Reviewed, UniProtKB/Swiss-Prot P41931 (DCOR_CAEEL)

Names and origin

Protein names

Recommended name:
    Ornithine decarboxylase
      Short name=ODC
    EC=4.1.1.17

Gene names

Name:	odc-1
ORF Names:	K11C4.4

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-ornithine = putrescine + CO2.
Cofactor	Pyridoxal phosphate.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Ontologies

Keywords
Biological process	Polyamine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	polyamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ornithine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 422	422	Ornithine decarboxylase		PRO_0000149898
Sites
	Active site	359	1	Proton donor; shared with dimeric partner By similarity
Amino acid modifications
	Modified residue	71	1	N6-(pyridoxal phosphate)lysine By similarity
Experimental info
	Sequence conflict	273 – 274	2	IA → YR in AAA88795. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P41931-1 [UniParc]. Last modified January 11, 2001. Version 2. Checksum: DD2E9707EE846B1D	FASTA	422	46,920
	10 20 30 40 50 60 MISQFEIIGD NKIGVLPKQV DQLQMCRDIA ASKDLQENDS SFMLVDLDKI IERFQLWKRE 70 80 90 100 110 120 LPMIEPFYAV KCNTDLVLIR ILASLGCGFD CASKDEIDIV MGTGVSAERI IYANPCKTRS 130 140 150 160 170 180 FIAHAMDRDV KMMTFDNPEE LLKIAKLHPN AEMILRIAVS DPTATCPLNL KFGADPIIAA 190 200 210 220 230 240 PQLLKTASEE GINVVGISFH VGSGCNDASA YRNALQHAKN LCEIGEGLGF KMDIIDMGGG 250 260 270 280 290 300 FPGAEHHNPF EKIAETIRDA LDEFFPDTNK RLIAEPGRFF AAGPFSLVAN IIHATEVPAS 310 320 330 340 350 360 KITKDPKDCA DHGYMYYIND GVYGSFNCIL FDHAHPIGSP LFDTDRNEKF MSTIWGPTCD 370 380 390 400 410 420 SLDLVEDKKL MPKMNVGEWL YYPDMGAYTL AAATTFNGFS KPVPMYVMSE EMWESIRDST HV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The ornithine decarboxylase gene of Caenorhabditis elegans: cloning, mapping and mutagenesis." Macrae M., Plasterk R.H., Coffino P. Genetics 140:517-525(1995) [PubMed: 7498733] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U03059 Genomic DNA. Translation: AAA88795.1. U64854 Genomic DNA. Translation: AAB18317.1.
PIR	T29143.
RefSeq	NP_504752.1.
UniGene	Cel.17530
3D structure databases
HSSP	HSSP built from PDB template 1F3T based on UniProtKB P07805.
ModBase	Search...
Protein-protein interaction databases
STRING	P41931.
Genome annotation databases
Ensembl	K11C4.4.1; K11C4.4.1; K11C4.4; Caenorhabditis elegans. [Genome view] K11C4.4.2; K11C4.4.2; K11C4.4; Caenorhabditis elegans. [Genome view]
GeneID	179079.
KEGG	cel:K11C4.4.
NMPDR	fig|6239.3.peg.18282.
UCSC	K11C4.4.1. c. elegans.
Organism-specific databases
CTD	179079.
WormBase	WBGene00003844. odc-1.
WormPep	K11C4.4. CE12114. [WorfDB]
Phylogenomic databases
OMA	CILFDHQ.
Enzyme and pathway databases
BRENDA	4.1.1.17. 672.
Gene expression databases
ArrayExpress	P41931.
Family and domain databases
InterPro	IPR000183. De-COase2. IPR002433. Orn_de-COase. [Graphical view]
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PRINTS	PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	903826.

Entry information

Entry name

DCOR_CAEEL

Accession

Primary (citable) accession number: P41931
Secondary accession number(s): Q94278

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 11, 2001
Last modified:	November 3, 2009
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project