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Protein

Ran-specific GTPase-activating protein 1

Gene

YRB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2.

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB-KW
  • Ran GTPase binding Source: SGD

GO - Biological processi

  • G1/S transition of mitotic cell cycle Source: SGD
  • protein import into nucleus Source: SGD
  • RNA export from nucleus Source: SGD
  • spindle organization Source: GO_Central
  • ubiquitin-dependent protein catabolic process Source: SGD

Keywordsi

Molecular functionGTPase activation
Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29624-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-specific GTPase-activating protein 1
Alternative name(s):
Chromosome stability protein 20
Perinuclear array-localized protein
Ran-binding protein 1
Short name:
RANBP1
Gene namesi
Name:YRB1
Synonyms:CST20, HTN1, SFO1
Ordered Locus Names:YDR002W
ORF Names:YD8119.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR002W
SGDiS000002409 YRB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002136701 – 201Ran-specific GTPase-activating protein 1Add BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP41920
PaxDbiP41920
PRIDEiP41920

PTM databases

iPTMnetiP41920

Interactioni

Subunit structurei

Interacts with GSP1 and PRP20.

GO - Molecular functioni

  • Ran GTPase binding Source: SGD

Protein-protein interaction databases

BioGridi32055264 interactors.
DIPiDIP-838N
IntActiP41920 6 interactors.
MINTiP41920
STRINGi4932.YDR002W

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi83 – 97Combined sources15
Turni98 – 101Combined sources4
Beta strandi102 – 116Combined sources15
Turni117 – 119Combined sources3
Beta strandi122 – 127Combined sources6
Turni129 – 131Combined sources3
Beta strandi134 – 139Combined sources6
Beta strandi147 – 149Combined sources3
Beta strandi153 – 163Combined sources11
Beta strandi165 – 168Combined sources4
Beta strandi170 – 180Combined sources11
Helixi181 – 199Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M1IX-ray2.00B11-201[»]
4GMXX-ray2.10B62-201[»]
4GPTX-ray2.22B62-201[»]
4HATX-ray1.78B62-201[»]
4HAUX-ray2.00B62-201[»]
4HAVX-ray2.00B62-201[»]
4HAWX-ray1.90B62-201[»]
4HAXX-ray2.28B62-201[»]
4HAYX-ray2.30B62-201[»]
4HAZX-ray1.90B62-201[»]
4HB0X-ray2.20B62-201[»]
4HB2X-ray1.80B62-201[»]
4HB3X-ray2.80B62-201[»]
4HB4X-ray2.05B62-201[»]
4WVFX-ray1.80B62-201[»]
5DH9X-ray2.55B62-201[»]
5DHAX-ray2.95B62-201[»]
5DHFX-ray2.29B62-201[»]
5DI9X-ray2.28B62-201[»]
5DIFX-ray2.09B62-201[»]
5JLJX-ray2.50B62-201[»]
5UWHX-ray2.26B62-201[»]
5UWIX-ray2.14B62-201[»]
5UWJX-ray2.22B62-201[»]
5UWOX-ray2.35B62-201[»]
5UWPX-ray2.05B62-201[»]
5UWQX-ray2.28B62-201[»]
5UWRX-ray2.24B62-201[»]
5UWSX-ray2.40B62-201[»]
5UWTX-ray2.34B62-201[»]
5UWUX-ray2.24B62-201[»]
5UWWX-ray2.15B62-201[»]
ProteinModelPortaliP41920
SMRiP41920
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41920

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 200RanBD1PROSITE-ProRule annotationAdd BLAST137

Sequence similaritiesi

Belongs to the RANBP1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00900000141073
HOGENOMiHOG000176323
InParanoidiP41920
KOiK15306
OMAiSEDVHFE
OrthoDBiEOG092C4THQ

Family and domain databases

Gene3Di2.30.29.301 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR000156 Ran_bind_dom
PfamiView protein in Pfam
PF00638 Ran_BP1, 1 hit
SMARTiView protein in SMART
SM00160 RanBD, 1 hit
PROSITEiView protein in PROSITE
PS50196 RANBD1, 1 hit

Sequencei

Sequence statusi: Complete.

P41920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEDKKPVV DKKEEAAPKP PSSAVFSMFG GKKAEKPETK KDEEDTKEET
60 70 80 90 100
KKEGDDAPES PDIHFEPVVH LEKVDVKTME EDEEVLYKVR AKLFRFDADA
110 120 130 140 150
KEWKERGTGD CKFLKNKKTN KVRILMRRDK TLKICANHII APEYTLKPNV
160 170 180 190 200
GSDRSWVYAC TADIAEGEAE AFTFAIRFGS KENADKFKEE FEKAQEINKK

A
Length:201
Mass (Da):22,953
Last modified:November 1, 1995 - v1
Checksum:i46C3766B0906A75B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33503 Genomic DNA Translation: CAA83911.1
X65925 Genomic DNA No translation available.
L38489 Genomic DNA Translation: AAA57276.1
Z48008 Genomic DNA Translation: CAA88062.1
BK006938 Genomic DNA Translation: DAA11849.1
PIRiS50219
RefSeqiNP_010285.1, NM_001180310.1

Genome annotation databases

EnsemblFungiiYDR002W; YDR002W; YDR002W
GeneIDi851565
KEGGisce:YDR002W

Similar proteinsi

Entry informationi

Entry nameiYRB1_YEAST
AccessioniPrimary (citable) accession number: P41920
Secondary accession number(s): D6VRY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome