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P41812 (POP1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleases P/MRP protein subunit POP1

EC=3.1.26.5
Alternative name(s):
RNA-processing protein POP1
RNases P/MRP 100.4 kDa subunit
Gene names
Name:POP1
Ordered Locus Names:YNL221C
ORF Names:N1285
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length875 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for processing of 5.8S rRNA (short form) at site A3 and for 5' and 3' processing of pre-tRNA. Ref.1 Ref.4

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Subunit structure

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex. Ref.1 Ref.4 Ref.7

Subcellular location

Cytoplasm. Nucleus Ref.5.

Miscellaneous

Present with 846 molecules/cell in log phase SD medium.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 875875Ribonucleases P/MRP protein subunit POP1
PRO_0000058514

Amino acid modifications

Modified residue5241Phosphothreonine Ref.8

Sequences

Sequence LengthMass (Da)Tools
P41812 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: E41EA9FFD6262FA9

FASTA875100,395
        10         20         30         40         50         60 
MSGSLSRGNG GKKVLNKNQL LKRNRIRNAR SIRAEAVAAS STKTGTPSDL SESGSKLNVD 

        70         80         90        100        110        120 
QFISSRQFEV KQLQLAMHNS KAASSTRIFQ ALPRKLRRRT ASHNVRRIPK RMRNRALREM 

       130        140        150        160        170        180 
RKSDQQDVLK GSSASSRKAH GLNAKQLYKA RMSIKLLRLA SKSTSMKLSM PPEVTSSNCH 

       190        200        210        220        230        240 
VRQKIKTLKR MIKESSTANP NIKLLNNRMG SYDCTGVNEL APIPKGRVKY TKRQKHFAWL 

       250        260        270        280        290        300 
PTHIWNAKRS HMMKRWGYQM VWAPTQKCFK LTHRLGGDTC SSDGALCMDS SYIGTIIVKD 

       310        320        330        340        350        360 
KSNDSEGDFL KSIIGKLTAE RANLRKYREG QVLFQGLIYS FNEENGEDST KPLGPCDVFW 

       370        380        390        400        410        420 
VQKDTAIIRL HPSIYTQVFN ILLQHKEKLT VQDCRYSLAS VTLKGAKALE SLASCLRSTE 

       430        440        450        460        470        480 
YSKSFEQFKM VSMITDHNAL PQRCTFAFEA IDPRHLAAPK KLNDSQRKTV NSDDILSLHE 

       490        500        510        520        530        540 
NYPQDEINAV FNELCDPESR TQSYNNQNTL KEISARRYKL LTATPNSINK TTVPFKESDD 

       550        560        570        580        590        600 
PSIPLVIIRR LKTRDWIVVL PWFWLLPLWH LLNRIPRMYH IGLRQFQQIQ YENKQLYFPD 

       610        620        630        640        650        660 
DYPFTQLGYI ENSFYKKEAS KTKWDRKPMG KRINFEKIKD IHNTKLPAYS GEIGDFFSSD 

       670        680        690        700        710        720 
WRFLQILRNG IDYLQRNDKT LELMDSKKTG QFNAQGVRDI NCVNDVLEFC KDYEAKTKAM 

       730        740        750        760        770        780 
SLSIEENIPV ALCKNRKCQF RTPDSISVNS SSFSLTFFPR CIIAVSCTLL ERGHPKDNAR 

       790        800        810        820        830        840 
IYQVPEKDLE HWLQLAKGVY RPNGRKDHDL KIPLPEVHDL IGFITSGTYH LNCGNGMGIG 

       850        860        870 
FIDHHAAIRQ PTRYVLIRNV GTNTYRLGEW SKISV 

« Hide

References

« Hide 'large scale' references
[1]"The POP1 gene encodes a protein component common to the RNase MRP and RNase P ribonucleoproteins."
Lygerou Z., Mitchell P., Petfalski E., Seraphin B., Tollervey D.
Genes Dev. 8:1423-1433(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT.
Strain: BSY295.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP."
Chamberlain J.R., Lee Y., Lane W.S., Engelke D.R.
Genes Dev. 12:1678-1690(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE RNASE P COMPLEX BY MASS SPECTROMETRY.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Characterization and purification of Saccharomyces cerevisiae RNase MRP reveals a new unique protein component."
Salinas K., Wierzbicki S., Zhou L., Schmitt M.E.
J. Biol. Chem. 280:11352-11360(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE RNASE MRP COMPLEX BY MASS SPECTROMETRY.
[8]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-524, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X80358 Genomic DNA. Translation: CAA56589.1.
Z71497 Genomic DNA. Translation: CAA96124.1.
BK006947 Genomic DNA. Translation: DAA10335.1.
PIRA53901.
RefSeqNP_014178.1. NM_001183059.1.

3D structure databases

ProteinModelPortalP41812.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35615. 29 interactions.
DIPDIP-4284N.
IntActP41812. 10 interactions.
MINTMINT-472608.
STRING4932.YNL221C.

Proteomic databases

MaxQBP41812.
PaxDbP41812.
PeptideAtlasP41812.
PRIDEP41812.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL221C; YNL221C; YNL221C.
GeneID855500.
KEGGsce:YNL221C.

Organism-specific databases

CYGDYNL221c.
SGDS000005165. POP1.

Phylogenomic databases

eggNOGNOG297409.
HOGENOMHOG000247847.
KOK01164.
OMAPPVMVED.
OrthoDBEOG7X3R0Z.

Enzyme and pathway databases

BioCycYEAST:YNL221C-MONOMER.

Gene expression databases

GenevestigatorP41812.

Family and domain databases

InterProIPR012590. POPLD.
IPR009723. RNase_P/MRP_POP1.
[Graphical view]
PfamPF06978. POP1. 1 hit.
PF08170. POPLD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio979496.
PROP41812.

Entry information

Entry namePOP1_YEAST
AccessionPrimary (citable) accession number: P41812
Secondary accession number(s): D6W0W9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD