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Protein

Sulfite efflux pump SSU1

Gene

SSU1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in efflux of free sulfite. Mutations in the SSU1 gene cause sensitivity to sulfite.2 Publications

GO - Molecular functioni

  • sulfite transmembrane transporter activity Source: SGD

GO - Biological processi

  • sulfite transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33996-MONOMER.

Protein family/group databases

TCDBi2.A.16.3.1. the telurite-resistance/dicarboxylate transporter (tdt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfite efflux pump SSU1
Alternative name(s):
Sulfite sensitivity protein SSU1
Gene namesi
Name:SSU1
Ordered Locus Names:YPL092W
ORF Names:LPG16W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL092W.
SGDiS000006013. SSU1.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 48ExtracellularSequence analysisAdd BLAST16
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 89CytoplasmicSequence analysisAdd BLAST20
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111 – 135ExtracellularSequence analysisAdd BLAST25
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 176CytoplasmicSequence analysisAdd BLAST20
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 220ExtracellularSequence analysisAdd BLAST23
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Topological domaini242 – 252CytoplasmicSequence analysisAdd BLAST11
Transmembranei253 – 275HelicalSequence analysisAdd BLAST23
Topological domaini276 – 309ExtracellularSequence analysisAdd BLAST34
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 350CytoplasmicSequence analysisAdd BLAST20
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Topological domaini372 – 387ExtracellularSequence analysisAdd BLAST16
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 458CytoplasmicSequence analysisAdd BLAST50

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722291 – 458Sulfite efflux pump SSU1Add BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei444PhosphoserineCombined sources1
Modified residuei448PhosphoserineCombined sources1
Modified residuei450PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP41930.

PTM databases

iPTMnetiP41930.

Interactioni

Protein-protein interaction databases

BioGridi36089. 12 interactors.
DIPiDIP-5056N.
IntActiP41930. 1 interactor.
MINTiMINT-493602.

Structurei

3D structure databases

ProteinModelPortaliP41930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP41930.
OMAiENHSESI.
OrthoDBiEOG092C45P2.

Family and domain databases

InterProiIPR004695. Voltage-dep_anion_channel.
[Graphical view]
PfamiPF03595. SLAC1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVANWVLALT RQFDPFMFMM VMGVGISSNI LYSFPYPARW LRICSYIMFA
60 70 80 90 100
IACLIFIAVQ ALQILHLIVY IKEKSFREYF NDFFRNMKHN LFWGTYPMGL
110 120 130 140 150
VTIINFLGAL SKANTTKSPT NARNLMIFVY VLWWYDLAVC LVIAWGISFL
160 170 180 190 200
IWHDYYPLEG IGNYPSYNIK MASENMKSVL LLDIIPLVVV ASSCGTFTMS
210 220 230 240 250
EIFFHAFNRN IQLITLVICA LTWLHAIIFV FILIAIYFWS LYINKIPPMT
260 270 280 290 300
QVFTLFLLLG PMGQGSFGVL LLTDNIKKYA GKYYPTDNIT REQEILTIAV
310 320 330 340 350
PWCFKILGMV SAMALLAMGY FFTVISVVSI LSYYNKKEIE NETGKVKRVY
360 370 380 390 400
TFHKGFWGMT FPMGTMSLGN EELYVQYNQY VPLYAFRVLG TIYGGVCVCW
410 420 430 440 450
SILCLLCTLH EYSKKMLHAA RKSSLFSESG TEKTTVSPYN SIESVEESNS

