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Protein

Apoptosis regulator ced-9

Gene

ced-9

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in programmed cell death (PCD, apoptosis). Egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3.6 Publications

GO - Molecular functioni

GO - Biological processi

  • apoptotic process involved in development Source: UniProtKB
  • extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
  • mitophagy Source: WormBase
  • negative regulation of apoptotic process Source: WormBase
  • negative regulation of intrinsic apoptotic signaling pathway Source: GO_Central
  • negative regulation of programmed cell death Source: WormBase
  • positive regulation of mitochondrial fusion Source: WormBase
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Protein family/group databases

TCDBi1.A.21.2.1. the bcl-2 (bcl-2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis regulator ced-9
Alternative name(s):
Cell death protein 9
Gene namesi
Name:ced-9
ORF Names:T07C4.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT07C4.8; CE25104; WBGene00000423; ced-9.

Subcellular locationi

GO - Cellular componenti

  • endomembrane system Source: UniProtKB-SubCell
  • membrane Source: WormBase
  • mitochondrial outer membrane Source: WormBase
  • mitochondrion Source: WormBase
  • organelle membrane Source: WormBase
  • perinuclear region of cytoplasm Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi149Y → N in N1653; lethal phenotype. 1 Publication1
Mutagenesisi169G → E in G169E; gain of function. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430971 – 280Apoptosis regulator ced-9Add BLAST280

Proteomic databases

EPDiP41958.
PaxDbiP41958.
PeptideAtlasiP41958.

PTM databases

iPTMnetiP41958.

Expressioni

Developmental stagei

Abundant expression is seen in embryos and adults.1 Publication

Gene expression databases

BgeeiWBGene00000423.

Interactioni

Subunit structurei

Interacts with ced-4 (PubMed:9027313). Interacts with egl-1 (PubMed:9604928, PubMed:12894216, PubMed:15383288). Interacts with dre-1; the interaction inhibits ced-9 activity, either directly or indirectly (PubMed:23431138).5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ced-3P425732EBI-494110,EBI-494247
ced-4P3042919EBI-494110,EBI-494118
egl-1O616677EBI-494110,EBI-495949

GO - Molecular functioni

Protein-protein interaction databases

BioGridi533094. 4 interactors.
DIPiDIP-250N.
IntActiP41958. 3 interactors.
MINTiMINT-1526902.
STRINGi6239.T07C4.8.

Structurei

Secondary structure

1280
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi72 – 74Combined sources3
Helixi76 – 78Combined sources3
Helixi80 – 94Combined sources15
Helixi111 – 138Combined sources28
Beta strandi140 – 143Combined sources4
Helixi146 – 153Combined sources8
Turni154 – 157Combined sources4
Beta strandi161 – 163Combined sources3
Helixi168 – 185Combined sources18
Turni189 – 191Combined sources3
Helixi192 – 194Combined sources3
Helixi195 – 211Combined sources17
Helixi214 – 217Combined sources4
Helixi221 – 239Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OHUX-ray2.03A/B68-242[»]
1TY4X-ray2.20A/B68-237[»]
2A5YX-ray2.60A48-251[»]
ProteinModelPortaliP41958.
SMRiP41958.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41958.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi80 – 99BH4Add BLAST20
Motifi160 – 179BH1Add BLAST20
Motifi213 – 229BH2Add BLAST17

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
HOGENOMiHOG000111534.
InParanoidiP41958.
KOiK20094.
OMAiYVEVVEC.
OrthoDBiEOG091G0QL0.
PhylomeDBiP41958.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR003093. Bcl2_BH4.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
[Graphical view]
SMARTiSM00265. BH4. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS50063. BH4_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41958-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRCTADNSL TNPAYRRRTM ATGEMKEFLG IKGTEPTDFG INSDAQDLPS
60 70 80 90 100
PSRQASTRRM SIGESIDGKI NDWEEPRLDI EGFVVDYFTH RIRQNGMEWF
110 120 130 140 150
GAPGLPCGVQ PEHEMMRVMG TIFEKKHAEN FETFCEQLLA VPRISFSLYQ
160 170 180 190 200
DVVRTVGNAQ TDQCPMSYGR LIGLISFGGF VAAKMMESVE LQGQVRNLFV
210 220 230 240 250
YTSLFIKTRI RNNWKEHNRS WDDFMTLGKQ MKEDYERAEA EKVGRRKQNR
260 270 280
RWSMIGAGVT AGAIGIVGVV VCGRMMFSLK
Length:280
Mass (Da):31,824
Last modified:November 1, 1995 - v1
Checksum:i7603675E490DD3EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26545 Genomic DNA. Translation: AAA20080.1.
Z29443 Genomic DNA. Translation: CAA82573.2.
PIRiA53189.
H88578.
RefSeqiNP_499284.1. NM_066883.5.
UniGeneiCel.6305.

Genome annotation databases

EnsemblMetazoaiT07C4.8; T07C4.8; WBGene00000423.
GeneIDi3565776.
KEGGicel:CELE_T07C4.8.
UCSCiT07C4.8.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26545 Genomic DNA. Translation: AAA20080.1.
Z29443 Genomic DNA. Translation: CAA82573.2.
PIRiA53189.
H88578.
RefSeqiNP_499284.1. NM_066883.5.
UniGeneiCel.6305.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OHUX-ray2.03A/B68-242[»]
1TY4X-ray2.20A/B68-237[»]
2A5YX-ray2.60A48-251[»]
ProteinModelPortaliP41958.
SMRiP41958.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi533094. 4 interactors.
DIPiDIP-250N.
IntActiP41958. 3 interactors.
MINTiMINT-1526902.
STRINGi6239.T07C4.8.

Protein family/group databases

TCDBi1.A.21.2.1. the bcl-2 (bcl-2) family.

PTM databases

iPTMnetiP41958.

Proteomic databases

EPDiP41958.
PaxDbiP41958.
PeptideAtlasiP41958.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT07C4.8; T07C4.8; WBGene00000423.
GeneIDi3565776.
KEGGicel:CELE_T07C4.8.
UCSCiT07C4.8.1. c. elegans.

Organism-specific databases

CTDi3565776.
WormBaseiT07C4.8; CE25104; WBGene00000423; ced-9.

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
HOGENOMiHOG000111534.
InParanoidiP41958.
KOiK20094.
OMAiYVEVVEC.
OrthoDBiEOG091G0QL0.
PhylomeDBiP41958.

Miscellaneous databases

EvolutionaryTraceiP41958.
PROiP41958.

Gene expression databases

BgeeiWBGene00000423.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR003093. Bcl2_BH4.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
[Graphical view]
SMARTiSM00265. BH4. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS50063. BH4_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCED9_CAEEL
AccessioniPrimary (citable) accession number: P41958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.