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Protein

Valine amino-acid permease

Gene

BAP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transport of isoleucine, leucine, valine, cysteine, methionine, phenylalanine, tyrosine and tryptophan.2 Publications

GO - Molecular functioni

  • amino acid transmembrane transporter activity Source: SGD

GO - Biological processi

  • amino acid transport Source: SGD
  • transmembrane transport Source: SGD

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29659-MONOMER

Protein family/group databases

TCDBi2.A.3.10.27 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Valine amino-acid permease
Alternative name(s):
Branched-chain amino-acid permease 3
Gene namesi
Name:BAP3
Synonyms:PAP1
Ordered Locus Names:YDR046C
ORF Names:YD9609.02C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR046C
SGDiS000002453 BAP3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 95CytoplasmicSequence analysisAdd BLAST95
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Topological domaini117 – 119ExtracellularSequence analysis3
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 169CytoplasmicSequence analysisAdd BLAST29
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 206ExtracellularSequence analysisAdd BLAST16
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 238CytoplasmicSequence analysisAdd BLAST11
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 284ExtracellularSequence analysisAdd BLAST25
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Topological domaini306 – 323CytoplasmicSequence analysisAdd BLAST18
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Topological domaini345 – 377ExtracellularSequence analysisAdd BLAST33
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Topological domaini399 – 423CytoplasmicSequence analysisAdd BLAST25
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445 – 449ExtracellularSequence analysis5
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471 – 502CytoplasmicSequence analysisAdd BLAST32
Transmembranei503 – 523HelicalSequence analysisAdd BLAST21
Topological domaini524 – 531ExtracellularSequence analysis8
Transmembranei532 – 552HelicalSequence analysisAdd BLAST21
Topological domaini553 – 604CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541471 – 604Valine amino-acid permeaseAdd BLAST604

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei79PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP41815
PRIDEiP41815

Interactioni

Protein-protein interaction databases

BioGridi32101, 162 interactors
DIPiDIP-7900N
IntActiP41815, 11 interactors
MINTiP41815
STRINGi4932.YDR046C

Structurei

3D structure databases

ProteinModelPortaliP41815
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744
HOGENOMiHOG000261848
InParanoidiP41815
OMAiATTWLFC
OrthoDBiEOG092C164R

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004762 Amino_acid_permease_fungi
IPR004840 Amoino_acid_permease_CS
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
TIGRFAMsiTIGR00913 2A0310, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P41815-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDPIVTSSK MEKSAEFEVT DSALYNNFNT STTASLTPEI KEHSEESRNG
60 70 80 90 100
LVHRFVDSFR RAESQRLEED NDLEDGTKSM KSNNHLKKSM KSRHVVMMSL
110 120 130 140 150
GTGIGTGLLV ANAKGLSLAG PGSLVIGYVM VSFVTYFMVQ AAGEMGVTYP
160 170 180 190 200
TLPGNFNAYN SIFISKSFGF ATTWLFCIQW LTVLPLELIT SSMTVKYWND
210 220 230 240 250
TINADVFIVI FYVFLLFIHF FGVKAYGETE FIFNSCKILM VAGFIILSVV
260 270 280 290 300
INCGGAGVDG YIGGKYWRDP GSFAEGSGAT RFKGICYILV SAYFSFGGIE
310 320 330 340 350
LFVLSINEQS NPRKSTPVAA KRSVYRILII YLLTMILIGF NVPHNNDQLM
360 370 380 390 400
GSGGSATHAS PYVLAASIHK VRVIPHIINA VILISVISVA NSALYAAPRL
410 420 430 440 450
MCSLAQQGYA PKFLNYIDRE GRPLRALVVC SLVGVVGFVA CSPQEEQAFT
460 470 480 490 500
WLAAIAGLSE LFTWSGIMLS HIRFRKAMKV QGRSLDEVGY KANTGIWGSY
510 520 530 540 550
YGVFFNMLVF MAQFWVALSP IGNGGKCDAQ AFFESYLAAP LWIFMYVGYM
560 570 580 590 600
VYKRDFTFLN PLDKIDLDFH RRVYDPEIMR QEDEENKERL KNSSIFVRVY

KFWC
Length:604
Mass (Da):67,365
Last modified:October 1, 1996 - v2
Checksum:i49A16DE4BA6B6E8A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti573 – 575VYD → GLR in CAA52970 (PubMed:8200527).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75076 Genomic DNA Translation: CAA52970.1
Z49209 Genomic DNA Translation: CAA89077.1
BK006938 Genomic DNA Translation: DAA11894.1
PIRiS54032
RefSeqiNP_010331.3, NM_001180354.3

Genome annotation databases

EnsemblFungiiYDR046C; YDR046C; YDR046C
GeneIDi851616
KEGGisce:YDR046C

Similar proteinsi

Entry informationi

Entry nameiBAP3_YEAST
AccessioniPrimary (citable) accession number: P41815
Secondary accession number(s): D6VS34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health