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P41888

- TNR3_SCHPO

UniProt

P41888 - TNR3_SCHPO

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Protein

Thiamine pyrophosphokinase

Gene
tnr3, SPAC6F12.05c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein predictedi

Functioni

Involved in the regulation of thiamine metabolism, phosphate metabolism, mating and cell growth.1 Publication

Catalytic activityi

ATP + thiamine = AMP + thiamine diphosphate.

GO - Molecular functioni

  1. 8-oxo-dGDP phosphatase activity Source: PomBase
  2. ATP binding Source: PomBase
  3. kinase activity Source: UniProtKB-KW
  4. magnesium ion binding Source: PomBase
  5. thiamine binding Source: PomBase
  6. thiamine diphosphokinase activity Source: PomBase

GO - Biological processi

  1. thiamine biosynthetic process Source: PomBase
  2. thiamine diphosphate biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine pyrophosphokinase (EC:2.7.6.2)
Short name:
TPK
Short name:
Thiamine kinase
Gene namesi
Name:tnr3
ORF Names:SPAC6F12.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC6F12.05c.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Thiamine pyrophosphokinasePRO_0000072610Add
BLAST

Proteomic databases

MaxQBiP41888.
PRIDEiP41888.

Interactioni

Protein-protein interaction databases

MINTiMINT-4690210.
STRINGi4896.SPAC6F12.05c-1.

Structurei

3D structure databases

ProteinModelPortaliP41888.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini136 – 276141Nudix hydrolaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0494.
KOiK00949.
OMAiVIPRIND.
OrthoDBiEOG708W8M.
PhylomeDBiP41888.

Family and domain databases

Gene3Di2.60.120.320. 1 hit.
3.40.50.10240. 1 hit.
3.90.79.10. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR006282. Thi_PPkinase.
IPR007373. Thiamin_PyroPKinase_B1-bd.
IPR007371. TPK_catalytic.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
PF04265. TPK_B1_binding. 1 hit.
PF04263. TPK_catalytic. 1 hit.
[Graphical view]
SMARTiSM00983. TPK_B1_binding. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
SSF63862. SSF63862. 1 hit.
SSF63999. SSF63999. 1 hit.
TIGRFAMsiTIGR01378. thi_PPkinase. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41888-1 [UniParc]FASTAAdd to Basket

« Hide

MAMSSITSAK QLNAEELLDE CDSFNGEFVP GTIPFRANGA AIGYVTPLVL    50
EILIKADNFK FNWVYVPGEY IEINASTFEK RTDILAKVLE HWRHNNTFGI 100
ADQWRNELYT VYGKSKKPVL AVERGGFWLF GFLSTGVHCT MYIPATKEHP 150
LRIWVPRRSP TKQTWPNYLD NSVAGGIAHG DSVIGTMIKE FSEEANLDVS 200
SMNLIPCGTV SYIKMEKRHW IQPELQYVFD LPVDDLVIPR INDGEVAGFS 250
LLPLNQVLHE LELKSFKPNC ALVLLDFLIR HGIITPQHPQ YLQTLERIHR 300
PLPVPVGKYE RGDSFEDTSK KAETCVPAKP QKATHQLAPC KAWLRDYDTD 350
QKFAVLLLNQ PIDIPDDRFR TLWKRASIRV CADGGANQLR NYDSSLKPDY 400
VVGDFDSLTD ETKAYYKEMG VNIVFDPCQN TTDFMKCHKI IKEHGIDTIF 450
VLCGMGGRVD HAIGNLNHLF WAASISEKNE VFLLTELNVS TLLQPGINHV 500
DCHDNIGLHC GLLPVGQSVY VKKTSGLEWN IEDRICQFGG LVSSCNVVTK 550
ATVTIEVNNF IVWTMETRL 569
Length:569
Mass (Da):64,236
Last modified:November 1, 1995 - v1
Checksum:i5118042478DF00FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84417 Genomic DNA. Translation: CAA59135.1.
CU329670 Genomic DNA. Translation: CAB11089.1.
PIRiS52350.
RefSeqiNP_593291.1. NM_001018721.2.

Genome annotation databases

EnsemblFungiiSPAC6F12.05c.1; SPAC6F12.05c.1:pep; SPAC6F12.05c.
GeneIDi2543032.
KEGGispo:SPAC6F12.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84417 Genomic DNA. Translation: CAA59135.1 .
CU329670 Genomic DNA. Translation: CAB11089.1 .
PIRi S52350.
RefSeqi NP_593291.1. NM_001018721.2.

3D structure databases

ProteinModelPortali P41888.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4690210.
STRINGi 4896.SPAC6F12.05c-1.

Proteomic databases

MaxQBi P41888.
PRIDEi P41888.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC6F12.05c.1 ; SPAC6F12.05c.1:pep ; SPAC6F12.05c .
GeneIDi 2543032.
KEGGi spo:SPAC6F12.05c.

Organism-specific databases

PomBasei SPAC6F12.05c.

Phylogenomic databases

eggNOGi COG0494.
KOi K00949.
OMAi VIPRIND.
OrthoDBi EOG708W8M.
PhylomeDBi P41888.

Miscellaneous databases

NextBioi 20804063.

Family and domain databases

Gene3Di 2.60.120.320. 1 hit.
3.40.50.10240. 1 hit.
3.90.79.10. 1 hit.
InterProi IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR006282. Thi_PPkinase.
IPR007373. Thiamin_PyroPKinase_B1-bd.
IPR007371. TPK_catalytic.
[Graphical view ]
Pfami PF00293. NUDIX. 1 hit.
PF04265. TPK_B1_binding. 1 hit.
PF04263. TPK_catalytic. 1 hit.
[Graphical view ]
SMARTi SM00983. TPK_B1_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF55811. SSF55811. 1 hit.
SSF63862. SSF63862. 1 hit.
SSF63999. SSF63999. 1 hit.
TIGRFAMsi TIGR01378. thi_PPkinase. 1 hit.
PROSITEi PS51462. NUDIX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Schizosaccharomyces pombe thiamine pyrophosphokinase is encoded by gene tnr3 and is a regulator of thiamine metabolism, phosphate metabolism, mating, and growth."
    Fankhauser H., Zurlinden A., Schweingruber A.-M., Edenharter E., Schweingruber M.E.
    J. Biol. Chem. 270:28457-28462(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Isolation and characterization of regulatory mutants from Schizosaccharomyces pombe involved in thiamine-regulated gene expression."
    Schweingruber A.-M., Fankhauser H., Dlugonski J., Steinmann-Loss C., Schweingruber M.E.
    Genetics 130:445-449(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTNR3_SCHPO
AccessioniPrimary (citable) accession number: P41888
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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