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Protein

60S ribosomal protein L10

Gene

RPL10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosomal large subunit assembly Source: SGD
  • translational termination Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32227-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L10
Alternative name(s):
L9
Ubiquinol-cytochrome C reductase complex subunit VI-requiring protein
Gene namesi
Name:RPL10
Synonyms:GRC5, QSR1
Ordered Locus Names:YLR075W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR075W.
SGDiS000004065. RPL10.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi194G → D in QSR1-1; synthetic lethal. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001471292 – 22160S ribosomal protein L10Add BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki101Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei143PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP41805.
PRIDEiP41805.

PTM databases

iPTMnetiP41805.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi31349. 93 interactors.
DIPiDIP-2507N.
IntActiP41805. 89 interactors.
MINTiMINT-1326100.

Structurei

Secondary structure

1221
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 11Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-I4-168[»]
3J6Xelectron microscopy6.10501-221[»]
3J6Yelectron microscopy6.10501-221[»]
3J77electron microscopy6.20601-221[»]
3J78electron microscopy6.30601-221[»]
4U3MX-ray3.00M0/m02-221[»]
4U3NX-ray3.20M0/m02-221[»]
4U3UX-ray2.90M0/m02-221[»]
4U4NX-ray3.10M0/m02-221[»]
4U4OX-ray3.60M0/m02-221[»]
4U4QX-ray3.00M0/m02-221[»]
4U4RX-ray2.80M0/m02-221[»]
4U4UX-ray3.00M0/m02-221[»]
4U4YX-ray3.20M0/m02-221[»]
4U4ZX-ray3.10M0/m02-221[»]
4U50X-ray3.20M0/m02-221[»]
4U51X-ray3.20M0/m02-221[»]
4U52X-ray3.00M0/m02-221[»]
4U53X-ray3.30M0/m02-221[»]
4U55X-ray3.20M0/m02-221[»]
4U56X-ray3.45M0/m02-221[»]
4U6FX-ray3.10M0/m02-221[»]
4V4Belectron microscopy11.70BI1-168[»]
4V6Ielectron microscopy8.80BI1-221[»]
4V7RX-ray4.00BJ/DJ1-221[»]
4V88X-ray3.00BI/DI1-221[»]
4V8Telectron microscopy8.10I1-221[»]
4V8Yelectron microscopy4.30BI2-221[»]
4V8Zelectron microscopy6.60BI2-221[»]
4V91electron microscopy3.70I1-221[»]
4ZOXX-ray1.60B1-20[»]
5APNelectron microscopy3.91I1-221[»]
5APOelectron microscopy3.41I1-221[»]
5DATX-ray3.15M0/m02-221[»]
5DC3X-ray3.25M0/m02-221[»]
5FCIX-ray3.40M0/m02-221[»]
5FCJX-ray3.10M0/m02-221[»]
5GAKelectron microscopy3.88s1-221[»]
5I4LX-ray3.10M0/m01-221[»]
5JUOelectron microscopy4.00N1-221[»]
5JUPelectron microscopy3.50N1-221[»]
5JUSelectron microscopy4.20N1-221[»]
5JUTelectron microscopy4.00N1-221[»]
5JUUelectron microscopy4.00N1-221[»]
ProteinModelPortaliP41805.
SMRiP41805.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41805.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati167 – 1811Add BLAST15
Repeati200 – 2162Add BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni167 – 2162 X 15-17 AA approximate repeatsAdd BLAST50

Sequence similaritiesi

Belongs to the ribosomal protein L10e family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000003897.
HOGENOMiHOG000223754.
InParanoidiP41805.
KOiK02866.
OMAiCKESNAK.
OrthoDBiEOG092C4HB9.

Family and domain databases

CDDicd01433. Ribosomal_L16_L10e. 1 hit.
Gene3Di3.90.1170.10. 1 hit.
InterProiIPR001197. Ribosomal_L10e.
IPR016180. Ribosomal_L10e/L16.
IPR018255. Ribosomal_L10e_CS.
[Graphical view]
PfamiPF00252. Ribosomal_L16. 1 hit.
[Graphical view]
PIRSFiPIRSF005590. Ribosomal_L10. 1 hit.
SUPFAMiSSF54686. SSF54686. 1 hit.
TIGRFAMsiTIGR00279. uL16_euk_arch. 1 hit.
PROSITEiPS01257. RIBOSOMAL_L10E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRPARCYR YQKNKPYPKS RYNRAVPDSK IRIYDLGKKK ATVDEFPLCV
60 70 80 90 100
HLVSNELEQL SSEALEAARI CANKYMTTVS GRDAFHLRVR VHPFHVLRIN
110 120 130 140 150
KMLSCAGADR LQQGMRGAWG KPHGLAARVD IGQIIFSVRT KDSNKDVVVE
160 170 180 190 200
GLRRARYKFP GQQKIILSKK WGFTNLDRPE YLKKREAGEV KDDGAFVKFL
210 220
SKKGSLENNI REFPEYFAAQ A
Length:221
Mass (Da):25,361
Last modified:November 1, 1995 - v1
Checksum:i6FF976A3800F347D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06952 Genomic DNA. Translation: AAA81534.1.
X78887 Genomic DNA. Translation: CAA55485.1.
Z73247 Genomic DNA. Translation: CAA97632.1.
AY693034 Genomic DNA. Translation: AAT93053.1.
BK006945 Genomic DNA. Translation: DAA09392.1.
PIRiA57296.
RefSeqiNP_013176.1. NM_001181962.1.

