Reviewed, UniProtKB/Swiss-Prot P41893 (PPAL_SCHPO)

Names and origin

Protein names

Recommended name:
    Low molecular weight phosphotyrosine protein phosphatase
    EC=3.1.3.48
Alternative name(s):
    Low molecular weight cytosolic acid phosphatase
    EC=3.1.3.2
    PTPase
    Small tyrosine phosphatase

Gene names

Name:	stp1
ORF Names:	SPAC1071.12c, SPAC926.01c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May contribute to dephosphorylation of 'Tyr-15' of cdc2.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphate monoester + H2O = an alcohol + phosphate.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro regulation of mitotic cell cycle Inferred from genetic interaction. Source: GeneDB_SPombe
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_SPombe nucleus Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	acid phosphatase activity Inferred from electronic annotation. Source: EC non-membrane spanning protein tyrosine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 156	156	Low molecular weight phosphotyrosine protein phosphatase		PRO_0000046564
Sites
	Active site	11	1	Nucleophile By similarity
	Active site	17	1	By similarity
	Active site	128	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P41893-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 536B433655FCB56A	FASTA	156	17,391
	10 20 30 40 50 60 MTKNIQVLFV CLGNICRSPM AEAVFRNEVE KAGLEARFDT IDSCGTGAWH VGNRPDPRTL 70 80 90 100 110 120 EVLKKNGIHT KHLARKLSTS DFKNFDYIFA MDSSNLRNIN RVKPQGSRAK VMLFGEYASP 130 140 150 GVSKIVDDPY YGGSDGFGDC YIQLVDFSQN FLKSIA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Low molecular weight protein-tyrosine phosphatases are highly conserved between fission yeast and man." Mondesert O., Moreno S., Russell P. J. Biol. Chem. 269:27996-27999(1994) [PubMed: 7961734] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 38366 / 972.
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L33929 mRNA. Translation: AAA61930.1. CU329670 Genomic DNA. Translation: CAB59888.1.
PIR	A55446.
RefSeq	XP_001713094.1.
3D structure databases
HSSP	HSSP built from PDB template 1D1P based on UniProtKB P40347.
ModBase	Search...
Protein-protein interaction databases
STRING	P41893.
Genome annotation databases
GeneID	3361433.
GenomeReviews	Gene locus stp1 in contig CU329670_GR.
KEGG	spo:SPAC1071.12c.
Organism-specific databases
GeneDB_Spombe	SPAC1071.12c.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-003106-MON.
BRENDA	3.1.3.2. 653. 3.1.3.48. 653.
Gene expression databases
ArrayExpress	P41893.
Family and domain databases
InterPro	IPR002115. Tyr_Pase_low_mol_wt_mml. IPR000106. Tyr_phospatase/Ars_reductase. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
PANTHER	PTHR11717. Low_mwt_PTPase. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
PRINTS	PR00719. LMWPTPASE. PR00720. MAMMALPTPASE.
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPAL_SCHPO

Accession

Primary (citable) accession number: P41893
Secondary accession number(s): Q9UTQ3, Q9UUG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	September 22, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)