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Protein

Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3

Gene

B0272.3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.

Pathway: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei165 – 1651Important for catalytic activityBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_272147. Beta oxidation of hexanoyl-CoA to butanoyl-CoA.
REACT_310127. Beta oxidation of butanoyl-CoA to acetyl-CoA.
REACT_312874. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.
REACT_334464. Beta oxidation of octanoyl-CoA to hexanoyl-CoA.
REACT_345702. Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA.
UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3 (EC:1.1.1.35)
Gene namesi
ORF Names:B0272.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiB0272.3; CE00852; WBGene00007129.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3PRO_0000109254Add
BLAST

Proteomic databases

PaxDbiP41938.
PRIDEiP41938.

2D gel databases

World-2DPAGE0020:P41938.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.B0272.3.2.

Structurei

3D structure databases

ProteinModelPortaliP41938.
SMRiP41938. Positions 22-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1250.
GeneTreeiENSGT00720000108673.
HOGENOMiHOG000141498.
InParanoidiP41938.
KOiK00022.
OMAiNCHGFIG.
PhylomeDBiP41938.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41938-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSTCTAAV RGLSTTAQLS KINNVTIIGA GLMGSGIAQV SANAKLNVTV
60 70 80 90 100
VDSNQSALEK AQQGIANSLK RVAKKKHADD AAAQTALVSS VLDRIKMSTN
110 120 130 140 150
VSDSVKDADL VIEAIVENID IKRKLFAEVE VAAKPTTLIT TNTSSLRLAD
160 170 180 190 200
IGLNLKDKSR FGGLHFFNPV PMMKLLEVVR HTETSDATFN QLVDYGKTVG
210 220 230 240 250
KTTVACKDTP GFIVNRLLVP YMFEALRLYE RGDASMEDID VAMKLGAGYP
260 270 280 290 300
MGPFELSDYV GLDTCKFIMD GWHAQYPEEV AFTPSPLLNS LVDSGKNGRK

SGEGFYKYK
Length:309
Mass (Da):33,380
Last modified:November 1, 1995 - v1
Checksum:i5FC90AFA754EDD73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46240 Genomic DNA. Translation: CAA86312.1.
PIRiT18685.
RefSeqiNP_509584.1. NM_077183.5.
UniGeneiCel.11538.

Genome annotation databases

EnsemblMetazoaiB0272.3; B0272.3; WBGene00007129.
GeneIDi181169.
KEGGicel:CELE_B0272.3.
UCSCiB0272.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46240 Genomic DNA. Translation: CAA86312.1.
PIRiT18685.
RefSeqiNP_509584.1. NM_077183.5.
UniGeneiCel.11538.

3D structure databases

ProteinModelPortaliP41938.
SMRiP41938. Positions 22-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.B0272.3.2.

2D gel databases

World-2DPAGE0020:P41938.

Proteomic databases

PaxDbiP41938.
PRIDEiP41938.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0272.3; B0272.3; WBGene00007129.
GeneIDi181169.
KEGGicel:CELE_B0272.3.
UCSCiB0272.3. c. elegans.

Organism-specific databases

CTDi181169.
WormBaseiB0272.3; CE00852; WBGene00007129.

Phylogenomic databases

eggNOGiCOG1250.
GeneTreeiENSGT00720000108673.
HOGENOMiHOG000141498.
InParanoidiP41938.
KOiK00022.
OMAiNCHGFIG.
PhylomeDBiP41938.

Enzyme and pathway databases

UniPathwayiUPA00659.
ReactomeiREACT_272147. Beta oxidation of hexanoyl-CoA to butanoyl-CoA.
REACT_310127. Beta oxidation of butanoyl-CoA to acetyl-CoA.
REACT_312874. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.
REACT_334464. Beta oxidation of octanoyl-CoA to hexanoyl-CoA.
REACT_345702. Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA.

Miscellaneous databases

NextBioi912706.
PROiP41938.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiHCDH2_CAEEL
AccessioniPrimary (citable) accession number: P41938
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 24, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.