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P41822

- FRI_AEDAE

UniProt

P41822 - FRI_AEDAE

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Protein

Ferritin subunit

Gene
FERH, AAEL007385
Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Protection against toxic levels of iron. Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.1 Publication

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Iron 1 By similarity
Metal bindingi92 – 921Iron 1 By similarity
Metal bindingi92 – 921Iron 2 By similarity
Metal bindingi95 – 951Iron 1 By similarity
Metal bindingi140 – 1401Iron 2 By similarity
Metal bindingi175 – 1751Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin subunit (EC:1.16.3.1)
Alternative name(s):
AeFer(H)
Ferritin heavy chain-like protein
Gene namesi
Name:FERH
ORF Names:AAEL007385
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27271 PublicationAdd
BLAST
Chaini28 – 209182Ferritin subunitPRO_0000008853Add
BLAST

Expressioni

Tissue specificityi

Larvae, pupae, and adult females. Detected in midgut.1 Publication

Inductioni

By blood meal, iron and hydrogen peroxide.1 Publication

Interactioni

Subunit structurei

Oligomer of 24 subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble ferric iron core is deposited By similarity.

Structurei

3D structure databases

ProteinModelPortaliP41822.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 193154Ferritin-like diironAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG278794.
HOGENOMiHOG000223383.
InParanoidiP41822.
KOiK00522.
OrthoDBiEOG75MVXP.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41822-1 [UniParc]FASTAAdd to Basket

« Hide

MMKSVFFGVV AITVAILSIY QETAQAQEQT VGATDNYQWD SVDDQCLAAL    50
HRQINKEFDA SIIYLKYAAY FAQEKINLPG FEKFFFHSAA EEREHGIKLI 100
EYALMRGKAP VDKHFKLNYD HEVPTVTTGE SALETALQKE VEVTKSIRGV 150
IKACEDGSND FHLADYLTGE YLDEQHKGQR ELAEKIATLK KMKKSAPKLG 200
EFLFDKNHM 209
Length:209
Mass (Da):23,747
Last modified:July 1, 2008 - v2
Checksum:i202953E800B17B9C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311Missing in EAT40925. 1 Publication
Sequence conflicti31 – 311Missing in EAT40926. 1 Publication
Sequence conflicti88 – 881S → A in AAA99996. 1 Publication
Sequence conflicti88 – 881S → A in AAK15639. 1 Publication
Sequence conflicti88 – 881S → A in AAL85607. 1 Publication
Sequence conflicti145 – 1451K → R in AAA99996. 1 Publication
Sequence conflicti145 – 1451K → R in AAK15639. 1 Publication
Sequence conflicti145 – 1451K → R in AAL85607. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37082 mRNA. Translation: AAA99996.1.
AF326342 mRNA. Translation: AAK15639.1.
AY064106 mRNA. Translation: AAL85607.1.
CH477437 Genomic DNA. Translation: EAT40925.1.
CH477437 Genomic DNA. Translation: EAT40926.1.
RefSeqiXP_001652731.1. XM_001652681.1.
XP_001652732.1. XM_001652682.1.
UniGeneiAae.4382.

Genome annotation databases

GeneIDi5569124.
KEGGiaag:AaeL_AAEL007385.
VectorBaseiAAEL007385. Aedes aegypti.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37082 mRNA. Translation: AAA99996.1 .
AF326342 mRNA. Translation: AAK15639.1 .
AY064106 mRNA. Translation: AAL85607.1 .
CH477437 Genomic DNA. Translation: EAT40925.1 .
CH477437 Genomic DNA. Translation: EAT40926.1 .
RefSeqi XP_001652731.1. XM_001652681.1.
XP_001652732.1. XM_001652682.1.
UniGenei Aae.4382.

3D structure databases

ProteinModelPortali P41822.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5569124.
KEGGi aag:AaeL_AAEL007385.
VectorBasei AAEL007385. Aedes aegypti.

Phylogenomic databases

eggNOGi NOG278794.
HOGENOMi HOG000223383.
InParanoidi P41822.
KOi K00522.
OrthoDBi EOG75MVXP.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of mosquito ferritin and cloning of a cDNA that encodes one subunit."
    Dunkov B.C., Zhang D., Choumarov K., Winzerling J.J., Law J.H.
    Arch. Insect Biochem. Physiol. 29:293-307(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 28-68.
    Strain: Rockefeller.
  2. "Aedes aegypti ferritin heavy chain-like protein."
    Morlais I., Severson D.W.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Red eye.
    Tissue: Midgut.
  3. "Single nucleotide polymorphism and codon usage bias in Aedes aegypti."
    Morlais I., Severson D.W.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Red eye.
    Tissue: Midgut.
  4. "Genome sequence of Aedes aegypti, a major arbovirus vector."
    Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
    , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.
    Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVPib12.
  5. Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFRI_AEDAE
AccessioniPrimary (citable) accession number: P41822
Secondary accession number(s): Q172H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 1, 2008
Last modified: February 19, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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