P41957 (CED9_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Apoptosis regulator ced-9

Alternative name(s):
Cell death protein 9

Gene names

Name:	ced-9
ORF Names:	CBG24606

Organism

Caenorhabditis briggsae [Reference proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a major role in programmed cell death (PCD, apoptosis). Egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3 By similarity.
Subunit structure	Interacts with ced-4 and egl-1 By similarity.
Subcellular location	Endomembrane system; Peripheral membrane protein By similarity. Mitochondrion membrane; Peripheral membrane protein By similarity. Note: Intracellular membranes, mitochondrial, and perinuclear region By similarity.
Developmental stage	Abundant expression is seen in the embryos and the adults.
Sequence similarities	Belongs to the Bcl-2 family.
Sequence caution	The sequence AAA20077.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Membrane Mitochondrion
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of apoptotic process Inferred from electronic annotation. Source: InterPro
Cellular_component	endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Apoptosis regulator ced-9		PRO_0000143096
Regions
	Motif	75 – 94	20	BH4
	Motif	154 – 174	21	BH1
	Motif	208 – 223	16	BH2

Sequences

	Sequence		Length	Mass (Da)
	P41957 [UniParc]. Last modified February 1, 2005. Version 2. Checksum: FF30C60C399322C1	FASTA	266	30,640
	10 20 30 40 50 60 MVDSMDMANS SQNTFRRRTM ATSEMREFLS TKDAEPNNFG MQTIPESPTP STPTRRMSIG 70 80 90 100 110 120 DSTRIYDWEE PRFNIQGFVV DYFTYRIAQN GLDWYDAPAL PDGVQKEHEM MRSLGTIFEK 130 140 150 160 170 180 RHMEMFENFS EQLLAVPKIS FSLYQEVVQT VGNSSNTPCP MSYGRLIGLI SFGGMVAAKM 190 200 210 220 230 240 MESAELQGQV RNLLMYTSLF IKTRIRQSWK EHNRSWADFM KLGQQMKEDY EKEKDAEEGK 250 260 RLKSWSIIGA SVIAVIVCGR IIFSFK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2." Hengartner M.O., Horvitz H.R. Cell 76:665-676(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L26546 Unassigned DNA. Translation: AAA20077.1. Different initiation. HE601354 Genomic DNA. Translation: CAP21182.1.
RefSeq	XP_002641306.1. XM_002641260.1.
3D structure databases
ProteinModelPortal	P41957.
SMR	P41957. Positions 67-231.
ModBase	Search...
Protein-protein interaction databases
STRING	6238.CBG24606.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	CBG24606; CBG24606; CBG24606.
GeneID	8583298.
KEGG	cbr:CBG24606.
Organism-specific databases
CTD	8583298.
WormBase	CBG24606; CBP12970; WBGene00042676; Cbr-ced-9.
Phylogenomic databases
eggNOG	NOG326862.
HOGENOM	HOG000111534.
OMA	LFIKTRI.
Family and domain databases
InterPro	IPR002475. Bcl2-like. IPR020717. Bcl2_BH1_motif_CS. IPR003093. Bcl2_BH4. IPR026298. Blc2_fam. [Graphical view]
PANTHER	PTHR11256. PTHR11256. 1 hit.
Pfam	PF00452. Bcl-2. 1 hit. PF02180. BH4. 1 hit. [Graphical view]
SMART	SM00265. BH4. 1 hit. [Graphical view]
PROSITE	PS50062. BCL2_FAMILY. 1 hit. PS01080. BH1. 1 hit. PS01258. BH2. False negative. PS01260. BH4_1. False negative. PS50063. BH4_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CED9_CAEBR

Accession

Primary (citable) accession number: P41957
Secondary accession number(s): A8WL37, Q60JB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	February 1, 2005
Last modified:	April 3, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project