Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P41893 (PPAL_SCHPO)

Last modified September 22, 2009. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Low molecular weight phosphotyrosine protein phosphatase
    EC=3.1.3.48
Alternative name(s):
    Low molecular weight cytosolic acid phosphatase
    EC=3.1.3.2
    PTPase
    Small tyrosine phosphatase
Gene names
Name: stp1
ORF Names: SPAC1071.12c, SPAC926.01c
OrganismSchizosaccharomyces pombe (Fission yeast) [Complete proteome]
Taxonomic identifier4896 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length156 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

May contribute to dephosphorylation of 'Tyr-15' of cdc2.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

A phosphate monoester + H2O = an alcohol + phosphate.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 156156Low molecular weight phosphotyrosine protein phosphatase
PRO_0000046564

Sites

Active site111Nucleophile By similarity
Active site171 By similarity
Active site1281Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
P41893-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 536B433655FCB56A

FASTA15617,391
        10         20         30         40         50         60 
MTKNIQVLFV CLGNICRSPM AEAVFRNEVE KAGLEARFDT IDSCGTGAWH VGNRPDPRTL 

        70         80         90        100        110        120 
EVLKKNGIHT KHLARKLSTS DFKNFDYIFA MDSSNLRNIN RVKPQGSRAK VMLFGEYASP 

       130        140        150 
GVSKIVDDPY YGGSDGFGDC YIQLVDFSQN FLKSIA 

« Hide

References

« Hide 'large scale' references
[1]"Low molecular weight protein-tyrosine phosphatases are highly conserved between fission yeast and man."
Mondesert O., Moreno S., Russell P.
J. Biol. Chem. 269:27996-27999(1994) [PubMed: 7961734] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ATCC 38366 / 972.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 38366 / 972.

Cross-references

Sequence databases

L33929 mRNA. Translation: AAA61930.1.
CU329670 Genomic DNA. Translation: CAB59888.1.
PIRA55446.
RefSeqXP_001713094.1.

3D structure databases

HSSPHSSP built from PDB template 1D1P based on UniProtKB P40347.
ModBaseSearch...

Protein-protein interaction databases

STRINGP41893.

Genome annotation databases

GeneID3361433.
GenomeReviewsGene locus stp1 in contig CU329670_GR.
KEGGspo:SPAC1071.12c.

Organism-specific databases

GeneDB_SpombeSPAC1071.12c.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-003106-MON.
BRENDA3.1.3.2. 653.
3.1.3.48. 653.

Gene expression databases

ArrayExpressP41893.

Family and domain databases

InterProIPR002115. Tyr_Pase_low_mol_wt_mml.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. Low_mwt_PTPase. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSPR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePPAL_SCHPO
AccessionPrimary (citable) accession number: P41893
Secondary accession number(s): Q9UTQ3, Q9UUG7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 22, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents