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P41809

- HKR1_YEAST

UniProt

P41809 - HKR1_YEAST

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Protein

Signaling mucin HKR1

Gene
HKR1, YDR420W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plasma membrane signaling mucin that promotes activation of the MAPK for the filamentous growth pathway. May regulate beta-glucan synthesis. Overexpression provides resistance to HM-1 killer toxin.2 Publications

GO - Molecular functioni

  1. osmosensor activity Source: SGD

GO - Biological processi

  1. (1->3)-beta-D-glucan biosynthetic process Source: SGD
  2. cellular bud site selection Source: SGD
  3. fungal-type cell wall organization Source: SGD
  4. hyperosmotic response Source: SGD
  5. osmosensory signaling pathway via Sho1 osmosensor Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29961-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Signaling mucin HKR1
Alternative name(s):
Hansenula MRAKII killer toxin-resistant protein 1
Gene namesi
Name:HKR1
Ordered Locus Names:YDR420W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR420w.
SGDiS000002828. HKR1.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 14851464Extracellular Reviewed predictionAdd
BLAST
Transmembranei1486 – 150621Helical; Reviewed predictionAdd
BLAST
Topological domaini1507 – 1802296Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
  3. site of polarized growth Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 18021781Signaling mucin HKR1PRO_0000021444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1252 – 12521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1293 – 12931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1342 – 13421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1400 – 14001N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Could be O-glycosylated in the serine/threonine-rich domain.

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

Expression is highly increased during spheroplast regeneration.1 Publication

Gene expression databases

GenevestigatoriP41809.

Interactioni

Protein-protein interaction databases

BioGridi32479. 73 interactions.
IntActiP41809. 3 interactions.
MINTiMINT-5223587.
STRINGi4932.YDR420W.

Structurei

3D structure databases

ProteinModelPortaliP41809.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati453 – 480281; approximateAdd
BLAST
Repeati481 – 508282Add
BLAST
Repeati509 – 536283Add
BLAST
Repeati537 – 564284Add
BLAST
Repeati565 – 592285Add
BLAST
Repeati593 – 620286Add
BLAST
Repeati621 – 648287Add
BLAST
Repeati649 – 676288Add
BLAST
Repeati677 – 704289Add
BLAST
Repeati705 – 7322810Add
BLAST
Repeati733 – 7602811Add
BLAST
Repeati761 – 7882812Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni453 – 78833612 X 28 AA tandem repeats of S-[AV]-[P]-V-A-V-S-S-T-Y-T-S-S-P-S-A-P-A-A-I-S-S-T-Y-T-S-S-PAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi23 – 14781456Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the HKR1/MSB2 family.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00740000116199.
OMAiYHESEVE.
OrthoDBiEOG78H456.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41809-1 [UniParc]FASTAAdd to Basket

