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Protein

GTP-binding nuclear protein Ran-2

Gene

RAN2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei71GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28GTPBy similarity8
Nucleotide bindingi125 – 128GTPBy similarity4
Nucleotide bindingi153 – 155GTPBy similarity3

GO - Molecular functioni

  • GTPase activity Source: TAIR
  • GTP binding Source: TAIR

GO - Biological processi

  • protein import into nucleus Source: TAIR
  • response to cadmium ion Source: TAIR
  • ribosomal subunit export from nucleus Source: GO_Central

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding nuclear protein Ran-2
Alternative name(s):
Ras-related nuclear protein 2
Gene namesi
Name:RAN2
Ordered Locus Names:At5g20020
ORF Names:F28I16.170
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G20020
TAIRilocus:2147715 AT5G20020

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002087181 – 221GTP-binding nuclear protein Ran-2Add BLAST221

Proteomic databases

PaxDbiP41917
PRIDEiP41917

Expressioni

Gene expression databases

ExpressionAtlasiP41917 baseline and differential
GenevisibleiP41917 AT

Interactioni

Subunit structurei

Found in a nuclear export complex with RanGTP, exportin and pre-miRNA (By similarity). Interacts with RanBP1a and RanBP1b (PubMed:9025305). Interacts with PHRIP1 (PubMed:17530257). Interacts with KPNB1 (PubMed:23582042).By similarity3 Publications

Protein-protein interaction databases

BioGridi17400, 9 interactors
IntActiP41917, 4 interactors
STRINGi3702.AT5G20020.1

Structurei

3D structure databases

ProteinModelPortaliP41917
SMRiP41917
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ran family.Curated

Phylogenomic databases

eggNOGiKOG0096 Eukaryota
ENOG410XNRS LUCA
HOGENOMiHOG000216664
InParanoidiP41917
KOiK07936
OMAiWHKDLVR
OrthoDBiEOG09360M7X
PhylomeDBiP41917

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR002041 Ran_GTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PANTHERiPTHR24071 PTHR24071, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
PRINTSiPR00627 GTPRANTC4
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51418 RAN, 1 hit

Sequencei

Sequence statusi: Complete.

P41917-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPNQQTVD YPSFKLVIVG DGGTGKTTFV KRHLTGEFEK KYEPTIGVEV
60 70 80 90 100
HPLDFFTNCG KIRFYCWDTA GQEKFGGLRD GYYIHGQCAI IMFDVTARLT
110 120 130 140 150
YKNVPTWHRD LCRVCENIPI VLCGNKVDVK NRQVKAKQVT FHRKKNLQYY
160 170 180 190 200
EISAKSNYNF EKPFLYLARK LAGDQNLHFV ESPALAPPEV HLDIAAQQQN
210 220
EADLAAAAAQ PLPDDDDDAF E
Length:221
Mass (Da):25,062
Last modified:June 6, 2002 - v3
Checksum:i349390AC56E05AFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198 – 199QQ → PK in CAA66048 (PubMed:9025305).Curated2
Sequence conflicti198 – 199QQ → PK in AAA32852 (PubMed:7987414).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97380 mRNA Translation: CAA66048.1
AF296836 Genomic DNA No translation available.
CP002688 Genomic DNA Translation: AED92780.1
AF370337 mRNA Translation: AAK44152.1
AY062997 mRNA Translation: AAL34171.1
BT000424 mRNA Translation: AAN17401.1
BT000659 mRNA Translation: AAN31806.1
BT006264 mRNA Translation: AAP13372.1
AK226813 mRNA Translation: BAE98909.1
L16790 mRNA Translation: AAA32852.1
RefSeqiNP_197502.1, NM_122009.4
UniGeneiAt.177

Genome annotation databases

EnsemblPlantsiAT5G20020.1; AT5G20020.1; AT5G20020
GeneIDi832124
GrameneiAT5G20020.1; AT5G20020.1; AT5G20020
KEGGiath:AT5G20020

Similar proteinsi

Entry informationi

Entry nameiRAN2_ARATH
AccessioniPrimary (citable) accession number: P41917
Secondary accession number(s): Q0WVD9, Q94K33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 6, 2002
Last modified: April 25, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health