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Protein

Repressor of RNA polymerase III transcription MAF1

Gene

MAF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.1 Publication

Miscellaneous

Present with 1720 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • RNA polymerase III core binding Source: SGD

GO - Biological processi

  • negative regulation of transcription by RNA polymerase III Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
  • transfer RNA gene-mediated silencing Source: SGD

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-29627-MONOMER
ReactomeiR-SCE-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Repressor of RNA polymerase III transcription MAF1
Gene namesi
Name:MAF1
Ordered Locus Names:YDR005C
ORF Names:YD8119.11C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR005C
SGDiS000002412 MAF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139721 – 395Repressor of RNA polymerase III transcription MAF1Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphoserineCombined sources1
Modified residuei209PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1
Modified residuei347PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated by PKA in a TORC1-dependent manner. Phosphorylation at PKA consensus sites RRxS/T decreases upon rapamycin treatment.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP41910
PaxDbiP41910
PRIDEiP41910

PTM databases

iPTMnetiP41910

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RPO31P040513EBI-10375,EBI-15810

GO - Molecular functioni

  • RNA polymerase III core binding Source: SGD

Protein-protein interaction databases

BioGridi32058, 270 interactors
DIPiDIP-5133N
IntActiP41910, 16 interactors
MINTiP41910
STRINGi4932.YDR005C

Structurei

3D structure databases

ProteinModelPortaliP41910
SMRiP41910
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MAF1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000006896
HOGENOMiHOG000065964
InParanoidiP41910
OMAiNFNTPDC
OrthoDBiEOG092C46ZG

Family and domain databases

Gene3Di3.40.1000.50, 1 hit
InterProiView protein in InterPro
IPR015257 Maf1
IPR038564 Maf1_sf
PANTHERiPTHR22504 PTHR22504, 1 hit
PfamiView protein in Pfam
PF09174 Maf1, 1 hit
PIRSFiPIRSF037240 RNA_polIII_Trep_MAF1, 1 hit

Sequencei

Sequence statusi: Complete.

P41910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFIDELDIE RVNQTLNFET NDCKIVGSCD IFTTKAVASD RKLYKTIDQH
60 70 80 90 100
LDTILQENEN YNATLQQQLA APETNQSPCS SPFYSNRRDS NSFWEQKRRI
110 120 130 140 150
SFSEYNSNNN TNNSNGNSSN NNNYSGPNGS SPATFPKSAK LNDQNLKELV
160 170 180 190 200
SNYDSGSMSS SSLDSSSKND ERIRRRSSSS ISSFKSGKSS NNNYSSGTAT
210 220 230 240 250
NNVNKRRKSS INERPSNLSL GPFGPINEPS SRKIFAYLIA ILNASYPDHD
260 270 280 290 300
FSSVEPTDFV KTSLKTFISK FENTLYSLGR QPEEWVWEVI NSHMTLSDCV
310 320 330 340 350
LFQYSPSNSF LEDEPGYLWN LIGFLYNRKR KRVAYLYLIC SRLNSSTGEV
360 370 380 390
EDALAKKPQG KLIIDDGSNE YEGEYDFTYD ENVIDDKSDQ EESLQ
Length:395
Mass (Da):44,733
Last modified:November 1, 1995 - v1
Checksum:i1AE6262D0BEBBB1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19492 Genomic DNA Translation: AAB51655.1
Z48008 Genomic DNA Translation: CAA88065.1
BK006938 Genomic DNA Translation: DAA11853.1
PIRiS50986
RefSeqiNP_010288.1, NM_001180313.1

Genome annotation databases

EnsemblFungiiYDR005C; YDR005C; YDR005C
GeneIDi851568
KEGGisce:YDR005C

Similar proteinsi

Entry informationi

Entry nameiMAF1_YEAST
AccessioniPrimary (citable) accession number: P41910
Secondary accession number(s): D6VRZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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