« Hide

MVSLKIKKIL LLVSLLNAIE AYSNDTIYST SYNNGIESTP SYSTSAISST     50
GSSNKENAIT SSSETTTMAG QYGESGSTTI MDEQETGTSS QYISVTTTTQ 100
TSDTMSSVKK STEIATPSSS IVPTPLQSYS DESQISQTLS HNPKSVAESD 150
SDTTSSESSS SVIISTSDSS AVPREISPII TTDSQISKEE GTLAQTSSIS 200
ETTRIAQMVT RVSQISSITA ASTIDGFSSE STQTDFSNTV SFENSVEEEY 250
AMSKSQLSES YSSSSTVYSG GESTADKTSS SPITSFSSSY SQTTSTETSE 300
SSRVAVGVSR PSSITQTTSI DSFSMSEVEL STYYDLSAGN YPDQELIVDR 350
PATSSTAETS SEASQGVSRE SNTFAVSSIS TTNFIVSSAS DTVVSTSSTN 400
TVPYSSVHST FVHATSSSTY ISSSLYSSPS LSASVSSHFG VAPFPSAYIS 450
FSSVPVAVSS TYTSSPSASV VVPSAYASSP SVPVAVSSTY TSSPSAPAAI 500
SSTYTSSPSA PVAVSSTYTS SPSAPAAISS TYTSSPSAPV AVSSTYTSSP 550
SAPAAISSTY TSSPSAPVAV SSTYTSSPSA PVAISSTYTS SPSVPVAVSS 600
TYTSSPSAPA AISSTYTSSP SAPVAVSSTY TSSPSAPAAI SSTYTSSPSV 650
PVAVSSTYTS SPSAPAAISS TYTSSPSVPV AVSSTYTSSP SAPAAISSTY 700
TSSPSAPVAV SSTYTSSPSA PAAISSTYTS SPSAPVAVSS TYTSSPSAPA 750
AISSTYTSSP SAPVAVSSTY TSSPSALVVL SSTSTSSPYD IVYSPSTFAA 800
ISSGYTPSPS ASVAMSSTSS SSPYDIVYSL SSSASRSSIA TYEFSPSPST 850
SLPTSSTYTY FSSAYAFEFS SERYSTTSTI APTQIHSTLS RITDFLLQTS 900
MAIQSIVSQQ ISTSSTLNDE IHSSALSVFN PSASNLVETS LIISSTQASI 950
TSPKNSAKIS SLQSQLSSST KNPYDTANKN TETSGRSTVV SNFLYTSSAA 1000
KPDNEKFSAT PTEITTISSS SHAYSLSIPS SHNSVTGLSH NFVDSSKSAT 1050
SFGYSSSSIS SIKLSKETIP ASKSVSNTQE RITSFTSTLR ANSQSEKSEG 1100
RNSVGSLQSS HISSNPSLST NTKVDSKSLS RKVSKTMGEN GEETGLTTTK 1150
TQYKSSSETS GSYSRSFTKI SIGPATTAVQ TQASTNSVFT APALSTYPTT 1200
PYPSPNSYAW LPTAIIVESS ETGPTTASFN PSITGSLPNA IEPAVAVSEP 1250
INHTLITIGF TAALNYVFLV QNPLSSAQIF NFLPLVLKYP FSNTSSELDN 1300
SIGELSTFIL SYRSGSSTTT LSPKSISSLS VVKKKKNQQK KNATKSTEDL 1350
HPPQVDTSSI AVKKIVPMVD SSKAYIVSVA EVYFPTEAVT YLQQLILDEN 1400
STLYSNPQTP LRSLAGLIDS GIPLGGLTLY GSGDGGYVPS LTSSSVLDSS 1450
KGNSQNIDGT YKYGALDDFI NSFTDSASAG KYAVKIIIFL IVLTIGVLLW 1500
LFVAFFAFRH RNILLKRHPR NCIGKSLNNE RELESTELSR SSSGNQVYNE 1550
KPPESENESV YSAVDDHYIV TGENTVYNTI HRLHYTINDD GDLLYRDAIP 1600
LDFDQTNGDD GSGIDSIVRD CVYDKNQDAT EAFLNDEESI SGILDVDENG 1650
DIRLYDSYSD NEESNSFHLP DEVIENYNKN HLCETKLHGL GTESCTTDDP 1700
DTGNQITNEF STGSQTCLPS TAYTTPLHTN SIKLHTLRYT ESSLPKPNQT 1750
LFSNLEDLEI EDIDDNGSVS DVHIEELDAL DEELYKRMSK VIKQQNHQTT 1800
KI 1802
Length:1,802
Mass (Da):188,948
Last modified:August 31, 2004 - v2
Checksum:i0FF726990C7CDC51
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti582 – 5821V → A in AAB30051. 1 Publication
Sequence conflicti594 – 5941V → A in AAB30051. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S69101 Genomic DNA. Translation: AAB30051.1.
U33007 Genomic DNA. Translation: AAB64857.1.
BK006938 Genomic DNA. Translation: DAA12260.1.
PIRiS69703.
RefSeqiNP_010708.1. NM_001180728.1.

Genome annotation databases

EnsemblFungiiYDR420W; YDR420W; YDR420W.
GeneIDi852030.
KEGGisce:YDR420W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S69101 Genomic DNA. Translation: AAB30051.1 .
U33007 Genomic DNA. Translation: AAB64857.1 .
BK006938 Genomic DNA. Translation: DAA12260.1 .
PIRi S69703.
RefSeqi NP_010708.1. NM_001180728.1.

3D structure databases

ProteinModelPortali P41809.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32479. 73 interactions.
IntActi P41809. 3 interactions.
MINTi MINT-5223587.
STRINGi 4932.YDR420W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDR420W ; YDR420W ; YDR420W .
GeneIDi 852030.
KEGGi sce:YDR420W.

Organism-specific databases

CYGDi YDR420w.
SGDi S000002828. HKR1.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00740000116199.
OMAi YHESEVE.
OrthoDBi EOG78H456.

Enzyme and pathway databases

BioCyci YEAST:G3O-29961-MONOMER.

Miscellaneous databases

NextBioi 970260.

Gene expression databases

Genevestigatori P41809.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the Saccharomyces cerevisiae gene whose overexpression overcomes the effects of HM-1 killer toxin, which inhibits beta-glucan synthesis."
    Kasahara S., Yamada H., Mio T., Shiratori Y., Miyamoto C., Yabe T., Nakajima T., Ichishima E., Furuichi Y.
    J. Bacteriol. 176:1488-1499(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 200358 / YNN 295.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "HKR1 encodes a cell surface protein that regulates both cell wall beta-glucan synthesis and budding pattern in the yeast Saccharomyces cerevisiae."
    Yabe T., Yamada-Okabe T., Kasahara S., Furuichi Y., Nakajima T., Ichishima E., Arisawa M., Yamada-Okabe H.
    J. Bacteriol. 178:477-483(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. "Variations in mRNA transcript levels of cell wall-associated genes of Saccharomyces cerevisiae following spheroplasting."
    Braley R., Chaffin W.L.
    FEMS Microbiol. Lett. 181:177-185(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  6. "The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response."
    Pitoniak A., Birkaya B., Dionne H.M., Vadaie N., Cullen P.J.
    Mol. Biol. Cell 20:3101-3114(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHKR1_YEAST
AccessioniPrimary (citable) accession number: P41809
Secondary accession number(s): D6VT50, Q04051
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 31, 2004
Last modified: June 11, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

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