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P41813

- FKH2_YEAST

UniProt

P41813 - FKH2_YEAST

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Protein
Fork head protein homolog 2
Gene
FKH2, YNL068C, N2403, YNL2403C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi339 – 43092Fork-head
Add
BLAST

GO - Molecular functioni

  1. DNA replication origin binding Source: SGD
  2. RNA polymerase II transcription factor binding Source: SGD
  3. RNA polymerase II transcription factor binding transcription factor activity Source: SGD
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. chromatin remodeling Source: SGD
  2. negative regulation of chromatin silencing at silent mating-type cassette Source: SGD
  3. negative regulation of pseudohyphal growth Source: SGD
  4. negative regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
  5. negative regulation of transcription involved in G2/M transition of mitotic cell cycle Source: SGD
  6. positive regulation of DNA-dependent DNA replication initiation Source: SGD
  7. positive regulation of transcription elongation from RNA polymerase II promoter Source: SGD
  8. positive regulation of transcription involved in G2/M transition of mitotic cell cycle Source: SGD
  9. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33098-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fork head protein homolog 2
Gene namesi
Name:FKH2
Ordered Locus Names:YNL068C
ORF Names:N2403, YNL2403C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL068c.
SGDiS000005012. FKH2.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. cytosol Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Fork head protein homolog 2
PRO_0000091904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei708 – 7081Phosphoserine1 Publication
Modified residuei832 – 8321Phosphoserine2 Publications
Modified residuei833 – 8331Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP41813.
PaxDbiP41813.
PeptideAtlasiP41813.
PRIDEiP41813.

Expressioni

Gene expression databases

GenevestigatoriP41813.

Interactioni

Subunit structurei

Interacts with NDD1.1 Publication

Protein-protein interaction databases

BioGridi35755. 132 interactions.
DIPiDIP-5944N.
IntActiP41813. 1 interaction.
MINTiMINT-673870.
STRINGi4932.YNL068C.

Structurei

3D structure databases

ProteinModelPortaliP41813.
SMRiP41813. Positions 340-427.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 15270FHA
Add
BLAST

Domaini

The FHA domain is necessary for the interaction with NDD1.1 Publication

Sequence similaritiesi

Contains 1 FHA domain.

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00750000117242.
HOGENOMiHOG000093809.
OMAiGMKWRIS.
OrthoDBiEOG7647BS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
SM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41813-1 [UniParc]FASTAAdd to Basket

« Hide

MSSSNFNEMN ELNMTQTNYG STKYTAQHHQ GVINAIISSL TAPDQPTTVS    50
LQYSNDKNMA TEIQAYAKLS GPNWTYYVKD LEVSIGRNTD PLNSALQENS 100
DGVKNSYRVN IDLGPAKVVS RKHAIIKYNM NIGGWELHIL GRNGAKVNFQ 150
RTHNGPNNPP IRLSSGTLLD IGGTQMMFIL PDSDPVVAPI CIEHLMPNLI 200
NMFGLEGNNN PLLRDIIKQS NYAKQRQLTS NQQIKGFKLY GSGGNAPFGS 250
GANLGPSEQG IFNNNNNSKN KNGYFTSINP NYTASTTTSN TINPQAASPQ 300
GPPNTIIAAN FVDSYKSSNA YPQALDFTSD LSHDENRNVK PPHSYATMIT 350
QAILSSPEGV ISLADIYKYI SSNYAYYRFA KSGWQNSIRH NLSLNKAFEK 400
VPRRPNEPGK GMKWRISESY QQEFLNKWNT GKVGKIRRGS SVARQLQLHM 450
AKFNSLPMEM DYRLSLNMAQ PPKRQLQSHN VLEPSNNNII EGFVQHVPSK 500
GNLPASQQSQ PPVSHQNQSQ QPPPQEQRQE IQFTFADTQN RNIALARPIK 550
TPQLQAPNSN ANLNQNNMKE YKESLHPPAI SISQMNRQSP NNALVSFTNA 600
CANSKIINNI SDSADKSTNN NGGTKMNLPA ISTSSLDENG NLEPTTTTSS 650
GNSNSVPQTG TTTSSLAANS LRLSQPYDTL LRSPTKAFHI TAMEAYTPER 700
GSANRARSPL HSNSNNTNNN GANNSNLQTS GMENKQTGLV LDSNVLKSME 750
SNNDNRRLTP STSKSQNVKS SPGVWNLLQF SSTNNTPAAD SGGNKRGFSI 800
NPDIKAKENE NATSEKDSDS NSNDLETKDI NSSPLKNQGG STANAKELIL 850
DTDGAKISII NN 862
Length:862
Mass (Da):94,374
Last modified:November 1, 1995 - v1
Checksum:i68A03F5EB7BB5CF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38850 Genomic DNA. Translation: AAA60939.1.
X86470 Genomic DNA. Translation: CAA60193.1.
Z71343 Genomic DNA. Translation: CAA95941.1.
Z71344 Genomic DNA. Translation: CAA95942.1.
U12141 Genomic DNA. Translation: AAA99643.1.
BK006947 Genomic DNA. Translation: DAA10477.1.
PIRiS53913.
RefSeqiNP_014331.3. NM_001182906.3.

