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P41920

- YRB1_YEAST

UniProt

P41920 - YRB1_YEAST

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Protein

Ran-specific GTPase-activating protein 1

Gene

YRB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2.

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW
  2. Ran GTPase binding Source: SGD

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: SGD
  2. protein import into nucleus Source: SGD
  3. RNA export from nucleus Source: SGD
  4. ubiquitin-dependent protein catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29624-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-specific GTPase-activating protein 1
Alternative name(s):
Chromosome stability protein 20
Perinuclear array-localized protein
Ran-binding protein 1
Short name:
RANBP1
Gene namesi
Name:YRB1
Synonyms:CST20, HTN1, SFO1
Ordered Locus Names:YDR002W
ORF Names:YD8119.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR002w.
SGDiS000002409. YRB1.

Subcellular locationi

Cytoplasm. Nucleus
Note: Shuttles between the nucleus and cytoplasm.

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Ran-specific GTPase-activating protein 1PRO_0000213670Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 601Phosphoserine4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP41920.
PaxDbiP41920.
PeptideAtlasiP41920.
PRIDEiP41920.

Expressioni

Gene expression databases

GenevestigatoriP41920.

Interactioni

Subunit structurei

Interacts with GSP1 and PRP20.

Protein-protein interaction databases

BioGridi32055. 68 interactions.
DIPiDIP-838N.
IntActiP41920. 4 interactions.
MINTiMINT-398068.
STRINGi4932.YDR002W.

Structurei

Secondary structure

1
201
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi83 – 9715
Turni98 – 1014
Beta strandi102 – 11615
Turni117 – 1193
Beta strandi122 – 1276
Turni129 – 1313
Beta strandi134 – 1396
Beta strandi153 – 16311
Beta strandi165 – 1684
Beta strandi170 – 18011
Helixi181 – 19919

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3M1IX-ray2.00B11-201[»]
4GMXX-ray2.10B62-201[»]
4GPTX-ray2.22B62-201[»]
4HATX-ray1.78B62-201[»]
4HAUX-ray2.00B62-201[»]
4HAVX-ray2.00B62-201[»]
4HAWX-ray1.90B62-201[»]
4HAXX-ray2.28B62-201[»]
4HAYX-ray2.30B62-201[»]
4HAZX-ray1.90B62-201[»]
4HB0X-ray2.20B62-201[»]
4HB2X-ray1.80B62-201[»]
4HB3X-ray2.80B62-201[»]
4HB4X-ray2.05B62-201[»]
ProteinModelPortaliP41920.
SMRiP41920. Positions 71-201.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41920.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 200137RanBD1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RANBP1 family.Curated
Contains 1 RanBD1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5171.
GeneTreeiENSGT00720000108825.
HOGENOMiHOG000176323.
InParanoidiP41920.
KOiK15306.
OMAiQLFKMRA.
OrthoDBiEOG7TF7N6.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR000156. Ran_bind_dom.
[Graphical view]
PfamiPF00638. Ran_BP1. 1 hit.
[Graphical view]
SMARTiSM00160. RanBD. 1 hit.
[Graphical view]
PROSITEiPS50196. RANBD1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41920-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSEDKKPVV DKKEEAAPKP PSSAVFSMFG GKKAEKPETK KDEEDTKEET
60 70 80 90 100
KKEGDDAPES PDIHFEPVVH LEKVDVKTME EDEEVLYKVR AKLFRFDADA
110 120 130 140 150
KEWKERGTGD CKFLKNKKTN KVRILMRRDK TLKICANHII APEYTLKPNV
160 170 180 190 200
GSDRSWVYAC TADIAEGEAE AFTFAIRFGS KENADKFKEE FEKAQEINKK

A
Length:201
Mass (Da):22,953
Last modified:November 1, 1995 - v1
Checksum:i46C3766B0906A75B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z33503 Genomic DNA. Translation: CAA83911.1.
X65925 Genomic DNA. No translation available.
L38489 Genomic DNA. Translation: AAA57276.1.
Z48008 Genomic DNA. Translation: CAA88062.1.
BK006938 Genomic DNA. Translation: DAA11849.1.
PIRiS50219.
RefSeqiNP_010285.1. NM_001180310.1.

