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Protein

Valine amino-acid permease

Gene

BAP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transport of isoleucine, leucine, valine, cysteine, methionine, phenylalanine, tyrosine and tryptophan.2 Publications

GO - Molecular functioni

GO - Biological processi

  • amino acid transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29659-MONOMER.

Protein family/group databases

TCDBi2.A.3.10.27. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Valine amino-acid permease
Alternative name(s):
Branched-chain amino-acid permease 3
Gene namesi
Name:BAP3
Synonyms:PAP1
Ordered Locus Names:YDR046C
ORF Names:YD9609.02C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR046C.
SGDiS000002453. BAP3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 95CytoplasmicSequence analysisAdd BLAST95
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Topological domaini117 – 119ExtracellularSequence analysis3
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 169CytoplasmicSequence analysisAdd BLAST29
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 206ExtracellularSequence analysisAdd BLAST16
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 238CytoplasmicSequence analysisAdd BLAST11
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 284ExtracellularSequence analysisAdd BLAST25
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Topological domaini306 – 323CytoplasmicSequence analysisAdd BLAST18
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Topological domaini345 – 377ExtracellularSequence analysisAdd BLAST33
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Topological domaini399 – 423CytoplasmicSequence analysisAdd BLAST25
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445 – 449ExtracellularSequence analysis5
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471 – 502CytoplasmicSequence analysisAdd BLAST32
Transmembranei503 – 523HelicalSequence analysisAdd BLAST21
Topological domaini524 – 531ExtracellularSequence analysis8
Transmembranei532 – 552HelicalSequence analysisAdd BLAST21
Topological domaini553 – 604CytoplasmicSequence analysisAdd BLAST52

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
  • vacuole Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541471 – 604Valine amino-acid permeaseAdd BLAST604

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei79PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP41815.

Interactioni

Protein-protein interaction databases

BioGridi32101. 17 interactors.
DIPiDIP-7900N.
IntActiP41815. 11 interactors.
MINTiMINT-1355630.

Structurei

3D structure databases

ProteinModelPortaliP41815.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiP41815.
OMAiATTWLFC.
OrthoDBiEOG092C164R.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41815-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDPIVTSSK MEKSAEFEVT DSALYNNFNT STTASLTPEI KEHSEESRNG
60 70 80 90 100
LVHRFVDSFR RAESQRLEED NDLEDGTKSM KSNNHLKKSM KSRHVVMMSL
110 120 130 140 150
GTGIGTGLLV ANAKGLSLAG PGSLVIGYVM VSFVTYFMVQ AAGEMGVTYP
160 170 180 190 200
TLPGNFNAYN SIFISKSFGF ATTWLFCIQW LTVLPLELIT SSMTVKYWND
210 220 230 240 250
TINADVFIVI FYVFLLFIHF FGVKAYGETE FIFNSCKILM VAGFIILSVV
260 270 280 290 300
INCGGAGVDG YIGGKYWRDP GSFAEGSGAT RFKGICYILV SAYFSFGGIE
310 320 330 340 350
LFVLSINEQS NPRKSTPVAA KRSVYRILII YLLTMILIGF NVPHNNDQLM
360 370 380 390 400
GSGGSATHAS PYVLAASIHK VRVIPHIINA VILISVISVA NSALYAAPRL
410 420 430 440 450
MCSLAQQGYA PKFLNYIDRE GRPLRALVVC SLVGVVGFVA CSPQEEQAFT
460 470 480 490 500
WLAAIAGLSE LFTWSGIMLS HIRFRKAMKV QGRSLDEVGY KANTGIWGSY
510 520 530 540 550
YGVFFNMLVF MAQFWVALSP IGNGGKCDAQ AFFESYLAAP LWIFMYVGYM
560 570 580 590 600
VYKRDFTFLN PLDKIDLDFH RRVYDPEIMR QEDEENKERL KNSSIFVRVY

KFWC
Length:604
Mass (Da):67,365
Last modified:October 1, 1996 - v2
Checksum:i49A16DE4BA6B6E8A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti573 – 575VYD → GLR in CAA52970 (PubMed:8200527).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75076 Genomic DNA. Translation: CAA52970.1.
Z49209 Genomic DNA. Translation: CAA89077.1.
BK006938 Genomic DNA. Translation: DAA11894.1.
PIRiS54032.
RefSeqiNP_010331.3. NM_001180354.3.

Genome annotation databases

EnsemblFungiiYDR046C; YDR046C; YDR046C.
GeneIDi851616.
KEGGisce:YDR046C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75076 Genomic DNA. Translation: CAA52970.1.
Z49209 Genomic DNA. Translation: CAA89077.1.
BK006938 Genomic DNA. Translation: DAA11894.1.
PIRiS54032.
RefSeqiNP_010331.3. NM_001180354.3.

3D structure databases

ProteinModelPortaliP41815.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32101. 17 interactors.
DIPiDIP-7900N.
IntActiP41815. 11 interactors.
MINTiMINT-1355630.

Protein family/group databases

TCDBi2.A.3.10.27. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PRIDEiP41815.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR046C; YDR046C; YDR046C.
GeneIDi851616.
KEGGisce:YDR046C.

Organism-specific databases

EuPathDBiFungiDB:YDR046C.
SGDiS000002453. BAP3.

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiP41815.
OMAiATTWLFC.
OrthoDBiEOG092C164R.

Enzyme and pathway databases

BioCyciYEAST:G3O-29659-MONOMER.

Miscellaneous databases

PROiP41815.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBAP3_YEAST
AccessioniPrimary (citable) accession number: P41815
Secondary accession number(s): D6VS34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.