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Protein

NADPH dehydrogenase 3

Gene

OYE3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Oxidizes beta-NADH, beta-NADPH, and alpha-NADPH.

Catalytic activityi

NADPH + acceptor = NADP+ + reduced acceptor.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38FMNBy similarity1
Binding sitei192FMNBy similarity1
Binding sitei192SubstrateBy similarity1
Binding sitei195SubstrateBy similarity1
Active sitei197Proton donorBy similarity1
Binding sitei244FMNBy similarity1
Binding sitei349FMNBy similarity1
Binding sitei376SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN, NADP

Enzyme and pathway databases

BioCyciYEAST:YPL171C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH dehydrogenase 3 (EC:1.6.99.1)
Alternative name(s):
Old yellow enzyme 3
Gene namesi
Name:OYE3
Ordered Locus Names:YPL171C
ORF Names:P2291
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL171C.
SGDiS000006092. OYE3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001944751 – 400NADPH dehydrogenase 3Add BLAST400

Proteomic databases

PRIDEiP41816.

Interactioni

Subunit structurei

Homodimer or heterodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
OYE2Q035582EBI-12734,EBI-12729

Protein-protein interaction databases

BioGridi36012. 44 interactors.
DIPiDIP-6338N.
IntActiP41816. 6 interactors.
MINTiMINT-4083787.

Structurei

3D structure databases

ProteinModelPortaliP41816.
SMRiP41816.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000116231.
InParanoidiP41816.
KOiK00354.
OrthoDBiEOG092C24WI.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
PfamiPF00724. Oxidored_FMN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41816-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFVKGFEPI SLRDTNLFEP IKIGNTQLAH RAVMPPLTRM RATHPGNIPN
60 70 80 90 100
KEWAAVYYGQ RAQRPGTMII TEGTFISPQA GGYDNAPGIW SDEQVAEWKN
110 120 130 140 150
IFLAIHDCQS FAWVQLWSLG WASFPDVLAR DGLRYDCASD RVYMNATLQE
160 170 180 190 200
KAKDANNLEH SLTKDDIKQY IKDYIHAAKN SIAAGADGVE IHSANGYLLN
210 220 230 240 250
QFLDPHSNKR TDEYGGTIEN RARFTLEVVD ALIETIGPER VGLRLSPYGT
260 270 280 290 300
FNSMSGGAEP GIIAQYSYVL GELEKRAKAG KRLAFVHLVE PRVTDPSLVE
310 320 330 340 350
GEGEYSEGTN DFAYSIWKGP IIRAGNYALH PEVVREQVKD PRTLIGYGRF
360 370 380 390 400
FISNPDLVYR LEEGLPLNKY DRSTFYTMSA EGYTDYPTYE EAVDLGWNKN
Length:400
Mass (Da):44,920
Last modified:January 23, 2007 - v2
Checksum:iCC66CAC4B0748FE1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78P → S in AAT93245 (PubMed:17322287).Curated1

Mass spectrometryi

Molecular mass is 44788 Da from positions 2 - 400. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29279 Genomic DNA. Translation: AAA64522.1.
Z73526 Genomic DNA. Translation: CAA97877.1.
Z73527 Genomic DNA. Translation: CAA97878.1.
AY693226 Genomic DNA. Translation: AAT93245.1.
X96770 Genomic DNA. Translation: CAA65573.1.
BK006949 Genomic DNA. Translation: DAA11263.1.
PIRiA55569.
RefSeqiNP_015154.1. NM_001183985.1.

Genome annotation databases

EnsemblFungiiYPL171C; YPL171C; YPL171C.
GeneIDi855932.
KEGGisce:YPL171C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29279 Genomic DNA. Translation: AAA64522.1.
Z73526 Genomic DNA. Translation: CAA97877.1.
Z73527 Genomic DNA. Translation: CAA97878.1.
AY693226 Genomic DNA. Translation: AAT93245.1.
X96770 Genomic DNA. Translation: CAA65573.1.
BK006949 Genomic DNA. Translation: DAA11263.1.
PIRiA55569.
RefSeqiNP_015154.1. NM_001183985.1.

3D structure databases

ProteinModelPortaliP41816.
SMRiP41816.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36012. 44 interactors.
DIPiDIP-6338N.
IntActiP41816. 6 interactors.
MINTiMINT-4083787.

Proteomic databases

PRIDEiP41816.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL171C; YPL171C; YPL171C.
GeneIDi855932.
KEGGisce:YPL171C.

Organism-specific databases

EuPathDBiFungiDB:YPL171C.
SGDiS000006092. OYE3.

Phylogenomic databases

HOGENOMiHOG000116231.
InParanoidiP41816.
KOiK00354.
OrthoDBiEOG092C24WI.

Enzyme and pathway databases

BioCyciYEAST:YPL171C-MONOMER.

Miscellaneous databases

PROiP41816.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
PfamiPF00724. Oxidored_FMN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOYE3_YEAST
AccessioniPrimary (citable) accession number: P41816
Secondary accession number(s): D6W3J7, E9P937
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.