ALDFTRLA
Length:458
Mass (Da):52,545
Last modified:May 1, 2007 - v5
Checksum:iFF55440526AA6E73
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti19M → V in strain: Ba194, CECT 10233, M5-7A, M5-7B, M7-8D, MMR2-1, MMR2-3, MMW1-12, ORM1-1, Sgu52E, Y-9, YPS396, YPS400, YPS598, YPS600, YPS602, YPS604, YPS606, YPS608 and YPS610. 1
Natural varianti52A → T in strain: ATCC 76625 / YPH499, Ba194, Bb32, M1-2A, M2-8, M5-7A, M5-7B, M7-8D, MMR2-1, MMR2-3, MMR2-5, MMW1-15, MMW1-15h2, MMW1-2, MMW1-2h2, MMW1-12, ORM1-1, S288c/ YPH1, Sgu52E, Sgu52F, Y-9, YPS396, YPS400, YPS598, YPS600, YPS602, YPS604, YPS606, YPS608 and YPS610. 1
Natural varianti90N → S in strain: Ba194, Bb32, M1-2A, M2-8, M5-7A, M5-7B, M7-8D, MMR2-5, MMW1-15h2, MMW1-2h2, Sgu52E, Sgu52F and Y-9. 1
Natural varianti122A → S in strain: Bb32, M1-2A, M2-8, MMR2-5, MMW1-15h2, MMW1-2h2 and Sgu52F. 1
Natural varianti157P → S in strain: Ba194, Bb32, M1-2A, M2-8, M5-7A, M5-7B, M7-8D, MMR2-1, MMR2-3, MMR2-5, MMW1-12, MMW1-15h2, MMW1-2h2, ORM1-1, Sgu52E, Sgu52F, Y-9, YPS396, YPS400, YPS598, YPS600, YPS602, YPS604, YPS606, YPS608 and YPS610. 1
Natural varianti164Y → H in strain: Bb32, M1-2A, M2-8, MMR2-5, MMW1-15h2, MMW1-2h2 and Sgu52F. 1
Natural varianti191A → T in strain: ATCC 76625 / YPH499,MMW1-15, MMW1-2 and S288c / YPH1. 1
Natural varianti344G → E in strain: Sgu52F. 1
Natural varianti345K → R in strain: ATCC 76625 / YPH499, MMW1-15 and MMW1-2. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20254 Genomic DNA. Translation: AAC49577.1.
AB002531 Genomic DNA. Translation: BAA19568.1.
AY949949 Genomic DNA. Translation: AAY27351.1.
AY949950 Genomic DNA. Translation: AAY27352.1.
AY949951 Genomic DNA. Translation: AAY27353.1.
AY949952 Genomic DNA. Translation: AAY27354.1.
AY949953 Genomic DNA. Translation: AAY27355.1.
AY949954 Genomic DNA. Translation: AAY27356.1.
AY949955 Genomic DNA. Translation: AAY27357.1.
AY949956 Genomic DNA. Translation: AAY27358.1.
AY949957 Genomic DNA. Translation: AAY27359.1.
AY949958 Genomic DNA. Translation: AAY27360.1.
AY949959 Genomic DNA. Translation: AAY27361.1.
AY949960 Genomic DNA. Translation: AAY27362.1.
AY949961 Genomic DNA. Translation: AAY27363.1.
AY949962 Genomic DNA. Translation: AAY27364.1.
AY949963 Genomic DNA. Translation: AAY27365.1.
AY949964 Genomic DNA. Translation: AAY27366.1.
AY949965 Genomic DNA. Translation: AAY27367.1.
AY949966 Genomic DNA. Translation: AAY27368.1.
AY949967 Genomic DNA. Translation: AAY27369.1.
AY949968 Genomic DNA. Translation: AAY27370.1.
AY949969 Genomic DNA. Translation: AAY27371.1.
AY949970 Genomic DNA. Translation: AAY27372.1.
AY949971 Genomic DNA. Translation: AAY27373.1.
AY949972 Genomic DNA. Translation: AAY27374.1.
AY949973 Genomic DNA. Translation: AAY27375.1.
AY949974 Genomic DNA. Translation: AAY27376.1.
AY949975 Genomic DNA. Translation: AAY27377.1.
AY949976 Genomic DNA. Translation: AAY27378.1.
AY949977 Genomic DNA. Translation: AAY27379.1.
U43281 Genomic DNA. Translation: AAB68207.1.
AY693225 Genomic DNA. Translation: AAT93244.1.
AJ458365 Genomic DNA. Translation: CAD30223.1.
AJ458367 Genomic DNA. Translation: CAD30225.1.
BK006949 Genomic DNA. Translation: DAA11341.1.
PIRiS61974.
RefSeqiNP_015233.1. NM_001183906.1.

