Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mannose-1-phosphate guanyltransferase

Gene

PSA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.1 Publication

Catalytic activityi

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Mannose-1-phosphate guanyltransferase (PSA1)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route), the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • mannose-1-phosphate guanylyltransferase activity Source: SGD

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell wall mannoprotein biosynthetic process Source: SGD
  • GDP-mannose biosynthetic process Source: SGD
  • protein glycosylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:YDL055C-MONOMER.
BRENDAi2.7.7.13. 984.
UniPathwayiUPA00126; UER00930.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-1-phosphate guanyltransferase (EC:2.7.7.13)
Alternative name(s):
ATP-mannose-1-phosphate guanylyltransferase
GDP-mannose pyrophosphorylase
NDP-hexose pyrophosphorylase
Gene namesi
Name:PSA1
Synonyms:MPG1, SRB1, VIG9
Ordered Locus Names:YDL055C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL055C.
SGDiS000002213. PSA1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Mannose-1-phosphate guanyltransferasePRO_0000068741Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei153 – 1531PhosphothreonineCombined sources
Cross-linki244 – 244Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP41940.
TopDownProteomicsiP41940.

PTM databases

iPTMnetiP41940.

Interactioni

Protein-protein interaction databases

BioGridi32003. 126 interactions.
DIPiDIP-4322N.
IntActiP41940. 446 interactions.
MINTiMINT-528646.

Structurei

3D structure databases

ProteinModelPortaliP41940.
SMRiP41940. Positions 1-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00530000063581.
HOGENOMiHOG000283479.
InParanoidiP41940.
KOiK00966.
OMAiNVRIEFS.
OrthoDBiEOG092C3YQK.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGLILVGGY GTRLRPLTLT VPKPLVEFGN RPMILHQIEA LANAGVTDIV
60 70 80 90 100
LAVNYRPEVM VETLKKYEKE YGVNITFSVE TEPLGTAGPL KLAEDVLKKD
110 120 130 140 150
NSPFFVLNSD VICEYPFKEL ADFHKAHGGK GTIVATKVDE PSKYGVIVHD
160 170 180 190 200
IATPNLIDRF VEKPKEFVGN RINAGLYILN PEVIDLIEMK PTSIEKETFP
210 220 230 240 250
ILVEEKQLYS FDLEGFWMDV GQPKDFLSGT VLYLNSLAKR QPKKLATGAN
260 270 280 290 300
IVGNALIDPT AKISSTAKIG PDVVIGPNVT IGDGVRITRS VVLCNSTIKN
310 320 330 340 350
HSLVKSTIVG WNSTVGQWCR LEGVTVLGDD VEVKDEIYIN GGKVLPHKSI
360
SDNVPKEAII M
Length:361
Mass (Da):39,566
Last modified:October 1, 1996 - v2
Checksum:iDBF1C39BEAE0B776
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501V → A in AAA69677 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19608 Genomic DNA. Translation: AAC49289.1.
U24437 Genomic DNA. Translation: AAA69677.1.
Z74103 Genomic DNA. Translation: CAA98617.1.
BK006938 Genomic DNA. Translation: DAA11801.1.
PIRiS67590.
RefSeqiNP_010228.1. NM_001180114.1.

Genome annotation databases

EnsemblFungiiYDL055C; YDL055C; YDL055C.
GeneIDi851504.
KEGGisce:YDL055C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19608 Genomic DNA. Translation: AAC49289.1.
U24437 Genomic DNA. Translation: AAA69677.1.
Z74103 Genomic DNA. Translation: CAA98617.1.
BK006938 Genomic DNA. Translation: DAA11801.1.
PIRiS67590.
RefSeqiNP_010228.1. NM_001180114.1.

3D structure databases

ProteinModelPortaliP41940.
SMRiP41940. Positions 1-359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32003. 126 interactions.
DIPiDIP-4322N.
IntActiP41940. 446 interactions.
MINTiMINT-528646.

PTM databases

iPTMnetiP41940.

Proteomic databases

MaxQBiP41940.
TopDownProteomicsiP41940.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL055C; YDL055C; YDL055C.
GeneIDi851504.
KEGGisce:YDL055C.

Organism-specific databases

EuPathDBiFungiDB:YDL055C.
SGDiS000002213. PSA1.

Phylogenomic databases

GeneTreeiENSGT00530000063581.
HOGENOMiHOG000283479.
InParanoidiP41940.
KOiK00966.
OMAiNVRIEFS.
OrthoDBiEOG092C3YQK.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00930.
BioCyciYEAST:YDL055C-MONOMER.
BRENDAi2.7.7.13. 984.

Miscellaneous databases

PROiP41940.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPG1_YEAST
AccessioniPrimary (citable) accession number: P41940
Secondary accession number(s): D6VRU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 97100 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.