P41938 (HCDH2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3
EC=1.1.1.35

Gene names

ORF Names:

B0272.3

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.
Pathway	Lipid metabolism; fatty acid beta-oxidation.
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Mitochondrion
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fatty acid beta-oxidation Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	3-hydroxyacyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: EC NAD+ binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3		PRO_0000109254
Sites
	Site	165	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	P41938 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 5FC90AFA754EDD73	FASTA	309	33,380
	10 20 30 40 50 60 MLSSTCTAAV RGLSTTAQLS KINNVTIIGA GLMGSGIAQV SANAKLNVTV VDSNQSALEK 70 80 90 100 110 120 AQQGIANSLK RVAKKKHADD AAAQTALVSS VLDRIKMSTN VSDSVKDADL VIEAIVENID 130 140 150 160 170 180 IKRKLFAEVE VAAKPTTLIT TNTSSLRLAD IGLNLKDKSR FGGLHFFNPV PMMKLLEVVR 190 200 210 220 230 240 HTETSDATFN QLVDYGKTVG KTTVACKDTP GFIVNRLLVP YMFEALRLYE RGDASMEDID 250 260 270 280 290 300 VAMKLGAGYP MGPFELSDYV GLDTCKFIMD GWHAQYPEEV AFTPSPLLNS LVDSGKNGRK SGEGFYKYK

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46240 Genomic DNA. Translation: CAA86312.1.
PIR	T18685.
RefSeq	NP_509584.1. NM_077183.5.
3D structure databases
ProteinModelPortal	P41938.
SMR	P41938. Positions 22-309.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.B0272.3.
2D gel databases
World-2DPAGE	0020:P41938.
Proteomic databases
PaxDb	P41938.
PRIDE	P41938.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	B0272.3.1; B0272.3.1; B0272.3. B0272.3.2; B0272.3.2; B0272.3.
GeneID	181169.
KEGG	cel:CELE_B0272.3.
UCSC	B0272.3. c. elegans.
Organism-specific databases
CTD	181169.
WormBase	B0272.3; CE00852; WBGene00007129.
Phylogenomic databases
eggNOG	COG1250.
GeneTree	ENSGT00700000104363.
HOGENOM	HOG000141498.
InParanoid	P41938.
KO	K00022.
OMA	PFELSDY.
Enzyme and pathway databases
UniPathway	UPA00659.
Family and domain databases
Gene3D	1.10.1040.10. 1 hit. 3.40.50.720. 1 hit.
InterPro	IPR022694. 3-OHacyl-CoA_DH. IPR006180. 3-OHacyl-CoA_DH_CS. IPR006176. 3-OHacyl-CoA_DH_NAD-bd. IPR006108. 3HC_DH_C. IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfam	PF00725. 3HCDH. 1 hit. PF02737. 3HCDH_N. 1 hit. [Graphical view]
PIRSF	PIRSF000105. HCDH. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00067. 3HCDH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	912706.

Entry information

Entry name

HCDH2_CAEEL

Accession

Primary (citable) accession number: P41938

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project