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P41812

- POP1_YEAST

UniProt

P41812 - POP1_YEAST

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Protein
Ribonucleases P/MRP protein subunit POP1
Gene
POP1, YNL221C, N1285
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for processing of 5.8S rRNA (short form) at site A3 and for 5' and 3' processing of pre-tRNA.2 Publications

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  1. RNA binding Source: SGD
  2. ribonuclease P activity Source: UniProtKB-EC

GO - Biological processi

  1. RNA phosphodiester bond hydrolysis Source: GOC
  2. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
  3. intronic box C/D snoRNA processing Source: SGD
  4. mRNA cleavage Source: SGD
  5. rRNA processing Source: SGD
  6. tRNA 5'-leader removal Source: InterPro
  7. tRNA processing Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

rRNA processing, tRNA processing

Enzyme and pathway databases

BioCyciYEAST:YNL221C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleases P/MRP protein subunit POP1 (EC:3.1.26.5)
Alternative name(s):
RNA-processing protein POP1
RNases P/MRP 100.4 kDa subunit
Gene namesi
Name:POP1
Ordered Locus Names:YNL221C
ORF Names:N1285
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL221c.
SGDiS000005165. POP1.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleolar ribonuclease P complex Source: SGD
  3. ribonuclease MRP complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 875875Ribonucleases P/MRP protein subunit POP1
PRO_0000058514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei524 – 5241Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP41812.
PaxDbiP41812.
PeptideAtlasiP41812.
PRIDEiP41812.

Expressioni

Gene expression databases

GenevestigatoriP41812.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.3 Publications

Protein-protein interaction databases

BioGridi35615. 29 interactions.
DIPiDIP-4284N.
IntActiP41812. 10 interactions.
MINTiMINT-472608.
STRINGi4932.YNL221C.

Structurei

3D structure databases

ProteinModelPortaliP41812.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG297409.
HOGENOMiHOG000247847.
KOiK01164.
OMAiPPVMVED.
OrthoDBiEOG7X3R0Z.

Family and domain databases

InterProiIPR012590. POPLD.
IPR009723. RNase_P/MRP_POP1.
[Graphical view]
PfamiPF06978. POP1. 1 hit.
PF08170. POPLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41812-1 [UniParc]FASTAAdd to Basket

« Hide

MSGSLSRGNG GKKVLNKNQL LKRNRIRNAR SIRAEAVAAS STKTGTPSDL    50
SESGSKLNVD QFISSRQFEV KQLQLAMHNS KAASSTRIFQ ALPRKLRRRT 100
ASHNVRRIPK RMRNRALREM RKSDQQDVLK GSSASSRKAH GLNAKQLYKA 150
RMSIKLLRLA SKSTSMKLSM PPEVTSSNCH VRQKIKTLKR MIKESSTANP 200
NIKLLNNRMG SYDCTGVNEL APIPKGRVKY TKRQKHFAWL PTHIWNAKRS 250
HMMKRWGYQM VWAPTQKCFK LTHRLGGDTC SSDGALCMDS SYIGTIIVKD 300
KSNDSEGDFL KSIIGKLTAE RANLRKYREG QVLFQGLIYS FNEENGEDST 350
KPLGPCDVFW VQKDTAIIRL HPSIYTQVFN ILLQHKEKLT VQDCRYSLAS 400
VTLKGAKALE SLASCLRSTE YSKSFEQFKM VSMITDHNAL PQRCTFAFEA 450
IDPRHLAAPK KLNDSQRKTV NSDDILSLHE NYPQDEINAV FNELCDPESR 500
TQSYNNQNTL KEISARRYKL LTATPNSINK TTVPFKESDD PSIPLVIIRR 550
LKTRDWIVVL PWFWLLPLWH LLNRIPRMYH IGLRQFQQIQ YENKQLYFPD 600
DYPFTQLGYI ENSFYKKEAS KTKWDRKPMG KRINFEKIKD IHNTKLPAYS 650
GEIGDFFSSD WRFLQILRNG IDYLQRNDKT LELMDSKKTG QFNAQGVRDI 700
NCVNDVLEFC KDYEAKTKAM SLSIEENIPV ALCKNRKCQF RTPDSISVNS 750
SSFSLTFFPR CIIAVSCTLL ERGHPKDNAR IYQVPEKDLE HWLQLAKGVY 800
RPNGRKDHDL KIPLPEVHDL IGFITSGTYH LNCGNGMGIG FIDHHAAIRQ 850
PTRYVLIRNV GTNTYRLGEW SKISV 875
Length:875
Mass (Da):100,395
Last modified:November 1, 1995 - v1
Checksum:iE41EA9FFD6262FA9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80358 Genomic DNA. Translation: CAA56589.1.
Z71497 Genomic DNA. Translation: CAA96124.1.
BK006947 Genomic DNA. Translation: DAA10335.1.
PIRiA53901.
RefSeqiNP_014178.1. NM_001183059.1.

Genome annotation databases

EnsemblFungiiYNL221C; YNL221C; YNL221C.
GeneIDi855500.
KEGGisce:YNL221C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80358 Genomic DNA. Translation: CAA56589.1 .
Z71497 Genomic DNA. Translation: CAA96124.1 .
BK006947 Genomic DNA. Translation: DAA10335.1 .
PIRi A53901.
RefSeqi NP_014178.1. NM_001183059.1.

3D structure databases

ProteinModelPortali P41812.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35615. 29 interactions.
DIPi DIP-4284N.
IntActi P41812. 10 interactions.
MINTi MINT-472608.
STRINGi 4932.YNL221C.

Proteomic databases

MaxQBi P41812.
PaxDbi P41812.
PeptideAtlasi P41812.
PRIDEi P41812.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL221C ; YNL221C ; YNL221C .
GeneIDi 855500.
KEGGi sce:YNL221C.

Organism-specific databases

CYGDi YNL221c.
SGDi S000005165. POP1.

Phylogenomic databases

eggNOGi NOG297409.
HOGENOMi HOG000247847.
KOi K01164.
OMAi PPVMVED.
OrthoDBi EOG7X3R0Z.

Enzyme and pathway databases

BioCyci YEAST:YNL221C-MONOMER.

Miscellaneous databases

NextBioi 979496.
PROi P41812.

Gene expression databases

Genevestigatori P41812.

Family and domain databases

InterProi IPR012590. POPLD.
IPR009723. RNase_P/MRP_POP1.
[Graphical view ]
Pfami PF06978. POP1. 1 hit.
PF08170. POPLD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The POP1 gene encodes a protein component common to the RNase MRP and RNase P ribonucleoproteins."
    Lygerou Z., Mitchell P., Petfalski E., Seraphin B., Tollervey D.
    Genes Dev. 8:1423-1433(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT.
    Strain: BSY295.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP."
    Chamberlain J.R., Lee Y., Lane W.S., Engelke D.R.
    Genes Dev. 12:1678-1690(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE RNASE P COMPLEX BY MASS SPECTROMETRY.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Characterization and purification of Saccharomyces cerevisiae RNase MRP reveals a new unique protein component."
    Salinas K., Wierzbicki S., Zhou L., Schmitt M.E.
    J. Biol. Chem. 280:11352-11360(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RNASE MRP COMPLEX BY MASS SPECTROMETRY.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-524, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPOP1_YEAST
AccessioniPrimary (citable) accession number: P41812
Secondary accession number(s): D6W0W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 846 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

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