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Protein

Steroid hormone receptor family member cnr14

Gene

cnr-14

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi148 – 223Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri151 – 171NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri187 – 211NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • dosage compensation by hypoactivation of X chromosome Source: WormBase
  • negative regulation of transcription from RNA polymerase II promoter Source: WormBase
  • primary sex determination Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid hormone receptor family member cnr14
Alternative name(s):
Nuclear receptor subfamily 1 group G member 1
Gene namesi
Name:cnr-14
Synonyms:nr1g1, sex-1
ORF Names:F44A6.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF44A6.2; CE03323; WBGene00004786; sex-1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535231 – 534Steroid hormone receptor family member cnr14Add BLAST534

Proteomic databases

PaxDbiP41830.
PeptideAtlasiP41830.

Expressioni

Tissue specificityi

Most abundant in embryos.

Gene expression databases

BgeeiWBGene00004786.

Interactioni

Protein-protein interaction databases

BioGridi46145. 10 interactors.
DIPiDIP-24967N.
IntActiP41830. 15 interactors.
STRINGi6239.F44A6.2.2.

Structurei

3D structure databases

ProteinModelPortaliP41830.
SMRiP41830.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri151 – 171NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri187 – 211NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IMDH. Eukaryota.
ENOG410YTU0. LUCA.
GeneTreeiENSGT00850000132242.
InParanoidiP41830.
KOiK08701.
OMAiRKIDYRC.
OrthoDBiEOG091G0E6M.
PhylomeDBiP41830.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFETKPNYL LLTNPDTPLS VCTSPYYSPS GKTASIPSSE ASKPEGTNGQ
60 70 80 90 100
WSHLPTGATY VTDEFSSEFQ IQNGSTAAQS GNANNYADPL SHRRYFNNVN
110 120 130 140 150
GYNHHQFYDT ASQASVSSPA TSVTSSLSPP DSLSNGHTTQ RHHIGKAISF
160 170 180 190 200
CKVCGDKASG YHYGVTSCEG CKGFFRRSIQ RKIDYRCLKQ QVCEIKRESR
210 220 230 240 250
NRCQYCRFKK CLDSGMSKDS VRQMKFRNAM RDDKSPDSVF VPEISTLERQ
260 270 280 290 300
EEVDAVYEAV LRAHTTFSFY TDIKIRSIVA RPFNVRINED SKMNRLNAWQ
310 320 330 340 350
IYAHEIDVDI KEVVNFVKEI PKFNFINGND KAVLLRKNAF PLYLLRIVRG
360 370 380 390 400
MSNRGLMLRD GRLIDFKSLQ LLYGSLADEM LAFANHIITI GCTDGDIALF
410 420 430 440 450
IVLILCQPLT TEQQFSTNFK SQLQLLEMFD FYKKVLFQKM TCRIDGCDTY
460 470 480 490 500
KQLMKCIHEL NRLNELHKQQ LNILRENLSF LNLPPLVVEM FQLSTLPLPV
510 520 530
NHNNQENQYT PAPEHQSPQP QQPTPNQQQT PVHC
Length:534
Mass (Da):60,848
Last modified:October 1, 1996 - v2
Checksum:iE6E888F18750E1B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13074 mRNA. Translation: AAA96982.1.
Z50858 Genomic DNA. Translation: CAA90722.1.
PIRiT22154.
RefSeqiNP_001024662.1. NM_001029491.2.
UniGeneiCel.17916.

Genome annotation databases

EnsemblMetazoaiF44A6.2.1; F44A6.2.1; WBGene00004786.
F44A6.2.2; F44A6.2.2; WBGene00004786.
GeneIDi181231.
KEGGicel:CELE_F44A6.2.
UCSCiF44A6.2.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13074 mRNA. Translation: AAA96982.1.
Z50858 Genomic DNA. Translation: CAA90722.1.
PIRiT22154.
RefSeqiNP_001024662.1. NM_001029491.2.
UniGeneiCel.17916.

3D structure databases

ProteinModelPortaliP41830.
SMRiP41830.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46145. 10 interactors.
DIPiDIP-24967N.
IntActiP41830. 15 interactors.
STRINGi6239.F44A6.2.2.

Proteomic databases

PaxDbiP41830.
PeptideAtlasiP41830.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF44A6.2.1; F44A6.2.1; WBGene00004786.
F44A6.2.2; F44A6.2.2; WBGene00004786.
GeneIDi181231.
KEGGicel:CELE_F44A6.2.
UCSCiF44A6.2.1. c. elegans.

Organism-specific databases

CTDi181231.
WormBaseiF44A6.2; CE03323; WBGene00004786; sex-1.

Phylogenomic databases

eggNOGiENOG410IMDH. Eukaryota.
ENOG410YTU0. LUCA.
GeneTreeiENSGT00850000132242.
InParanoidiP41830.
KOiK08701.
OMAiRKIDYRC.
OrthoDBiEOG091G0E6M.
PhylomeDBiP41830.

Miscellaneous databases

PROiP41830.

Gene expression databases

BgeeiWBGene00004786.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNR14_CAEEL
AccessioniPrimary (citable) accession number: P41830
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.