Genome annotation databases

EnsemblFungiiYLR075W; YLR075W; YLR075W.
GeneIDi850764.
KEGGisce:YLR075W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06952 Genomic DNA. Translation: AAA81534.1.
X78887 Genomic DNA. Translation: CAA55485.1.
Z73247 Genomic DNA. Translation: CAA97632.1.
AY693034 Genomic DNA. Translation: AAT93053.1.
BK006945 Genomic DNA. Translation: DAA09392.1.
PIRiA57296.
RefSeqiNP_013176.1. NM_001181962.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-I4-168[»]
3J6Xelectron microscopy6.10501-221[»]
3J6Yelectron microscopy6.10501-221[»]
3J77electron microscopy6.20601-221[»]
3J78electron microscopy6.30601-221[»]
4U3MX-ray3.00M0/m02-221[»]
4U3NX-ray3.20M0/m02-221[»]
4U3UX-ray2.90M0/m02-221[»]
4U4NX-ray3.10M0/m02-221[»]
4U4OX-ray3.60M0/m02-221[»]
4U4QX-ray3.00M0/m02-221[»]
4U4RX-ray2.80M0/m02-221[»]
4U4UX-ray3.00M0/m02-221[»]
4U4YX-ray3.20M0/m02-221[»]
4U4ZX-ray3.10M0/m02-221[»]
4U50X-ray3.20M0/m02-221[»]
4U51X-ray3.20M0/m02-221[»]
4U52X-ray3.00M0/m02-221[»]
4U53X-ray3.30M0/m02-221[»]
4U55X-ray3.20M0/m02-221[»]
4U56X-ray3.45M0/m02-221[»]
4U6FX-ray3.10M0/m02-221[»]
4V4Belectron microscopy11.70BI1-168[»]
4V6Ielectron microscopy8.80BI1-221[»]
4V7RX-ray4.00BJ/DJ1-221[»]
4V88X-ray3.00BI/DI1-221[»]
4V8Telectron microscopy8.10I1-221[»]
4V8Yelectron microscopy4.30BI2-221[»]
4V8Zelectron microscopy6.60BI2-221[»]
4V91electron microscopy3.70I1-221[»]
4ZOXX-ray1.60B1-20[»]
5APNelectron microscopy3.91I1-221[»]
5APOelectron microscopy3.41I1-221[»]
5DATX-ray3.15M0/m02-221[»]
5DC3X-ray3.25M0/m02-221[»]
5FCIX-ray3.40M0/m02-221[»]
5FCJX-ray3.10M0/m02-221[»]
5GAKelectron microscopy3.88s1-221[»]
5I4LX-ray3.10M0/m01-221[»]
5JUOelectron microscopy4.00N1-221[»]
5JUPelectron microscopy3.50N1-221[»]
5JUSelectron microscopy4.20N1-221[»]
5JUTelectron microscopy4.00N1-221[»]
5JUUelectron microscopy4.00N1-221[»]
ProteinModelPortaliP41805.
SMRiP41805.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31349. 93 interactors.
DIPiDIP-2507N.
IntActiP41805. 89 interactors.
MINTiMINT-1326100.

PTM databases

iPTMnetiP41805.

Proteomic databases

MaxQBiP41805.
PRIDEiP41805.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR075W; YLR075W; YLR075W.
GeneIDi850764.
KEGGisce:YLR075W.

Organism-specific databases

EuPathDBiFungiDB:YLR075W.
SGDiS000004065. RPL10.

Phylogenomic databases

GeneTreeiENSGT00390000003897.
HOGENOMiHOG000223754.
InParanoidiP41805.
KOiK02866.
OMAiCKESNAK.
OrthoDBiEOG092C4HB9.

Enzyme and pathway databases

BioCyciYEAST:G3O-32227-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

EvolutionaryTraceiP41805.
PROiP41805.

Family and domain databases

CDDicd01433. Ribosomal_L16_L10e. 1 hit.
Gene3Di3.90.1170.10. 1 hit.
InterProiIPR001197. Ribosomal_L10e.
IPR016180. Ribosomal_L10e/L16.
IPR018255. Ribosomal_L10e_CS.
[Graphical view]
PfamiPF00252. Ribosomal_L16. 1 hit.
[Graphical view]
PIRSFiPIRSF005590. Ribosomal_L10. 1 hit.
SUPFAMiSSF54686. SSF54686. 1 hit.
TIGRFAMsiTIGR00279. uL16_euk_arch. 1 hit.
PROSITEiPS01257. RIBOSOMAL_L10E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL10_YEAST
AccessioniPrimary (citable) accession number: P41805
Secondary accession number(s): D6VY76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.