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Protein

Homeobox protein ceh-18

Gene

ceh-18

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Affects, directly or indirectly, a sheath cell signal that causes oocytes to maintain diakinesis arrest. Also participates in directing gonad migration and in specifying the differentiated phenotypes of epidermal cells during postembryonic development.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi421 – 48060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • sequence-specific DNA binding Source: InterPro
  • sequence-specific DNA binding transcription factor activity Source: WormBase

GO - Biological processi

  • epidermis development Source: WormBase
  • germ cell migration Source: WormBase
  • multicellular organismal development Source: UniProtKB-KW
  • negative regulation of oocyte maturation Source: WormBase
  • oocyte maturation Source: WormBase
  • ovulation Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_310634. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
REACT_318607. RNA Polymerase III Abortive And Retractive Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein ceh-18
Gene namesi
Name:ceh-18
ORF Names:ZC64.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiZC64.3a; CE25674; WBGene00000441; ceh-18.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Homeobox protein ceh-18PRO_0000100782Add
BLAST

Proteomic databases

PaxDbiP41934.
PRIDEiP41934.

Expressioni

Tissue specificityi

Expressed in the gonadal sheath cells that signal the oocyte, but not in the oocyte. Also found in the syncytial hypodermal cells located throughout the body.

Developmental stagei

Expressed by the distal tip cell of the somatic gonad from early L2 larval stage through the adult stage.

Gene expression databases

ExpressionAtlasiP41934. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi45607. 7 interactions.
IntActiP41934. 16 interactions.
STRINGi6239.ZC64.3a.

Structurei

3D structure databases

ProteinModelPortaliP41934.
SMRiP41934. Positions 294-478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini290 – 36475POU-specificPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi48 – 7225Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the POU transcription factor family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG317282.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000020247.
InParanoidiP41934.
OMAiMNQRNAL.
OrthoDBiEOG7DJSMG.
PhylomeDBiP41934.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTLENTFQF LAEVFEANGG CLVTERVSPS LSGASKRKSR PVKRIITEDE
60 70 80 90 100
VIPEEEVVEE EEEEKVEQPS EEVTCPAMQV DATDAILASL RQIANNDLSE
110 120 130 140 150
HCIREDEGNT SAEVFSNGNG EDMEQAGLAG TDLLRRVADM LQGNHNGSLN
160 170 180 190 200
SHFLQQQFAA FKETVDPTPV STNGNGLLTP ITTQLSPLFT STDAFNSPEK
210 220 230 240 250
LLQAIMTPSL GFLGANGLGA SNSGLLSSPL IAPSPTLLQS LMNTPTQPTA
260 270 280 290 300
SLTPKKAENR PPVVSQTLKA SKRRLFDDTS RIEAASMSGD DRIDMNELEA
310 320 330 340 350
FAQTFKKQRI KFGFTQGDVG VALGKRYGTD FSQTTISRFE ALNLSFKNMC
360 370 380 390 400
KLRPLLKEWL ADVEMAIEGG ATVTDLIDKK TIHNGNHHTI HHVDIHETSI
410 420 430 440 450
SNSISSVTAS SLLSREQHVK RRRKRTNLDM NQRNALDTFF ALNPRPDHDK
460 470 480 490 500
MTDIANSLEL DRDVVRVWFC NRRQKMRRVD EPIEGEMVTP SVSPVFPHFS
510 520 530 540
SMSALEQIQE AARLASCQAS NDDSDGTSGS PDAPSNDGCS DL
Length:542
Mass (Da):59,480
Last modified:November 1, 1995 - v1
Checksum:i34A97C7CC4B850E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16367 mRNA. Translation: AAA52203.1.
FO081410 Genomic DNA. Translation: CCD71431.1.
PIRiA54963.
RefSeqiNP_741758.1. NM_171659.4.
UniGeneiCel.18139.

Genome annotation databases

EnsemblMetazoaiZC64.3a; ZC64.3a; WBGene00000441.
GeneIDi180671.
UCSCiZC64.3b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16367 mRNA. Translation: AAA52203.1.
FO081410 Genomic DNA. Translation: CCD71431.1.
PIRiA54963.
RefSeqiNP_741758.1. NM_171659.4.
UniGeneiCel.18139.

3D structure databases

ProteinModelPortaliP41934.
SMRiP41934. Positions 294-478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi45607. 7 interactions.
IntActiP41934. 16 interactions.
STRINGi6239.ZC64.3a.

Proteomic databases

PaxDbiP41934.
PRIDEiP41934.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZC64.3a; ZC64.3a; WBGene00000441.
GeneIDi180671.
UCSCiZC64.3b. c. elegans.

Organism-specific databases

CTDi180671.
WormBaseiZC64.3a; CE25674; WBGene00000441; ceh-18.

Phylogenomic databases

eggNOGiNOG317282.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000020247.
InParanoidiP41934.
OMAiMNQRNAL.
OrthoDBiEOG7DJSMG.
PhylomeDBiP41934.

Enzyme and pathway databases

ReactomeiREACT_310634. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
REACT_318607. RNA Polymerase III Abortive And Retractive Initiation.

Miscellaneous databases

NextBioi910380.
PROiP41934.

Gene expression databases

ExpressionAtlasiP41934. baseline and differential.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation."
    Greenstein D., Hird S., Plasterk R.H.A., Andachi Y., Kohara Y., Wang B., Finney M., Ruvkun G.
    Genes Dev. 8:1935-1948(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiHM18_CAEEL
AccessioniPrimary (citable) accession number: P41934
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 22, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.