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P41920 (YRB1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ran-specific GTPase-activating protein 1
Alternative name(s):
Chromosome stability protein 20
Perinuclear array-localized protein
Ran-binding protein 1
Short name=RANBP1
Gene names
Name:YRB1
Synonyms:CST20, HTN1, SFO1
Ordered Locus Names:YDR002W
ORF Names:YD8119.08
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2.

Subunit structure

Interacts with GSP1 and PRP20.

Subcellular location

Cytoplasm. Nucleus. Note: Shuttles between the nucleus and cytoplasm.

Sequence similarities

Belongs to the RANBP1 family.

Contains 1 RanBD1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 201201Ran-specific GTPase-activating protein 1
PRO_0000213670

Regions

Domain64 – 200137RanBD1

Amino acid modifications

Modified residue601Phosphoserine Ref.9 Ref.10 Ref.11 Ref.12

Secondary structure

................... 201
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P41920 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 46C3766B0906A75B

FASTA20122,953
        10         20         30         40         50         60 
MSSEDKKPVV DKKEEAAPKP PSSAVFSMFG GKKAEKPETK KDEEDTKEET KKEGDDAPES 

        70         80         90        100        110        120 
PDIHFEPVVH LEKVDVKTME EDEEVLYKVR AKLFRFDADA KEWKERGTGD CKFLKNKKTN 

       130        140        150        160        170        180 
KVRILMRRDK TLKICANHII APEYTLKPNV GSDRSWVYAC TADIAEGEAE AFTFAIRFGS 

       190        200 
KENADKFKEE FEKAQEINKK A 

« Hide

References

« Hide 'large scale' references
[1]"Yeast homologue of mammalian Ran binding protein 1."
Butler G., Wolfe K.H.
Biochim. Biophys. Acta 1219:711-712(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: H9.
[2]"Molecular analysis of the neutral trehalase gene from Saccharomyces cerevisiae."
Kopp M., Mueller H., Holzer H.
J. Biol. Chem. 268:4766-4774(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast."
Ouspenski I.I., Mueller U.W., Matynia A., Sazer S., Elledge S.J., Brinkley B.R.
J. Biol. Chem. 270:1975-1978(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
[4]Trueheart J., Richards S., Macara I.G., Thorner J.
Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[7]"Mutants in a yeast Ran binding protein are defective in nuclear transport."
Schlenstedt G., Wong D.H., Koepp D.M., Silver P.A.
EMBO J. 14:5367-5378(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[8]"Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway."
Kunzler M., Gerstberger T., Stutz F., Bischoff F.R., Hurt E.
Mol. Cell. Biol. 20:4295-4308(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[9]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[10]"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z33503 Genomic DNA. Translation: CAA83911.1.
X65925 Genomic DNA. No translation available.
L38489 Genomic DNA. Translation: AAA57276.1.
Z48008 Genomic DNA. Translation: CAA88062.1.
BK006938 Genomic DNA. Translation: DAA11849.1.
PIRS50219.
RefSeqNP_010285.1. NM_001180310.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3M1IX-ray2.00B11-201[»]
4GMXX-ray2.10B62-201[»]
4GPTX-ray2.22B62-201[»]
4HATX-ray1.78B62-201[»]
4HAUX-ray2.00B62-201[»]
4HAVX-ray2.00B62-201[»]
4HAWX-ray1.90B62-201[»]
4HAXX-ray2.28B62-201[»]
4HAYX-ray2.30B62-201[»]
4HAZX-ray1.90B62-201[»]
4HB0X-ray2.20B62-201[»]
4HB2X-ray1.80B62-201[»]
4HB3X-ray2.80B62-201[»]
4HB4X-ray2.05B62-201[»]
ProteinModelPortalP41920.
SMRP41920. Positions 71-201.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid32055. 67 interactions.
DIPDIP-838N.
IntActP41920. 4 interactions.
MINTMINT-398068.
STRING4932.YDR002W.

Proteomic databases

PaxDbP41920.
PeptideAtlasP41920.
PRIDEP41920.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDR002W; YDR002W; YDR002W.
GeneID851565.
KEGGsce:YDR002W.

Organism-specific databases

CYGDYDR002w.
SGDS000002409. YRB1.

Phylogenomic databases

eggNOGCOG5171.
GeneTreeENSGT00720000108825.
HOGENOMHOG000176323.
KOK15306.
OMAQLFKMRA.
OrthoDBEOG7TF7N6.

Enzyme and pathway databases

BioCycYEAST:G3O-29624-MONOMER.

Gene expression databases

GenevestigatorP41920.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR011993. PH_like_dom.
IPR000156. Ran_bind_dom.
[Graphical view]
PfamPF00638. Ran_BP1. 1 hit.
[Graphical view]
SMARTSM00160. RanBD. 1 hit.
[Graphical view]
PROSITEPS50196. RANBD1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP41920.
NextBio969007.
PROP41920.

Entry information

Entry nameYRB1_YEAST
AccessionPrimary (citable) accession number: P41920
Secondary accession number(s): D6VRY9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references