Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein CUP9

Gene

CUP9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable DNA-binding protein which plays a role in protecting yeast cells against copper toxicity. May regulate the expression of important copper homeostatic genes.

Miscellaneous

Present with 521 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi162 – 224Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34072-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CUP9
Gene namesi
Name:CUP9
Ordered Locus Names:YPL177C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL177C.
SGDiS000006098. CUP9.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488591 – 306Homeobox protein CUP9Add BLAST306

Proteomic databases

MaxQBiP41817.
PRIDEiP41817.

Interactioni

GO - Molecular functioni

  • RNA polymerase II repressing transcription factor binding Source: SGD

Protein-protein interaction databases

BioGridi36006. 130 interactors.
DIPiDIP-7745N.
IntActiP41817. 1 interactor.
MINTiMINT-2784076.
STRINGi4932.YPL177C.

Structurei

3D structure databases

ProteinModelPortaliP41817.
SMRiP41817.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/CUP9 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00550000074260.
InParanoidiP41817.
OrthoDBiEOG092C582M.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
PfamiView protein in Pfam
PF05920. Homeobox_KN. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P41817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYNCEIQNR NSKNVDNQVS LPPIQVLFNS IEKRSMPELA FSNIEYSHGN
60 70 80 90 100
LRSSTEEQNY PAPVLLPQHH SIAYPAINSG GTSTTATPTA STVETSKTSS
110 120 130 140 150
SAMDTQSQYG SSKKSKSASD DAKPCYKSAP IYEIINKEKD AGAQYNRPFS
160 170 180 190 200
DFVESKSRRK QNSGRRSNLP KETVQILNTW LLNHLNNPYP TQQEKRELLI
210 220 230 240 250
KTGLTKIQLS NWFINVRRRK IFSDYYTLVN SIPNDNANNT PVERVQNVSA
260 270 280 290 300
YHNTLSATNN TMYDATSTCS TDYELSKRFA HAPVTRRKKL IDRLEELKKL

SNPDMN
Length:306
Mass (Da):34,654
Last modified:November 1, 1995 - v1
Checksum:i898ABAF32919302E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36815 Genomic DNA. Translation: AAA66189.1.
Z73533 Genomic DNA. Translation: CAA97884.1.
AY692914 Genomic DNA. Translation: AAT92933.1.
BK006949 Genomic DNA. Translation: DAA11257.1.
PIRiA56344.
RefSeqiNP_015148.1. NM_001183991.1.

Genome annotation databases

EnsemblFungiiYPL177C; YPL177C; YPL177C.
GeneIDi855926.
KEGGisce:YPL177C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCUP9_YEAST
AccessioniPrimary (citable) accession number: P41817
Secondary accession number(s): D6W3J1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 5, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names