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Protein

Mannose-1-phosphate guanyltransferase

Gene

PSA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.1 Publication

Miscellaneous

Present with 97100 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Mannose-1-phosphate guanyltransferase (PSA1)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route), the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • mannose-1-phosphate guanylyltransferase activity Source: SGD

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell wall mannoprotein biosynthetic process Source: SGD
  • GDP-mannose biosynthetic process Source: SGD
  • protein glycosylation Source: SGD

Keywordsi

Molecular functionTransferase
Biological processCell cycle
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:YDL055C-MONOMER
BRENDAi2.7.7.13 984
UniPathwayiUPA00126; UER00930

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-1-phosphate guanyltransferase (EC:2.7.7.13)
Alternative name(s):
ATP-mannose-1-phosphate guanylyltransferase
GDP-mannose pyrophosphorylase
NDP-hexose pyrophosphorylase
Gene namesi
Name:PSA1
Synonyms:MPG1, SRB1, VIG9
Ordered Locus Names:YDL055C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL055C
SGDiS000002213 PSA1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000687411 – 361Mannose-1-phosphate guanyltransferaseAdd BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei153PhosphothreonineCombined sources1
Cross-linki244Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP41940
PaxDbiP41940
PRIDEiP41940
TopDownProteomicsiP41940

PTM databases

iPTMnetiP41940

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32003138 interactors.
DIPiDIP-4322N
IntActiP41940 493 interactors.
MINTiP41940
STRINGi4932.YDL055C

Structurei

3D structure databases

ProteinModelPortaliP41940
SMRiP41940
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00530000063581
HOGENOMiHOG000283479
InParanoidiP41940
KOiK00966
OMAiYWMDVGQ
OrthoDBiEOG092C3YQK

Family and domain databases

Gene3Di3.90.550.101 hit
InterProiView protein in InterPro
IPR001451 Hexapep
IPR018357 Hexapep_transf_CS
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF00132 Hexapep, 1 hit
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS00101 HEXAPEP_TRANSFERASES, 2 hits

Sequencei

Sequence statusi: Complete.

P41940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGLILVGGY GTRLRPLTLT VPKPLVEFGN RPMILHQIEA LANAGVTDIV
60 70 80 90 100
LAVNYRPEVM VETLKKYEKE YGVNITFSVE TEPLGTAGPL KLAEDVLKKD
110 120 130 140 150
NSPFFVLNSD VICEYPFKEL ADFHKAHGGK GTIVATKVDE PSKYGVIVHD
160 170 180 190 200
IATPNLIDRF VEKPKEFVGN RINAGLYILN PEVIDLIEMK PTSIEKETFP
210 220 230 240 250
ILVEEKQLYS FDLEGFWMDV GQPKDFLSGT VLYLNSLAKR QPKKLATGAN
260 270 280 290 300
IVGNALIDPT AKISSTAKIG PDVVIGPNVT IGDGVRITRS VVLCNSTIKN
310 320 330 340 350
HSLVKSTIVG WNSTVGQWCR LEGVTVLGDD VEVKDEIYIN GGKVLPHKSI
360
SDNVPKEAII M
Length:361
Mass (Da):39,566
Last modified:October 1, 1996 - v2
Checksum:iDBF1C39BEAE0B776
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50V → A in AAA69677 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19608 Genomic DNA Translation: AAC49289.1
U24437 Genomic DNA Translation: AAA69677.1
Z74103 Genomic DNA Translation: CAA98617.1
BK006938 Genomic DNA Translation: DAA11801.1
PIRiS67590
RefSeqiNP_010228.1, NM_001180114.1

Genome annotation databases

EnsemblFungiiYDL055C; YDL055C; YDL055C
GeneIDi851504
KEGGisce:YDL055C

Similar proteinsi

Entry informationi

Entry nameiMPG1_YEAST
AccessioniPrimary (citable) accession number: P41940
Secondary accession number(s): D6VRU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome