60S ribosomal protein L10 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P41805 (RL10_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 110. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
60S ribosomal protein L10

Alternative name(s):
L9
Ubiquinol-cytochrome C reductase complex subunit VI-requiring protein

Gene names

Name:	RPL10
Synonyms:	GRC5, QSR1
Ordered Locus Names:	YLR075W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). Ref.7
Subcellular location	Cytoplasm Ref.9.
Sequence similarities	Belongs to the ribosomal protein L10e family.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Repeat
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytoplasmic translation Traceable author statement Ref.7. Source: SGD ribosomal large subunit assembly Inferred from mutant phenotype PubMed 18824477 PubMed 9580698. Source: SGD translational termination Inferred from mutant phenotype PubMed 18824477. Source: SGD
Cellular_component	cytosolic large ribosomal subunit Traceable author statement Ref.7. Source: SGD
Molecular_function	structural constituent of ribosome Traceable author statement Ref.7. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TSC10	P38342	1	EBI-15270,EBI-21124

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed Ref.8

Chain

2 – 221

220

60S ribosomal protein L10

PRO_0000147129

Regions

Repeat

167 – 181

Repeat

200 – 216

Region

167 – 216

2 X 15-17 AA approximate repeats

Amino acid modifications

Modified residue

104

Phosphoserine Ref.11

Modified residue

143

Phosphoserine Ref.10

Modified residue

205

Phosphoserine Ref.10

Experimental info

Mutagenesis

194

G → D in QSR1-1; synthetic lethal. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P41805 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 6FF976A3800F347D
Show »

FASTA

221

25,361

        10         20         30         40         50         60 
MARRPARCYR YQKNKPYPKS RYNRAVPDSK IRIYDLGKKK ATVDEFPLCV HLVSNELEQL 

        70         80         90        100        110        120 
SSEALEAARI CANKYMTTVS GRDAFHLRVR VHPFHVLRIN KMLSCAGADR LQQGMRGAWG 

       130        140        150        160        170        180 
KPHGLAARVD IGQIIFSVRT KDSNKDVVVE GLRRARYKFP GQQKIILSKK WGFTNLDRPE 

       190        200        210        220 
YLKKREAGEV KDDGAFVKFL SKKGSLENNI REFPEYFAAQ A

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"QSR1, an essential yeast gene with a genetic relationship to a subunit of the mitochondrial cytochrome bc1 complex, is homologous to a gene implicated in eukaryotic cell differentiation." Tron T., Yang M., Dick F.A., Schmitt M.E., Trumpower B.L. J. Biol. Chem. 270:9961-9970(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS OF GLY-194.
[2]	"The yeast growth control gene GRC5 is highly homologous to the mammalian putative tumor suppressor gene QM." Koller H.T., Klade T., Ellinger A., Breitenbach M. Yeast 12:53-65(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. Hoheisel J.D. Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[6]	"Ribosomal protein L9 is the product of GRC5, a homolog of the putative tumor suppressor QM in S. cerevisiae." Nika J., Erickson F.L., Hannig E.M. Yeast 13:1155-1166(1997) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION AS A RIBOSOMAL PROTEIN.
[7]	"The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae." Planta R.J., Mager W.H. Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE, SUBUNIT.
[8]	"The action of N-terminal acetyltransferases on yeast ribosomal proteins." Arnold R.J., Polevoda B., Reilly J.P., Sherman F. J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract] Cited for: CLEAVAGE OF INITIATOR METHIONINE.
[9]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[10]	"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143 AND SER-205, MASS SPECTROMETRY. Strain: ADR376.
[11]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, MASS SPECTROMETRY.
[12]	"Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions." Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J. Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract] Cited for: 3D-STRUCTURE MODELING OF 4-168, ELECTRON MICROSCOPY.
[13]	"Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation." Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J. EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract] Cited for: 3D-STRUCTURE MODELING OF 2-169, ELECTRON MICROSCOPY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U06952 Genomic DNA. Translation: AAA81534.1.
X78887 Genomic DNA. Translation: CAA55485.1.
Z73247 Genomic DNA. Translation: CAA97632.1.
AY693034 Genomic DNA. Translation: AAT93053.1.
BK006945 Genomic DNA. Translation: DAA09392.1.

PIR

A57296.

RefSeq

NP_013176.1. NM_001181962.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1K5Y	model	-	I	4-168	[»]
1S1I	electron microscopy	11.70	I	1-168	[»]
3IZS	electron microscopy	-	I	1-221	[»]
3O58	X-ray	4.00	J	1-221	[»]
3O5H	X-ray	4.00	J	1-221	[»]
3U5E	X-ray	3.00	I	1-221	[»]
3U5I	X-ray	3.00	I	1-221	[»]
4B6A	electron microscopy	8.10	I	1-221	[»]

ProteinModelPortal

P41805.

SMR

P41805. Positions 2-221.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-2507N.

IntAct

P41805. 84 interactions.

MINT

MINT-1326100.

STRING

4932.YLR075W.

Proteomic databases

PaxDb

P41805.

PeptideAtlas

P41805.

PRIDE

P41805.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YLR075W; YLR075W; YLR075W.

GeneID

850764.

KEGG

sce:YLR075W.

Organism-specific databases

CYGD

YLR075w.

SGD

S000004065. RPL10.

Phylogenomic databases

eggNOG

COG0197.

GeneTree

ENSGT00390000003897.

HOGENOM

HOG000223754.

K02866.

OMA

PYTRKEY.

OrthoDB

EOG4578GQ.

Gene expression databases

Genevestigator

P41805.

GermOnline

YLR075W. Saccharomyces cerevisiae.

Family and domain databases

InterPro

IPR001197. Ribosomal_L10e.
IPR016180. Ribosomal_L10e/L16.
IPR018255. Ribosomal_L10e_CS.
[Graphical view]

Pfam

PF00252. Ribosomal_L16. 1 hit.
[Graphical view]

PIRSF

PIRSF005590. Ribosomal_L10. 1 hit.

SUPFAM

SSF54686. Ribosomal_L10e/L16. 1 hit.

TIGRFAMs

TIGR00279. L10e. 1 hit.

PROSITE

PS01257. RIBOSOMAL_L10E. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P41805.

NextBio

966921.

Entry information

Entry name

RL10_YEAST

Accession

Primary (citable) accession number: P41805
Secondary accession number(s): D6VY76

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents