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P41938

- HCDH2_CAEEL

UniProt

P41938 - HCDH2_CAEEL

Protein

Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3

Gene

B0272.3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei165 – 1651Important for catalytic activityBy similarity

    GO - Molecular functioni

    1. 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-EC
    2. NAD+ binding Source: InterPro

    GO - Biological processi

    1. fatty acid beta-oxidation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00659.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3 (EC:1.1.1.35)
    Gene namesi
    ORF Names:B0272.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiB0272.3; CE00852; WBGene00007129.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3PRO_0000109254Add
    BLAST

    Proteomic databases

    PaxDbiP41938.
    PRIDEiP41938.

    2D gel databases

    World-2DPAGE0020:P41938.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi6239.B0272.3.

    Structurei

    3D structure databases

    ProteinModelPortaliP41938.
    SMRiP41938. Positions 22-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1250.
    GeneTreeiENSGT00720000108673.
    HOGENOMiHOG000141498.
    InParanoidiP41938.
    KOiK00022.
    OMAiWSLNKLK.
    PhylomeDBiP41938.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR022694. 3-OHacyl-CoA_DH.
    IPR006180. 3-OHacyl-CoA_DH_CS.
    IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000105. HCDH. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    PROSITEiPS00067. 3HCDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41938-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSSTCTAAV RGLSTTAQLS KINNVTIIGA GLMGSGIAQV SANAKLNVTV    50
    VDSNQSALEK AQQGIANSLK RVAKKKHADD AAAQTALVSS VLDRIKMSTN 100
    VSDSVKDADL VIEAIVENID IKRKLFAEVE VAAKPTTLIT TNTSSLRLAD 150
    IGLNLKDKSR FGGLHFFNPV PMMKLLEVVR HTETSDATFN QLVDYGKTVG 200
    KTTVACKDTP GFIVNRLLVP YMFEALRLYE RGDASMEDID VAMKLGAGYP 250
    MGPFELSDYV GLDTCKFIMD GWHAQYPEEV AFTPSPLLNS LVDSGKNGRK 300
    SGEGFYKYK 309
    Length:309
    Mass (Da):33,380
    Last modified:November 1, 1995 - v1
    Checksum:i5FC90AFA754EDD73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46240 Genomic DNA. Translation: CAA86312.1.
    PIRiT18685.
    RefSeqiNP_509584.1. NM_077183.5.
    UniGeneiCel.11538.

    Genome annotation databases

    EnsemblMetazoaiB0272.3; B0272.3; WBGene00007129.
    GeneIDi181169.
    KEGGicel:CELE_B0272.3.
    UCSCiB0272.3. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46240 Genomic DNA. Translation: CAA86312.1 .
    PIRi T18685.
    RefSeqi NP_509584.1. NM_077183.5.
    UniGenei Cel.11538.

    3D structure databases

    ProteinModelPortali P41938.
    SMRi P41938. Positions 22-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.B0272.3.

    2D gel databases

    World-2DPAGE 0020:P41938.

    Proteomic databases

    PaxDbi P41938.
    PRIDEi P41938.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai B0272.3 ; B0272.3 ; WBGene00007129 .
    GeneIDi 181169.
    KEGGi cel:CELE_B0272.3.
    UCSCi B0272.3. c. elegans.

    Organism-specific databases

    CTDi 181169.
    WormBasei B0272.3 ; CE00852 ; WBGene00007129 .

    Phylogenomic databases

    eggNOGi COG1250.
    GeneTreei ENSGT00720000108673.
    HOGENOMi HOG000141498.
    InParanoidi P41938.
    KOi K00022.
    OMAi WSLNKLK.
    PhylomeDBi P41938.

    Enzyme and pathway databases

    UniPathwayi UPA00659 .

    Miscellaneous databases

    NextBioi 912706.
    PROi P41938.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR022694. 3-OHacyl-CoA_DH.
    IPR006180. 3-OHacyl-CoA_DH_CS.
    IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000105. HCDH. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    PROSITEi PS00067. 3HCDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiHCDH2_CAEEL
    AccessioniPrimary (citable) accession number: P41938
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3