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Protein

Heat shock protein 90 homolog

Gene

swo1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). Interacts with the wee1 protein kinase; which requires swo1 for its activation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38ATPBy similarity1
Binding sitei80ATPBy similarity1
Binding sitei99ATPBy similarity1
Binding sitei125ATP; via amide nitrogenBy similarity1
Binding sitei375ATPBy similarity1

GO - Molecular functioni

  • ATPase activity Source: CACAO
  • ATP binding Source: PomBase
  • unfolded protein binding Source: PomBase

GO - Biological processi

  • 'de novo' protein folding Source: PomBase
  • chaperone-mediated protein folding Source: CACAO
  • protein folding Source: PomBase
  • response to stress Source: InterPro

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-SPO-3371511 HSF1 activation
R-SPO-3371571 HSF1-dependent transactivation
R-SPO-6798695 Neutrophil degranulation
R-SPO-844456 The NLRP3 inflammasome

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 90 homolog
Gene namesi
Name:swo1
Synonyms:hsp90
ORF Names:SPAC926.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC926.04c
PomBaseiSPAC926.04c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000629631 – 704Heat shock protein 90 homologAdd BLAST704

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei245Phosphoserine1 Publication1
Modified residuei277Phosphoserine1 Publication1
Modified residuei286Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP41887
PaxDbiP41887
PRIDEiP41887

PTM databases

iPTMnetiP41887

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

  • unfolded protein binding Source: PomBase

Protein-protein interaction databases

BioGridi279956, 21 interactors
IntActiP41887, 1 interactor
STRINGi4896.SPAC926.04c.1

Structurei

3D structure databases

ProteinModelPortaliP41887
SMRiP41887
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi700 – 704TPR repeat-binding5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi220 – 226Poly-Glu7

Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

HOGENOMiHOG000031988
InParanoidiP41887
KOiK04079
OMAiVKRHSEF
OrthoDBiEOG092C1GW3
PhylomeDBiP41887

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit

Sequencei

Sequence statusi: Complete.

P41887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTETFKFE AEISQLMSLI INTVYSNKEI FLRELISNAS DALDKIRYQS
60 70 80 90 100
LSDPHALDAE KDLFIRITPD KENKILSIRD TGIGMTKNDL INNLGVIAKS
110 120 130 140 150
GTKQFMEAAA SGADISMIGQ FGVGFYSAYL VADKVQVVSK HNDDEQYIWE
160 170 180 190 200
SSAGGSFTVT LDTDGPRLLR GTEIRLFMKE DQLQYLEEKT IKDTVKKHSE
210 220 230 240 250
FISYPIQLVV TREVEKEVPE EEETEEVKNE EDDKAPKIEE VDDESEKKEK
260 270 280 290 300
KTKKVKETTT ETEELNKTKP IWTRNPSEVT KEEYASFYKS LTNDWEDHLA
310 320 330 340 350
VKHFSVEGQL EFRAILFVPR RAPMDLFEAK RKKNNIKLYV RRVFITDDCE
360 370 380 390 400
ELIPEWLGFI KGVVDSEDLP LNLSREMLQQ NKIMKVIRKN LVRRCLDMFN
410 420 430 440 450
EIAEDKENFK TFYDAFSKNL KLGIHEDAAN RPALAKLLRY NSLNSPDDLI
460 470 480 490 500
SLEDYITKMP EHQKNIYFIT GESKQAVENS PFLEIFRAKK FDVLFMVDPI
510 520 530 540 550
DEYAVTQLKE FEGKKLVNIT KDGLELEETD EEKAAREKLE KEYEEFAKQL
560 570 580 590 600
KTILGDKVEK VVVSNKIVGS PCLLTTGQYG WSANMERIMK AQALRDTSMS
610 620 630 640 650
AYMSSRKTFE INPKSPIIAE LKKKVEENGA EDRSVKDLAT ILYETALLSS
660 670 680 690 700
GFTLDDPSAY AQRINRLISL GLSIDEEEEA PIEEISTESV AAENNAESKM

EEVD
Length:704
Mass (Da):80,596
Last modified:August 14, 2001 - v2
Checksum:i4E18B95722840768
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10 – 11EA → DW in AAC41646 (PubMed:7813446).Curated2
Sequence conflicti77S → T in AAC41646 (PubMed:7813446).Curated1
Sequence conflicti591 – 594AQAL → LKPS in AAC41646 (PubMed:7813446).Curated4
Sequence conflicti655D → H in AAC41646 (PubMed:7813446).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35550 Genomic DNA Translation: AAC41646.1
CU329670 Genomic DNA Translation: CAB54152.1
PIRiS51795
T39202
RefSeqiNP_594365.1, NM_001019786.2

Genome annotation databases

EnsemblFungiiSPAC926.04c.1; SPAC926.04c.1:pep; SPAC926.04c
GeneIDi2543539
KEGGispo:SPAC926.04c

Similar proteinsi

Entry informationi

Entry nameiHSP90_SCHPO
AccessioniPrimary (citable) accession number: P41887
Secondary accession number(s): Q9UUG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 14, 2001
Last modified: March 28, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health