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P41893

- PPAL_SCHPO

UniProt

P41893 - PPAL_SCHPO

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Protein

Low molecular weight phosphotyrosine protein phosphatase

Gene

stp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May contribute to dephosphorylation of 'Tyr-15' of cdc2.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei11 – 111NucleophileBy similarity
Active sitei17 – 171By similarity
Active sitei128 – 1281Proton donorBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. non-membrane spanning protein tyrosine phosphatase activity Source: PomBase
  3. protein tyrosine phosphatase activity Source: PomBase

GO - Biological processi

  1. peptidyl-tyrosine dephosphorylation Source: PomBase
  2. signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight phosphotyrosine protein phosphatase (EC:3.1.3.48)
Alternative name(s):
Low molecular weight cytosolic acid phosphatase (EC:3.1.3.2)
PTPase
Small tyrosine phosphatase
Gene namesi
Name:stp1
ORF Names:SPAC1071.12c, SPAC926.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC1071.12c.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156Low molecular weight phosphotyrosine protein phosphatasePRO_0000046564Add
BLAST

Proteomic databases

MaxQBiP41893.
PaxDbiP41893.

Interactioni

Protein-protein interaction databases

BioGridi280509. 12 interactions.
MINTiMINT-4690293.
STRINGi4896.SPAC1071.12c-1.

Structurei

3D structure databases

ProteinModelPortaliP41893.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0394.
HOGENOMiHOG000273094.
InParanoidiP41893.
KOiK14394.
OMAiEIMSADL.
OrthoDBiEOG7P2Z4K.
PhylomeDBiP41893.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF7. PTHR11717:SF7. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

P41893-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKNIQVLFV CLGNICRSPM AEAVFRNEVE KAGLEARFDT IDSCGTGAWH
60 70 80 90 100
VGNRPDPRTL EVLKKNGIHT KHLARKLSTS DFKNFDYIFA MDSSNLRNIN
110 120 130 140 150
RVKPQGSRAK VMLFGEYASP GVSKIVDDPY YGGSDGFGDC YIQLVDFSQN

FLKSIA
Length:156
Mass (Da):17,391
Last modified:November 1, 1995 - v1
Checksum:i536B433655FCB56A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33929 mRNA. Translation: AAA61930.1.
CU329670 Genomic DNA. Translation: CAB59888.1.
PIRiA55446.
RefSeqiXP_001713094.1. XM_001713042.2.

Genome annotation databases

EnsemblFungiiSPAC1071.12c.1; SPAC1071.12c.1:pep; SPAC1071.12c.
GeneIDi3361433.
KEGGispo:SPAC1071.12c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33929 mRNA. Translation: AAA61930.1 .
CU329670 Genomic DNA. Translation: CAB59888.1 .
PIRi A55446.
RefSeqi XP_001713094.1. XM_001713042.2.

3D structure databases

ProteinModelPortali P41893.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 280509. 12 interactions.
MINTi MINT-4690293.
STRINGi 4896.SPAC1071.12c-1.

Proteomic databases

MaxQBi P41893.
PaxDbi P41893.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC1071.12c.1 ; SPAC1071.12c.1:pep ; SPAC1071.12c .
GeneIDi 3361433.
KEGGi spo:SPAC1071.12c.

Organism-specific databases

PomBasei SPAC1071.12c.

Phylogenomic databases

eggNOGi COG0394.
HOGENOMi HOG000273094.
InParanoidi P41893.
KOi K14394.
OMAi EIMSADL.
OrthoDBi EOG7P2Z4K.
PhylomeDBi P41893.

Miscellaneous databases

NextBioi 20811481.
PROi P41893.

Family and domain databases

InterProi IPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view ]
PANTHERi PTHR11717:SF7. PTHR11717:SF7. 1 hit.
Pfami PF01451. LMWPc. 1 hit.
[Graphical view ]
PRINTSi PR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTi SM00226. LMWPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52788. SSF52788. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Low molecular weight protein-tyrosine phosphatases are highly conserved between fission yeast and man."
    Mondesert O., Moreno S., Russell P.
    J. Biol. Chem. 269:27996-27999(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPPAL_SCHPO
AccessioniPrimary (citable) accession number: P41893
Secondary accession number(s): Q9UTQ3, Q9UUG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3