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P41934

- HM18_CAEEL

UniProt

P41934 - HM18_CAEEL

Protein

Homeobox protein ceh-18

Gene

ceh-18

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Affects, directly or indirectly, a sheath cell signal that causes oocytes to maintain diakinesis arrest. Also participates in directing gonad migration and in specifying the differentiated phenotypes of epidermal cells during postembryonic development.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi421 – 48060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: WormBase

    GO - Biological processi

    1. epidermis development Source: WormBase
    2. germ cell migration Source: WormBase
    3. negative regulation of oocyte maturation Source: WormBase
    4. oocyte maturation Source: WormBase
    5. ovulation Source: WormBase

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein ceh-18
    Gene namesi
    Name:ceh-18
    ORF Names:ZC64.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiZC64.3a; CE25674; WBGene00000441; ceh-18.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: WormBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 542542Homeobox protein ceh-18PRO_0000100782Add
    BLAST

    Proteomic databases

    PaxDbiP41934.
    PRIDEiP41934.

    Expressioni

    Tissue specificityi

    Expressed in the gonadal sheath cells that signal the oocyte, but not in the oocyte. Also found in the syncytial hypodermal cells located throughout the body.

    Developmental stagei

    Expressed by the distal tip cell of the somatic gonad from early L2 larval stage through the adult stage.

    Interactioni

    Protein-protein interaction databases

    BioGridi45607. 7 interactions.
    IntActiP41934. 16 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP41934.
    SMRiP41934. Positions 294-478.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini290 – 36475POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi48 – 7225Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the POU transcription factor family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG317282.
    GeneTreeiENSGT00750000117373.
    HOGENOMiHOG000020247.
    InParanoidiP41934.
    OMAiMNQRNAL.
    OrthoDBiEOG7DJSMG.
    PhylomeDBiP41934.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41934-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTLENTFQF LAEVFEANGG CLVTERVSPS LSGASKRKSR PVKRIITEDE    50
    VIPEEEVVEE EEEEKVEQPS EEVTCPAMQV DATDAILASL RQIANNDLSE 100
    HCIREDEGNT SAEVFSNGNG EDMEQAGLAG TDLLRRVADM LQGNHNGSLN 150
    SHFLQQQFAA FKETVDPTPV STNGNGLLTP ITTQLSPLFT STDAFNSPEK 200
    LLQAIMTPSL GFLGANGLGA SNSGLLSSPL IAPSPTLLQS LMNTPTQPTA 250
    SLTPKKAENR PPVVSQTLKA SKRRLFDDTS RIEAASMSGD DRIDMNELEA 300
    FAQTFKKQRI KFGFTQGDVG VALGKRYGTD FSQTTISRFE ALNLSFKNMC 350
    KLRPLLKEWL ADVEMAIEGG ATVTDLIDKK TIHNGNHHTI HHVDIHETSI 400
    SNSISSVTAS SLLSREQHVK RRRKRTNLDM NQRNALDTFF ALNPRPDHDK 450
    MTDIANSLEL DRDVVRVWFC NRRQKMRRVD EPIEGEMVTP SVSPVFPHFS 500
    SMSALEQIQE AARLASCQAS NDDSDGTSGS PDAPSNDGCS DL 542
    Length:542
    Mass (Da):59,480
    Last modified:November 1, 1995 - v1
    Checksum:i34A97C7CC4B850E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U16367 mRNA. Translation: AAA52203.1.
    FO081410 Genomic DNA. Translation: CCD71431.1.
    PIRiA54963.
    RefSeqiNP_741758.1. NM_171659.4.
    UniGeneiCel.18139.

    Genome annotation databases

    EnsemblMetazoaiZC64.3a; ZC64.3a; WBGene00000441.
    GeneIDi180671.
    KEGGicel:CELE_ZC64.3.
    UCSCiZC64.3b. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U16367 mRNA. Translation: AAA52203.1 .
    FO081410 Genomic DNA. Translation: CCD71431.1 .
    PIRi A54963.
    RefSeqi NP_741758.1. NM_171659.4.
    UniGenei Cel.18139.

    3D structure databases

    ProteinModelPortali P41934.
    SMRi P41934. Positions 294-478.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 45607. 7 interactions.
    IntActi P41934. 16 interactions.

    Proteomic databases

    PaxDbi P41934.
    PRIDEi P41934.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai ZC64.3a ; ZC64.3a ; WBGene00000441 .
    GeneIDi 180671.
    KEGGi cel:CELE_ZC64.3.
    UCSCi ZC64.3b. c. elegans.

    Organism-specific databases

    CTDi 180671.
    WormBasei ZC64.3a ; CE25674 ; WBGene00000441 ; ceh-18.

    Phylogenomic databases

    eggNOGi NOG317282.
    GeneTreei ENSGT00750000117373.
    HOGENOMi HOG000020247.
    InParanoidi P41934.
    OMAi MNQRNAL.
    OrthoDBi EOG7DJSMG.
    PhylomeDBi P41934.

    Miscellaneous databases

    NextBioi 910380.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation."
      Greenstein D., Hird S., Plasterk R.H.A., Andachi Y., Kohara Y., Wang B., Finney M., Ruvkun G.
      Genes Dev. 8:1935-1948(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiHM18_CAEEL
    AccessioniPrimary (citable) accession number: P41934
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3