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Protein

GTP-binding nuclear protein Ran-2

Gene

RAN2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTPBy similarity8
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi125 – 128GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: TAIR
  • GTP binding Source: TAIR

GO - Biological processi

  • protein import into nucleus Source: TAIR
  • response to cadmium ion Source: TAIR
  • ribosomal subunit export from nucleus Source: GO_Central
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-203927. MicroRNA (miRNA) biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding nuclear protein Ran-2
Alternative name(s):
Ras-related nuclear protein 2
Gene namesi
Name:RAN2
Ordered Locus Names:At5g20020
ORF Names:F28I16.170
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G20020.

Subcellular locationi

  • Nucleus 1 Publication
  • Nucleus envelope 1 Publication

  • Note: Localized in the perinuclear region with the highest concentration at the nuclear envelope at the interphase.

GO - Cellular componenti

  • cytoplasm Source: TAIR
  • Golgi apparatus Source: TAIR
  • nuclear envelope Source: UniProtKB-SubCell
  • nucleolus Source: TAIR
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002087181 – 221GTP-binding nuclear protein Ran-2Add BLAST221

Proteomic databases

PaxDbiP41917.
PRIDEiP41917.

Expressioni

Gene expression databases

GenevisibleiP41917. AT.

Interactioni

Subunit structurei

Interacts with RanBP1a and RanBP1b (PubMed:9025305). Interacts with PHRIP1 (PubMed:17530257). Interacts with KPNB1 (PubMed:23582042).3 Publications

Protein-protein interaction databases

BioGridi17400. 9 interactors.
IntActiP41917. 2 interactors.
STRINGi3702.AT5G20020.1.

Structurei

3D structure databases

ProteinModelPortaliP41917.
SMRiP41917.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ran family.Curated

Phylogenomic databases

eggNOGiKOG0096. Eukaryota.
ENOG410XNRS. LUCA.
HOGENOMiHOG000216664.
InParanoidiP41917.
KOiK07936.
OMAiIDPRTIQ.
OrthoDBiEOG09360M7X.
PhylomeDBiP41917.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51418. RAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41917-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPNQQTVD YPSFKLVIVG DGGTGKTTFV KRHLTGEFEK KYEPTIGVEV
60 70 80 90 100
HPLDFFTNCG KIRFYCWDTA GQEKFGGLRD GYYIHGQCAI IMFDVTARLT
110 120 130 140 150
YKNVPTWHRD LCRVCENIPI VLCGNKVDVK NRQVKAKQVT FHRKKNLQYY
160 170 180 190 200
EISAKSNYNF EKPFLYLARK LAGDQNLHFV ESPALAPPEV HLDIAAQQQN
210 220
EADLAAAAAQ PLPDDDDDAF E
Length:221
Mass (Da):25,062
Last modified:June 6, 2002 - v3
Checksum:i349390AC56E05AFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198 – 199QQ → PK in CAA66048 (PubMed:9025305).Curated2
Sequence conflicti198 – 199QQ → PK in AAA32852 (PubMed:7987414).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97380 mRNA. Translation: CAA66048.1.
AF296836 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED92780.1.
AF370337 mRNA. Translation: AAK44152.1.
AY062997 mRNA. Translation: AAL34171.1.
BT000424 mRNA. Translation: AAN17401.1.
BT000659 mRNA. Translation: AAN31806.1.
BT006264 mRNA. Translation: AAP13372.1.
AK226813 mRNA. Translation: BAE98909.1.
L16790 mRNA. Translation: AAA32852.1.
RefSeqiNP_197502.1. NM_122009.4.
UniGeneiAt.177.

Genome annotation databases

EnsemblPlantsiAT5G20020.1; AT5G20020.1; AT5G20020.
GeneIDi832124.
GrameneiAT5G20020.1; AT5G20020.1; AT5G20020.
KEGGiath:AT5G20020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97380 mRNA. Translation: CAA66048.1.
AF296836 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED92780.1.
AF370337 mRNA. Translation: AAK44152.1.
AY062997 mRNA. Translation: AAL34171.1.
BT000424 mRNA. Translation: AAN17401.1.
BT000659 mRNA. Translation: AAN31806.1.
BT006264 mRNA. Translation: AAP13372.1.
AK226813 mRNA. Translation: BAE98909.1.
L16790 mRNA. Translation: AAA32852.1.
RefSeqiNP_197502.1. NM_122009.4.
UniGeneiAt.177.

3D structure databases

ProteinModelPortaliP41917.
SMRiP41917.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi17400. 9 interactors.
IntActiP41917. 2 interactors.
STRINGi3702.AT5G20020.1.

Proteomic databases

PaxDbiP41917.
PRIDEiP41917.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G20020.1; AT5G20020.1; AT5G20020.
GeneIDi832124.
GrameneiAT5G20020.1; AT5G20020.1; AT5G20020.
KEGGiath:AT5G20020.

Organism-specific databases

TAIRiAT5G20020.

Phylogenomic databases

eggNOGiKOG0096. Eukaryota.
ENOG410XNRS. LUCA.
HOGENOMiHOG000216664.
InParanoidiP41917.
KOiK07936.
OMAiIDPRTIQ.
OrthoDBiEOG09360M7X.
PhylomeDBiP41917.

Enzyme and pathway databases

ReactomeiR-ATH-203927. MicroRNA (miRNA) biogenesis.

Miscellaneous databases

PROiP41917.

Gene expression databases

GenevisibleiP41917. AT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51418. RAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAN2_ARATH
AccessioniPrimary (citable) accession number: P41917
Secondary accession number(s): Q0WVD9, Q94K33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 6, 2002
Last modified: November 30, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.