Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Low molecular weight phosphotyrosine protein phosphatase

Gene

stp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May contribute to dephosphorylation of 'Tyr-15' of cdc2.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11NucleophileBy similarity1
Active sitei17By similarity1
Active sitei128Proton donorBy similarity1

GO - Molecular functioni

  • acid phosphatase activity Source: UniProtKB-EC
  • non-membrane spanning protein tyrosine phosphatase activity Source: PomBase
  • protein tyrosine phosphatase activity Source: PomBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight phosphotyrosine protein phosphatase (EC:3.1.3.48)
Alternative name(s):
Low molecular weight cytosolic acid phosphatase (EC:3.1.3.2)
PTPase
Small tyrosine phosphatase
Gene namesi
Name:stp1
ORF Names:SPAC1071.12c, SPAC926.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1071.12c
PomBaseiSPAC1071.12c stp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465641 – 156Low molecular weight phosphotyrosine protein phosphataseAdd BLAST156

Proteomic databases

MaxQBiP41893
PaxDbiP41893
PRIDEiP41893

PTM databases

iPTMnetiP41893

Interactioni

Protein-protein interaction databases

BioGridi28050911 interactors.
STRINGi4896.SPAC1071.12c.1

Structurei

3D structure databases

ProteinModelPortaliP41893
SMRiP41893
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000273094
InParanoidiP41893
KOiK14394
OMAiAGTGSWH
OrthoDBiEOG092C5FEA
PhylomeDBiP41893

Family and domain databases

InterProiView protein in InterPro
IPR023485 Ptyr_pPase
IPR036196 Ptyr_pPase_sf
IPR002115 Tyr_Pase_low_mol_wt_mml
IPR017867 Tyr_phospatase_low_mol_wt
PfamiView protein in Pfam
PF01451 LMWPc, 1 hit
PRINTSiPR00719 LMWPTPASE
PR00720 MAMMALPTPASE
SMARTiView protein in SMART
SM00226 LMWPc, 1 hit
SUPFAMiSSF52788 SSF52788, 1 hit

Sequencei

Sequence statusi: Complete.

P41893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKNIQVLFV CLGNICRSPM AEAVFRNEVE KAGLEARFDT IDSCGTGAWH
60 70 80 90 100
VGNRPDPRTL EVLKKNGIHT KHLARKLSTS DFKNFDYIFA MDSSNLRNIN
110 120 130 140 150
RVKPQGSRAK VMLFGEYASP GVSKIVDDPY YGGSDGFGDC YIQLVDFSQN

FLKSIA
Length:156
Mass (Da):17,391
Last modified:November 1, 1995 - v1
Checksum:i536B433655FCB56A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33929 mRNA Translation: AAA61930.1
CU329670 Genomic DNA Translation: CAB59888.1
PIRiA55446
RefSeqiXP_001713094.1, XM_001713042.2

Genome annotation databases

EnsemblFungiiSPAC1071.12c.1; SPAC1071.12c.1:pep; SPAC1071.12c
KEGGispo:SPAC1071.12c

Similar proteinsi

Entry informationi

Entry nameiPPAL_SCHPO
AccessioniPrimary (citable) accession number: P41893
Secondary accession number(s): Q9UTQ3, Q9UUG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome