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Protein

Metallothionein-like protein CRS5

Gene

CRS5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Critical role in copper (specific) homeostasis and detoxification. May protect by directly chelating and sequestering copper ions.

GO - Molecular functioni

  • copper ion binding Source: SGD

GO - Biological processi

  • response to metal ion Source: SGD

Keywordsi

LigandCopper, Metal-binding, Metal-thiolate cluster

Enzyme and pathway databases

BioCyciYEAST:G3O-33577-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-like protein CRS5
Gene namesi
Name:CRS5
Ordered Locus Names:YOR031W
ORF Names:O2675
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Organism-specific databases

SGDiS000005557. CRS5.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973701 – 69Metallothionein-like protein CRS5Add BLAST69

Proteomic databases

PRIDEiP41902.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TFCP2Q128003EBI-5162,EBI-717422From Homo sapiens.

Protein-protein interaction databases

BioGridi34433. 152 interactors.
DIPiDIP-5511N.
IntActiP41902. 5 interactors.
MINTiMINT-532527.
STRINGi4932.YOR031W.

Structurei

3D structure databases

ProteinModelPortaliP41902.
SMRiP41902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OMAiCKCETTC.
OrthoDBiEOG092C5QV0.

Family and domain databases

InterProiView protein in InterPro
IPR035715. Crs5.
PfamiView protein in Pfam
PF12809. Metallothi_Euk2. 1 hit.

Sequencei

Sequence statusi: Complete.

P41902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVKICDCEG ECCKDSCHCG STCLPSCSGG EKCKCDHSTG SPQCKSCGEK
60
CKCETTCTCE KSKCNCEKC
Length:69
Mass (Da):7,321
Last modified:November 1, 1995 - v1
Checksum:iCEEF91203A813FF4
GO

Sequence cautioni

The sequence X87331 differs from that shown. Reason: Erroneous termination at position 9. Translated as Glu.Curated
The sequence Z74939 differs from that shown. Reason: Erroneous termination at position 9. Translated as Glu.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29056 Genomic DNA. Translation: AAA66061.1.
X87331 Genomic DNA. No translation available.
Z74939 Genomic DNA. No translation available.
PIRiA55011.

Genome annotation databases

EnsemblFungiiYOR031W; YOR031W; YOR031W.

Similar proteinsi

Entry informationi

Entry nameiCRS5_YEAST
AccessioniPrimary (citable) accession number: P41902
Secondary accession number(s): D6W296
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 27, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene unlikely to encode a functional protein. Strain S288c has a stop codon in position 9, which disrupts the gene coding for this protein. Because of that it is not part of the S.cerevisiae S288c complete/reference proteome set.1 Publication

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names