Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADPH dehydrogenase 3

Gene

OYE3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Oxidizes beta-NADH, beta-NADPH, and alpha-NADPH.

Catalytic activityi

NADPH + acceptor = NADP+ + reduced acceptor.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38FMNBy similarity1
Binding sitei192FMNBy similarity1
Binding sitei192SubstrateBy similarity1
Binding sitei195SubstrateBy similarity1
Active sitei197Proton donorBy similarity1
Binding sitei244FMNBy similarity1
Binding sitei349FMNBy similarity1
Binding sitei376SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: SGD

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN, NADP

Enzyme and pathway databases

BioCyciYEAST:YPL171C-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH dehydrogenase 3 (EC:1.6.99.1)
Alternative name(s):
Old yellow enzyme 3
Gene namesi
Name:OYE3
Ordered Locus Names:YPL171C
ORF Names:P2291
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL171C
SGDiS000006092 OYE3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001944751 – 400NADPH dehydrogenase 3Add BLAST400

Proteomic databases

PaxDbiP41816
PRIDEiP41816

Interactioni

Subunit structurei

Homodimer or heterodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
OYE2Q035582EBI-12734,EBI-12729

Protein-protein interaction databases

BioGridi36012, 105 interactors
DIPiDIP-6338N
IntActiP41816, 7 interactors
STRINGi4932.YPL171C

Structurei

Secondary structure

1400
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 18Combined sources3
Beta strandi21 – 23Combined sources3
Beta strandi26 – 30Combined sources5
Beta strandi32 – 34Combined sources3
Turni44 – 47Combined sources4
Turni51 – 53Combined sources3
Helixi54 – 61Combined sources8
Beta strandi68 – 70Combined sources3
Beta strandi74 – 77Combined sources4
Helixi78 – 80Combined sources3
Helixi92 – 107Combined sources16
Beta strandi111 – 117Combined sources7
Helixi120 – 122Combined sources3
Helixi125 – 130Combined sources6
Beta strandi135 – 138Combined sources4
Helixi146 – 154Combined sources9
Beta strandi159 – 161Combined sources3
Helixi164 – 183Combined sources20
Beta strandi187 – 192Combined sources6
Helixi198 – 203Combined sources6
Turni205 – 207Combined sources3
Beta strandi215 – 217Combined sources3
Helixi218 – 221Combined sources4
Helixi223 – 236Combined sources14
Helixi238 – 240Combined sources3
Beta strandi241 – 245Combined sources5
Turni251 – 253Combined sources3
Helixi256 – 258Combined sources3
Helixi262 – 278Combined sources17
Beta strandi284 – 289Combined sources6
Helixi311 – 316Combined sources6
Beta strandi321 – 326Combined sources6
Helixi331 – 337Combined sources7
Beta strandi343 – 346Combined sources4
Helixi349 – 353Combined sources5
Helixi357 – 363Combined sources7
Helixi372 – 374Combined sources3
Beta strandi375 – 380Combined sources6
Turni381 – 383Combined sources3
Helixi389 – 394Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5V4PX-ray1.88A/B1-400[»]
5V4VX-ray1.80A/B1-400[»]
ProteinModelPortaliP41816
SMRiP41816
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00530000064642
HOGENOMiHOG000116231
InParanoidiP41816
KOiK00354
OMAiQHRIGMA
OrthoDBiEOG092C24WI

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001155 OxRdtase_FMN_N
PfamiView protein in Pfam
PF00724 Oxidored_FMN, 1 hit

Sequencei

Sequence statusi: Complete.

P41816-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFVKGFEPI SLRDTNLFEP IKIGNTQLAH RAVMPPLTRM RATHPGNIPN
60 70 80 90 100
KEWAAVYYGQ RAQRPGTMII TEGTFISPQA GGYDNAPGIW SDEQVAEWKN
110 120 130 140 150
IFLAIHDCQS FAWVQLWSLG WASFPDVLAR DGLRYDCASD RVYMNATLQE
160 170 180 190 200
KAKDANNLEH SLTKDDIKQY IKDYIHAAKN SIAAGADGVE IHSANGYLLN
210 220 230 240 250
QFLDPHSNKR TDEYGGTIEN RARFTLEVVD ALIETIGPER VGLRLSPYGT
260 270 280 290 300
FNSMSGGAEP GIIAQYSYVL GELEKRAKAG KRLAFVHLVE PRVTDPSLVE
310 320 330 340 350
GEGEYSEGTN DFAYSIWKGP IIRAGNYALH PEVVREQVKD PRTLIGYGRF
360 370 380 390 400
FISNPDLVYR LEEGLPLNKY DRSTFYTMSA EGYTDYPTYE EAVDLGWNKN
Length:400
Mass (Da):44,920
Last modified:January 23, 2007 - v2
Checksum:iCC66CAC4B0748FE1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78P → S in AAT93245 (PubMed:17322287).Curated1

Mass spectrometryi

Molecular mass is 44788 Da from positions 2 - 400. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29279 Genomic DNA Translation: AAA64522.1
Z73526 Genomic DNA Translation: CAA97877.1
Z73527 Genomic DNA Translation: CAA97878.1
AY693226 Genomic DNA Translation: AAT93245.1
X96770 Genomic DNA Translation: CAA65573.1
BK006949 Genomic DNA Translation: DAA11263.1
PIRiA55569
RefSeqiNP_015154.1, NM_001183985.1

Genome annotation databases

EnsemblFungiiYPL171C; YPL171C; YPL171C
GeneIDi855932
KEGGisce:YPL171C

Similar proteinsi

Entry informationi

Entry nameiOYE3_YEAST
AccessioniPrimary (citable) accession number: P41816
Secondary accession number(s): D6W3J7, E9P937
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health