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P41813

- FKH2_YEAST

UniProt

P41813 - FKH2_YEAST

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Protein

Fork head protein homolog 2

Gene

FKH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi339 – 43092Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA replication origin binding Source: SGD
  2. RNA polymerase II transcription factor binding Source: SGD
  3. RNA polymerase II transcription factor binding transcription factor activity Source: SGD
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. chromatin remodeling Source: SGD
  2. negative regulation of chromatin silencing at silent mating-type cassette Source: SGD
  3. negative regulation of pseudohyphal growth Source: SGD
  4. negative regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
  5. negative regulation of transcription involved in G2/M transition of mitotic cell cycle Source: SGD
  6. positive regulation of DNA-dependent DNA replication initiation Source: SGD
  7. positive regulation of transcription elongation from RNA polymerase II promoter Source: SGD
  8. positive regulation of transcription involved in G2/M transition of mitotic cell cycle Source: SGD
  9. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33098-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fork head protein homolog 2
Gene namesi
Name:FKH2
Ordered Locus Names:YNL068C
ORF Names:N2403, YNL2403C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL068c.
SGDiS000005012. FKH2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytosol Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Fork head protein homolog 2PRO_0000091904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei708 – 7081Phosphoserine1 Publication
Modified residuei832 – 8321Phosphoserine2 Publications
Modified residuei833 – 8331Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP41813.
PaxDbiP41813.
PeptideAtlasiP41813.
PRIDEiP41813.

Expressioni

Gene expression databases

GenevestigatoriP41813.

Interactioni

Subunit structurei

Interacts with NDD1.1 Publication

Protein-protein interaction databases

BioGridi35755. 133 interactions.
DIPiDIP-5944N.
IntActiP41813. 1 interaction.
MINTiMINT-673870.
STRINGi4932.YNL068C.

Structurei

3D structure databases

ProteinModelPortaliP41813.
SMRiP41813. Positions 340-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 15270FHAPROSITE-ProRule annotationAdd
BLAST

Domaini

The FHA domain is necessary for the interaction with NDD1.1 Publication

Sequence similaritiesi

Contains 1 FHA domain.PROSITE-ProRule annotation
Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118794.
HOGENOMiHOG000093809.
InParanoidiP41813.
OMAiGMKWRIS.
OrthoDBiEOG7647BS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
SM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41813-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSSNFNEMN ELNMTQTNYG STKYTAQHHQ GVINAIISSL TAPDQPTTVS
60 70 80 90 100
LQYSNDKNMA TEIQAYAKLS GPNWTYYVKD LEVSIGRNTD PLNSALQENS
110 120 130 140 150
DGVKNSYRVN IDLGPAKVVS RKHAIIKYNM NIGGWELHIL GRNGAKVNFQ
160 170 180 190 200
RTHNGPNNPP IRLSSGTLLD IGGTQMMFIL PDSDPVVAPI CIEHLMPNLI
210 220 230 240 250
NMFGLEGNNN PLLRDIIKQS NYAKQRQLTS NQQIKGFKLY GSGGNAPFGS
260 270 280 290 300
GANLGPSEQG IFNNNNNSKN KNGYFTSINP NYTASTTTSN TINPQAASPQ
310 320 330 340 350
GPPNTIIAAN FVDSYKSSNA YPQALDFTSD LSHDENRNVK PPHSYATMIT
360 370 380 390 400
QAILSSPEGV ISLADIYKYI SSNYAYYRFA KSGWQNSIRH NLSLNKAFEK
410 420 430 440 450
VPRRPNEPGK GMKWRISESY QQEFLNKWNT GKVGKIRRGS SVARQLQLHM
460 470 480 490 500
AKFNSLPMEM DYRLSLNMAQ PPKRQLQSHN VLEPSNNNII EGFVQHVPSK
510 520 530 540 550
GNLPASQQSQ PPVSHQNQSQ QPPPQEQRQE IQFTFADTQN RNIALARPIK
560 570 580 590 600
TPQLQAPNSN ANLNQNNMKE YKESLHPPAI SISQMNRQSP NNALVSFTNA
610 620 630 640 650
CANSKIINNI SDSADKSTNN NGGTKMNLPA ISTSSLDENG NLEPTTTTSS
660 670 680 690 700
GNSNSVPQTG TTTSSLAANS LRLSQPYDTL LRSPTKAFHI TAMEAYTPER
710 720 730 740 750
GSANRARSPL HSNSNNTNNN GANNSNLQTS GMENKQTGLV LDSNVLKSME
760 770 780 790 800
SNNDNRRLTP STSKSQNVKS SPGVWNLLQF SSTNNTPAAD SGGNKRGFSI
810 820 830 840 850
NPDIKAKENE NATSEKDSDS NSNDLETKDI NSSPLKNQGG STANAKELIL
860
DTDGAKISII NN
Length:862
Mass (Da):94,374
Last modified:November 1, 1995 - v1
Checksum:i68A03F5EB7BB5CF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38850 Genomic DNA. Translation: AAA60939.1.
X86470 Genomic DNA. Translation: CAA60193.1.
Z71343 Genomic DNA. Translation: CAA95941.1.
Z71344 Genomic DNA. Translation: CAA95942.1.
U12141 Genomic DNA. Translation: AAA99643.1.
BK006947 Genomic DNA. Translation: DAA10477.1.
PIRiS53913.
RefSeqiNP_014331.3. NM_001182906.3.

