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P41893 (PPAL_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Low molecular weight phosphotyrosine protein phosphatase
EC=3.1.3.48
Alternative name(s):
Low molecular weight cytosolic acid phosphatase
EC=3.1.3.2
PTPase
Small tyrosine phosphatase
Gene names
Name:stp1
ORF Names:SPAC1071.12c, SPAC926.01c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length156 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May contribute to dephosphorylation of 'Tyr-15' of cdc2.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

A phosphate monoester + H2O = an alcohol + phosphate.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processregulation of mitotic cell cycle

Inferred from genetic interaction. Source: GeneDB_Spombe

   Cellular componentcytosol

Inferred from direct assay. Source: GeneDB_Spombe

nucleus

Inferred from direct assay. Source: GeneDB_Spombe

   Molecular functionacid phosphatase activity

Inferred from electronic annotation. Source: EC

non-membrane spanning protein tyrosine phosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 156156Low molecular weight phosphotyrosine protein phosphatase
PRO_0000046564

Sites

Active site111Nucleophile By similarity
Active site171 By similarity
Active site1281Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
P41893 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 536B433655FCB56A

FASTA15617,391
        10         20         30         40         50         60 
MTKNIQVLFV CLGNICRSPM AEAVFRNEVE KAGLEARFDT IDSCGTGAWH VGNRPDPRTL 

        70         80         90        100        110        120 
EVLKKNGIHT KHLARKLSTS DFKNFDYIFA MDSSNLRNIN RVKPQGSRAK VMLFGEYASP 

       130        140        150 
GVSKIVDDPY YGGSDGFGDC YIQLVDFSQN FLKSIA

« Hide

References

« Hide 'large scale' references
[1]"Low molecular weight protein-tyrosine phosphatases are highly conserved between fission yeast and man."
Mondesert O., Moreno S., Russell P.
J. Biol. Chem. 269:27996-27999(1994) [PubMed: 7961734] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L33929 mRNA. Translation: AAA61930.1.
CU329670 Genomic DNA. Translation: CAB59888.1.
PIRA55446.
RefSeqXP_001713094.1. XM_001713042.1.

3D structure databases

ProteinModelPortalP41893.
ModBaseSearch...

Protein-protein interaction databases

STRINGP41893.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC1071.12c.1; SPAC1071.12c.1:pep; SPAC1071.12c.
GeneID3361433.
GenomeReviewsGene locus stp1 in contig CU329670_GR.
KEGGspo:SPAC1071.12c.

Organism-specific databases

GeneDB_SpombeSPAC1071.12c.

Phylogenomic databases

eggNOGfuNOG09909.
GeneTreeEFGT00050000005735.
HOGENOMHBG730979.
OMAEDPWYGG.
OrthoDBEOG4SXRP0.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-003106-MONOMER.

Gene expression databases

ArrayExpressP41893.

Family and domain databases

InterProIPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
KOK14394.
PANTHERPTHR11717. Low_mwt_PTPase. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSPR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. Tyr_Pase_low_mol_wt. 1 hit.
ProtoNetSearch...

Entry information

Entry namePPAL_SCHPO
AccessionPrimary (citable) accession number: P41893
Secondary accession number(s): Q9UTQ3, Q9UUG7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 14, 2011
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

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