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Protein

14-3-3-like protein 1

Gene

par-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • asymmetric protein localization involved in cell fate determination Source: WormBase
  • cell fate specification Source: WormBase
  • determination of adult lifespan Source: UniProtKB
  • embryo development ending in birth or egg hatching Source: WormBase
  • establishment of mitotic spindle orientation Source: WormBase
  • first cell cycle pseudocleavage Source: WormBase
  • heat acclimation Source: UniProtKB
  • meiotic cell cycle Source: WormBase
  • polarity specification of anterior/posterior axis Source: WormBase
  • pronuclear migration Source: WormBase
  • protein export from nucleus Source: WormBase
  • regulation of mitotic cell cycle Source: WormBase
  • reproduction Source: WormBase
  • zygote asymmetric cell division Source: WormBase

Enzyme and pathway databases

ReactomeiR-CEL-392517 Rap1 signalling
R-CEL-430116 GP1b-IX-V activation signalling
R-CEL-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-CEL-450604 KSRP (KHSRP) binds and destabilizes mRNA
R-CEL-5625740 RHO GTPases activate PKNs
R-CEL-5673000 RAF activation
R-CEL-5674135 MAP2K and MAPK activation
R-CEL-5675221 Negative regulation of MAPK pathway
R-CEL-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-CEL-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
SignaLinkiP41932

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3-like protein 1
Alternative name(s):
Partitioning defective protein 5
Gene namesi
Name:par-5
Synonyms:ftt-1
ORF Names:M117.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiM117.2a ; CE06200 ; WBGene00003920 ; par-5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000586471 – 24814-3-3-like protein 1Add BLAST248

Proteomic databases

EPDiP41932
PaxDbiP41932
PeptideAtlasiP41932
PRIDEiP41932

PTM databases

iPTMnetiP41932

Expressioni

Gene expression databases

BgeeiWBGene00003920
ExpressionAtlasiP41932 baseline

Interactioni

Subunit structurei

Interacts with daf-16 and sir-2.1 (PubMed:16777605). Interacts with atgl-1 (PubMed:26098762).2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi43208, 16 interactors
DIPiDIP-27044N
IntActiP41932, 14 interactors
STRINGi6239.M117.2.1

Structurei

3D structure databases

ProteinModelPortaliP41932
SMRiP41932
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGiKOG0841 Eukaryota
COG5040 LUCA
GeneTreeiENSGT00760000119116
HOGENOMiHOG000240379
InParanoidiP41932
KOiK06630
OMAiKKQQMGR
OrthoDBiEOG091G0VKY
PhylomeDBiP41932

Family and domain databases

Gene3Di1.20.190.20, 1 hit
InterProiView protein in InterPro
IPR000308 14-3-3
IPR023409 14-3-3_CS
IPR036815 14-3-3_dom_sf
IPR023410 14-3-3_domain
PANTHERiPTHR18860 PTHR18860, 1 hit
PfamiView protein in Pfam
PF00244 14-3-3, 1 hit
PIRSFiPIRSF000868 14-3-3, 1 hit
PRINTSiPR00305 1433ZETA
SMARTiView protein in SMART
SM00101 14_3_3, 1 hit
SUPFAMiSSF48445 SSF48445, 1 hit
PROSITEiView protein in PROSITE
PS00796 1433_1, 1 hit
PS00797 1433_2, 1 hit

Sequencei

Sequence statusi: Complete.

P41932-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTVEELVQ RAKLAEQAER YDDMAAAMKK VTEQGQELSN EERNLLSVAY
60 70 80 90 100
KNVVGARRSS WRVISSIEQK TEGSEKKQQL AKEYRVKVEQ ELNDICQDVL
110 120 130 140 150
KLLDEFLIVK AGAAESKVFY LKMKGDYYRY LAEVASEDRA AVVEKSQKAY
160 170 180 190 200
QEALDIAKDK MQPTHPIRLG LALNFSVFYY EILNTPEHAC QLAKQAFDDA
210 220 230 240
IAELDTLNED SYKDSTLIMQ LLRDNLTLWT SDVGAEDQEQ EGNQEAGN
Length:248
Mass (Da):28,191
Last modified:July 22, 2008 - v2
Checksum:iABBE0DA27D9341AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118V → A in AAA61872 (PubMed:7926802).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05038 mRNA Translation: AAA61872.1
Z73910 Genomic DNA Translation: CAA98138.1
PIRiJC2581
T23759
RefSeqiNP_502235.1, NM_069834.5
UniGeneiCel.17302

Genome annotation databases

EnsemblMetazoaiM117.2a.1; M117.2a.1; WBGene00003920
M117.2a.2; M117.2a.2; WBGene00003920
M117.2a.3; M117.2a.3; WBGene00003920
GeneIDi178113
KEGGicel:CELE_M117.2
UCSCiM117.2.2 c. elegans

Similar proteinsi

Entry informationi

Entry namei14331_CAEEL
AccessioniPrimary (citable) accession number: P41932
Secondary accession number(s): Q21537
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 22, 2008
Last modified: March 28, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health