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Protein

Vacuolar ATPase assembly integral membrane protein VMA21

Gene

VMA21

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions with VOA1 in assembly of the integral membrane sector (also called V0 sector) of the V-ATPase in the endoplasmic reticulum. Escorts the assembled V0 sector in COPII vesicles. Also required for normal packaging of the SNARE BOS1 and possibly the ER to Golgi transport receptor ERV29.UniRule annotation6 Publications

GO - Biological processi

  • vacuolar proton-transporting V-type ATPase complex assembly Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30815-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar ATPase assembly integral membrane protein VMA21UniRule annotation
Gene namesi
Name:VMA21UniRule annotation
Ordered Locus Names:YGR105W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR105W.
SGDiS000003337. VMA21.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicUniRule annotationAdd BLAST13
Transmembranei14 – 34HelicalUniRule annotationAdd BLAST21
Topological domaini35 – 38LumenalUniRule annotation4
Transmembranei39 – 59HelicalUniRule annotationAdd BLAST21
Topological domaini60 – 77CytoplasmicUniRule annotationAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi74 – 75KK → QQ: Mislocalizes to the vacuole membrane and stay associated with the V0 sector after transport out of the ER. 2 Publications2
Mutagenesisi74K → Q: Secretion from ER. 1
Mutagenesisi75K → Q: Secretion from ER. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000658751 – 77Vacuolar ATPase assembly integral membrane protein VMA21Add BLAST77

Proteomic databases

MaxQBiP41806.
TopDownProteomicsiP41806.

Interactioni

Protein-protein interaction databases

BioGridi33348. 585 interactors.
DIPiDIP-5526N.
IntActiP41806. 10 interactors.
MINTiMINT-496678.

Structurei

3D structure databases

ProteinModelPortaliP41806.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi74 – 77Prevents secretion from ER4

Sequence similaritiesi

Belongs to the VMA21 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000234560.
InParanoidiP41806.
OMAiVKLMFFT.
OrthoDBiEOG092C5PNH.

Family and domain databases

HAMAPiMF_03058. VMA21. 1 hit.
InterProiIPR019013. Vma21.
[Graphical view]
PANTHERiPTHR31792. PTHR31792. 1 hit.
PfamiPF09446. VMA21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41806-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDVPRAVI NKLMLFTAAM VVLPVLTFFI IQQFTPNTLI SGGLAAAMAN
60 70
VVLIVYIVVA FREDTEDHKV DGNKKED
Length:77
Mass (Da):8,435
Last modified:November 1, 1995 - v1
Checksum:iD09719B2A2839A4B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70V → G in AAS56142 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09329 Genomic DNA. Translation: AAA74455.1.
Z72890 Genomic DNA. Translation: CAA97109.1.
AY557816 Genomic DNA. Translation: AAS56142.1.
BK006941 Genomic DNA. Translation: DAA08198.1.
PIRiS47941.
RefSeqiNP_011619.3. NM_001181234.3.

Genome annotation databases

EnsemblFungiiYGR105W; YGR105W; YGR105W.
GeneIDi852997.
KEGGisce:YGR105W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09329 Genomic DNA. Translation: AAA74455.1.
Z72890 Genomic DNA. Translation: CAA97109.1.
AY557816 Genomic DNA. Translation: AAS56142.1.
BK006941 Genomic DNA. Translation: DAA08198.1.
PIRiS47941.
RefSeqiNP_011619.3. NM_001181234.3.

3D structure databases

ProteinModelPortaliP41806.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33348. 585 interactors.
DIPiDIP-5526N.
IntActiP41806. 10 interactors.
MINTiMINT-496678.

Proteomic databases

MaxQBiP41806.
TopDownProteomicsiP41806.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR105W; YGR105W; YGR105W.
GeneIDi852997.
KEGGisce:YGR105W.

Organism-specific databases

EuPathDBiFungiDB:YGR105W.
SGDiS000003337. VMA21.

Phylogenomic databases

HOGENOMiHOG000234560.
InParanoidiP41806.
OMAiVKLMFFT.
OrthoDBiEOG092C5PNH.

Enzyme and pathway databases

BioCyciYEAST:G3O-30815-MONOMER.

Miscellaneous databases

PROiP41806.

Family and domain databases

HAMAPiMF_03058. VMA21. 1 hit.
InterProiIPR019013. Vma21.
[Graphical view]
PANTHERiPTHR31792. PTHR31792. 1 hit.
PfamiPF09446. VMA21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVMA21_YEAST
AccessioniPrimary (citable) accession number: P41806
Secondary accession number(s): D6VUN7, Q6Q5Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1480 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.