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P41938

- HCDH2_CAEEL

UniProt

P41938 - HCDH2_CAEEL

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Protein

Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3

Gene

B0272.3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei165 – 1651Important for catalytic activityBy similarity

GO - Molecular functioni

  1. 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-EC
  2. NAD+ binding Source: InterPro

GO - Biological processi

  1. fatty acid beta-oxidation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_238172. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.
REACT_250068. Beta oxidation of hexanoyl-CoA to butanoyl-CoA.
REACT_253635. Beta oxidation of butanoyl-CoA to acetyl-CoA.
REACT_257351. Beta oxidation of octanoyl-CoA to hexanoyl-CoA.
REACT_259901. Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA.
UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3 (EC:1.1.1.35)
Gene namesi
ORF Names:B0272.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiB0272.3; CE00852; WBGene00007129.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3PRO_0000109254Add
BLAST

Proteomic databases

PaxDbiP41938.
PRIDEiP41938.

2D gel databases

World-2DPAGE0020:P41938.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.B0272.3.

Structurei

3D structure databases

ProteinModelPortaliP41938.
SMRiP41938. Positions 22-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1250.
GeneTreeiENSGT00720000108673.
HOGENOMiHOG000141498.
InParanoidiP41938.
KOiK00022.
OMAiWSLNKLK.
PhylomeDBiP41938.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41938-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSSTCTAAV RGLSTTAQLS KINNVTIIGA GLMGSGIAQV SANAKLNVTV
60 70 80 90 100
VDSNQSALEK AQQGIANSLK RVAKKKHADD AAAQTALVSS VLDRIKMSTN
110 120 130 140 150
VSDSVKDADL VIEAIVENID IKRKLFAEVE VAAKPTTLIT TNTSSLRLAD
160 170 180 190 200
IGLNLKDKSR FGGLHFFNPV PMMKLLEVVR HTETSDATFN QLVDYGKTVG
210 220 230 240 250
KTTVACKDTP GFIVNRLLVP YMFEALRLYE RGDASMEDID VAMKLGAGYP
260 270 280 290 300
MGPFELSDYV GLDTCKFIMD GWHAQYPEEV AFTPSPLLNS LVDSGKNGRK

SGEGFYKYK
Length:309
Mass (Da):33,380
Last modified:November 1, 1995 - v1
Checksum:i5FC90AFA754EDD73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46240 Genomic DNA. Translation: CAA86312.1.
PIRiT18685.
RefSeqiNP_509584.1. NM_077183.5.
UniGeneiCel.11538.

Genome annotation databases

EnsemblMetazoaiB0272.3; B0272.3; WBGene00007129.
GeneIDi181169.
KEGGicel:CELE_B0272.3.
UCSCiB0272.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46240 Genomic DNA. Translation: CAA86312.1 .
PIRi T18685.
RefSeqi NP_509584.1. NM_077183.5.
UniGenei Cel.11538.

3D structure databases

ProteinModelPortali P41938.
SMRi P41938. Positions 22-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.B0272.3.

2D gel databases

World-2DPAGE 0020:P41938.

Proteomic databases

PaxDbi P41938.
PRIDEi P41938.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai B0272.3 ; B0272.3 ; WBGene00007129 .
GeneIDi 181169.
KEGGi cel:CELE_B0272.3.
UCSCi B0272.3. c. elegans.

Organism-specific databases

CTDi 181169.
WormBasei B0272.3 ; CE00852 ; WBGene00007129 .

Phylogenomic databases

eggNOGi COG1250.
GeneTreei ENSGT00720000108673.
HOGENOMi HOG000141498.
InParanoidi P41938.
KOi K00022.
OMAi WSLNKLK.
PhylomeDBi P41938.

Enzyme and pathway databases

UniPathwayi UPA00659 .
Reactomei REACT_238172. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.
REACT_250068. Beta oxidation of hexanoyl-CoA to butanoyl-CoA.
REACT_253635. Beta oxidation of butanoyl-CoA to acetyl-CoA.
REACT_257351. Beta oxidation of octanoyl-CoA to hexanoyl-CoA.
REACT_259901. Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA.

Miscellaneous databases

NextBioi 912706.
PROi P41938.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000105. HCDH. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
PROSITEi PS00067. 3HCDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiHCDH2_CAEEL
AccessioniPrimary (citable) accession number: P41938
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3