Genome annotation databases

EnsemblFungiiYPL092W; YPL092W; YPL092W.
GeneIDi856013.
KEGGisce:YPL092W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20254 Genomic DNA. Translation: AAC49577.1.
AB002531 Genomic DNA. Translation: BAA19568.1.
AY949949 Genomic DNA. Translation: AAY27351.1.
AY949950 Genomic DNA. Translation: AAY27352.1.
AY949951 Genomic DNA. Translation: AAY27353.1.
AY949952 Genomic DNA. Translation: AAY27354.1.
AY949953 Genomic DNA. Translation: AAY27355.1.
AY949954 Genomic DNA. Translation: AAY27356.1.
AY949955 Genomic DNA. Translation: AAY27357.1.
AY949956 Genomic DNA. Translation: AAY27358.1.
AY949957 Genomic DNA. Translation: AAY27359.1.
AY949958 Genomic DNA. Translation: AAY27360.1.
AY949959 Genomic DNA. Translation: AAY27361.1.
AY949960 Genomic DNA. Translation: AAY27362.1.
AY949961 Genomic DNA. Translation: AAY27363.1.
AY949962 Genomic DNA. Translation: AAY27364.1.
AY949963 Genomic DNA. Translation: AAY27365.1.
AY949964 Genomic DNA. Translation: AAY27366.1.
AY949965 Genomic DNA. Translation: AAY27367.1.
AY949966 Genomic DNA. Translation: AAY27368.1.
AY949967 Genomic DNA. Translation: AAY27369.1.
AY949968 Genomic DNA. Translation: AAY27370.1.
AY949969 Genomic DNA. Translation: AAY27371.1.
AY949970 Genomic DNA. Translation: AAY27372.1.
AY949971 Genomic DNA. Translation: AAY27373.1.
AY949972 Genomic DNA. Translation: AAY27374.1.
AY949973 Genomic DNA. Translation: AAY27375.1.
AY949974 Genomic DNA. Translation: AAY27376.1.
AY949975 Genomic DNA. Translation: AAY27377.1.
AY949976 Genomic DNA. Translation: AAY27378.1.
AY949977 Genomic DNA. Translation: AAY27379.1.
U43281 Genomic DNA. Translation: AAB68207.1.
AY693225 Genomic DNA. Translation: AAT93244.1.
AJ458365 Genomic DNA. Translation: CAD30223.1.
AJ458367 Genomic DNA. Translation: CAD30225.1.
BK006949 Genomic DNA. Translation: DAA11341.1.
PIRiS61974.
RefSeqiNP_015233.1. NM_001183906.1.

3D structure databases

ProteinModelPortaliP41930.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36089. 12 interactors.
DIPiDIP-5056N.
IntActiP41930. 1 interactor.
MINTiMINT-493602.

Protein family/group databases

TCDBi2.A.16.3.1. the telurite-resistance/dicarboxylate transporter (tdt) family.

PTM databases

iPTMnetiP41930.

Proteomic databases

PRIDEiP41930.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL092W; YPL092W; YPL092W.
GeneIDi856013.
KEGGisce:YPL092W.

Organism-specific databases

EuPathDBiFungiDB:YPL092W.
SGDiS000006013. SSU1.

Phylogenomic databases

InParanoidiP41930.
OMAiENHSESI.
OrthoDBiEOG092C45P2.

Enzyme and pathway databases

BioCyciYEAST:G3O-33996-MONOMER.

Miscellaneous databases

PROiP41930.

Family and domain databases

InterProiIPR004695. Voltage-dep_anion_channel.
[Graphical view]
PfamiPF03595. SLAC1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSU1_YEAST
AccessioniPrimary (citable) accession number: P41930
Secondary accession number(s): D6W3S5
, P87026, Q02893, Q2VQ61, Q2VQ65, Q2VQ70, Q2VQ74, Q2VQ76, Q2VQ77, Q8J1R0, Q8J1R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 1, 2007
Last modified: November 2, 2016
This is version 119 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.