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Protein

Sporulation-regulated protein 3

Gene

SPR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Septins are GTPases involved in cytokinesis that assemble into filaments and form a ring at the cleavage site. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei168GTP; via amide nitrogenBy similarity1
Binding sitei315GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi116 – 123GTPBy similarity8
Nucleotide bindingi247 – 255GTPBy similarity9

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • structural molecule activity Source: SGD

GO - Biological processi

  • ascospore formation Source: SGD

Keywordsi

Biological processSporulation
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30776-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Sporulation-regulated protein 3
Gene namesi
Name:SPR3
Ordered Locus Names:YGR059W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR059W
SGDiS000003291 SPR3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735021 – 512Sporulation-regulated protein 3Add BLAST512

Proteomic databases

PaxDbiP41901
PRIDEiP41901

Expressioni

Developmental stagei

Sporulation-specific.

Interactioni

Subunit structurei

Interacts with other septin proteins such as SPR28 to form a ring at the bud neck.1 Publication

Protein-protein interaction databases

BioGridi33304, 123 interactors
DIPiDIP-3011N
IntActiP41901, 2 interactors
MINTiP41901
STRINGi4932.YGR059W

Structurei

3D structure databases

ProteinModelPortaliP41901
SMRiP41901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 365Septin-type GPROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 123G1 motifPROSITE-ProRule annotation8
Regioni165 – 168G3 motifPROSITE-ProRule annotation4
Regioni246 – 249G4 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili376 – 406Sequence analysisAdd BLAST31
Coiled coili451 – 496Sequence analysisAdd BLAST46

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00880000138554
InParanoidiP41901
KOiK12773
OMAiIIEWSPE
OrthoDBiEOG092C3HL6

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequencei

Sequence statusi: Complete.

P41901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSKGSRLST DCPVEFPKIV SGFAEEVKIR RQSSQGQYAV DSHPPKSPEL
60 70 80 90 100
KHRRQRSSSF VNGKCRNRDL PLLDNKKAQE INTNSHGQDI GIKNLPRQRE
110 120 130 140 150
LLNAKNGIDF TLMVAGQSGL GKTTFINSLF STSLIDDDIK ENKPIIRYKS
160 170 180 190 200
IVEGDGTHLN FNVIDTPGFG NNMDNAFTWR TMVNYIDEEI RSYIFQEEQP
210 220 230 240 250
DRTKMVDNRV HCCLYFLRPS NKGIDTLDVV TMKKLAKRVN LIPVIAKSDL
260 270 280 290 300
LTKEELKNFK TQVREIIRVQ DIPVCFFFGD EVLNATQDIF QKYPFSIIAS
310 320 330 340 350
NEYIFNEKGE KVKGRQYKWG AVDIENEKYC DFKILQKTIF DWNLIDLVES
360 370 380 390 400
TEDYYEKCRS EMLRTRLLKA RDCLTTKSVD ITEEQRKFLE EEMNFDEIEE
410 420 430 440 450
NKLKNYKCYE IINKTVMDKV ATEWDPEFIT RQLEAKKKFN ELSNREISKF
460 470 480 490 500
RDWKKSLFME QENFNQEIEQ LNHKLENLQL ECQDLEYKLL IGKSSNSHST
510
DSATLVNVHI KR
Length:512
Mass (Da):59,845
Last modified:November 1, 1995 - v1
Checksum:i1FC55B13E6A88F5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26E → D in AAC13870 (PubMed:7590307).Curated1
Sequence conflicti250L → C in AAC13870 (PubMed:7590307).Curated1
Sequence conflicti263V → L in AAC13870 (PubMed:7590307).Curated1
Sequence conflicti317Y → H in AAC13870 (PubMed:7590307).Curated1
Sequence conflicti481E → G in AAC13870 (PubMed:7590307).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31767 Genomic DNA Translation: AAC37482.1
U24129 Genomic DNA Translation: AAC13870.1
Z72844 Genomic DNA Translation: CAA97061.1
BK006941 Genomic DNA Translation: DAA08155.1
PIRiS48524
RefSeqiNP_011573.3, NM_001181188.3

Genome annotation databases

EnsemblFungiiYGR059W; YGR059W; YGR059W
GeneIDi852950
KEGGisce:YGR059W

Similar proteinsi

Entry informationi

Entry nameiSPR3_YEAST
AccessioniPrimary (citable) accession number: P41901
Secondary accession number(s): D6VUJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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