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Protein

14-3-3-like protein 1

Gene

par-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • asymmetric protein localization involved in cell fate determination Source: WormBase
  • cell fate specification Source: WormBase
  • embryo development ending in birth or egg hatching Source: WormBase
  • establishment of mitotic spindle orientation Source: WormBase
  • first cell cycle pseudocleavage Source: WormBase
  • meiotic nuclear division Source: WormBase
  • polarity specification of anterior/posterior axis Source: WormBase
  • pronuclear migration Source: WormBase
  • protein export from nucleus Source: WormBase
  • regulation of mitotic cell cycle Source: WormBase
  • reproduction Source: WormBase
  • zygote asymmetric cell division Source: WormBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CEL-392517. Rap1 signalling.
R-CEL-430116. GP1b-IX-V activation signalling.
R-CEL-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
R-CEL-450604. KSRP (KHSRP) binds and destabilizes mRNA.
R-CEL-5625740. RHO GTPases activate PKNs.
R-CEL-5673000. RAF activation.
R-CEL-5674135. MAP2K and MAPK activation.
R-CEL-5675221. Negative regulation of MAPK pathway.
R-CEL-6804114. TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
R-CEL-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
SignaLinkiP41932.

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3-like protein 1
Alternative name(s):
Partitioning defective protein 5
Gene namesi
Name:par-5
Synonyms:ftt-1
ORF Names:M117.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiM117.2a; CE06200; WBGene00003920; par-5.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: WormBase
  • cytoplasm Source: WormBase
  • nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000586471 – 24814-3-3-like protein 1Add BLAST248

Proteomic databases

EPDiP41932.
PaxDbiP41932.
PeptideAtlasiP41932.
PRIDEiP41932.

PTM databases

iPTMnetiP41932.

Expressioni

Gene expression databases

BgeeiWBGene00003920.
ExpressionAtlasiP41932. differential.

Interactioni

Subunit structurei

Interacts with daf-16 and sir-2.1 (PubMed:16777605). Interacts with atgl-1 (PubMed:26098762).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
hcf-1G5EC232EBI-318108,EBI-4480523
let-756Q111843EBI-318108,EBI-3843983
pop-1Q106662EBI-318108,EBI-317870
sir-2.1Q219213EBI-318108,EBI-966082

Protein-protein interaction databases

BioGridi43208. 16 interactors.
DIPiDIP-27044N.
IntActiP41932. 12 interactors.
MINTiMINT-1117537.
STRINGi6239.M117.2.1.

Structurei

3D structure databases

ProteinModelPortaliP41932.
SMRiP41932.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
InParanoidiP41932.
KOiK06630.
OMAiCNDVLXT.
OrthoDBiEOG091G0VKY.
PhylomeDBiP41932.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41932-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTVEELVQ RAKLAEQAER YDDMAAAMKK VTEQGQELSN EERNLLSVAY
60 70 80 90 100
KNVVGARRSS WRVISSIEQK TEGSEKKQQL AKEYRVKVEQ ELNDICQDVL
110 120 130 140 150
KLLDEFLIVK AGAAESKVFY LKMKGDYYRY LAEVASEDRA AVVEKSQKAY
160 170 180 190 200
QEALDIAKDK MQPTHPIRLG LALNFSVFYY EILNTPEHAC QLAKQAFDDA
210 220 230 240
IAELDTLNED SYKDSTLIMQ LLRDNLTLWT SDVGAEDQEQ EGNQEAGN
Length:248
Mass (Da):28,191
Last modified:July 22, 2008 - v2
Checksum:iABBE0DA27D9341AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118V → A in AAA61872 (PubMed:7926802).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05038 mRNA. Translation: AAA61872.1.
Z73910 Genomic DNA. Translation: CAA98138.1.
PIRiJC2581.
T23759.
RefSeqiNP_502235.1. NM_069834.5.
UniGeneiCel.17302.

Genome annotation databases

EnsemblMetazoaiM117.2a.1; M117.2a.1; WBGene00003920.
M117.2a.2; M117.2a.2; WBGene00003920.
GeneIDi178113.
KEGGicel:CELE_M117.2.
UCSCiM117.2.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05038 mRNA. Translation: AAA61872.1.
Z73910 Genomic DNA. Translation: CAA98138.1.
PIRiJC2581.
T23759.
RefSeqiNP_502235.1. NM_069834.5.
UniGeneiCel.17302.

3D structure databases

ProteinModelPortaliP41932.
SMRiP41932.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi43208. 16 interactors.
DIPiDIP-27044N.
IntActiP41932. 12 interactors.
MINTiMINT-1117537.
STRINGi6239.M117.2.1.

PTM databases

iPTMnetiP41932.

Proteomic databases

EPDiP41932.
PaxDbiP41932.
PeptideAtlasiP41932.
PRIDEiP41932.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiM117.2a.1; M117.2a.1; WBGene00003920.
M117.2a.2; M117.2a.2; WBGene00003920.
GeneIDi178113.
KEGGicel:CELE_M117.2.
UCSCiM117.2.2. c. elegans.

Organism-specific databases

CTDi178113.
WormBaseiM117.2a; CE06200; WBGene00003920; par-5.

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
InParanoidiP41932.
KOiK06630.
OMAiCNDVLXT.
OrthoDBiEOG091G0VKY.
PhylomeDBiP41932.

Enzyme and pathway databases

ReactomeiR-CEL-392517. Rap1 signalling.
R-CEL-430116. GP1b-IX-V activation signalling.
R-CEL-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
R-CEL-450604. KSRP (KHSRP) binds and destabilizes mRNA.
R-CEL-5625740. RHO GTPases activate PKNs.
R-CEL-5673000. RAF activation.
R-CEL-5674135. MAP2K and MAPK activation.
R-CEL-5675221. Negative regulation of MAPK pathway.
R-CEL-6804114. TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
R-CEL-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
SignaLinkiP41932.

Miscellaneous databases

PROiP41932.

Gene expression databases

BgeeiWBGene00003920.
ExpressionAtlasiP41932. differential.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei14331_CAEEL
AccessioniPrimary (citable) accession number: P41932
Secondary accession number(s): Q21537
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 22, 2008
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.