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Protein

Ribonucleases P/MRP protein subunit POP1

Gene

POP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for processing of 5.8S rRNA (short form) at site A3 and for 5' and 3' processing of pre-tRNA.2 Publications

Miscellaneous

Present with 846 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  • ribonuclease P activity Source: UniProtKB-EC
  • RNA binding Source: SGD

GO - Biological processi

  • intronic box C/D snoRNA processing Source: SGD
  • nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay Source: SGD
  • rRNA processing Source: SGD
  • tRNA 5'-leader removal Source: InterPro
  • tRNA processing Source: SGD

Keywordsi

Molecular functionHydrolase
Biological processrRNA processing, tRNA processing

Enzyme and pathway databases

BioCyciYEAST:YNL221C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleases P/MRP protein subunit POP1 (EC:3.1.26.5)
Alternative name(s):
RNA-processing protein POP1
RNases P/MRP 100.4 kDa subunit
Gene namesi
Name:POP1
Ordered Locus Names:YNL221C
ORF Names:N1285
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL221C.
SGDiS000005165. POP1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000585141 – 875Ribonucleases P/MRP protein subunit POP1Add BLAST875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei524PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP41812.
PRIDEiP41812.

PTM databases

iPTMnetiP41812.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35615. 329 interactors.
DIPiDIP-4284N.
IntActiP41812. 19 interactors.
MINTiMINT-472608.
STRINGi4932.YNL221C.

Structurei

3D structure databases

ProteinModelPortaliP41812.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000247847.
InParanoidiP41812.
KOiK01164.
OMAiIPKYITA.
OrthoDBiEOG092C0U6N.

Family and domain databases

InterProiView protein in InterPro
IPR012590. POPLD.
IPR009723. RNase_P/MRP_POP1.
PfamiView protein in Pfam
PF06978. POP1. 1 hit.
PF08170. POPLD. 1 hit.

Sequencei

Sequence statusi: Complete.

P41812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSLSRGNG GKKVLNKNQL LKRNRIRNAR SIRAEAVAAS STKTGTPSDL
60 70 80 90 100
SESGSKLNVD QFISSRQFEV KQLQLAMHNS KAASSTRIFQ ALPRKLRRRT
110 120 130 140 150
ASHNVRRIPK RMRNRALREM RKSDQQDVLK GSSASSRKAH GLNAKQLYKA
160 170 180 190 200
RMSIKLLRLA SKSTSMKLSM PPEVTSSNCH VRQKIKTLKR MIKESSTANP
210 220 230 240 250
NIKLLNNRMG SYDCTGVNEL APIPKGRVKY TKRQKHFAWL PTHIWNAKRS
260 270 280 290 300
HMMKRWGYQM VWAPTQKCFK LTHRLGGDTC SSDGALCMDS SYIGTIIVKD
310 320 330 340 350
KSNDSEGDFL KSIIGKLTAE RANLRKYREG QVLFQGLIYS FNEENGEDST
360 370 380 390 400
KPLGPCDVFW VQKDTAIIRL HPSIYTQVFN ILLQHKEKLT VQDCRYSLAS
410 420 430 440 450
VTLKGAKALE SLASCLRSTE YSKSFEQFKM VSMITDHNAL PQRCTFAFEA
460 470 480 490 500
IDPRHLAAPK KLNDSQRKTV NSDDILSLHE NYPQDEINAV FNELCDPESR
510 520 530 540 550
TQSYNNQNTL KEISARRYKL LTATPNSINK TTVPFKESDD PSIPLVIIRR
560 570 580 590 600
LKTRDWIVVL PWFWLLPLWH LLNRIPRMYH IGLRQFQQIQ YENKQLYFPD
610 620 630 640 650
DYPFTQLGYI ENSFYKKEAS KTKWDRKPMG KRINFEKIKD IHNTKLPAYS
660 670 680 690 700
GEIGDFFSSD WRFLQILRNG IDYLQRNDKT LELMDSKKTG QFNAQGVRDI
710 720 730 740 750
NCVNDVLEFC KDYEAKTKAM SLSIEENIPV ALCKNRKCQF RTPDSISVNS
760 770 780 790 800
SSFSLTFFPR CIIAVSCTLL ERGHPKDNAR IYQVPEKDLE HWLQLAKGVY
810 820 830 840 850
RPNGRKDHDL KIPLPEVHDL IGFITSGTYH LNCGNGMGIG FIDHHAAIRQ
860 870
PTRYVLIRNV GTNTYRLGEW SKISV
Length:875
Mass (Da):100,395
Last modified:November 1, 1995 - v1
Checksum:iE41EA9FFD6262FA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80358 Genomic DNA. Translation: CAA56589.1.
Z71497 Genomic DNA. Translation: CAA96124.1.
BK006947 Genomic DNA. Translation: DAA10335.1.
PIRiA53901.
RefSeqiNP_014178.1. NM_001183059.1.

Genome annotation databases

EnsemblFungiiYNL221C; YNL221C; YNL221C.
GeneIDi855500.
KEGGisce:YNL221C.

Similar proteinsi

Entry informationi

Entry nameiPOP1_YEAST
AccessioniPrimary (citable) accession number: P41812
Secondary accession number(s): D6W0W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 27, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names