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Protein

GTP-binding nuclear protein Ran-1

Gene

RAN1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTPBy similarity8
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi125 – 128GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: TAIR
  • GTP binding Source: TAIR

GO - Biological processi

  • protein import into nucleus Source: TAIR
  • response to cadmium ion Source: TAIR
  • response to salt stress Source: TAIR
  • small GTPase mediated signal transduction Source: InterPro

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-203927. MicroRNA (miRNA) biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding nuclear protein Ran-1
Alternative name(s):
Ras-related nuclear protein 1
Gene namesi
Name:RAN1
Ordered Locus Names:At5g20010
ORF Names:F28I16.160
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRilocus:2147700. AT5G20010.

Subcellular locationi

GO - Cellular componenti

  • apoplast Source: TAIR
  • cell wall Source: TAIR
  • cytosol Source: TAIR
  • Golgi apparatus Source: TAIR
  • nucleus Source: UniProtKB-SubCell
  • plasma membrane Source: TAIR

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002087171 – 221GTP-binding nuclear protein Ran-1Add BLAST221

Proteomic databases

PaxDbiP41916.
PRIDEiP41916.

PTM databases

iPTMnetiP41916.

Expressioni

Inductioni

Regulated by light.1 Publication

Gene expression databases

ExpressionAtlasiP41916. baseline and differential.
GenevisibleiP41916. AT.

Interactioni

Subunit structurei

Interacts with RANBP1A and RANBP1B (PubMed:9025305). Interacts with TRN1 (PubMed:14756317). Interacts with ATX1 (PubMed:17223078). Interacts with KPNB1 (PubMed:23582042). Binds to XPO1 (PubMed:10652141).5 Publications

Protein-protein interaction databases

BioGridi17399. 11 interactors.
IntActiP41916. 4 interactors.
MINTiMINT-1163760.
STRINGi3702.AT5G20010.1.

Structurei

3D structure databases

ProteinModelPortaliP41916.
SMRiP41916.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ran family.Curated

Phylogenomic databases

eggNOGiKOG0096. Eukaryota.
ENOG410XNRS. LUCA.
HOGENOMiHOG000216664.
KOiK07936.
OMAiKKNLQVC.
OrthoDBiEOG09360M7X.
PhylomeDBiP41916.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51418. RAN. 1 hit.

Sequencei

Sequence statusi: Complete.

P41916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPNQQTVD YPSFKLVIVG DGGTGKTTFV KRHLTGEFEK KYEPTIGVEV
60 70 80 90 100
HPLDFFTNCG KIRFYCWDTA GQEKFGGLRD GYYIHGQCAI IMFDVTARLT
110 120 130 140 150
YKNVPTWHRD LCRVCENIPI VLCGNKVDVK NRQVKAKQVT FHRKKNLQYY
160 170 180 190 200
EISAKSNYNF EKPFLYLARK LAGDQNLHFV ETPALAPPEV HIDIADQQKN
210 220
EAELLQAAAQ PLPDDDDDIF E
Length:221
Mass (Da):25,276
Last modified:November 1, 1995 - v1
Checksum:i672097A226E51A64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16789 mRNA. Translation: AAA32851.1.
X97379 mRNA. Translation: CAA66047.1.
AF296836 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED92779.1.
AF428417 mRNA. Translation: AAL16185.1.
AY125542 mRNA. Translation: AAM78052.1.
AY088774 mRNA. Translation: AAM67087.1.
RefSeqiNP_197501.1. NM_122008.3.
UniGeneiAt.18604.
At.23000.

Genome annotation databases

EnsemblPlantsiAT5G20010.1; AT5G20010.1; AT5G20010.
GeneIDi832123.
GrameneiAT5G20010.1; AT5G20010.1; AT5G20010.
KEGGiath:AT5G20010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16789 mRNA. Translation: AAA32851.1.
X97379 mRNA. Translation: CAA66047.1.
AF296836 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED92779.1.
AF428417 mRNA. Translation: AAL16185.1.
AY125542 mRNA. Translation: AAM78052.1.
AY088774 mRNA. Translation: AAM67087.1.
RefSeqiNP_197501.1. NM_122008.3.
UniGeneiAt.18604.
At.23000.

3D structure databases

ProteinModelPortaliP41916.
SMRiP41916.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi17399. 11 interactors.
IntActiP41916. 4 interactors.
MINTiMINT-1163760.
STRINGi3702.AT5G20010.1.

PTM databases

iPTMnetiP41916.

Proteomic databases

PaxDbiP41916.
PRIDEiP41916.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G20010.1; AT5G20010.1; AT5G20010.
GeneIDi832123.
GrameneiAT5G20010.1; AT5G20010.1; AT5G20010.
KEGGiath:AT5G20010.

Organism-specific databases

AraportiAT5G20010.
TAIRilocus:2147700. AT5G20010.

Phylogenomic databases

eggNOGiKOG0096. Eukaryota.
ENOG410XNRS. LUCA.
HOGENOMiHOG000216664.
KOiK07936.
OMAiKKNLQVC.
OrthoDBiEOG09360M7X.
PhylomeDBiP41916.

Enzyme and pathway databases

ReactomeiR-ATH-203927. MicroRNA (miRNA) biogenesis.

Miscellaneous databases

PROiP41916.

Gene expression databases

ExpressionAtlasiP41916. baseline and differential.
GenevisibleiP41916. AT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51418. RAN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRAN1_ARATH
AccessioniPrimary (citable) accession number: P41916
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 15, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.