Genome annotation databases

EnsemblFungiiYNL068C; YNL068C; YNL068C.
GeneIDi855656.
KEGGisce:YNL068C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38850 Genomic DNA. Translation: AAA60939.1 .
X86470 Genomic DNA. Translation: CAA60193.1 .
Z71343 Genomic DNA. Translation: CAA95941.1 .
Z71344 Genomic DNA. Translation: CAA95942.1 .
U12141 Genomic DNA. Translation: AAA99643.1 .
BK006947 Genomic DNA. Translation: DAA10477.1 .
PIRi S53913.
RefSeqi NP_014331.3. NM_001182906.3.

3D structure databases

ProteinModelPortali P41813.
SMRi P41813. Positions 340-427.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35755. 132 interactions.
DIPi DIP-5944N.
IntActi P41813. 1 interaction.
MINTi MINT-673870.
STRINGi 4932.YNL068C.

Proteomic databases

MaxQBi P41813.
PaxDbi P41813.
PeptideAtlasi P41813.
PRIDEi P41813.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL068C ; YNL068C ; YNL068C .
GeneIDi 855656.
KEGGi sce:YNL068C.

Organism-specific databases

CYGDi YNL068c.
SGDi S000005012. FKH2.

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00750000117242.
HOGENOMi HOG000093809.
OMAi GMKWRIS.
OrthoDBi EOG7647BS.

Enzyme and pathway databases

BioCyci YEAST:G3O-33098-MONOMER.

Miscellaneous databases

NextBioi 979914.

Gene expression databases

Genevestigatori P41813.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.200.20. 1 hit.
InterProi IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00498. FHA. 1 hit.
PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
SM00240. FHA. 1 hit.
[Graphical view ]
SUPFAMi SSF49879. SSF49879. 1 hit.
PROSITEi PS50006. FHA_DOMAIN. 1 hit.
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two fork head homologs in S. cerevisiae."
    Zhu G., Davis T.N.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Sequencing a cosmid clone of Saccharomyces cerevisiae chromosome XIV reveals 12 new open reading frames (ORFs) and an ancient duplication of six ORFs."
    Poehlmann R., Philippsen P.
    Yeast 12:391-402(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from Saccharomyces cerevisiae."
    Bergez P., Doignon F., Crouzet M.
    Yeast 11:967-974(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-440.
    Strain: S288c / FY1676.
  6. "Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity: a mechanism for CLB cluster gene activation."
    Reynolds D., Shi B.J., McLean C., Katsis F., Kemp B., Dalton S.
    Genes Dev. 17:1789-1802(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN, INTERACTION WITH NDD1.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832 AND SER-833, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-708; SER-832 AND SER-833, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFKH2_YEAST
AccessioniPrimary (citable) accession number: P41813
Secondary accession number(s): D6W1B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 656 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

Similar proteinsi