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Protein

Homeobox protein CUP9

Gene

CUP9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable DNA-binding protein which plays a role in protecting yeast cells against copper toxicity. May regulate the expression of important copper homeostatic genes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi162 – 22463Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34072-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CUP9
Gene namesi
Name:CUP9
Ordered Locus Names:YPL177C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL177C.
SGDiS000006098. CUP9.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Homeobox protein CUP9PRO_0000048859Add
BLAST

Proteomic databases

MaxQBiP41817.

Interactioni

GO - Molecular functioni

  • RNA polymerase II repressing transcription factor binding Source: SGD

Protein-protein interaction databases

BioGridi36006. 70 interactions.
DIPiDIP-7745N.
IntActiP41817. 1 interaction.
MINTiMINT-2784076.

Structurei

3D structure databases

ProteinModelPortaliP41817.
SMRiP41817. Positions 169-219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/CUP9 homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00550000074260.
InParanoidiP41817.
OrthoDBiEOG7BP8FC.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYNCEIQNR NSKNVDNQVS LPPIQVLFNS IEKRSMPELA FSNIEYSHGN
60 70 80 90 100
LRSSTEEQNY PAPVLLPQHH SIAYPAINSG GTSTTATPTA STVETSKTSS
110 120 130 140 150
SAMDTQSQYG SSKKSKSASD DAKPCYKSAP IYEIINKEKD AGAQYNRPFS
160 170 180 190 200
DFVESKSRRK QNSGRRSNLP KETVQILNTW LLNHLNNPYP TQQEKRELLI
210 220 230 240 250
KTGLTKIQLS NWFINVRRRK IFSDYYTLVN SIPNDNANNT PVERVQNVSA
260 270 280 290 300
YHNTLSATNN TMYDATSTCS TDYELSKRFA HAPVTRRKKL IDRLEELKKL

SNPDMN
Length:306
Mass (Da):34,654
Last modified:November 1, 1995 - v1
Checksum:i898ABAF32919302E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36815 Genomic DNA. Translation: AAA66189.1.
Z73533 Genomic DNA. Translation: CAA97884.1.
AY692914 Genomic DNA. Translation: AAT92933.1.
BK006949 Genomic DNA. Translation: DAA11257.1.
PIRiA56344.
RefSeqiNP_015148.1. NM_001183991.1.

Genome annotation databases

EnsemblFungiiYPL177C; YPL177C; YPL177C.
GeneIDi855926.
KEGGisce:YPL177C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36815 Genomic DNA. Translation: AAA66189.1.
Z73533 Genomic DNA. Translation: CAA97884.1.
AY692914 Genomic DNA. Translation: AAT92933.1.
BK006949 Genomic DNA. Translation: DAA11257.1.
PIRiA56344.
RefSeqiNP_015148.1. NM_001183991.1.

3D structure databases

ProteinModelPortaliP41817.
SMRiP41817. Positions 169-219.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36006. 70 interactions.
DIPiDIP-7745N.
IntActiP41817. 1 interaction.
MINTiMINT-2784076.

Proteomic databases

MaxQBiP41817.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL177C; YPL177C; YPL177C.
GeneIDi855926.
KEGGisce:YPL177C.

Organism-specific databases

EuPathDBiFungiDB:YPL177C.
SGDiS000006098. CUP9.

Phylogenomic databases

GeneTreeiENSGT00550000074260.
InParanoidiP41817.
OrthoDBiEOG7BP8FC.

Enzyme and pathway databases

BioCyciYEAST:G3O-34072-MONOMER.

Miscellaneous databases

NextBioi980657.
PROiP41817.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and analysis of a Saccharomyces cerevisiae copper homeostasis gene encoding a homeodomain protein."
    Knight S.A.B., Tamai K.T., Kosman D.J., Thiele D.J.
    Mol. Cell. Biol. 14:7792-7804(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DTY86.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCUP9_YEAST
AccessioniPrimary (citable) accession number: P41817
Secondary accession number(s): D6W3J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 521 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.