P41929 (LYC1_YARLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysine acetyltransferase
Short name=LAT
EC=2.3.1.32

Alternative name(s):
Lysine N(6)-acetyltransferase

Gene names

Name:	LYC1
Ordered Locus Names:	YALI0E05533g

Organism

Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]

Taxonomic identifier

284591 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia › Yarrowia lipolytica

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	Acetyl phosphate + L-lysine = phosphate + N(6)-acetyl-L-lysine.
Pathway	Amino-acid degradation; L-lysine degradation via acetylation pathway; glutarate from L-lysine: step 1/6.
Sequence caution	The sequence CAA45112.1 differs from that shown. Reason: Frameshift at positions 18, 44, 150 and 259.

Ontologies

Keywords
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	L-lysine catabolic process to glutarate, by acetylation Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	lysine N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Lysine acetyltransferase		PRO_0000084531
Experimental info
	Sequence conflict	275	1	I → Y in CAA45112. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P41929 [UniParc]. Last modified October 11, 2004. Version 2. Checksum: 8B9D2C6A972A907D	FASTA	392	43,935
	10 20 30 40 50 60 MSLREITSPD EIRDTRSFSH LEWGAFLSID DYNHREEIVL GHTPMCKNRL KSWGLYIEDG 70 80 90 100 110 120 TRVAACETLE RPALVQCKDG KIKSTSTFSI GAVFTPKEHR GKGYASVMMK QMASGIPFKP 130 140 150 160 170 180 TLTDADIIKA TGVSDVDQTL RVTPLWSDVG TFYEKFGWIG TTDLQYVFEV DGSASQNGVN 190 200 210 220 230 240 GTPNGTNGTN GVNGHTNGTN GHSSAVKYLS EEDVYRLADV EASSFASDFE KFPFKGSYKC 250 260 270 280 290 300 GIVPDRTVYE WHLARAKFLA KFAKVPEPKV FGAQIGDSWM AWHHMYNARE LVILRAKLAK 310 320 330 340 350 360 AEDLVELIAA AKNHLCKDGF SDQINKIILW EQEREWNHIV DGLSYDAIDQ AIEKSQGKRE 370 380 390 HRGSSIPAVM FVEYKLQKDA MEFVDHGKLT WC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"LYC1 is the structural gene for lysine N-6-acetyl transferase in yeast." Beckerich J.-M., Lambert M., Gaillardin C. Curr. Genet. 25:24-29(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.
[2]	"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X63548 Genomic DNA. Translation: CAA45112.1. Frameshift. CR382131 Genomic DNA. Translation: CAG79170.1.
PIR	S39816.
RefSeq	XP_503589.1. XM_503589.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2911519.
KEGG	yli:YALI0E05533g.
Phylogenomic databases
eggNOG	NOG69559.
OMA	WHLERER.
OrthoDB	EOG4PZNHH.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-8145.
UniPathway	UPA00869; UER00841.
Family and domain databases
Gene3D	3.40.630.30. 1 hit.
InterPro	IPR016181. Acyl_CoA_acyltransferase. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LYC1_YARLI

Accession

Primary (citable) accession number: P41929
Secondary accession number(s): Q6C6X3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program