Genome annotation databases

EnsemblFungiiYDR002W; YDR002W; YDR002W.
GeneIDi851565.
KEGGisce:YDR002W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z33503 Genomic DNA. Translation: CAA83911.1 .
X65925 Genomic DNA. No translation available.
L38489 Genomic DNA. Translation: AAA57276.1 .
Z48008 Genomic DNA. Translation: CAA88062.1 .
BK006938 Genomic DNA. Translation: DAA11849.1 .
PIRi S50219.
RefSeqi NP_010285.1. NM_001180310.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3M1I X-ray 2.00 B 11-201 [» ]
4GMX X-ray 2.10 B 62-201 [» ]
4GPT X-ray 2.22 B 62-201 [» ]
4HAT X-ray 1.78 B 62-201 [» ]
4HAU X-ray 2.00 B 62-201 [» ]
4HAV X-ray 2.00 B 62-201 [» ]
4HAW X-ray 1.90 B 62-201 [» ]
4HAX X-ray 2.28 B 62-201 [» ]
4HAY X-ray 2.30 B 62-201 [» ]
4HAZ X-ray 1.90 B 62-201 [» ]
4HB0 X-ray 2.20 B 62-201 [» ]
4HB2 X-ray 1.80 B 62-201 [» ]
4HB3 X-ray 2.80 B 62-201 [» ]
4HB4 X-ray 2.05 B 62-201 [» ]
ProteinModelPortali P41920.
SMRi P41920. Positions 71-201.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32055. 68 interactions.
DIPi DIP-838N.
IntActi P41920. 4 interactions.
MINTi MINT-398068.
STRINGi 4932.YDR002W.

Proteomic databases

MaxQBi P41920.
PaxDbi P41920.
PeptideAtlasi P41920.
PRIDEi P41920.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDR002W ; YDR002W ; YDR002W .
GeneIDi 851565.
KEGGi sce:YDR002W.

Organism-specific databases

CYGDi YDR002w.
SGDi S000002409. YRB1.

Phylogenomic databases

eggNOGi COG5171.
GeneTreei ENSGT00720000108825.
HOGENOMi HOG000176323.
InParanoidi P41920.
KOi K15306.
OMAi QLFKMRA.
OrthoDBi EOG7TF7N6.

Enzyme and pathway databases

BioCyci YEAST:G3O-29624-MONOMER.

Miscellaneous databases

EvolutionaryTracei P41920.
NextBioi 969007.
PROi P41920.

Gene expression databases

Genevestigatori P41920.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR011993. PH_like_dom.
IPR000156. Ran_bind_dom.
[Graphical view ]
Pfami PF00638. Ran_BP1. 1 hit.
[Graphical view ]
SMARTi SM00160. RanBD. 1 hit.
[Graphical view ]
PROSITEi PS50196. RANBD1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Yeast homologue of mammalian Ran binding protein 1."
    Butler G., Wolfe K.H.
    Biochim. Biophys. Acta 1219:711-712(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: H9.
  2. "Molecular analysis of the neutral trehalase gene from Saccharomyces cerevisiae."
    Kopp M., Mueller H., Holzer H.
    J. Biol. Chem. 268:4766-4774(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast."
    Ouspenski I.I., Mueller U.W., Matynia A., Sazer S., Elledge S.J., Brinkley B.R.
    J. Biol. Chem. 270:1975-1978(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
  4. Trueheart J., Richards S., Macara I.G., Thorner J.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  7. "Mutants in a yeast Ran binding protein are defective in nuclear transport."
    Schlenstedt G., Wong D.H., Koepp D.M., Silver P.A.
    EMBO J. 14:5367-5378(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  8. "Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway."
    Kunzler M., Gerstberger T., Stutz F., Bischoff F.R., Hurt E.
    Mol. Cell. Biol. 20:4295-4308(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  9. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  10. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYRB1_YEAST
AccessioniPrimary (citable) accession number: P41920
Secondary accession number(s): D6VRY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3