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Protein

Drosomycin

Gene

Drs

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possesses antifungal activity and is active against a relatively broad spectrum of filamentous fungi (PubMed:8808632, PubMed:12872120). It inhibits spore germination at high concentrations and at low concentrations delays growth of hyphae which subsequently exhibit abnormal morphology (PubMed:7806546). Spz C-106 in the hemolymph controls expression of the antifungal peptide by acting as a ligand of Tl and inducing an intracellular signaling pathway (PubMed:8808632). Part of a psh-dependent Toll pathway, which may function in activating the systematic immune response in response to localized melanization of the tracheal system (PubMed:18854145).4 Publications

GO - Biological processi

  • antibacterial humoral response Source: FlyBase
  • antifungal humoral response Source: UniProtKB
  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • cytolysis in other organism Source: FlyBase
  • defense response Source: FlyBase
  • defense response to fungus Source: FlyBase
  • defense response to Gram-negative bacterium Source: FlyBase
  • defense response to protozoan Source: FlyBase
  • innate immune response Source: FlyBase
  • response to bacterium Source: FlyBase

Keywordsi

Molecular functionAntimicrobial, Fungicide

Protein family/group databases

TCDBi8.B.1.1.9 the long (4c-c) scorpion toxin (l-st) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Drosomycin
Alternative name(s):
Cysteine-rich peptide
Gene namesi
Name:Drs
Synonyms:CRP
ORF Names:CG10810
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0283461 Drs

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000000703821 – 261 Publication6
ChainiPRO_000000703927 – 70DrosomycinAdd BLAST44

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 70
Disulfide bondi37 ↔ 59
Disulfide bondi45 ↔ 65
Disulfide bondi49 ↔ 67

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP41964
PRIDEiP41964

Expressioni

Tissue specificityi

Synthesized in the fat body and is secreted into the blood (PubMed:9736738). In hemolymph 6 hours after immune challenge, levels of expression increase for first 24 hours and persist for the following three weeks (PubMed:9736738). In larvae, expressed in the visceral branches and posterior spiracles of the trachea (PubMed:22022271).2 Publications

Inductioni

Up-regulated by septic injury caused by the Gram-positive bacteria M.luteus and the fungus C.albicans, and by M.luteus or E.faecalis-derived peptidoglycans and by B.subtilis or A.oryzae proteases (PubMed:19590012). Up-regulated by Gram-negative bacteria in the respiratory epithelium (PubMed:22022271). Up-regulated in the trachea and fat body in response to tracheal melanization, either by spontaneous melanization or melanization resulting from infection by bacteria (E.coli and M.luteus) or the fungus B.bassiana (PubMed:18854145).3 Publications

Gene expression databases

BgeeiFBgn0010381
ExpressionAtlasiP41964 differential
GenevisibleiP41964 DM

Interactioni

Protein-protein interaction databases

DIPiDIP-18879N
IntActiP41964, 3 interactors
STRINGi7227.FBpp0072935

Structurei

Secondary structure

170
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni39 – 41Combined sources3
Helixi42 – 52Combined sources11
Beta strandi54 – 60Combined sources7
Turni61 – 63Combined sources3
Beta strandi64 – 68Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MYNNMR-A27-70[»]
ProteinModelPortaliP41964
SMRiP41964
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41964

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiP41964
KOiK20670
OMAiHETCRRV
PhylomeDBiP41964

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR003614 Scorpion_toxin-like
IPR036574 Scorpion_toxin-like_sf
SMARTiView protein in SMART
SM00505 Knot1, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41964-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQIKYLFAL FAVLMLVVLG ANEADADCLS GRYKGPCAVW DNETCRRVCK
60 70
EEGRSSGHCS PSLKCWCEGC
Length:70
Mass (Da):7,752
Last modified:November 1, 1995 - v1
Checksum:i1A702E959ECEF181
GO

Mass spectrometryi

Molecular mass is 4889.5 Da from positions 27 - 70. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75595 mRNA Translation: CAA53267.1
AJ885056 Genomic DNA Translation: CAI76995.1
AJ885057 Genomic DNA Translation: CAI77002.1
AJ885058 Genomic DNA Translation: CAI77009.1
AJ885059 Genomic DNA Translation: CAI77016.1
AJ885060 Genomic DNA Translation: CAI77023.1
AJ885061 Genomic DNA Translation: CAI77030.1
AJ885062 Genomic DNA Translation: CAI77037.1
AJ885063 Genomic DNA Translation: CAI77044.1
AJ885064 Genomic DNA Translation: CAI77051.1
AJ885065 Genomic DNA Translation: CAI77058.1
AJ885066 Genomic DNA Translation: CAI77065.1
AJ885067 Genomic DNA Translation: CAI77072.1
AJ885068 Genomic DNA Translation: CAI77079.1
AJ885069 Genomic DNA Translation: CAI77086.1
AJ885070 Genomic DNA Translation: CAI77093.1
AJ885071 Genomic DNA Translation: CAI77100.1
AJ885072 Genomic DNA Translation: CAI77107.1
AJ885073 Genomic DNA Translation: CAI77114.1
AJ885074 Genomic DNA Translation: CAI77121.1
AJ885075 Genomic DNA Translation: CAI77128.1
AJ885086 Genomic DNA Translation: CAI77205.1
AE014296 Genomic DNA Translation: AAF47767.2
AY119009 mRNA Translation: AAM50869.1
PIRiA55824
RefSeqiNP_523901.1, NM_079177.4
UniGeneiDm.14479

Genome annotation databases

EnsemblMetazoaiFBtr0073073; FBpp0072935; FBgn0283461
GeneIDi38419
KEGGidme:Dmel_CG10810

Similar proteinsi

Entry informationi

Entry nameiDMYC_DROME
AccessioniPrimary (citable) accession number: P41964
Secondary accession number(s): Q2UYN5, Q9VZQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health