Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ran-specific GTPase-activating protein 1

Gene

YRB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2.

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB-KW
  • Ran GTPase binding Source: SGD

GO - Biological processi

  • G1/S transition of mitotic cell cycle Source: SGD
  • protein import into nucleus Source: SGD
  • RNA export from nucleus Source: SGD
  • spindle organization Source: GO_Central
  • ubiquitin-dependent protein catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29624-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-specific GTPase-activating protein 1
Alternative name(s):
Chromosome stability protein 20
Perinuclear array-localized protein
Ran-binding protein 1
Short name:
RANBP1
Gene namesi
Name:YRB1
Synonyms:CST20, HTN1, SFO1
Ordered Locus Names:YDR002W
ORF Names:YD8119.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR002W.
SGDiS000002409. YRB1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002136701 – 201Ran-specific GTPase-activating protein 1Add BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP41920.
PRIDEiP41920.

PTM databases

iPTMnetiP41920.

Interactioni

Subunit structurei

Interacts with GSP1 and PRP20.

GO - Molecular functioni

  • Ran GTPase binding Source: SGD

Protein-protein interaction databases

BioGridi32055. 68 interactors.
DIPiDIP-838N.
IntActiP41920. 4 interactors.
MINTiMINT-398068.

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi83 – 97Combined sources15
Turni98 – 101Combined sources4
Beta strandi102 – 116Combined sources15
Turni117 – 119Combined sources3
Beta strandi122 – 127Combined sources6
Turni129 – 131Combined sources3
Beta strandi134 – 139Combined sources6
Beta strandi153 – 163Combined sources11
Beta strandi165 – 168Combined sources4
Beta strandi170 – 180Combined sources11
Helixi181 – 199Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M1IX-ray2.00B11-201[»]
4GMXX-ray2.10B62-201[»]
4GPTX-ray2.22B62-201[»]
4HATX-ray1.78B62-201[»]
4HAUX-ray2.00B62-201[»]
4HAVX-ray2.00B62-201[»]
4HAWX-ray1.90B62-201[»]
4HAXX-ray2.28B62-201[»]
4HAYX-ray2.30B62-201[»]
4HAZX-ray1.90B62-201[»]
4HB0X-ray2.20B62-201[»]
4HB2X-ray1.80B62-201[»]
4HB3X-ray2.80B62-201[»]
4HB4X-ray2.05B62-201[»]
4WVFX-ray1.80B62-201[»]
5DH9X-ray2.55B62-201[»]
5DHAX-ray2.95B62-201[»]
5DHFX-ray2.29B62-201[»]
5DI9X-ray2.28B62-201[»]
5DIFX-ray2.09B62-201[»]
5JLJX-ray2.50B62-201[»]
ProteinModelPortaliP41920.
SMRiP41920.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41920.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 200RanBD1PROSITE-ProRule annotationAdd BLAST137

Sequence similaritiesi

Belongs to the RANBP1 family.Curated
Contains 1 RanBD1 domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00840000129823.
HOGENOMiHOG000176323.
InParanoidiP41920.
KOiK15306.
OMAiDTQEWKE.
OrthoDBiEOG092C4THQ.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR000156. Ran_bind_dom.
[Graphical view]
PfamiPF00638. Ran_BP1. 1 hit.
[Graphical view]
SMARTiSM00160. RanBD. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50196. RANBD1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEDKKPVV DKKEEAAPKP PSSAVFSMFG GKKAEKPETK KDEEDTKEET
60 70 80 90 100
KKEGDDAPES PDIHFEPVVH LEKVDVKTME EDEEVLYKVR AKLFRFDADA
110 120 130 140 150
KEWKERGTGD CKFLKNKKTN KVRILMRRDK TLKICANHII APEYTLKPNV
160 170 180 190 200
GSDRSWVYAC TADIAEGEAE AFTFAIRFGS KENADKFKEE FEKAQEINKK

A
Length:201
Mass (Da):22,953
Last modified:November 1, 1995 - v1
Checksum:i46C3766B0906A75B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33503 Genomic DNA. Translation: CAA83911.1.
X65925 Genomic DNA. No translation available.
L38489 Genomic DNA. Translation: AAA57276.1.
Z48008 Genomic DNA. Translation: CAA88062.1.
BK006938 Genomic DNA. Translation: DAA11849.1.
PIRiS50219.
RefSeqiNP_010285.1. NM_001180310.1.

Genome annotation databases

EnsemblFungiiYDR002W; YDR002W; YDR002W.
GeneIDi851565.
KEGGisce:YDR002W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33503 Genomic DNA. Translation: CAA83911.1.
X65925 Genomic DNA. No translation available.
L38489 Genomic DNA. Translation: AAA57276.1.
Z48008 Genomic DNA. Translation: CAA88062.1.
BK006938 Genomic DNA. Translation: DAA11849.1.
PIRiS50219.
RefSeqiNP_010285.1. NM_001180310.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M1IX-ray2.00B11-201[»]
4GMXX-ray2.10B62-201[»]
4GPTX-ray2.22B62-201[»]
4HATX-ray1.78B62-201[»]
4HAUX-ray2.00B62-201[»]
4HAVX-ray2.00B62-201[»]
4HAWX-ray1.90B62-201[»]
4HAXX-ray2.28B62-201[»]
4HAYX-ray2.30B62-201[»]
4HAZX-ray1.90B62-201[»]
4HB0X-ray2.20B62-201[»]
4HB2X-ray1.80B62-201[»]
4HB3X-ray2.80B62-201[»]
4HB4X-ray2.05B62-201[»]
4WVFX-ray1.80B62-201[»]
5DH9X-ray2.55B62-201[»]
5DHAX-ray2.95B62-201[»]
5DHFX-ray2.29B62-201[»]
5DI9X-ray2.28B62-201[»]
5DIFX-ray2.09B62-201[»]
5JLJX-ray2.50B62-201[»]
ProteinModelPortaliP41920.
SMRiP41920.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32055. 68 interactors.
DIPiDIP-838N.
IntActiP41920. 4 interactors.
MINTiMINT-398068.

PTM databases

iPTMnetiP41920.

Proteomic databases

MaxQBiP41920.
PRIDEiP41920.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR002W; YDR002W; YDR002W.
GeneIDi851565.
KEGGisce:YDR002W.

Organism-specific databases

EuPathDBiFungiDB:YDR002W.
SGDiS000002409. YRB1.

Phylogenomic databases

GeneTreeiENSGT00840000129823.
HOGENOMiHOG000176323.
InParanoidiP41920.
KOiK15306.
OMAiDTQEWKE.
OrthoDBiEOG092C4THQ.

Enzyme and pathway databases

BioCyciYEAST:G3O-29624-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP41920.
PROiP41920.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR000156. Ran_bind_dom.
[Graphical view]
PfamiPF00638. Ran_BP1. 1 hit.
[Graphical view]
SMARTiSM00160. RanBD. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50196. RANBD1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYRB1_YEAST
AccessioniPrimary (citable) accession number: P41920
Secondary accession number(s): D6VRY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.