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P41818

- GLC8_YEAST

UniProt

P41818 - GLC8_YEAST

Protein

Protein GLC8

Gene

GLC8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Modulator of GLC7 type-1 protein phosphatase.

    GO - Molecular functioni

    1. enzyme activator activity Source: SGD
    2. protein binding Source: IntAct
    3. protein phosphatase inhibitor activity Source: InterPro

    GO - Biological processi

    1. chromosome segregation Source: SGD
    2. glycogen biosynthetic process Source: SGD
    3. positive regulation of catalytic activity Source: GOC
    4. regulation of phosphoprotein phosphatase activity Source: InterPro
    5. regulation of signal transduction Source: InterPro

    Keywords - Biological processi

    Carbohydrate metabolism, Glycogen metabolism

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32975-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein GLC8
    Gene namesi
    Name:GLC8
    Ordered Locus Names:YMR311C
    ORF Names:YM9924.03C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR311c.
    SGDiS000004928. GLC8.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229Protein GLC8PRO_0000071517Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei12 – 121Phosphoserine3 Publications
    Modified residuei118 – 1181Phosphothreonine; by PHO851 Publication
    Modified residuei158 – 1581Phosphoserine3 Publications
    Modified residuei184 – 1841Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated by the cyclin-CDKs PCL6-PHO85 and PCL7-PHO85. Phosphorylation of Thr-118 inactivates GLC8.5 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP41818.
    PaxDbiP41818.
    PeptideAtlasiP41818.

    Expressioni

    Gene expression databases

    GenevestigatoriP41818.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GLC7P325983EBI-7629,EBI-13715

    Protein-protein interaction databases

    BioGridi35491. 42 interactions.
    DIPiDIP-2349N.
    IntActiP41818. 1 interaction.
    MINTiMINT-674661.
    STRINGi4932.YMR311C.

    Structurei

    3D structure databases

    ProteinModelPortaliP41818.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG43787.
    HOGENOMiHOG000000770.
    KOiK16833.
    OMAiENDEDSP.
    OrthoDBiEOG71P2P8.

    Family and domain databases

    InterProiIPR007062. PPI-2.
    [Graphical view]
    PfamiPF04979. IPP-2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41818-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGGILKNPLA LSPEQLAQQD PETLEEFRRQ VYENTQKNAK LTSHKRNIPG    50
    LDNTKEEGEI IGTSSTFLPK DTLSLKHEQD MLAKMTPEER VQWNQRNLAE 100
    NEITKKQFQD IHIDEPKTPY QGAVDPHGEY YRVDDDEDED NSDKKPCQVA 150
    NDDIDDLSLG EPEFEIKENK QPDFETNDEN DEDSPEARHK KFEEMRKKHY 200
    DVRAIFNKKS REALKDEDED EDDSTTKEP 229
    Length:229
    Mass (Da):26,649
    Last modified:November 1, 1995 - v1
    Checksum:iD4017CA8B3B089C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22000 Genomic DNA. Translation: AAA53673.1.
    Z54141 Genomic DNA. Translation: CAA90829.1.
    AY557977 Genomic DNA. Translation: AAS56303.1.
    BK006946 Genomic DNA. Translation: DAA10212.1.
    PIRiS47859.
    RefSeqiNP_014042.1. NM_001182822.1.

    Genome annotation databases

    EnsemblFungiiYMR311C; YMR311C; YMR311C.
    GeneIDi855359.
    KEGGisce:YMR311C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22000 Genomic DNA. Translation: AAA53673.1 .
    Z54141 Genomic DNA. Translation: CAA90829.1 .
    AY557977 Genomic DNA. Translation: AAS56303.1 .
    BK006946 Genomic DNA. Translation: DAA10212.1 .
    PIRi S47859.
    RefSeqi NP_014042.1. NM_001182822.1.

    3D structure databases

    ProteinModelPortali P41818.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35491. 42 interactions.
    DIPi DIP-2349N.
    IntActi P41818. 1 interaction.
    MINTi MINT-674661.
    STRINGi 4932.YMR311C.

    Proteomic databases

    MaxQBi P41818.
    PaxDbi P41818.
    PeptideAtlasi P41818.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR311C ; YMR311C ; YMR311C .
    GeneIDi 855359.
    KEGGi sce:YMR311C.

    Organism-specific databases

    CYGDi YMR311c.
    SGDi S000004928. GLC8.

    Phylogenomic databases

    eggNOGi NOG43787.
    HOGENOMi HOG000000770.
    KOi K16833.
    OMAi ENDEDSP.
    OrthoDBi EOG71P2P8.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32975-MONOMER.

    Miscellaneous databases

    NextBioi 979127.

    Gene expression databases

    Genevestigatori P41818.

    Family and domain databases

    InterProi IPR007062. PPI-2.
    [Graphical view ]
    Pfami PF04979. IPP-2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of glycogen-deficient glc mutants of Saccharomyces cerevisiae."
      Cannon J.F., Pringle J.R., Fiechter A., Khalil M.
      Genetics 136:485-503(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Pho85 phosphorylates the Glc7 protein phosphatase regulator Glc8 in vivo."
      Tan Y.S.H., Morcos P.A., Cannon J.F.
      J. Biol. Chem. 278:147-153(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-118.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
      Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
      Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: YAL6B.
    8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-158 AND SER-184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-158 AND SER-184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGLC8_YEAST
    AccessioniPrimary (citable) accession number: P41818
    Secondary accession number(s): D6W0D8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3440 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3