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P41893

- PPAL_SCHPO

UniProt

P41893 - PPAL_SCHPO

Protein

Low molecular weight phosphotyrosine protein phosphatase

Gene

stp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    May contribute to dephosphorylation of 'Tyr-15' of cdc2.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei11 – 111NucleophileBy similarity
    Active sitei17 – 171By similarity
    Active sitei128 – 1281Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC
    2. non-membrane spanning protein tyrosine phosphatase activity Source: PomBase
    3. protein tyrosine phosphatase activity Source: PomBase

    GO - Biological processi

    1. peptidyl-tyrosine dephosphorylation Source: PomBase
    2. signal transduction Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low molecular weight phosphotyrosine protein phosphatase (EC:3.1.3.48)
    Alternative name(s):
    Low molecular weight cytosolic acid phosphatase (EC:3.1.3.2)
    PTPase
    Small tyrosine phosphatase
    Gene namesi
    Name:stp1
    ORF Names:SPAC1071.12c, SPAC926.01c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC1071.12c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 156156Low molecular weight phosphotyrosine protein phosphatasePRO_0000046564Add
    BLAST

    Proteomic databases

    MaxQBiP41893.
    PaxDbiP41893.

    Interactioni

    Protein-protein interaction databases

    BioGridi280509. 12 interactions.
    MINTiMINT-4690293.
    STRINGi4896.SPAC1071.12c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP41893.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0394.
    HOGENOMiHOG000273094.
    KOiK14394.
    OMAiEIMSADL.
    OrthoDBiEOG7P2Z4K.
    PhylomeDBiP41893.

    Family and domain databases

    InterProiIPR023485. Ptyr_pPase_SF.
    IPR002115. Tyr_Pase_low_mol_wt_mml.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view]
    PANTHERiPTHR11717. PTHR11717. 1 hit.
    PfamiPF01451. LMWPc. 1 hit.
    [Graphical view]
    PRINTSiPR00719. LMWPTPASE.
    PR00720. MAMMALPTPASE.
    SMARTiSM00226. LMWPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P41893-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKNIQVLFV CLGNICRSPM AEAVFRNEVE KAGLEARFDT IDSCGTGAWH    50
    VGNRPDPRTL EVLKKNGIHT KHLARKLSTS DFKNFDYIFA MDSSNLRNIN 100
    RVKPQGSRAK VMLFGEYASP GVSKIVDDPY YGGSDGFGDC YIQLVDFSQN 150
    FLKSIA 156
    Length:156
    Mass (Da):17,391
    Last modified:November 1, 1995 - v1
    Checksum:i536B433655FCB56A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33929 mRNA. Translation: AAA61930.1.
    CU329670 Genomic DNA. Translation: CAB59888.1.
    PIRiA55446.
    RefSeqiXP_001713094.1. XM_001713042.2.

    Genome annotation databases

    EnsemblFungiiSPAC1071.12c.1; SPAC1071.12c.1:pep; SPAC1071.12c.
    GeneIDi3361433.
    KEGGispo:SPAC1071.12c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33929 mRNA. Translation: AAA61930.1 .
    CU329670 Genomic DNA. Translation: CAB59888.1 .
    PIRi A55446.
    RefSeqi XP_001713094.1. XM_001713042.2.

    3D structure databases

    ProteinModelPortali P41893.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 280509. 12 interactions.
    MINTi MINT-4690293.
    STRINGi 4896.SPAC1071.12c-1.

    Proteomic databases

    MaxQBi P41893.
    PaxDbi P41893.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC1071.12c.1 ; SPAC1071.12c.1:pep ; SPAC1071.12c .
    GeneIDi 3361433.
    KEGGi spo:SPAC1071.12c.

    Organism-specific databases

    PomBasei SPAC1071.12c.

    Phylogenomic databases

    eggNOGi COG0394.
    HOGENOMi HOG000273094.
    KOi K14394.
    OMAi EIMSADL.
    OrthoDBi EOG7P2Z4K.
    PhylomeDBi P41893.

    Miscellaneous databases

    NextBioi 20811481.
    PROi P41893.

    Family and domain databases

    InterProi IPR023485. Ptyr_pPase_SF.
    IPR002115. Tyr_Pase_low_mol_wt_mml.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view ]
    PANTHERi PTHR11717. PTHR11717. 1 hit.
    Pfami PF01451. LMWPc. 1 hit.
    [Graphical view ]
    PRINTSi PR00719. LMWPTPASE.
    PR00720. MAMMALPTPASE.
    SMARTi SM00226. LMWPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52788. SSF52788. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Low molecular weight protein-tyrosine phosphatases are highly conserved between fission yeast and man."
      Mondesert O., Moreno S., Russell P.
      J. Biol. Chem. 269:27996-27999(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 972 / ATCC 24843.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPPAL_SCHPO
    AccessioniPrimary (citable) accession number: P41893
    Secondary accession number(s): Q9UTQ3, Q9UUG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3