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P41934

- HM18_CAEEL

UniProt

P41934 - HM18_CAEEL

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Protein

Homeobox protein ceh-18

Gene
ceh-18, ZC64.3
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Affects, directly or indirectly, a sheath cell signal that causes oocytes to maintain diakinesis arrest. Also participates in directing gonad migration and in specifying the differentiated phenotypes of epidermal cells during postembryonic development.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi421 – 48060HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: WormBase

GO - Biological processi

  1. epidermis development Source: WormBase
  2. germ cell migration Source: WormBase
  3. negative regulation of oocyte maturation Source: WormBase
  4. oocyte maturation Source: WormBase
  5. ovulation Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein ceh-18
Gene namesi
Name:ceh-18
ORF Names:ZC64.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiZC64.3a; CE25674; WBGene00000441; ceh-18.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Homeobox protein ceh-18PRO_0000100782Add
BLAST

Proteomic databases

PaxDbiP41934.
PRIDEiP41934.

Expressioni

Tissue specificityi

Expressed in the gonadal sheath cells that signal the oocyte, but not in the oocyte. Also found in the syncytial hypodermal cells located throughout the body.

Developmental stagei

Expressed by the distal tip cell of the somatic gonad from early L2 larval stage through the adult stage.

Interactioni

Protein-protein interaction databases

BioGridi45607. 7 interactions.
IntActiP41934. 16 interactions.

Structurei

3D structure databases

ProteinModelPortaliP41934.
SMRiP41934. Positions 294-478.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini290 – 36475POU-specificAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi48 – 7225Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG317282.
GeneTreeiENSGT00750000117373.
HOGENOMiHOG000020247.
InParanoidiP41934.
OMAiMNQRNAL.
OrthoDBiEOG7DJSMG.
PhylomeDBiP41934.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41934-1 [UniParc]FASTAAdd to Basket

« Hide

MNTLENTFQF LAEVFEANGG CLVTERVSPS LSGASKRKSR PVKRIITEDE    50
VIPEEEVVEE EEEEKVEQPS EEVTCPAMQV DATDAILASL RQIANNDLSE 100
HCIREDEGNT SAEVFSNGNG EDMEQAGLAG TDLLRRVADM LQGNHNGSLN 150
SHFLQQQFAA FKETVDPTPV STNGNGLLTP ITTQLSPLFT STDAFNSPEK 200
LLQAIMTPSL GFLGANGLGA SNSGLLSSPL IAPSPTLLQS LMNTPTQPTA 250
SLTPKKAENR PPVVSQTLKA SKRRLFDDTS RIEAASMSGD DRIDMNELEA 300
FAQTFKKQRI KFGFTQGDVG VALGKRYGTD FSQTTISRFE ALNLSFKNMC 350
KLRPLLKEWL ADVEMAIEGG ATVTDLIDKK TIHNGNHHTI HHVDIHETSI 400
SNSISSVTAS SLLSREQHVK RRRKRTNLDM NQRNALDTFF ALNPRPDHDK 450
MTDIANSLEL DRDVVRVWFC NRRQKMRRVD EPIEGEMVTP SVSPVFPHFS 500
SMSALEQIQE AARLASCQAS NDDSDGTSGS PDAPSNDGCS DL 542
Length:542
Mass (Da):59,480
Last modified:November 1, 1995 - v1
Checksum:i34A97C7CC4B850E6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U16367 mRNA. Translation: AAA52203.1.
FO081410 Genomic DNA. Translation: CCD71431.1.
PIRiA54963.
RefSeqiNP_741758.1. NM_171659.4.
UniGeneiCel.18139.

Genome annotation databases

EnsemblMetazoaiZC64.3a; ZC64.3a; WBGene00000441.
GeneIDi180671.
KEGGicel:CELE_ZC64.3.
UCSCiZC64.3b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U16367 mRNA. Translation: AAA52203.1 .
FO081410 Genomic DNA. Translation: CCD71431.1 .
PIRi A54963.
RefSeqi NP_741758.1. NM_171659.4.
UniGenei Cel.18139.

3D structure databases

ProteinModelPortali P41934.
SMRi P41934. Positions 294-478.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 45607. 7 interactions.
IntActi P41934. 16 interactions.

Proteomic databases

PaxDbi P41934.
PRIDEi P41934.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai ZC64.3a ; ZC64.3a ; WBGene00000441 .
GeneIDi 180671.
KEGGi cel:CELE_ZC64.3.
UCSCi ZC64.3b. c. elegans.

Organism-specific databases

CTDi 180671.
WormBasei ZC64.3a ; CE25674 ; WBGene00000441 ; ceh-18.

Phylogenomic databases

eggNOGi NOG317282.
GeneTreei ENSGT00750000117373.
HOGENOMi HOG000020247.
InParanoidi P41934.
OMAi MNQRNAL.
OrthoDBi EOG7DJSMG.
PhylomeDBi P41934.

Miscellaneous databases

NextBioi 910380.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation."
    Greenstein D., Hird S., Plasterk R.H.A., Andachi Y., Kohara Y., Wang B., Finney M., Ruvkun G.
    Genes Dev. 8:1935-1948(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiHM18_CAEEL
AccessioniPrimary (citable) accession number: P41934
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi