Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P41818

- GLC8_YEAST

UniProt

P41818 - GLC8_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein GLC8

Gene

GLC8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Modulator of GLC7 type-1 protein phosphatase.

GO - Molecular functioni

  1. enzyme activator activity Source: SGD
  2. protein phosphatase inhibitor activity Source: InterPro

GO - Biological processi

  1. chromosome segregation Source: SGD
  2. glycogen biosynthetic process Source: SGD
  3. positive regulation of catalytic activity Source: GOC
  4. regulation of phosphoprotein phosphatase activity Source: InterPro
  5. regulation of signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Enzyme and pathway databases

BioCyciYEAST:G3O-32975-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GLC8
Gene namesi
Name:GLC8
Ordered Locus Names:YMR311C
ORF Names:YM9924.03C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR311c.
SGDiS000004928. GLC8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Protein GLC8PRO_0000071517Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121Phosphoserine3 Publications
Modified residuei118 – 1181Phosphothreonine; by PHO851 Publication
Modified residuei158 – 1581Phosphoserine3 Publications
Modified residuei184 – 1841Phosphoserine2 Publications

Post-translational modificationi

Phosphorylated by the cyclin-CDKs PCL6-PHO85 and PCL7-PHO85. Phosphorylation of Thr-118 inactivates GLC8.5 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP41818.
PaxDbiP41818.
PeptideAtlasiP41818.

Expressioni

Gene expression databases

GenevestigatoriP41818.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GLC7P325983EBI-7629,EBI-13715

Protein-protein interaction databases

BioGridi35491. 42 interactions.
DIPiDIP-2349N.
IntActiP41818. 1 interaction.
MINTiMINT-674661.
STRINGi4932.YMR311C.

Structurei

3D structure databases

ProteinModelPortaliP41818.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG43787.
HOGENOMiHOG000000770.
InParanoidiP41818.
KOiK16833.
OMAiENDEDSP.
OrthoDBiEOG71P2P8.

Family and domain databases

InterProiIPR007062. PPI-2.
[Graphical view]
PfamiPF04979. IPP-2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41818-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGGILKNPLA LSPEQLAQQD PETLEEFRRQ VYENTQKNAK LTSHKRNIPG
60 70 80 90 100
LDNTKEEGEI IGTSSTFLPK DTLSLKHEQD MLAKMTPEER VQWNQRNLAE
110 120 130 140 150
NEITKKQFQD IHIDEPKTPY QGAVDPHGEY YRVDDDEDED NSDKKPCQVA
160 170 180 190 200
NDDIDDLSLG EPEFEIKENK QPDFETNDEN DEDSPEARHK KFEEMRKKHY
210 220
DVRAIFNKKS REALKDEDED EDDSTTKEP
Length:229
Mass (Da):26,649
Last modified:November 1, 1995 - v1
Checksum:iD4017CA8B3B089C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22000 Genomic DNA. Translation: AAA53673.1.
Z54141 Genomic DNA. Translation: CAA90829.1.
AY557977 Genomic DNA. Translation: AAS56303.1.
BK006946 Genomic DNA. Translation: DAA10212.1.
PIRiS47859.
RefSeqiNP_014042.1. NM_001182822.1.

Genome annotation databases

EnsemblFungiiYMR311C; YMR311C; YMR311C.
GeneIDi855359.
KEGGisce:YMR311C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22000 Genomic DNA. Translation: AAA53673.1 .
Z54141 Genomic DNA. Translation: CAA90829.1 .
AY557977 Genomic DNA. Translation: AAS56303.1 .
BK006946 Genomic DNA. Translation: DAA10212.1 .
PIRi S47859.
RefSeqi NP_014042.1. NM_001182822.1.

3D structure databases

ProteinModelPortali P41818.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35491. 42 interactions.
DIPi DIP-2349N.
IntActi P41818. 1 interaction.
MINTi MINT-674661.
STRINGi 4932.YMR311C.

Proteomic databases

MaxQBi P41818.
PaxDbi P41818.
PeptideAtlasi P41818.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR311C ; YMR311C ; YMR311C .
GeneIDi 855359.
KEGGi sce:YMR311C.

Organism-specific databases

CYGDi YMR311c.
SGDi S000004928. GLC8.

Phylogenomic databases

eggNOGi NOG43787.
HOGENOMi HOG000000770.
InParanoidi P41818.
KOi K16833.
OMAi ENDEDSP.
OrthoDBi EOG71P2P8.

Enzyme and pathway databases

BioCyci YEAST:G3O-32975-MONOMER.

Miscellaneous databases

NextBioi 979127.

Gene expression databases

Genevestigatori P41818.

Family and domain databases

InterProi IPR007062. PPI-2.
[Graphical view ]
Pfami PF04979. IPP-2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of glycogen-deficient glc mutants of Saccharomyces cerevisiae."
    Cannon J.F., Pringle J.R., Fiechter A., Khalil M.
    Genetics 136:485-503(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Pho85 phosphorylates the Glc7 protein phosphatase regulator Glc8 in vivo."
    Tan Y.S.H., Morcos P.A., Cannon J.F.
    J. Biol. Chem. 278:147-153(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-118.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
    Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
    Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: YAL6B.
  8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-158 AND SER-184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-158 AND SER-184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGLC8_YEAST
AccessioniPrimary (citable) accession number: P41818
Secondary accession number(s): D6W0D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3440 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3