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P41888

- TNR3_SCHPO

UniProt

P41888 - TNR3_SCHPO

Protein

Thiamine pyrophosphokinase

Gene

tnr3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Involved in the regulation of thiamine metabolism, phosphate metabolism, mating and cell growth.1 Publication

    Catalytic activityi

    ATP + thiamine = AMP + thiamine diphosphate.

    GO - Molecular functioni

    1. 8-oxo-dGDP phosphatase activity Source: PomBase
    2. ATP binding Source: PomBase
    3. kinase activity Source: UniProtKB-KW
    4. magnesium ion binding Source: PomBase
    5. thiamine binding Source: PomBase
    6. thiamine diphosphokinase activity Source: PomBase

    GO - Biological processi

    1. thiamine biosynthetic process Source: PomBase
    2. thiamine diphosphate biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thiamine pyrophosphokinase (EC:2.7.6.2)
    Short name:
    TPK
    Short name:
    Thiamine kinase
    Gene namesi
    Name:tnr3
    ORF Names:SPAC6F12.05c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC6F12.05c.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 569569Thiamine pyrophosphokinasePRO_0000072610Add
    BLAST

    Proteomic databases

    MaxQBiP41888.
    PRIDEiP41888.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4690210.
    STRINGi4896.SPAC6F12.05c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP41888.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini136 – 276141Nudix hydrolasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0494.
    KOiK00949.
    OMAiVIPRIND.
    OrthoDBiEOG708W8M.
    PhylomeDBiP41888.

    Family and domain databases

    Gene3Di2.60.120.320. 1 hit.
    3.40.50.10240. 1 hit.
    3.90.79.10. 1 hit.
    InterProiIPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    IPR006282. Thi_PPkinase.
    IPR007373. Thiamin_PyroPKinase_B1-bd.
    IPR007371. TPK_catalytic.
    [Graphical view]
    PfamiPF00293. NUDIX. 1 hit.
    PF04265. TPK_B1_binding. 1 hit.
    PF04263. TPK_catalytic. 1 hit.
    [Graphical view]
    SMARTiSM00983. TPK_B1_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF55811. SSF55811. 1 hit.
    SSF63862. SSF63862. 1 hit.
    SSF63999. SSF63999. 1 hit.
    TIGRFAMsiTIGR01378. thi_PPkinase. 1 hit.
    PROSITEiPS51462. NUDIX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41888-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMSSITSAK QLNAEELLDE CDSFNGEFVP GTIPFRANGA AIGYVTPLVL    50
    EILIKADNFK FNWVYVPGEY IEINASTFEK RTDILAKVLE HWRHNNTFGI 100
    ADQWRNELYT VYGKSKKPVL AVERGGFWLF GFLSTGVHCT MYIPATKEHP 150
    LRIWVPRRSP TKQTWPNYLD NSVAGGIAHG DSVIGTMIKE FSEEANLDVS 200
    SMNLIPCGTV SYIKMEKRHW IQPELQYVFD LPVDDLVIPR INDGEVAGFS 250
    LLPLNQVLHE LELKSFKPNC ALVLLDFLIR HGIITPQHPQ YLQTLERIHR 300
    PLPVPVGKYE RGDSFEDTSK KAETCVPAKP QKATHQLAPC KAWLRDYDTD 350
    QKFAVLLLNQ PIDIPDDRFR TLWKRASIRV CADGGANQLR NYDSSLKPDY 400
    VVGDFDSLTD ETKAYYKEMG VNIVFDPCQN TTDFMKCHKI IKEHGIDTIF 450
    VLCGMGGRVD HAIGNLNHLF WAASISEKNE VFLLTELNVS TLLQPGINHV 500
    DCHDNIGLHC GLLPVGQSVY VKKTSGLEWN IEDRICQFGG LVSSCNVVTK 550
    ATVTIEVNNF IVWTMETRL 569
    Length:569
    Mass (Da):64,236
    Last modified:November 1, 1995 - v1
    Checksum:i5118042478DF00FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84417 Genomic DNA. Translation: CAA59135.1.
    CU329670 Genomic DNA. Translation: CAB11089.1.
    PIRiS52350.
    RefSeqiNP_593291.1. NM_001018721.2.

    Genome annotation databases

    EnsemblFungiiSPAC6F12.05c.1; SPAC6F12.05c.1:pep; SPAC6F12.05c.
    GeneIDi2543032.
    KEGGispo:SPAC6F12.05c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84417 Genomic DNA. Translation: CAA59135.1 .
    CU329670 Genomic DNA. Translation: CAB11089.1 .
    PIRi S52350.
    RefSeqi NP_593291.1. NM_001018721.2.

    3D structure databases

    ProteinModelPortali P41888.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4690210.
    STRINGi 4896.SPAC6F12.05c-1.

    Proteomic databases

    MaxQBi P41888.
    PRIDEi P41888.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC6F12.05c.1 ; SPAC6F12.05c.1:pep ; SPAC6F12.05c .
    GeneIDi 2543032.
    KEGGi spo:SPAC6F12.05c.

    Organism-specific databases

    PomBasei SPAC6F12.05c.

    Phylogenomic databases

    eggNOGi COG0494.
    KOi K00949.
    OMAi VIPRIND.
    OrthoDBi EOG708W8M.
    PhylomeDBi P41888.

    Miscellaneous databases

    NextBioi 20804063.

    Family and domain databases

    Gene3Di 2.60.120.320. 1 hit.
    3.40.50.10240. 1 hit.
    3.90.79.10. 1 hit.
    InterProi IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    IPR006282. Thi_PPkinase.
    IPR007373. Thiamin_PyroPKinase_B1-bd.
    IPR007371. TPK_catalytic.
    [Graphical view ]
    Pfami PF00293. NUDIX. 1 hit.
    PF04265. TPK_B1_binding. 1 hit.
    PF04263. TPK_catalytic. 1 hit.
    [Graphical view ]
    SMARTi SM00983. TPK_B1_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55811. SSF55811. 1 hit.
    SSF63862. SSF63862. 1 hit.
    SSF63999. SSF63999. 1 hit.
    TIGRFAMsi TIGR01378. thi_PPkinase. 1 hit.
    PROSITEi PS51462. NUDIX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Schizosaccharomyces pombe thiamine pyrophosphokinase is encoded by gene tnr3 and is a regulator of thiamine metabolism, phosphate metabolism, mating, and growth."
      Fankhauser H., Zurlinden A., Schweingruber A.-M., Edenharter E., Schweingruber M.E.
      J. Biol. Chem. 270:28457-28462(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. "Isolation and characterization of regulatory mutants from Schizosaccharomyces pombe involved in thiamine-regulated gene expression."
      Schweingruber A.-M., Fankhauser H., Dlugonski J., Steinmann-Loss C., Schweingruber M.E.
      Genetics 130:445-449(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTNR3_SCHPO
    AccessioniPrimary (citable) accession number: P41888
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3