Reviewed,
UniProtKB/Swiss-Prot P41831 (KPR1_SCHPO)
Last modified
November 3, 2009.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Ribose-phosphate pyrophosphokinase 1 EC=2.7.6.1 Alternative name(s): Phosphoribosyl pyrophosphate synthetase 1 | ||||
| Gene names |
| ||||
| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4896 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 409 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | 5-phosphoribose 1-diphosphate synthetase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthetases By similarity. |
| Catalytic activity | ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. |
| Pathway | |
| Subcellular location | |
| Sequence similarities | Belongs to the ribose-phosphate pyrophosphokinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytosol Ref.3 Inferred from direct assay. Source: GeneDB_SPombe nucleus Ref.3Inferred from direct assay. Source: GeneDB_SPombe |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activityInferred from electronic annotation. Source: UniProtKB-KW magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW ribose phosphate diphosphokinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 409 | 409 | Ribose-phosphate pyrophosphokinase 1 | PRO_0000141091 | |||||
Sites | |||||||||
| Metal binding | 128 | 1 | Magnesium Potential | ||||||
| Metal binding | 130 | 1 | Magnesium Potential | ||||||
| Metal binding | 143 | 1 | Magnesium Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 199 | 1 | Phosphoserine By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | Hilti N. Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 38366 / 972. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
| [3] | "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
Cross-references
Sequence databases | |
|---|---|
| X83866 Genomic DNA. Translation: CAA58747.1. CU329670 Genomic DNA. Translation: CAB11484.1. | |
| PIR | S51326. |
| RefSeq | NP_593826.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1DKR based on UniProtKB P14193. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P41831. |
Genome annotation databases | |
| GeneID | 2543525. |
| GenomeReviews | Gene locus prs1 in contig CU329670_GR. |
| KEGG | spo:SPAC4A8.14. |
| NMPDR | fig|4896.1.peg.3796. |
Organism-specific databases | |
| GeneDB_Spombe | SPAC4A8.14. |
Phylogenomic databases | |
| OMA | NDCLEVQ. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-001478-MON. |
| BRENDA | 2.7.6.1. 653. |
Gene expression databases | |
| ArrayExpress | P41831. |
Family and domain databases | |
| InterPro | IPR000842. PRib-PP_synthetase_CS. IPR005946. PRPP_kinase. [Graphical view] |
| TIGRFAMs | TIGR01251. ribP_PPkin. 1 hit. |
| PROSITE | PS00114. PRPP_SYNTHETASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KPR1_SCHPO | ||||||||
| Accession | Primary (citable) accession number: P41831 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


