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P41920

- YRB1_YEAST

UniProt

P41920 - YRB1_YEAST

Protein

Ran-specific GTPase-activating protein 1

Gene

YRB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2.

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB-KW
    2. Ran GTPase binding Source: SGD

    GO - Biological processi

    1. G1/S transition of mitotic cell cycle Source: SGD
    2. protein import into nucleus Source: SGD
    3. RNA export from nucleus Source: SGD
    4. ubiquitin-dependent protein catabolic process Source: SGD

    Keywords - Molecular functioni

    GTPase activation

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29624-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ran-specific GTPase-activating protein 1
    Alternative name(s):
    Chromosome stability protein 20
    Perinuclear array-localized protein
    Ran-binding protein 1
    Short name:
    RANBP1
    Gene namesi
    Name:YRB1
    Synonyms:CST20, HTN1, SFO1
    Ordered Locus Names:YDR002W
    ORF Names:YD8119.08
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR002w.
    SGDiS000002409. YRB1.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Shuttles between the nucleus and cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: SGD
    2. nucleus Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 201201Ran-specific GTPase-activating protein 1PRO_0000213670Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei60 – 601Phosphoserine4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP41920.
    PaxDbiP41920.
    PeptideAtlasiP41920.
    PRIDEiP41920.

    Expressioni

    Gene expression databases

    GenevestigatoriP41920.

    Interactioni

    Subunit structurei

    Interacts with GSP1 and PRP20.

    Protein-protein interaction databases

    BioGridi32055. 67 interactions.
    DIPiDIP-838N.
    IntActiP41920. 4 interactions.
    MINTiMINT-398068.
    STRINGi4932.YDR002W.

    Structurei

    Secondary structure

    1
    201
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi83 – 9715
    Turni98 – 1014
    Beta strandi102 – 11615
    Turni117 – 1193
    Beta strandi122 – 1276
    Turni129 – 1313
    Beta strandi134 – 1396
    Beta strandi153 – 16311
    Beta strandi165 – 1684
    Beta strandi170 – 18011
    Helixi181 – 19919

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3M1IX-ray2.00B11-201[»]
    4GMXX-ray2.10B62-201[»]
    4GPTX-ray2.22B62-201[»]
    4HATX-ray1.78B62-201[»]
    4HAUX-ray2.00B62-201[»]
    4HAVX-ray2.00B62-201[»]
    4HAWX-ray1.90B62-201[»]
    4HAXX-ray2.28B62-201[»]
    4HAYX-ray2.30B62-201[»]
    4HAZX-ray1.90B62-201[»]
    4HB0X-ray2.20B62-201[»]
    4HB2X-ray1.80B62-201[»]
    4HB3X-ray2.80B62-201[»]
    4HB4X-ray2.05B62-201[»]
    ProteinModelPortaliP41920.
    SMRiP41920. Positions 71-201.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP41920.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 200137RanBD1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RANBP1 family.Curated
    Contains 1 RanBD1 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5171.
    GeneTreeiENSGT00720000108825.
    HOGENOMiHOG000176323.
    KOiK15306.
    OMAiQLFKMRA.
    OrthoDBiEOG7TF7N6.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR000156. Ran_bind_dom.
    [Graphical view]
    PfamiPF00638. Ran_BP1. 1 hit.
    [Graphical view]
    SMARTiSM00160. RanBD. 1 hit.
    [Graphical view]
    PROSITEiPS50196. RANBD1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41920-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSEDKKPVV DKKEEAAPKP PSSAVFSMFG GKKAEKPETK KDEEDTKEET    50
    KKEGDDAPES PDIHFEPVVH LEKVDVKTME EDEEVLYKVR AKLFRFDADA 100
    KEWKERGTGD CKFLKNKKTN KVRILMRRDK TLKICANHII APEYTLKPNV 150
    GSDRSWVYAC TADIAEGEAE AFTFAIRFGS KENADKFKEE FEKAQEINKK 200
    A 201
    Length:201
    Mass (Da):22,953
    Last modified:November 1, 1995 - v1
    Checksum:i46C3766B0906A75B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z33503 Genomic DNA. Translation: CAA83911.1.
    X65925 Genomic DNA. No translation available.
    L38489 Genomic DNA. Translation: AAA57276.1.
    Z48008 Genomic DNA. Translation: CAA88062.1.
    BK006938 Genomic DNA. Translation: DAA11849.1.
    PIRiS50219.
    RefSeqiNP_010285.1. NM_001180310.1.

    Genome annotation databases

    EnsemblFungiiYDR002W; YDR002W; YDR002W.
    GeneIDi851565.
    KEGGisce:YDR002W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z33503 Genomic DNA. Translation: CAA83911.1 .
    X65925 Genomic DNA. No translation available.
    L38489 Genomic DNA. Translation: AAA57276.1 .
    Z48008 Genomic DNA. Translation: CAA88062.1 .
    BK006938 Genomic DNA. Translation: DAA11849.1 .
    PIRi S50219.
    RefSeqi NP_010285.1. NM_001180310.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3M1I X-ray 2.00 B 11-201 [» ]
    4GMX X-ray 2.10 B 62-201 [» ]
    4GPT X-ray 2.22 B 62-201 [» ]
    4HAT X-ray 1.78 B 62-201 [» ]
    4HAU X-ray 2.00 B 62-201 [» ]
    4HAV X-ray 2.00 B 62-201 [» ]
    4HAW X-ray 1.90 B 62-201 [» ]
    4HAX X-ray 2.28 B 62-201 [» ]
    4HAY X-ray 2.30 B 62-201 [» ]
    4HAZ X-ray 1.90 B 62-201 [» ]
    4HB0 X-ray 2.20 B 62-201 [» ]
    4HB2 X-ray 1.80 B 62-201 [» ]
    4HB3 X-ray 2.80 B 62-201 [» ]
    4HB4 X-ray 2.05 B 62-201 [» ]
    ProteinModelPortali P41920.
    SMRi P41920. Positions 71-201.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32055. 67 interactions.
    DIPi DIP-838N.
    IntActi P41920. 4 interactions.
    MINTi MINT-398068.
    STRINGi 4932.YDR002W.

    Proteomic databases

    MaxQBi P41920.
    PaxDbi P41920.
    PeptideAtlasi P41920.
    PRIDEi P41920.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR002W ; YDR002W ; YDR002W .
    GeneIDi 851565.
    KEGGi sce:YDR002W.

    Organism-specific databases

    CYGDi YDR002w.
    SGDi S000002409. YRB1.

    Phylogenomic databases

    eggNOGi COG5171.
    GeneTreei ENSGT00720000108825.
    HOGENOMi HOG000176323.
    KOi K15306.
    OMAi QLFKMRA.
    OrthoDBi EOG7TF7N6.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29624-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P41920.
    NextBioi 969007.
    PROi P41920.

    Gene expression databases

    Genevestigatori P41920.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR000156. Ran_bind_dom.
    [Graphical view ]
    Pfami PF00638. Ran_BP1. 1 hit.
    [Graphical view ]
    SMARTi SM00160. RanBD. 1 hit.
    [Graphical view ]
    PROSITEi PS50196. RANBD1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Yeast homologue of mammalian Ran binding protein 1."
      Butler G., Wolfe K.H.
      Biochim. Biophys. Acta 1219:711-712(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: H9.
    2. "Molecular analysis of the neutral trehalase gene from Saccharomyces cerevisiae."
      Kopp M., Mueller H., Holzer H.
      J. Biol. Chem. 268:4766-4774(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast."
      Ouspenski I.I., Mueller U.W., Matynia A., Sazer S., Elledge S.J., Brinkley B.R.
      J. Biol. Chem. 270:1975-1978(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    4. Trueheart J., Richards S., Macara I.G., Thorner J.
      Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    7. "Mutants in a yeast Ran binding protein are defective in nuclear transport."
      Schlenstedt G., Wong D.H., Koepp D.M., Silver P.A.
      EMBO J. 14:5367-5378(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    8. "Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway."
      Kunzler M., Gerstberger T., Stutz F., Bischoff F.R., Hurt E.
      Mol. Cell. Biol. 20:4295-4308(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    9. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    10. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYRB1_YEAST
    AccessioniPrimary (citable) accession number: P41920
    Secondary accession number(s): D6VRY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3