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P41938 (HCDH2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3

EC=1.1.1.35
Gene names
ORF Names:B0272.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.

Pathway

Lipid metabolism; fatty acid beta-oxidation.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   Cellular componentMitochondrion
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfatty acid beta-oxidation

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-hydroxyacyl-CoA dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

NAD+ binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3
PRO_0000109254

Sites

Site1651Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
P41938 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 5FC90AFA754EDD73

FASTA30933,380
        10         20         30         40         50         60 
MLSSTCTAAV RGLSTTAQLS KINNVTIIGA GLMGSGIAQV SANAKLNVTV VDSNQSALEK 

        70         80         90        100        110        120 
AQQGIANSLK RVAKKKHADD AAAQTALVSS VLDRIKMSTN VSDSVKDADL VIEAIVENID 

       130        140        150        160        170        180 
IKRKLFAEVE VAAKPTTLIT TNTSSLRLAD IGLNLKDKSR FGGLHFFNPV PMMKLLEVVR 

       190        200        210        220        230        240 
HTETSDATFN QLVDYGKTVG KTTVACKDTP GFIVNRLLVP YMFEALRLYE RGDASMEDID 

       250        260        270        280        290        300 
VAMKLGAGYP MGPFELSDYV GLDTCKFIMD GWHAQYPEEV AFTPSPLLNS LVDSGKNGRK 


SGEGFYKYK 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46240 Genomic DNA. Translation: CAA86312.1.
PIRT18685.
RefSeqNP_509584.1. NM_077183.5.
UniGeneCel.11538.

3D structure databases

ProteinModelPortalP41938.
SMRP41938. Positions 22-308.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.B0272.3.

2D gel databases

World-2DPAGE0020:P41938.

Proteomic databases

PaxDbP41938.
PRIDEP41938.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaB0272.3; B0272.3; WBGene00007129.
GeneID181169.
KEGGcel:CELE_B0272.3.
UCSCB0272.3. c. elegans.

Organism-specific databases

CTD181169.
WormBaseB0272.3; CE00852; WBGene00007129.

Phylogenomic databases

eggNOGCOG1250.
GeneTreeENSGT00720000108673.
HOGENOMHOG000141498.
InParanoidP41938.
KOK00022.
OMAWSLNKLK.
PhylomeDBP41938.

Enzyme and pathway databases

UniPathwayUPA00659.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFPIRSF000105. HCDH. 1 hit.
SUPFAMSSF48179. SSF48179. 1 hit.
PROSITEPS00067. 3HCDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio912706.
PROP41938.

Entry information

Entry nameHCDH2_CAEEL
AccessionPrimary (citable) accession number: P41938
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase