Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coatomer subunit beta

Gene

SEC26

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for mitochondrial morphology.2 Publications

Miscellaneous

Present with 26000 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29813-MONOMER
ReactomeiR-SCE-6798695 Neutrophil degranulation
R-SCE-6807878 COPI-mediated anterograde transport
R-SCE-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit beta
Alternative name(s):
Beta-coat protein
Short name:
Beta-COP
Gene namesi
Name:SEC26
Ordered Locus Names:YDR238C
ORF Names:YD8419.05C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR238C
SGDiS000002646 SEC26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Causes a block in ER to Golgi transport. Exhibits exaggerated ER structures displaying interconnected networks of ER cisternae. Cells arrest at all stages of the vegetative cycle.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi334 – 336DLD → NAN: Loses ability to recognize arginine (R)-based ER localization signals in proteins. Recognition of C-terminal di-lysine signals present in proteins is unimpaired. 1 Publication3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938391 – 973Coatomer subunit betaAdd BLAST973

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei181PhosphoserineCombined sources1
Modified residuei540PhosphoserineCombined sources1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP41810
PaxDbiP41810
PRIDEiP41810

PTM databases

iPTMnetiP41810

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. The complex interacts with ARF1 and PAB1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ERV41Q046513EBI-4869,EBI-27850

Protein-protein interaction databases

BioGridi32289, 643 interactors
DIPiDIP-6467N
IntActiP41810, 36 interactors
MINTiP41810
STRINGi4932.YDR238C

Structurei

3D structure databases

ProteinModelPortaliP41810
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati98 – 133HEAT 1Add BLAST36
Repeati134 – 170HEAT 2Add BLAST37
Repeati279 – 317HEAT 3Add BLAST39
Repeati318 – 354HEAT 4Add BLAST37

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000005270
HOGENOMiHOG000207417
InParanoidiP41810
KOiK17301
OMAiQCGFMAA
OrthoDBiEOG092C0QZM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR002553 Clathrin/coatomer_adapt-like_N
IPR011710 Coatomer_bsu_C
IPR016460 COPB1
IPR029446 COPB1_appendage_platform_dom
PANTHERiPTHR10635 PTHR10635, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF07718 Coatamer_beta_C, 1 hit
PF14806 Coatomer_b_Cpla, 1 hit
PIRSFiPIRSF005727 Coatomer_beta_subunit, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

Sequencei

Sequence statusi: Complete.

P41810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSLSSQPAY TLVFDPSPSM ETYSSTDFQK ALEKGSDEQK IDTMKSILVT
60 70 80 90 100
MLEGNPMPEL LMHIIRFVMP SKNKELKKLL YFYWEIVPKL AEDGKLRHEM
110 120 130 140 150
ILVCNAIQHD LQHPNEYIRG NTLRFLTKLR EAELLEQMVP SVLACLEYRH
160 170 180 190 200
AYVRKYAILA VFSIFKVSEH LLPDAKEIIN SFIVAETDPI CKRNAFIGLA
210 220 230 240 250
ELDRENALHY LENNIADIEN LDPLLQAVFV QFIRQDANRT PALKAQYIEL
260 270 280 290 300
LMELLSTTTS DEVIFETALA LTVLSANPNV LVPAVNKLID LAVKVSDNNI
310 320 330 340 350
KLIVLDRIQD INANNVGALE ELTLDILRVL NAEDLDVRSK ALDISMDLAT
360 370 380 390 400
SRNAEDVVQL LKKELQTTVN NPDQDKAMQY RQLLIKTIRT VAVNFVEMAA
410 420 430 440 450
SVVSLLLDFI GDLNSVAASG IIAFIKEVIE KYPQLRANIL ENMVQTLDKV
460 470 480 490 500
RSAKAYRGAL WIMGEYAEGE SEIQHCWKHI RNSVGEVPIL QSEIKKLTQN
510 520 530 540 550
QEHTEENEVD ATAKPTGPVI LPDGTYATES AFDVKTSQKS VTDEERDSRP
560 570 580 590 600
PIRRFVLSGD FYTAAILANT IIKLVLKFEN VSKNKTVINA LKAEALLILV
610 620 630 640 650
SIVRVGQSSL VEKKIDEDSL ERVMTSISIL LDEVNPEEKK EEVKLLEVAF
660 670 680 690 700
LDTTKSSFKR QIEIAKKNKH KRALKDSCKN IEPIDTPISF RQFAGVDSTN
710 720 730 740 750
VQKDSIEEDL QLAMKGDAIH ATSSSSISKL KKIVPLCGFS DPVYAEACIT
760 770 780 790 800
NNQFDVVLDV LLVNQTKETL KNLHVQFATL GDLKIIDTPQ KTNVIPHGFH
810 820 830 840 850
KFTVTVKVSS ADTGVIFGNI IYDGAHGEDA RYVILNDVHV DIMDYIKPAT
860 870 880 890 900
ADDEHFRTMW NAFEWENKIS VKSQLPTLHA YLRELVKGTN MGILTPSESL
910 920 930 940 950
GEDDCRFLSC NLYAKSSFGE DALANLCIEK DSKTNDVIGY VRIRSKGQGL
960 970
ALSLGDRVAL IAKKTNKLAL THV
Length:973
Mass (Da):109,019
Last modified:November 1, 1997 - v2
Checksum:i885420DB026BCFA3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti412D → E in AAA61710 (PubMed:7929113).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11236 Genomic DNA Translation: AAA61710.1
Z49701 Genomic DNA Translation: CAA89724.1
BK006938 Genomic DNA Translation: DAA12079.1
PIRiS54534
RefSeqiNP_010524.3, NM_001180546.3

Genome annotation databases

EnsemblFungiiYDR238C; YDR238C; YDR238C
GeneIDi851824
KEGGisce:YDR238C

Similar proteinsi

Entry informationi

Entry nameiCOPB_YEAST
AccessioniPrimary (citable) accession number: P41810
Secondary accession number(s): D6VSL9, Q03779
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health