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Protein

GTP-binding nuclear protein Ran-1

Gene

RAN1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278GTPBy similarity
Nucleotide bindingi68 – 725GTPBy similarity
Nucleotide bindingi125 – 1284GTPBy similarity

GO - Molecular functioni

  1. GTPase activity Source: TAIR
  2. GTP binding Source: TAIR

GO - Biological processi

  1. protein import into nucleus Source: TAIR
  2. response to cadmium ion Source: TAIR
  3. response to salt stress Source: TAIR
  4. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT5G20010-MONOMER.
ReactomeiREACT_255398. MicroRNA (miRNA) biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding nuclear protein Ran-1
Alternative name(s):
Ras-related nuclear protein 1
Gene namesi
Name:RAN1
Ordered Locus Names:At5g20010
ORF Names:F28I16.160
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G20010.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. apoplast Source: TAIR
  2. cell wall Source: TAIR
  3. cytosol Source: TAIR
  4. Golgi apparatus Source: TAIR
  5. nucleus Source: UniProtKB-SubCell
  6. plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221GTP-binding nuclear protein Ran-1PRO_0000208717Add
BLAST

Proteomic databases

PaxDbiP41916.
PRIDEiP41916.

Expressioni

Inductioni

Regulated by light.1 Publication

Gene expression databases

GenevestigatoriP41916.

Interactioni

Subunit structurei

Interacts with RANBP1A and RANBP1B (PubMed:9025305). Interacts with TRN1 (PubMed:14756317). Interacts with ATX1 (PubMed:17223078). Interacts with KPNB1 (PubMed:23582042).4 Publications

Protein-protein interaction databases

BioGridi17399. 9 interactions.
IntActiP41916. 4 interactions.
MINTiMINT-1163760.
STRINGi3702.AT5G20010.1-P.

Structurei

3D structure databases

ProteinModelPortaliP41916.
SMRiP41916. Positions 14-204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ran family.Curated

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000216664.
KOiK07936.
OMAiLKMEHEL.
PhylomeDBiP41916.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00627. GTPRANTC4.
SMARTiSM00176. RAN. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51418. RAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41916-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALPNQQTVD YPSFKLVIVG DGGTGKTTFV KRHLTGEFEK KYEPTIGVEV
60 70 80 90 100
HPLDFFTNCG KIRFYCWDTA GQEKFGGLRD GYYIHGQCAI IMFDVTARLT
110 120 130 140 150
YKNVPTWHRD LCRVCENIPI VLCGNKVDVK NRQVKAKQVT FHRKKNLQYY
160 170 180 190 200
EISAKSNYNF EKPFLYLARK LAGDQNLHFV ETPALAPPEV HIDIADQQKN
210 220
EAELLQAAAQ PLPDDDDDIF E
Length:221
Mass (Da):25,276
Last modified:November 1, 1995 - v1
Checksum:i672097A226E51A64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16789 mRNA. Translation: AAA32851.1.
X97379 mRNA. Translation: CAA66047.1.
AF296836 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED92779.1.
AF428417 mRNA. Translation: AAL16185.1.
AY125542 mRNA. Translation: AAM78052.1.
AY088774 mRNA. Translation: AAM67087.1.
RefSeqiNP_197501.1. NM_122008.2.
UniGeneiAt.18604.
At.23000.

Genome annotation databases

EnsemblPlantsiAT5G20010.1; AT5G20010.1; AT5G20010.
GeneIDi832123.
KEGGiath:AT5G20010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16789 mRNA. Translation: AAA32851.1.
X97379 mRNA. Translation: CAA66047.1.
AF296836 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED92779.1.
AF428417 mRNA. Translation: AAL16185.1.
AY125542 mRNA. Translation: AAM78052.1.
AY088774 mRNA. Translation: AAM67087.1.
RefSeqiNP_197501.1. NM_122008.2.
UniGeneiAt.18604.
At.23000.

3D structure databases

ProteinModelPortaliP41916.
SMRiP41916. Positions 14-204.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi17399. 9 interactions.
IntActiP41916. 4 interactions.
MINTiMINT-1163760.
STRINGi3702.AT5G20010.1-P.

Proteomic databases

PaxDbiP41916.
PRIDEiP41916.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G20010.1; AT5G20010.1; AT5G20010.
GeneIDi832123.
KEGGiath:AT5G20010.

Organism-specific databases

TAIRiAT5G20010.

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000216664.
KOiK07936.
OMAiLKMEHEL.
PhylomeDBiP41916.

Enzyme and pathway databases

BioCyciARA:AT5G20010-MONOMER.
ReactomeiREACT_255398. MicroRNA (miRNA) biogenesis.

Gene expression databases

GenevestigatoriP41916.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00627. GTPRANTC4.
SMARTiSM00176. RAN. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51418. RAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Phenotype of the fission yeast cell cycle regulatory mutant pim1-46 is suppressed by a tobacco cDNA encoding a small, Ran-like GTP-binding protein."
    Merkle T., Haizel T., Matsumoto T., Harter K., Dallmann G., Nagy F.
    Plant J. 6:555-565(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization of proteins that interact with the GTP-bound form of the regulatory GTPase Ran in Arabidopsis."
    Haizel T., Merkle T., Pay A., Fejes E., Nagy F.
    Plant J. 11:93-103(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RANBP1A AND RANBP1B.
  3. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Arabidopsis transportin1 is the nuclear import receptor for the circadian clock-regulated RNA-binding protein AtGRP7."
    Ziemienowicz A., Haasen D., Staiger D., Merkle T.
    Plant Mol. Biol. 53:201-212(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRN1.
  8. "Analysis of the small GTPase gene superfamily of Arabidopsis."
    Vernoud V., Horton A.C., Yang Z., Nielsen E.
    Plant Physiol. 131:1191-1208(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  9. Cited for: INTERACTION WITH ATX1.
  10. "Phytochrome-mediated differential gene expression of plant Ran/TC4 small G-proteins."
    Lee Y., Kim M.-H., Kim S.-K., Kim S.-H.
    Planta 228:215-224(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  11. "An Arabidopsis homolog of importin beta1 is required for ABA response and drought tolerance."
    Luo Y., Wang Z., Ji H., Fang H., Wang S., Tian L., Li X.
    Plant J. 75:377-389(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KPNB1.

Entry informationi

Entry nameiRAN1_ARATH
AccessioniPrimary (citable) accession number: P41916
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.