051Sufficient for interaction with MAD2L2 By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the ETS family.

Phylogenomic databases

eggNOGiNOG269367.
GeneTreeiENSGT00750000117271.
HOGENOMiHOG000237332.
HOVERGENiHBG004344.
InParanoidiQ3V1M9.
KOiK04375.
OMAiPNPLEAC.
OrthoDBiEOG7NPFTD.
TreeFamiTF317732.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41969-1 [UniParc]FASTAAdd to Basket

« Hide

MDPSVTLWQF LLQLLREQGN GHIISWTSRD GGEFKLVDAE EVARLWGLRK    50
NKTNMNYDKL SRALRYYYDK NIIRKVSGQK FVYKFVSYPE VAGCSTEDCP 100
PQPEVSVTSA IAMAPATVHA GPGDTATGKP GTPKGAGMTG QGGLARSSRN 150
EYMRSGLYST FTIQSLQPQP QPPIPPRPAS VLPNTTPAGV PAPASGSRST 200
SPNPLEACLE AEEAGLPLQV ILTPPEAPNQ KSEELSLDPS FGHPQPPEVK 250
VEGPKEELEA ARAGGFSSEA VKAEPEVSAS EGLLARLPAI LTENTAQVCG 300
LSTSTTEITQ PQKGRKPRDL ELPLSPSLLG GQGPERTPGS GTSSGLQAPG 350
PALTPSLLPT HTLTPVLLTP SSLPPSIHFW STLSPIAPRS PAKLSFQFPS 400
SGSAQVHIPS ISVDGLSTPV VLSPGPQKP 429
Length:429
Mass (Da):45,271
Last modified:July 27, 2011 - v3
Checksum:i2E1C5B80790C6DA7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331P → T in CAA85391. 1 Publication
Sequence conflicti249 – 2491V → A in CAA60715. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87257 mRNA. Translation: CAA60715.1.
AK132354 mRNA. Translation: BAE21121.1.
AL671853 Genomic DNA. Translation: CAM19337.1.
CH466625 Genomic DNA. Translation: EDL00733.1.
Z36939 mRNA. Translation: CAA85391.1.
CCDSiCCDS30048.1.
PIRiJC4965.
RefSeqiNP_031948.4. NM_007922.5.
UniGeneiMm.405823.
Mm.490895.

Genome annotation databases

EnsembliENSMUST00000009550; ENSMUSP00000009550; ENSMUSG00000009406.
GeneIDi13712.
KEGGimmu:13712.
UCSCiuc009suc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87257 mRNA. Translation: CAA60715.1 .
AK132354 mRNA. Translation: BAE21121.1 .
AL671853 Genomic DNA. Translation: CAM19337.1 .
CH466625 Genomic DNA. Translation: EDL00733.1 .
Z36939 mRNA. Translation: CAA85391.1 .
CCDSi CCDS30048.1.
PIRi JC4965.
RefSeqi NP_031948.4. NM_007922.5.
UniGenei Mm.405823.
Mm.490895.

3D structure databases

ProteinModelPortali P41969.
SMRi P41969. Positions 5-90.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199429. 2 interactions.
STRINGi 10090.ENSMUSP00000009550.

PTM databases

PhosphoSitei P41969.

Proteomic databases

PRIDEi P41969.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000009550 ; ENSMUSP00000009550 ; ENSMUSG00000009406 .
GeneIDi 13712.
KEGGi mmu:13712.
UCSCi uc009suc.2. mouse.

Organism-specific databases

CTDi 2002.
MGIi MGI:101833. Elk1.

Phylogenomic databases

eggNOGi NOG269367.
GeneTreei ENSGT00750000117271.
HOGENOMi HOG000237332.
HOVERGENi HBG004344.
InParanoidi Q3V1M9.
KOi K04375.
OMAi PNPLEAC.
OrthoDBi EOG7NPFTD.
TreeFami TF317732.

Enzyme and pathway databases

Reactomei REACT_215063. ERK/MAPK targets.

Miscellaneous databases

NextBioi 284482.
PROi P41969.
SOURCEi Search...

Gene expression databases

ArrayExpressi P41969.
Bgeei P41969.
CleanExi MM_ELK1.
Genevestigatori P41969.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
[Graphical view ]
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Embryo.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Net, a new ets transcription factor that is activated by Ras."
    Giovane A., Pintzas A., Maira S.-M., Sobieszczuk P., Wasylyk B.
    Genes Dev. 8:1502-1513(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-224.
    Tissue: Embryo.

Entry informationi

Entry nameiELK1_MOUSE
AccessioniPrimary (citable) accession number: P41969
Secondary accession number(s): Q3V1M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi