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P41822

- FRI_AEDAE

UniProt

P41822 - FRI_AEDAE

Protein

Ferritin subunit

Gene

FERH

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Protection against toxic levels of iron. Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.1 Publication

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi57 – 571Iron 1PROSITE-ProRule annotation
    Metal bindingi92 – 921Iron 1PROSITE-ProRule annotation
    Metal bindingi92 – 921Iron 2PROSITE-ProRule annotation
    Metal bindingi95 – 951Iron 1PROSITE-ProRule annotation
    Metal bindingi140 – 1401Iron 2PROSITE-ProRule annotation
    Metal bindingi175 – 1751Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. iron ion transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin subunit (EC:1.16.3.1)
    Alternative name(s):
    AeFer(H)
    Ferritin heavy chain-like protein
    Gene namesi
    Name:FERH
    ORF Names:AAEL007385
    OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
    Taxonomic identifieri7159 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
    ProteomesiUP000008820: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 27271 PublicationAdd
    BLAST
    Chaini28 – 209182Ferritin subunitPRO_0000008853Add
    BLAST

    Expressioni

    Tissue specificityi

    Larvae, pupae, and adult females. Detected in midgut.1 Publication

    Inductioni

    By blood meal, iron and hydrogen peroxide.1 Publication

    Interactioni

    Subunit structurei

    Oligomer of 24 subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble ferric iron core is deposited By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP41822.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 193154Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG278794.
    HOGENOMiHOG000223383.
    InParanoidiP41822.
    KOiK00522.
    OrthoDBiEOG75MVXP.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P41822-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMKSVFFGVV AITVAILSIY QETAQAQEQT VGATDNYQWD SVDDQCLAAL    50
    HRQINKEFDA SIIYLKYAAY FAQEKINLPG FEKFFFHSAA EEREHGIKLI 100
    EYALMRGKAP VDKHFKLNYD HEVPTVTTGE SALETALQKE VEVTKSIRGV 150
    IKACEDGSND FHLADYLTGE YLDEQHKGQR ELAEKIATLK KMKKSAPKLG 200
    EFLFDKNHM 209
    Length:209
    Mass (Da):23,747
    Last modified:July 1, 2008 - v2
    Checksum:i202953E800B17B9C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311Missing in EAT40925. (PubMed:17510324)Curated
    Sequence conflicti31 – 311Missing in EAT40926. (PubMed:17510324)Curated
    Sequence conflicti88 – 881S → A in AAA99996. (PubMed:7655055)Curated
    Sequence conflicti88 – 881S → A in AAK15639. 1 PublicationCurated
    Sequence conflicti88 – 881S → A in AAL85607. 1 PublicationCurated
    Sequence conflicti145 – 1451K → R in AAA99996. (PubMed:7655055)Curated
    Sequence conflicti145 – 1451K → R in AAK15639. 1 PublicationCurated
    Sequence conflicti145 – 1451K → R in AAL85607. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37082 mRNA. Translation: AAA99996.1.
    AF326342 mRNA. Translation: AAK15639.1.
    AY064106 mRNA. Translation: AAL85607.1.
    CH477437 Genomic DNA. Translation: EAT40925.1.
    CH477437 Genomic DNA. Translation: EAT40926.1.
    RefSeqiXP_001652731.1. XM_001652681.1.
    XP_001652732.1. XM_001652682.1.
    UniGeneiAae.4382.

    Genome annotation databases

    GeneIDi5569124.
    KEGGiaag:AaeL_AAEL007385.
    VectorBaseiAAEL007385. Aedes aegypti.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37082 mRNA. Translation: AAA99996.1 .
    AF326342 mRNA. Translation: AAK15639.1 .
    AY064106 mRNA. Translation: AAL85607.1 .
    CH477437 Genomic DNA. Translation: EAT40925.1 .
    CH477437 Genomic DNA. Translation: EAT40926.1 .
    RefSeqi XP_001652731.1. XM_001652681.1.
    XP_001652732.1. XM_001652682.1.
    UniGenei Aae.4382.

    3D structure databases

    ProteinModelPortali P41822.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5569124.
    KEGGi aag:AaeL_AAEL007385.
    VectorBasei AAEL007385. Aedes aegypti.

    Phylogenomic databases

    eggNOGi NOG278794.
    HOGENOMi HOG000223383.
    InParanoidi P41822.
    KOi K00522.
    OrthoDBi EOG75MVXP.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of mosquito ferritin and cloning of a cDNA that encodes one subunit."
      Dunkov B.C., Zhang D., Choumarov K., Winzerling J.J., Law J.H.
      Arch. Insect Biochem. Physiol. 29:293-307(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 28-68.
      Strain: Rockefeller.
    2. "Aedes aegypti ferritin heavy chain-like protein."
      Morlais I., Severson D.W.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Red eye.
      Tissue: Midgut.
    3. "Single nucleotide polymorphism and codon usage bias in Aedes aegypti."
      Morlais I., Severson D.W.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Red eye.
      Tissue: Midgut.
    4. "Genome sequence of Aedes aegypti, a major arbovirus vector."
      Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
      , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.
      Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LVPib12.
    5. Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFRI_AEDAE
    AccessioniPrimary (citable) accession number: P41822
    Secondary accession number(s): Q172H1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3