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Protein

Drosomycin

Gene

Drs

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possesses antifungal activity and is active against a relatively broad spectrum of filamentous fungi. It inhibits spore germination at high concentrations and at low concentrations delays growth of hyphae which subsequently exhibit abnormal morphology. Spz C-106 in the hemolymph controls expression of the antifungal peptide by acting as a ligand of Tl and inducing an intracellular signaling pathway.2 Publications

GO - Biological processi

  • antibacterial humoral response Source: FlyBase
  • antifungal humoral response Source: FlyBase
  • cytolysis in other organism Source: FlyBase
  • defense response Source: FlyBase
  • defense response to fungus Source: FlyBase
  • defense response to Gram-negative bacterium Source: FlyBase
  • defense response to protozoan Source: FlyBase
  • innate immune response Source: FlyBase
  • response to bacterium Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Fungicide

Protein family/group databases

TCDBi8.B.1.1.9. the long (4c-c) scorpion toxin (l-st) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Drosomycin
Alternative name(s):
Cysteine-rich peptide
Gene namesi
Name:Drs
Synonyms:CRP
ORF Names:CG10810
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0283461. Drs.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Propeptidei21 – 2661 PublicationPRO_0000007038
Chaini27 – 7044DrosomycinPRO_0000007039Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 70
Disulfide bondi37 ↔ 59
Disulfide bondi45 ↔ 65
Disulfide bondi49 ↔ 67

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP41964.
PRIDEiP41964.

Expressioni

Tissue specificityi

Synthesized in the fat body and is secreted into the blood. In hemolymph 6 hours after immune challenge, levels of expression increase for first 24 hours and persist for the following three weeks.1 Publication

Gene expression databases

BgeeiFBgn0010381.
GenevisibleiP41964. DM.

Interactioni

Protein-protein interaction databases

DIPiDIP-18879N.
MINTiMINT-291861.
STRINGi7227.FBpp0072935.

Structurei

Secondary structure

1
70
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni39 – 413Combined sources
Helixi42 – 5211Combined sources
Beta strandi54 – 607Combined sources
Turni61 – 633Combined sources
Beta strandi64 – 685Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MYNNMR-A27-70[»]
ProteinModelPortaliP41964.
SMRiP41964. Positions 27-70.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41964.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00840000130934.
InParanoidiP41964.
OMAiHETCRRV.
PhylomeDBiP41964.

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
[Graphical view]
SMARTiSM00505. Knot1. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41964-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQIKYLFAL FAVLMLVVLG ANEADADCLS GRYKGPCAVW DNETCRRVCK
60 70
EEGRSSGHCS PSLKCWCEGC
Length:70
Mass (Da):7,752
Last modified:November 1, 1995 - v1
Checksum:i1A702E959ECEF181
GO

Mass spectrometryi

Molecular mass is 4889.5 Da from positions 27 - 70. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75595 mRNA. Translation: CAA53267.1.
AJ885056 Genomic DNA. Translation: CAI76995.1.
AJ885057 Genomic DNA. Translation: CAI77002.1.
AJ885058 Genomic DNA. Translation: CAI77009.1.
AJ885059 Genomic DNA. Translation: CAI77016.1.
AJ885060 Genomic DNA. Translation: CAI77023.1.
AJ885061 Genomic DNA. Translation: CAI77030.1.
AJ885062 Genomic DNA. Translation: CAI77037.1.
AJ885063 Genomic DNA. Translation: CAI77044.1.
AJ885064 Genomic DNA. Translation: CAI77051.1.
AJ885065 Genomic DNA. Translation: CAI77058.1.
AJ885066 Genomic DNA. Translation: CAI77065.1.
AJ885067 Genomic DNA. Translation: CAI77072.1.
AJ885068 Genomic DNA. Translation: CAI77079.1.
AJ885069 Genomic DNA. Translation: CAI77086.1.
AJ885070 Genomic DNA. Translation: CAI77093.1.
AJ885071 Genomic DNA. Translation: CAI77100.1.
AJ885072 Genomic DNA. Translation: CAI77107.1.
AJ885073 Genomic DNA. Translation: CAI77114.1.
AJ885074 Genomic DNA. Translation: CAI77121.1.
AJ885075 Genomic DNA. Translation: CAI77128.1.
AJ885086 Genomic DNA. Translation: CAI77205.1.
AE014296 Genomic DNA. Translation: AAF47767.2.
AY119009 mRNA. Translation: AAM50869.1.
PIRiA55824.
RefSeqiNP_523901.1. NM_079177.4.
UniGeneiDm.14479.

Genome annotation databases

EnsemblMetazoaiFBtr0073073; FBpp0072935; FBgn0010381.
GeneIDi38419.
KEGGidme:Dmel_CG10810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75595 mRNA. Translation: CAA53267.1.
AJ885056 Genomic DNA. Translation: CAI76995.1.
AJ885057 Genomic DNA. Translation: CAI77002.1.
AJ885058 Genomic DNA. Translation: CAI77009.1.
AJ885059 Genomic DNA. Translation: CAI77016.1.
AJ885060 Genomic DNA. Translation: CAI77023.1.
AJ885061 Genomic DNA. Translation: CAI77030.1.
AJ885062 Genomic DNA. Translation: CAI77037.1.
AJ885063 Genomic DNA. Translation: CAI77044.1.
AJ885064 Genomic DNA. Translation: CAI77051.1.
AJ885065 Genomic DNA. Translation: CAI77058.1.
AJ885066 Genomic DNA. Translation: CAI77065.1.
AJ885067 Genomic DNA. Translation: CAI77072.1.
AJ885068 Genomic DNA. Translation: CAI77079.1.
AJ885069 Genomic DNA. Translation: CAI77086.1.
AJ885070 Genomic DNA. Translation: CAI77093.1.
AJ885071 Genomic DNA. Translation: CAI77100.1.
AJ885072 Genomic DNA. Translation: CAI77107.1.
AJ885073 Genomic DNA. Translation: CAI77114.1.
AJ885074 Genomic DNA. Translation: CAI77121.1.
AJ885075 Genomic DNA. Translation: CAI77128.1.
AJ885086 Genomic DNA. Translation: CAI77205.1.
AE014296 Genomic DNA. Translation: AAF47767.2.
AY119009 mRNA. Translation: AAM50869.1.
PIRiA55824.
RefSeqiNP_523901.1. NM_079177.4.
UniGeneiDm.14479.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MYNNMR-A27-70[»]
ProteinModelPortaliP41964.
SMRiP41964. Positions 27-70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-18879N.
MINTiMINT-291861.
STRINGi7227.FBpp0072935.

Protein family/group databases

TCDBi8.B.1.1.9. the long (4c-c) scorpion toxin (l-st) superfamily.

Proteomic databases

PaxDbiP41964.
PRIDEiP41964.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0073073; FBpp0072935; FBgn0010381.
GeneIDi38419.
KEGGidme:Dmel_CG10810.

Organism-specific databases

CTDi38419.
FlyBaseiFBgn0283461. Drs.

Phylogenomic databases

GeneTreeiENSGT00840000130934.
InParanoidiP41964.
OMAiHETCRRV.
PhylomeDBiP41964.

Miscellaneous databases

EvolutionaryTraceiP41964.
GenomeRNAii38419.
PROiP41964.

Gene expression databases

BgeeiFBgn0010381.
GenevisibleiP41964. DM.

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
[Graphical view]
SMARTiSM00505. Knot1. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDMYC_DROME
AccessioniPrimary (citable) accession number: P41964
Secondary accession number(s): Q2UYN5, Q9VZQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.