Genome annotation databases

EnsemblFungiiYNL068C; YNL068C; YNL068C.
GeneIDi855656.
KEGGisce:YNL068C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38850 Genomic DNA. Translation: AAA60939.1 .
X86470 Genomic DNA. Translation: CAA60193.1 .
Z71343 Genomic DNA. Translation: CAA95941.1 .
Z71344 Genomic DNA. Translation: CAA95942.1 .
U12141 Genomic DNA. Translation: AAA99643.1 .
BK006947 Genomic DNA. Translation: DAA10477.1 .
PIRi S53913.
RefSeqi NP_014331.3. NM_001182906.3.

3D structure databases

ProteinModelPortali P41813.
SMRi P41813. Positions 340-427.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35755. 133 interactions.
DIPi DIP-5944N.
IntActi P41813. 1 interaction.
MINTi MINT-673870.
STRINGi 4932.YNL068C.

Proteomic databases

MaxQBi P41813.
PaxDbi P41813.
PeptideAtlasi P41813.
PRIDEi P41813.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL068C ; YNL068C ; YNL068C .
GeneIDi 855656.
KEGGi sce:YNL068C.

Organism-specific databases

CYGDi YNL068c.
SGDi S000005012. FKH2.

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00760000118794.
HOGENOMi HOG000093809.
InParanoidi P41813.
OMAi GMKWRIS.
OrthoDBi EOG7647BS.

Enzyme and pathway databases

BioCyci YEAST:G3O-33098-MONOMER.

Miscellaneous databases

NextBioi 979914.

Gene expression databases

Genevestigatori P41813.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.200.20. 1 hit.
InterProi IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00498. FHA. 1 hit.
PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
SM00240. FHA. 1 hit.
[Graphical view ]
SUPFAMi SSF49879. SSF49879. 1 hit.
PROSITEi PS50006. FHA_DOMAIN. 1 hit.
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two fork head homologs in S. cerevisiae."
    Zhu G., Davis T.N.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Sequencing a cosmid clone of Saccharomyces cerevisiae chromosome XIV reveals 12 new open reading frames (ORFs) and an ancient duplication of six ORFs."
    Poehlmann R., Philippsen P.
    Yeast 12:391-402(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from Saccharomyces cerevisiae."
    Bergez P., Doignon F., Crouzet M.
    Yeast 11:967-974(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-440.
    Strain: S288c / FY1676.
  6. "Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity: a mechanism for CLB cluster gene activation."
    Reynolds D., Shi B.J., McLean C., Katsis F., Kemp B., Dalton S.
    Genes Dev. 17:1789-1802(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN, INTERACTION WITH NDD1.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832 AND SER-833, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-708; SER-832 AND SER-833, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFKH2_YEAST
AccessioniPrimary (citable) accession number: P41813
Secondary accession number(s): D6W1B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 656 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3