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P41916 (RAN1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP-binding nuclear protein Ran-1
Alternative name(s):
Ras-related nuclear protein 1
Gene names
Name:RAN1
Ordered Locus Names:At5g20010
ORF Names:F28I16.160
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle By similarity.

Subunit structure

Interacts with RANBP1A and RANBP1B. Interacts with TRN1 and ATX1. Ref.2 Ref.7 Ref.9

Subcellular location

Nucleus By similarity.

Induction

Regulated by light. Ref.10

Sequence similarities

Belongs to the small GTPase superfamily. Ran family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 221221GTP-binding nuclear protein Ran-1
PRO_0000208717

Regions

Nucleotide binding20 – 278GTP By similarity
Nucleotide binding68 – 725GTP By similarity
Nucleotide binding125 – 1284GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
P41916 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 672097A226E51A64

FASTA22125,276
        10         20         30         40         50         60 
MALPNQQTVD YPSFKLVIVG DGGTGKTTFV KRHLTGEFEK KYEPTIGVEV HPLDFFTNCG 

        70         80         90        100        110        120 
KIRFYCWDTA GQEKFGGLRD GYYIHGQCAI IMFDVTARLT YKNVPTWHRD LCRVCENIPI 

       130        140        150        160        170        180 
VLCGNKVDVK NRQVKAKQVT FHRKKNLQYY EISAKSNYNF EKPFLYLARK LAGDQNLHFV 

       190        200        210        220 
ETPALAPPEV HIDIADQQKN EAELLQAAAQ PLPDDDDDIF E 

« Hide

References

« Hide 'large scale' references
[1]"Phenotype of the fission yeast cell cycle regulatory mutant pim1-46 is suppressed by a tobacco cDNA encoding a small, Ran-like GTP-binding protein."
Merkle T., Haizel T., Matsumoto T., Harter K., Dallmann G., Nagy F.
Plant J. 6:555-565(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization of proteins that interact with the GTP-bound form of the regulatory GTPase Ran in Arabidopsis."
Haizel T., Merkle T., Pay A., Fejes E., Nagy F.
Plant J. 11:93-103(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RANBP1A AND RANBP1B.
[3]"Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K. expand/collapse author list , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[4]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[5]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[6]"Full-length cDNA from Arabidopsis thaliana."
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]"Arabidopsis transportin1 is the nuclear import receptor for the circadian clock-regulated RNA-binding protein AtGRP7."
Ziemienowicz A., Haasen D., Staiger D., Merkle T.
Plant Mol. Biol. 53:201-212(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TRN1.
[8]"Analysis of the small GTPase gene superfamily of Arabidopsis."
Vernoud V., Horton A.C., Yang Z., Nielsen E.
Plant Physiol. 131:1191-1208(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[9]"Higher plants possess two different types of ATX1-like copper chaperones."
Puig S., Mira H., Dorcey E., Sancenon V., Andres-Colas N., Garcia-Molina A., Burkhead J.L., Gogolin K.A., Abdel-Ghany S.E., Thiele D.J., Ecker J.R., Pilon M., Penarrubia L.
Biochem. Biophys. Res. Commun. 354:385-390(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ATX1.
[10]"Phytochrome-mediated differential gene expression of plant Ran/TC4 small G-proteins."
Lee Y., Kim M.-H., Kim S.-K., Kim S.-H.
Planta 228:215-224(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L16789 mRNA. Translation: AAA32851.1.
X97379 mRNA. Translation: CAA66047.1.
AF296836 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED92779.1.
AF428417 mRNA. Translation: AAL16185.1.
AY125542 mRNA. Translation: AAM78052.1.
AY088774 mRNA. Translation: AAM67087.1.
RefSeqNP_197501.1. NM_122008.2.
UniGeneAt.18604.
At.23000.

3D structure databases

ProteinModelPortalP41916.
SMRP41916. Positions 14-204.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid17399. 9 interactions.
IntActP41916. 4 interactions.
MINTMINT-1163760.
STRING3702.AT5G20010.1-P.

Proteomic databases

PaxDbP41916.
PRIDEP41916.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT5G20010.1; AT5G20010.1; AT5G20010.
GeneID832123.
KEGGath:AT5G20010.

Organism-specific databases

TAIRAT5G20010.

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000216664.
InParanoidP41916.
KOK07936.
OMAPEVHIDI.
ProtClustDBPLN03071.

Enzyme and pathway databases

BioCycARA:AT5G20010-MONOMER.

Gene expression databases

ArrayExpressP41916.
GenevestigatorP41916.

Family and domain databases

InterProIPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00627. GTPRANTC4.
SMARTSM00176. RAN. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51418. RAN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRAN1_ARATH
AccessionPrimary (citable) accession number: P41916
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names