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P41934 (HM18_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein ceh-18
Gene names
Name:ceh-18
ORF Names:ZC64.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length542 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Affects, directly or indirectly, a sheath cell signal that causes oocytes to maintain diakinesis arrest. Also participates in directing gonad migration and in specifying the differentiated phenotypes of epidermal cells during postembryonic development.

Subcellular location

Nucleus.

Tissue specificity

Expressed in the gonadal sheath cells that signal the oocyte, but not in the oocyte. Also found in the syncytial hypodermal cells located throughout the body.

Developmental stage

Expressed by the distal tip cell of the somatic gonad from early L2 larval stage through the adult stage.

Sequence similarities

Belongs to the POU transcription factor family.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 542542Homeobox protein ceh-18
PRO_0000100782

Regions

Domain290 – 36475POU-specific
DNA binding421 – 48060Homeobox
Compositional bias48 – 7225Glu-rich (acidic)

Sequences

Sequence LengthMass (Da)Tools
P41934 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 34A97C7CC4B850E6

FASTA54259,480
        10         20         30         40         50         60 
MNTLENTFQF LAEVFEANGG CLVTERVSPS LSGASKRKSR PVKRIITEDE VIPEEEVVEE 

        70         80         90        100        110        120 
EEEEKVEQPS EEVTCPAMQV DATDAILASL RQIANNDLSE HCIREDEGNT SAEVFSNGNG 

       130        140        150        160        170        180 
EDMEQAGLAG TDLLRRVADM LQGNHNGSLN SHFLQQQFAA FKETVDPTPV STNGNGLLTP 

       190        200        210        220        230        240 
ITTQLSPLFT STDAFNSPEK LLQAIMTPSL GFLGANGLGA SNSGLLSSPL IAPSPTLLQS 

       250        260        270        280        290        300 
LMNTPTQPTA SLTPKKAENR PPVVSQTLKA SKRRLFDDTS RIEAASMSGD DRIDMNELEA 

       310        320        330        340        350        360 
FAQTFKKQRI KFGFTQGDVG VALGKRYGTD FSQTTISRFE ALNLSFKNMC KLRPLLKEWL 

       370        380        390        400        410        420 
ADVEMAIEGG ATVTDLIDKK TIHNGNHHTI HHVDIHETSI SNSISSVTAS SLLSREQHVK 

       430        440        450        460        470        480 
RRRKRTNLDM NQRNALDTFF ALNPRPDHDK MTDIANSLEL DRDVVRVWFC NRRQKMRRVD 

       490        500        510        520        530        540 
EPIEGEMVTP SVSPVFPHFS SMSALEQIQE AARLASCQAS NDDSDGTSGS PDAPSNDGCS 


DL 

« Hide

References

« Hide 'large scale' references
[1]"Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation."
Greenstein D., Hird S., Plasterk R.H.A., Andachi Y., Kohara Y., Wang B., Finney M., Ruvkun G.
Genes Dev. 8:1935-1948(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U16367 mRNA. Translation: AAA52203.1.
FO081410 Genomic DNA. Translation: CCD71431.1.
PIRA54963.
RefSeqNP_741758.1. NM_171659.4.
UniGeneCel.18139.

3D structure databases

ProteinModelPortalP41934.
SMRP41934. Positions 294-478.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid45607. 7 interactions.
IntActP41934. 16 interactions.

Proteomic databases

PaxDbP41934.
PRIDEP41934.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZC64.3a; ZC64.3a; WBGene00000441.
GeneID180671.
KEGGcel:CELE_ZC64.3.
UCSCZC64.3b. c. elegans.

Organism-specific databases

CTD180671.
WormBaseZC64.3a; CE25674; WBGene00000441; ceh-18.

Phylogenomic databases

eggNOGNOG317282.
GeneTreeENSGT00750000117373.
HOGENOMHOG000020247.
InParanoidP41934.
OMAMNQRNAL.
OrthoDBEOG7DJSMG.
PhylomeDBP41934.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio910380.

Entry information

Entry nameHM18_CAEEL
AccessionPrimary (citable) accession number: P41934
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase