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Protein

Homeobox protein CUP9

Gene

CUP9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable DNA-binding protein which plays a role in protecting yeast cells against copper toxicity. May regulate the expression of important copper homeostatic genes.

Miscellaneous

Present with 521 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi162 – 224Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34072-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CUP9
Gene namesi
Name:CUP9
Ordered Locus Names:YPL177C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL177C
SGDiS000006098 CUP9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488591 – 306Homeobox protein CUP9Add BLAST306

Proteomic databases

MaxQBiP41817
PaxDbiP41817
PRIDEiP41817

Interactioni

GO - Molecular functioni

  • RNA polymerase II repressing transcription factor binding Source: SGD

Protein-protein interaction databases

BioGridi36006, 132 interactors
DIPiDIP-7745N
IntActiP41817, 2 interactors
MINTiP41817
STRINGi4932.YPL177C

Structurei

3D structure databases

ProteinModelPortaliP41817
SMRiP41817
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/CUP9 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00550000074260
InParanoidiP41817
OrthoDBiEOG092C582M

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P41817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYNCEIQNR NSKNVDNQVS LPPIQVLFNS IEKRSMPELA FSNIEYSHGN
60 70 80 90 100
LRSSTEEQNY PAPVLLPQHH SIAYPAINSG GTSTTATPTA STVETSKTSS
110 120 130 140 150
SAMDTQSQYG SSKKSKSASD DAKPCYKSAP IYEIINKEKD AGAQYNRPFS
160 170 180 190 200
DFVESKSRRK QNSGRRSNLP KETVQILNTW LLNHLNNPYP TQQEKRELLI
210 220 230 240 250
KTGLTKIQLS NWFINVRRRK IFSDYYTLVN SIPNDNANNT PVERVQNVSA
260 270 280 290 300
YHNTLSATNN TMYDATSTCS TDYELSKRFA HAPVTRRKKL IDRLEELKKL

SNPDMN
Length:306
Mass (Da):34,654
Last modified:November 1, 1995 - v1
Checksum:i898ABAF32919302E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36815 Genomic DNA Translation: AAA66189.1
Z73533 Genomic DNA Translation: CAA97884.1
AY692914 Genomic DNA Translation: AAT92933.1
BK006949 Genomic DNA Translation: DAA11257.1
PIRiA56344
RefSeqiNP_015148.1, NM_001183991.1

Genome annotation databases

EnsemblFungiiYPL177C; YPL177C; YPL177C
GeneIDi855926
KEGGisce:YPL177C

Similar proteinsi

Entry informationi

Entry nameiCUP9_YEAST
AccessioniPrimary (citable) accession number: P41817
Secondary accession number(s): D6W3J1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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