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Protein

Ferritin subunit

Gene

FERH

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protection against toxic levels of iron. Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.1 Publication

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57Iron 1PROSITE-ProRule annotation1
Metal bindingi92Iron 1PROSITE-ProRule annotation1
Metal bindingi92Iron 2PROSITE-ProRule annotation1
Metal bindingi95Iron 1PROSITE-ProRule annotation1
Metal bindingi140Iron 2PROSITE-ProRule annotation1
Metal bindingi175Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin subunit (EC:1.16.3.1)
Alternative name(s):
AeFer(H)
Ferritin heavy chain-like protein
Gene namesi
Name:FERH
ORF Names:AAEL007385
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
Proteomesi
  • UP000008820 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000000885328 – 209Ferritin subunitAdd BLAST182

Proteomic databases

PRIDEiP41822.

Expressioni

Tissue specificityi

Larvae, pupae, and adult females. Detected in midgut.1 Publication

Inductioni

By blood meal, iron and hydrogen peroxide.1 Publication

Interactioni

Subunit structurei

Oligomer of 24 subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble ferric iron core is deposited (By similarity).By similarity

Protein-protein interaction databases

STRINGi7159.AAEL007385-PA.

Structurei

3D structure databases

ProteinModelPortaliP41822.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 193Ferritin-like diironPROSITE-ProRule annotationAdd BLAST154

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2332. Eukaryota.
COG1528. LUCA.
HOGENOMiHOG000223383.
InParanoidiP41822.
KOiK00522.
OrthoDBiEOG091G0K3V.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41822-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKSVFFGVV AITVAILSIY QETAQAQEQT VGATDNYQWD SVDDQCLAAL
60 70 80 90 100
HRQINKEFDA SIIYLKYAAY FAQEKINLPG FEKFFFHSAA EEREHGIKLI
110 120 130 140 150
EYALMRGKAP VDKHFKLNYD HEVPTVTTGE SALETALQKE VEVTKSIRGV
160 170 180 190 200
IKACEDGSND FHLADYLTGE YLDEQHKGQR ELAEKIATLK KMKKSAPKLG

EFLFDKNHM
Length:209
Mass (Da):23,747
Last modified:July 1, 2008 - v2
Checksum:i202953E800B17B9C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31Missing in EAT40925 (PubMed:17510324).Curated1
Sequence conflicti31Missing in EAT40926 (PubMed:17510324).Curated1
Sequence conflicti88S → A in AAA99996 (PubMed:7655055).Curated1
Sequence conflicti88S → A in AAK15639 (Ref. 2) Curated1
Sequence conflicti88S → A in AAL85607 (Ref. 3) Curated1
Sequence conflicti145K → R in AAA99996 (PubMed:7655055).Curated1
Sequence conflicti145K → R in AAK15639 (Ref. 2) Curated1
Sequence conflicti145K → R in AAL85607 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37082 mRNA. Translation: AAA99996.1.
AF326342 mRNA. Translation: AAK15639.1.
AY064106 mRNA. Translation: AAL85607.1.
CH477437 Genomic DNA. Translation: EAT40925.1.
CH477437 Genomic DNA. Translation: EAT40926.1.
RefSeqiXP_001652731.1. XM_001652681.1.
XP_001652732.1. XM_001652682.1.
UniGeneiAae.4382.

Genome annotation databases

GeneIDi5569124.
KEGGiaag:AaeL_AAEL007385.
VectorBaseiAAEL007385-RA; AAEL007385-PA; AAEL007385.
AAEL007385-RB; AAEL007385-PB; AAEL007385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37082 mRNA. Translation: AAA99996.1.
AF326342 mRNA. Translation: AAK15639.1.
AY064106 mRNA. Translation: AAL85607.1.
CH477437 Genomic DNA. Translation: EAT40925.1.
CH477437 Genomic DNA. Translation: EAT40926.1.
RefSeqiXP_001652731.1. XM_001652681.1.
XP_001652732.1. XM_001652682.1.
UniGeneiAae.4382.

3D structure databases

ProteinModelPortaliP41822.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7159.AAEL007385-PA.

Proteomic databases

PRIDEiP41822.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5569124.
KEGGiaag:AaeL_AAEL007385.
VectorBaseiAAEL007385-RA; AAEL007385-PA; AAEL007385.
AAEL007385-RB; AAEL007385-PB; AAEL007385.

Organism-specific databases

CTDi5569124.

Phylogenomic databases

eggNOGiKOG2332. Eukaryota.
COG1528. LUCA.
HOGENOMiHOG000223383.
InParanoidiP41822.
KOiK00522.
OrthoDBiEOG091G0K3V.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFRI_AEDAE
AccessioniPrimary (citable) accession number: P41822
Secondary accession number(s): Q172H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 1, 2008
Last modified: October 5, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.