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P41888 (TNR3_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thiamine pyrophosphokinase

Short name=TPK
Short name=Thiamine kinase
EC=2.7.6.2
Gene names
Name:tnr3
ORF Names:SPAC6F12.05c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length569 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Function

Involved in the regulation of thiamine metabolism, phosphate metabolism, mating and cell growth. Ref.3

Catalytic activity

ATP + thiamine = AMP + thiamine diphosphate.

Subcellular location

Cytoplasm Ref.4.

Sequence similarities

Contains 1 nudix hydrolase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 569569Thiamine pyrophosphokinase
PRO_0000072610

Regions

Domain136 – 276141Nudix hydrolase

Sequences

Sequence LengthMass (Da)Tools
P41888 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 5118042478DF00FC

FASTA56964,236
        10         20         30         40         50         60 
MAMSSITSAK QLNAEELLDE CDSFNGEFVP GTIPFRANGA AIGYVTPLVL EILIKADNFK 

        70         80         90        100        110        120 
FNWVYVPGEY IEINASTFEK RTDILAKVLE HWRHNNTFGI ADQWRNELYT VYGKSKKPVL 

       130        140        150        160        170        180 
AVERGGFWLF GFLSTGVHCT MYIPATKEHP LRIWVPRRSP TKQTWPNYLD NSVAGGIAHG 

       190        200        210        220        230        240 
DSVIGTMIKE FSEEANLDVS SMNLIPCGTV SYIKMEKRHW IQPELQYVFD LPVDDLVIPR 

       250        260        270        280        290        300 
INDGEVAGFS LLPLNQVLHE LELKSFKPNC ALVLLDFLIR HGIITPQHPQ YLQTLERIHR 

       310        320        330        340        350        360 
PLPVPVGKYE RGDSFEDTSK KAETCVPAKP QKATHQLAPC KAWLRDYDTD QKFAVLLLNQ 

       370        380        390        400        410        420 
PIDIPDDRFR TLWKRASIRV CADGGANQLR NYDSSLKPDY VVGDFDSLTD ETKAYYKEMG 

       430        440        450        460        470        480 
VNIVFDPCQN TTDFMKCHKI IKEHGIDTIF VLCGMGGRVD HAIGNLNHLF WAASISEKNE 

       490        500        510        520        530        540 
VFLLTELNVS TLLQPGINHV DCHDNIGLHC GLLPVGQSVY VKKTSGLEWN IEDRICQFGG 

       550        560 
LVSSCNVVTK ATVTIEVNNF IVWTMETRL 

« Hide

References

« Hide 'large scale' references
[1]"Schizosaccharomyces pombe thiamine pyrophosphokinase is encoded by gene tnr3 and is a regulator of thiamine metabolism, phosphate metabolism, mating, and growth."
Fankhauser H., Zurlinden A., Schweingruber A.-M., Edenharter E., Schweingruber M.E.
J. Biol. Chem. 270:28457-28462(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Isolation and characterization of regulatory mutants from Schizosaccharomyces pombe involved in thiamine-regulated gene expression."
Schweingruber A.-M., Fankhauser H., Dlugonski J., Steinmann-Loss C., Schweingruber M.E.
Genetics 130:445-449(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X84417 Genomic DNA. Translation: CAA59135.1.
CU329670 Genomic DNA. Translation: CAB11089.1.
PIRS52350.
RefSeqNP_593291.1. NM_001018721.2.

3D structure databases

ProteinModelPortalP41888.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4690210.
STRING4896.SPAC6F12.05c-1.

Proteomic databases

PRIDEP41888.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC6F12.05c.1; SPAC6F12.05c.1:pep; SPAC6F12.05c.
GeneID2543032.
KEGGspo:SPAC6F12.05c.

Organism-specific databases

PomBaseSPAC6F12.05c.

Phylogenomic databases

eggNOGCOG0494.
KOK00949.
OrthoDBEOG708W8M.
PhylomeDBP41888.

Family and domain databases

Gene3D2.60.120.320. 1 hit.
3.40.50.10240. 1 hit.
3.90.79.10. 1 hit.
InterProIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR006282. Thi_PPkinase.
IPR007373. Thiamin_PyroPKinase_B1-bd.
IPR007371. TPK_catalytic.
[Graphical view]
PfamPF00293. NUDIX. 1 hit.
PF04265. TPK_B1_binding. 1 hit.
PF04263. TPK_catalytic. 1 hit.
[Graphical view]
SMARTSM00983. TPK_B1_binding. 1 hit.
[Graphical view]
SUPFAMSSF55811. SSF55811. 1 hit.
SSF63862. SSF63862. 1 hit.
SSF63999. SSF63999. 1 hit.
TIGRFAMsTIGR01378. thi_PPkinase. 1 hit.
PROSITEPS51462. NUDIX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804063.

Entry information

Entry nameTNR3_SCHPO
AccessionPrimary (citable) accession number: P41888
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names