P41893 (PPAL_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low molecular weight phosphotyrosine protein phosphatase
EC=3.1.3.48

Alternative name(s):
Low molecular weight cytosolic acid phosphatase
EC=3.1.3.2
PTPase
Small tyrosine phosphatase

Gene names

Name:	stp1
ORF Names:	SPAC1071.12c, SPAC926.01c

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May contribute to dephosphorylation of 'Tyr-15' of cdc2.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphate monoester + H2O = an alcohol + phosphate.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of mitotic cell cycle Inferred from genetic interaction PubMed 7654712. Source: PomBase signal transduction Non-traceable author statement. Source: PomBase
Cellular_component	cytosol Inferred from direct assay PubMed 16823372. Source: PomBase nucleus Inferred from direct assay PubMed 16823372. Source: PomBase
Molecular_function	acid phosphatase activity Inferred from electronic annotation. Source: EC non-membrane spanning protein tyrosine phosphatase activity Inferred from sequence model. Source: PomBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 156	156	Low molecular weight phosphotyrosine protein phosphatase		PRO_0000046564
Sites
	Active site	11	1	Nucleophile By similarity
	Active site	17	1	By similarity
	Active site	128	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P41893 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 536B433655FCB56A	FASTA	156	17,391
	10 20 30 40 50 60 MTKNIQVLFV CLGNICRSPM AEAVFRNEVE KAGLEARFDT IDSCGTGAWH VGNRPDPRTL 70 80 90 100 110 120 EVLKKNGIHT KHLARKLSTS DFKNFDYIFA MDSSNLRNIN RVKPQGSRAK VMLFGEYASP 130 140 150 GVSKIVDDPY YGGSDGFGDC YIQLVDFSQN FLKSIA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Low molecular weight protein-tyrosine phosphatases are highly conserved between fission yeast and man." Mondesert O., Moreno S., Russell P. J. Biol. Chem. 269:27996-27999(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 972 / ATCC 24843.
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L33929 mRNA. Translation: AAA61930.1. CU329670 Genomic DNA. Translation: CAB59888.1.
PIR	A55446.
RefSeq	XP_001713094.1. XM_001713042.2.
3D structure databases
ProteinModelPortal	P41893.
ModBase	Search...
Protein-protein interaction databases
STRING	4896.SPAC1071.12c-1.
Proteomic databases
PaxDb	P41893.
PRIDE	P41893.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPAC1071.12c.1; SPAC1071.12c.1:pep; SPAC1071.12c.
GeneID	3361433.
KEGG	spo:SPAC1071.12c.
Organism-specific databases
PomBase	SPAC1071.12c.
Phylogenomic databases
eggNOG	COG0394.
HOGENOM	HOG000273094.
KO	K14394.
OMA	FETAYQQ.
OrthoDB	EOG4SXRP0.
Family and domain databases
InterPro	IPR023485. Ptyr_pPase_SF. IPR002115. Tyr_Pase_low_mol_wt_mml. IPR000106. Tyr_phospatase/Ars_reductase. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
PANTHER	PTHR11717. PTHR11717. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
PRINTS	PR00719. LMWPTPASE. PR00720. MAMMALPTPASE.
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
SUPFAM	SSF52788. Tyr_Pase_low_mol_wt. 1 hit.
ProtoNet	Search...
Other
NextBio	20811481.

Entry information

Entry name

PPAL_SCHPO

Accession

Primary (citable) accession number: P41893
Secondary accession number(s): Q9UTQ3, Q9UUG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program