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P41822

- FRI_AEDAE

UniProt

P41822 - FRI_AEDAE

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Protein

Ferritin subunit

Gene

FERH

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Protection against toxic levels of iron. Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.1 Publication

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Iron 1PROSITE-ProRule annotation
Metal bindingi92 – 921Iron 1PROSITE-ProRule annotation
Metal bindingi92 – 921Iron 2PROSITE-ProRule annotation
Metal bindingi95 – 951Iron 1PROSITE-ProRule annotation
Metal bindingi140 – 1401Iron 2PROSITE-ProRule annotation
Metal bindingi175 – 1751Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin subunit (EC:1.16.3.1)
Alternative name(s):
AeFer(H)
Ferritin heavy chain-like protein
Gene namesi
Name:FERH
ORF Names:AAEL007385
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27271 PublicationAdd
BLAST
Chaini28 – 209182Ferritin subunitPRO_0000008853Add
BLAST

Expressioni

Tissue specificityi

Larvae, pupae, and adult females. Detected in midgut.1 Publication

Inductioni

By blood meal, iron and hydrogen peroxide.1 Publication

Interactioni

Subunit structurei

Oligomer of 24 subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble ferric iron core is deposited By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliP41822.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 193154Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG278794.
HOGENOMiHOG000223383.
InParanoidiP41822.
KOiK00522.
OrthoDBiEOG75MVXP.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41822-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMKSVFFGVV AITVAILSIY QETAQAQEQT VGATDNYQWD SVDDQCLAAL
60 70 80 90 100
HRQINKEFDA SIIYLKYAAY FAQEKINLPG FEKFFFHSAA EEREHGIKLI
110 120 130 140 150
EYALMRGKAP VDKHFKLNYD HEVPTVTTGE SALETALQKE VEVTKSIRGV
160 170 180 190 200
IKACEDGSND FHLADYLTGE YLDEQHKGQR ELAEKIATLK KMKKSAPKLG

EFLFDKNHM
Length:209
Mass (Da):23,747
Last modified:July 1, 2008 - v2
Checksum:i202953E800B17B9C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311Missing in EAT40925. (PubMed:17510324)Curated
Sequence conflicti31 – 311Missing in EAT40926. (PubMed:17510324)Curated
Sequence conflicti88 – 881S → A in AAA99996. (PubMed:7655055)Curated
Sequence conflicti88 – 881S → A in AAK15639. 1 PublicationCurated
Sequence conflicti88 – 881S → A in AAL85607. 1 PublicationCurated
Sequence conflicti145 – 1451K → R in AAA99996. (PubMed:7655055)Curated
Sequence conflicti145 – 1451K → R in AAK15639. 1 PublicationCurated
Sequence conflicti145 – 1451K → R in AAL85607. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37082 mRNA. Translation: AAA99996.1.
AF326342 mRNA. Translation: AAK15639.1.
AY064106 mRNA. Translation: AAL85607.1.
CH477437 Genomic DNA. Translation: EAT40925.1.
CH477437 Genomic DNA. Translation: EAT40926.1.
RefSeqiXP_001652731.1. XM_001652681.1.
XP_001652732.1. XM_001652682.1.
UniGeneiAae.4382.

Genome annotation databases

GeneIDi5569124.
KEGGiaag:AaeL_AAEL007385.
VectorBaseiAAEL007385. Aedes aegypti.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37082 mRNA. Translation: AAA99996.1 .
AF326342 mRNA. Translation: AAK15639.1 .
AY064106 mRNA. Translation: AAL85607.1 .
CH477437 Genomic DNA. Translation: EAT40925.1 .
CH477437 Genomic DNA. Translation: EAT40926.1 .
RefSeqi XP_001652731.1. XM_001652681.1.
XP_001652732.1. XM_001652682.1.
UniGenei Aae.4382.

3D structure databases

ProteinModelPortali P41822.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5569124.
KEGGi aag:AaeL_AAEL007385.
VectorBasei AAEL007385. Aedes aegypti.

Phylogenomic databases

eggNOGi NOG278794.
HOGENOMi HOG000223383.
InParanoidi P41822.
KOi K00522.
OrthoDBi EOG75MVXP.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of mosquito ferritin and cloning of a cDNA that encodes one subunit."
    Dunkov B.C., Zhang D., Choumarov K., Winzerling J.J., Law J.H.
    Arch. Insect Biochem. Physiol. 29:293-307(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 28-68.
    Strain: Rockefeller.
  2. "Aedes aegypti ferritin heavy chain-like protein."
    Morlais I., Severson D.W.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Red eye.
    Tissue: Midgut.
  3. "Single nucleotide polymorphism and codon usage bias in Aedes aegypti."
    Morlais I., Severson D.W.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Red eye.
    Tissue: Midgut.
  4. "Genome sequence of Aedes aegypti, a major arbovirus vector."
    Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
    , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.
    Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVPib12.
  5. Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFRI_AEDAE
AccessioniPrimary (citable) accession number: P41822
Secondary accession number(s): Q172H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3