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Protein

GTP-binding nuclear protein Ran-1

Gene

RAN1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei71GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28GTPBy similarity8
Nucleotide bindingi125 – 128GTPBy similarity4
Nucleotide bindingi153 – 155GTPBy similarity3

GO - Molecular functioni

  • GTPase activity Source: TAIR
  • GTP binding Source: TAIR

GO - Biological processi

  • protein import into nucleus Source: TAIR
  • response to cadmium ion Source: TAIR
  • response to salt stress Source: TAIR
  • ribosomal subunit export from nucleus Source: GO_Central
  • signal transduction Source: InterPro

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding nuclear protein Ran-1
Alternative name(s):
Ras-related nuclear protein 1
Gene namesi
Name:RAN1
Ordered Locus Names:At5g20010
ORF Names:F28I16.160
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G20010.
TAIRilocus:2147700. AT5G20010.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002087171 – 221GTP-binding nuclear protein Ran-1Add BLAST221

Proteomic databases

PaxDbiP41916.
PRIDEiP41916.

PTM databases

iPTMnetiP41916.

Expressioni

Inductioni

Regulated by light.1 Publication

Gene expression databases

ExpressionAtlasiP41916. baseline and differential.
GenevisibleiP41916. AT.

Interactioni

Subunit structurei

Found in a nuclear export complex with RanGTP, exportin and pre-miRNA (By similarity). Interacts with RANBP1A and RANBP1B (PubMed:9025305). Interacts with TRN1 (PubMed:14756317). Interacts with ATX1 (PubMed:17223078). Interacts with KPNB1 (PubMed:23582042). Binds to XPO1 (PubMed:10652141). Interacts with MOS14 (PubMed:21738492).By similarity6 Publications

Protein-protein interaction databases

BioGridi17399. 11 interactors.
IntActiP41916. 4 interactors.
MINTiMINT-1163760.
STRINGi3702.AT5G20010.1.

Structurei

3D structure databases

ProteinModelPortaliP41916.
SMRiP41916.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ran family.Curated

Phylogenomic databases

eggNOGiKOG0096. Eukaryota.
ENOG410XNRS. LUCA.
HOGENOMiHOG000216664.
KOiK07936.
OMAiCANKIDI.
OrthoDBiEOG09360M7X.
PhylomeDBiP41916.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51418. RAN. 1 hit.

Sequencei

Sequence statusi: Complete.

P41916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPNQQTVD YPSFKLVIVG DGGTGKTTFV KRHLTGEFEK KYEPTIGVEV
60 70 80 90 100
HPLDFFTNCG KIRFYCWDTA GQEKFGGLRD GYYIHGQCAI IMFDVTARLT
110 120 130 140 150
YKNVPTWHRD LCRVCENIPI VLCGNKVDVK NRQVKAKQVT FHRKKNLQYY
160 170 180 190 200
EISAKSNYNF EKPFLYLARK LAGDQNLHFV ETPALAPPEV HIDIADQQKN
210 220
EAELLQAAAQ PLPDDDDDIF E
Length:221
Mass (Da):25,276
Last modified:November 1, 1995 - v1
Checksum:i672097A226E51A64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16789 mRNA. Translation: AAA32851.1.
X97379 mRNA. Translation: CAA66047.1.
AF296836 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED92779.1.
AF428417 mRNA. Translation: AAL16185.1.
AY125542 mRNA. Translation: AAM78052.1.
AY088774 mRNA. Translation: AAM67087.1.
RefSeqiNP_197501.1. NM_122008.3.
UniGeneiAt.18604.
At.23000.

Genome annotation databases

EnsemblPlantsiAT5G20010.1; AT5G20010.1; AT5G20010.
GeneIDi832123.
GrameneiAT5G20010.1; AT5G20010.1; AT5G20010.
KEGGiath:AT5G20010.

Similar proteinsi

Entry informationi

Entry nameiRAN1_ARATH
AccessioniPrimary (citable) accession number: P41916
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 27, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families