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Protein

Valine amino-acid permease

Gene

BAP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transport of isoleucine, leucine, valine, cysteine, methionine, phenylalanine, tyrosine and tryptophan.2 Publications

GO - Molecular functioni

  • amino acid transmembrane transporter activity Source: SGD

GO - Biological processi

  • amino acid transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29659-MONOMER.

Protein family/group databases

TCDBi2.A.3.10.27. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Valine amino-acid permease
Alternative name(s):
Branched-chain amino-acid permease 3
Gene namesi
Name:BAP3
Synonyms:PAP1
Ordered Locus Names:YDR046C
ORF Names:YD9609.02C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR046C.
SGDiS000002453. BAP3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9595CytoplasmicSequence analysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence analysisAdd
BLAST
Topological domaini117 – 1193ExtracellularSequence analysis
Transmembranei120 – 14021HelicalSequence analysisAdd
BLAST
Topological domaini141 – 16929CytoplasmicSequence analysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence analysisAdd
BLAST
Topological domaini191 – 20616ExtracellularSequence analysisAdd
BLAST
Transmembranei207 – 22721HelicalSequence analysisAdd
BLAST
Topological domaini228 – 23811CytoplasmicSequence analysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST
Topological domaini260 – 28425ExtracellularSequence analysisAdd
BLAST
Transmembranei285 – 30521HelicalSequence analysisAdd
BLAST
Topological domaini306 – 32318CytoplasmicSequence analysisAdd
BLAST
Transmembranei324 – 34421HelicalSequence analysisAdd
BLAST
Topological domaini345 – 37733ExtracellularSequence analysisAdd
BLAST
Transmembranei378 – 39821HelicalSequence analysisAdd
BLAST
Topological domaini399 – 42325CytoplasmicSequence analysisAdd
BLAST
Transmembranei424 – 44421HelicalSequence analysisAdd
BLAST
Topological domaini445 – 4495ExtracellularSequence analysis
Transmembranei450 – 47021HelicalSequence analysisAdd
BLAST
Topological domaini471 – 50232CytoplasmicSequence analysisAdd
BLAST
Transmembranei503 – 52321HelicalSequence analysisAdd
BLAST
Topological domaini524 – 5318ExtracellularSequence analysis
Transmembranei532 – 55221HelicalSequence analysisAdd
BLAST
Topological domaini553 – 60452CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 604604Valine amino-acid permeasePRO_0000054147Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphoserineBy similarity
Modified residuei79 – 791PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PeptideAtlasiP41815.

Interactioni

Protein-protein interaction databases

BioGridi32101. 17 interactions.
DIPiDIP-7900N.
IntActiP41815. 11 interactions.
MINTiMINT-1355630.

Structurei

3D structure databases

ProteinModelPortaliP41815.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiP41815.
OMAiATTWLFC.
OrthoDBiEOG74J9HZ.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41815-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDPIVTSSK MEKSAEFEVT DSALYNNFNT STTASLTPEI KEHSEESRNG
60 70 80 90 100
LVHRFVDSFR RAESQRLEED NDLEDGTKSM KSNNHLKKSM KSRHVVMMSL
110 120 130 140 150
GTGIGTGLLV ANAKGLSLAG PGSLVIGYVM VSFVTYFMVQ AAGEMGVTYP
160 170 180 190 200
TLPGNFNAYN SIFISKSFGF ATTWLFCIQW LTVLPLELIT SSMTVKYWND
210 220 230 240 250
TINADVFIVI FYVFLLFIHF FGVKAYGETE FIFNSCKILM VAGFIILSVV
260 270 280 290 300
INCGGAGVDG YIGGKYWRDP GSFAEGSGAT RFKGICYILV SAYFSFGGIE
310 320 330 340 350
LFVLSINEQS NPRKSTPVAA KRSVYRILII YLLTMILIGF NVPHNNDQLM
360 370 380 390 400
GSGGSATHAS PYVLAASIHK VRVIPHIINA VILISVISVA NSALYAAPRL
410 420 430 440 450
MCSLAQQGYA PKFLNYIDRE GRPLRALVVC SLVGVVGFVA CSPQEEQAFT
460 470 480 490 500
WLAAIAGLSE LFTWSGIMLS HIRFRKAMKV QGRSLDEVGY KANTGIWGSY
510 520 530 540 550
YGVFFNMLVF MAQFWVALSP IGNGGKCDAQ AFFESYLAAP LWIFMYVGYM
560 570 580 590 600
VYKRDFTFLN PLDKIDLDFH RRVYDPEIMR QEDEENKERL KNSSIFVRVY

KFWC
Length:604
Mass (Da):67,365
Last modified:October 1, 1996 - v2
Checksum:i49A16DE4BA6B6E8A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti573 – 5753VYD → GLR in CAA52970 (PubMed:8200527).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75076 Genomic DNA. Translation: CAA52970.1.
Z49209 Genomic DNA. Translation: CAA89077.1.
BK006938 Genomic DNA. Translation: DAA11894.1.
PIRiS54032.
RefSeqiNP_010331.3. NM_001180354.3.

Genome annotation databases

EnsemblFungiiYDR046C; YDR046C; YDR046C.
GeneIDi851616.
KEGGisce:YDR046C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75076 Genomic DNA. Translation: CAA52970.1.
Z49209 Genomic DNA. Translation: CAA89077.1.
BK006938 Genomic DNA. Translation: DAA11894.1.
PIRiS54032.
RefSeqiNP_010331.3. NM_001180354.3.

3D structure databases

ProteinModelPortaliP41815.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32101. 17 interactions.
DIPiDIP-7900N.
IntActiP41815. 11 interactions.
MINTiMINT-1355630.

Protein family/group databases

TCDBi2.A.3.10.27. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PeptideAtlasiP41815.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR046C; YDR046C; YDR046C.
GeneIDi851616.
KEGGisce:YDR046C.

Organism-specific databases

EuPathDBiFungiDB:YDR046C.
SGDiS000002453. BAP3.

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiP41815.
OMAiATTWLFC.
OrthoDBiEOG74J9HZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-29659-MONOMER.

Miscellaneous databases

NextBioi969142.
PROiP41815.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal organization of a gene encoding a putative amino-acid permease from Saccharomyces cerevisiae."
    Mai B., Lipp M.
    Gene 143:129-133(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-575.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Cysteine uptake by Saccharomyces cerevisiae is accomplished by multiple permeases."
    During-Olsen L., Regenberg B., Gjermansen C., Kielland-Brandt M.C., Hansen J.
    Curr. Genet. 35:609-617(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN L-CYSTEINE UPTAKE.
  5. "Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae."
    Regenberg B., During-Olsen L., Kielland-Brandt M.C., Holmberg S.
    Curr. Genet. 36:317-328(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiBAP3_YEAST
AccessioniPrimary (citable) accession number: P41815
Secondary accession number(s): D6VS34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: May 11, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.