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P41916

- RAN1_ARATH

UniProt

P41916 - RAN1_ARATH

Protein

GTP-binding nuclear protein Ran-1

Gene

RAN1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi20 – 278GTPBy similarity
    Nucleotide bindingi68 – 725GTPBy similarity
    Nucleotide bindingi125 – 1284GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: TAIR
    2. GTP binding Source: TAIR
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. protein import into nucleus Source: TAIR
    2. response to cadmium ion Source: TAIR
    3. response to salt stress Source: TAIR
    4. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT5G20010-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP-binding nuclear protein Ran-1
    Alternative name(s):
    Ras-related nuclear protein 1
    Gene namesi
    Name:RAN1
    Ordered Locus Names:At5g20010
    ORF Names:F28I16.160
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G20010.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. apoplast Source: TAIR
    2. cell wall Source: TAIR
    3. cytosol Source: TAIR
    4. Golgi apparatus Source: TAIR
    5. nucleus Source: UniProtKB-SubCell
    6. plasma membrane Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 221221GTP-binding nuclear protein Ran-1PRO_0000208717Add
    BLAST

    Proteomic databases

    PaxDbiP41916.
    PRIDEiP41916.

    Expressioni

    Inductioni

    Regulated by light.1 Publication

    Gene expression databases

    GenevestigatoriP41916.

    Interactioni

    Subunit structurei

    Interacts with RANBP1A and RANBP1B. Interacts with TRN1 and ATX1.3 Publications

    Protein-protein interaction databases

    BioGridi17399. 9 interactions.
    IntActiP41916. 4 interactions.
    MINTiMINT-1163760.
    STRINGi3702.AT5G20010.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliP41916.
    SMRiP41916. Positions 14-204.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Ran family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000216664.
    InParanoidiP41916.
    KOiK07936.
    OMAiPEVHIDI.
    PhylomeDBiP41916.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR002041. Ran_GTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00627. GTPRANTC4.
    SMARTiSM00176. RAN. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51418. RAN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41916-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPNQQTVD YPSFKLVIVG DGGTGKTTFV KRHLTGEFEK KYEPTIGVEV    50
    HPLDFFTNCG KIRFYCWDTA GQEKFGGLRD GYYIHGQCAI IMFDVTARLT 100
    YKNVPTWHRD LCRVCENIPI VLCGNKVDVK NRQVKAKQVT FHRKKNLQYY 150
    EISAKSNYNF EKPFLYLARK LAGDQNLHFV ETPALAPPEV HIDIADQQKN 200
    EAELLQAAAQ PLPDDDDDIF E 221
    Length:221
    Mass (Da):25,276
    Last modified:November 1, 1995 - v1
    Checksum:i672097A226E51A64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L16789 mRNA. Translation: AAA32851.1.
    X97379 mRNA. Translation: CAA66047.1.
    AF296836 Genomic DNA. No translation available.
    CP002688 Genomic DNA. Translation: AED92779.1.
    AF428417 mRNA. Translation: AAL16185.1.
    AY125542 mRNA. Translation: AAM78052.1.
    AY088774 mRNA. Translation: AAM67087.1.
    RefSeqiNP_197501.1. NM_122008.2.
    UniGeneiAt.18604.
    At.23000.

    Genome annotation databases

    EnsemblPlantsiAT5G20010.1; AT5G20010.1; AT5G20010.
    GeneIDi832123.
    KEGGiath:AT5G20010.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L16789 mRNA. Translation: AAA32851.1 .
    X97379 mRNA. Translation: CAA66047.1 .
    AF296836 Genomic DNA. No translation available.
    CP002688 Genomic DNA. Translation: AED92779.1 .
    AF428417 mRNA. Translation: AAL16185.1 .
    AY125542 mRNA. Translation: AAM78052.1 .
    AY088774 mRNA. Translation: AAM67087.1 .
    RefSeqi NP_197501.1. NM_122008.2.
    UniGenei At.18604.
    At.23000.

    3D structure databases

    ProteinModelPortali P41916.
    SMRi P41916. Positions 14-204.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 17399. 9 interactions.
    IntActi P41916. 4 interactions.
    MINTi MINT-1163760.
    STRINGi 3702.AT5G20010.1-P.

    Proteomic databases

    PaxDbi P41916.
    PRIDEi P41916.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G20010.1 ; AT5G20010.1 ; AT5G20010 .
    GeneIDi 832123.
    KEGGi ath:AT5G20010.

    Organism-specific databases

    TAIRi AT5G20010.

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000216664.
    InParanoidi P41916.
    KOi K07936.
    OMAi PEVHIDI.
    PhylomeDBi P41916.

    Enzyme and pathway databases

    BioCyci ARA:AT5G20010-MONOMER.

    Gene expression databases

    Genevestigatori P41916.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR002041. Ran_GTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00627. GTPRANTC4.
    SMARTi SM00176. RAN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51418. RAN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phenotype of the fission yeast cell cycle regulatory mutant pim1-46 is suppressed by a tobacco cDNA encoding a small, Ran-like GTP-binding protein."
      Merkle T., Haizel T., Matsumoto T., Harter K., Dallmann G., Nagy F.
      Plant J. 6:555-565(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization of proteins that interact with the GTP-bound form of the regulatory GTPase Ran in Arabidopsis."
      Haizel T., Merkle T., Pay A., Fejes E., Nagy F.
      Plant J. 11:93-103(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RANBP1A AND RANBP1B.
    3. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
      Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
      , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
      Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    4. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    6. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Arabidopsis transportin1 is the nuclear import receptor for the circadian clock-regulated RNA-binding protein AtGRP7."
      Ziemienowicz A., Haasen D., Staiger D., Merkle T.
      Plant Mol. Biol. 53:201-212(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRN1.
    8. "Analysis of the small GTPase gene superfamily of Arabidopsis."
      Vernoud V., Horton A.C., Yang Z., Nielsen E.
      Plant Physiol. 131:1191-1208(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    9. Cited for: INTERACTION WITH ATX1.
    10. "Phytochrome-mediated differential gene expression of plant Ran/TC4 small G-proteins."
      Lee Y., Kim M.-H., Kim S.-K., Kim S.-H.
      Planta 228:215-224(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiRAN1_ARATH
    AccessioniPrimary (citable) accession number: P41916
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3