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P41805 (RL10_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
60S ribosomal protein L10
Alternative name(s):
L9
Ubiquinol-cytochrome C reductase complex subunit VI-requiring protein
Gene names
Name:RPL10
Synonyms:GRC5, QSR1
Ordered Locus Names:YLR075W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). Ref.7

Subcellular location

Cytoplasm Ref.9.

Sequence similarities

Belongs to the ribosomal protein L10e family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.8
Chain2 – 22122060S ribosomal protein L10
PRO_0000147129

Regions

Repeat167 – 181151
Repeat200 – 216172
Region167 – 216502 X 15-17 AA approximate repeats

Amino acid modifications

Modified residue1431Phosphoserine Ref.10
Modified residue2051Phosphoserine Ref.10 Ref.11

Experimental info

Mutagenesis1941G → D in QSR1-1; synthetic lethal. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P41805 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 6FF976A3800F347D

FASTA22125,361
        10         20         30         40         50         60 
MARRPARCYR YQKNKPYPKS RYNRAVPDSK IRIYDLGKKK ATVDEFPLCV HLVSNELEQL 

        70         80         90        100        110        120 
SSEALEAARI CANKYMTTVS GRDAFHLRVR VHPFHVLRIN KMLSCAGADR LQQGMRGAWG 

       130        140        150        160        170        180 
KPHGLAARVD IGQIIFSVRT KDSNKDVVVE GLRRARYKFP GQQKIILSKK WGFTNLDRPE 

       190        200        210        220 
YLKKREAGEV KDDGAFVKFL SKKGSLENNI REFPEYFAAQ A 

« Hide

References

« Hide 'large scale' references
[1]"QSR1, an essential yeast gene with a genetic relationship to a subunit of the mitochondrial cytochrome bc1 complex, is homologous to a gene implicated in eukaryotic cell differentiation."
Tron T., Yang M., Dick F.A., Schmitt M.E., Trumpower B.L.
J. Biol. Chem. 270:9961-9970(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS OF GLY-194.
[2]"The yeast growth control gene GRC5 is highly homologous to the mammalian putative tumor suppressor gene QM."
Koller H.T., Klade T., Ellinger A., Breitenbach M.
Yeast 12:53-65(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"Ribosomal protein L9 is the product of GRC5, a homolog of the putative tumor suppressor QM in S. cerevisiae."
Nika J., Erickson F.L., Hannig E.M.
Yeast 13:1155-1166(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS A RIBOSOMAL PROTEIN.
[7]"The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
Planta R.J., Mager W.H.
Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE, SUBUNIT.
[8]"The action of N-terminal acetyltransferases on yeast ribosomal proteins."
Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CLEAVAGE OF INITIATOR METHIONINE.
[9]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[10]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143 AND SER-205, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[11]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-205, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Sites of ubiquitin attachment in Saccharomyces cerevisiae."
Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING OF 4-168, ELECTRON MICROSCOPY.
[14]"Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING OF 2-169, ELECTRON MICROSCOPY.
[15]"Crystal structure of the eukaryotic ribosome."
Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
[16]"The structure of the eukaryotic ribosome at 3.0 A resolution."
Ben-Shem A., Garreau de Loubresse N., Melnikov S., Jenner L., Yusupova G., Yusupov M.
Science 334:1524-1529(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U06952 Genomic DNA. Translation: AAA81534.1.
X78887 Genomic DNA. Translation: CAA55485.1.
Z73247 Genomic DNA. Translation: CAA97632.1.
AY693034 Genomic DNA. Translation: AAT93053.1.
BK006945 Genomic DNA. Translation: DAA09392.1.
PIRA57296.
RefSeqNP_013176.1. NM_001181962.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-I4-168[»]
1S1Ielectron microscopy11.70I1-168[»]
3IZSelectron microscopy-I1-221[»]
3O58X-ray4.00J1-221[»]
3O5HX-ray4.00J1-221[»]
3U5EX-ray3.00I1-221[»]
3U5IX-ray3.00I1-221[»]
4B6Aelectron microscopy8.10I1-221[»]
4BYNelectron microscopy4.30I2-221[»]
4BYUelectron microscopy6.60I2-221[»]
ProteinModelPortalP41805.
SMRP41805. Positions 2-221.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31349. 138 interactions.
DIPDIP-2507N.
IntActP41805. 89 interactions.
MINTMINT-1326100.
STRING4932.YLR075W.

Proteomic databases

MaxQBP41805.
PaxDbP41805.
PeptideAtlasP41805.
PRIDEP41805.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR075W; YLR075W; YLR075W.
GeneID850764.
KEGGsce:YLR075W.

Organism-specific databases

CYGDYLR075w.
SGDS000004065. RPL10.

Phylogenomic databases

eggNOGCOG0197.
GeneTreeENSGT00390000003897.
HOGENOMHOG000223754.
KOK02866.
OMAMVKNCGK.
OrthoDBEOG71P2N4.

Enzyme and pathway databases

BioCycYEAST:G3O-32227-MONOMER.

Gene expression databases

GenevestigatorP41805.

Family and domain databases

Gene3D3.90.1170.10. 1 hit.
InterProIPR001197. Ribosomal_L10e.
IPR016180. Ribosomal_L10e/L16.
IPR018255. Ribosomal_L10e_CS.
[Graphical view]
PfamPF00252. Ribosomal_L16. 1 hit.
[Graphical view]
PIRSFPIRSF005590. Ribosomal_L10. 1 hit.
SUPFAMSSF54686. SSF54686. 1 hit.
TIGRFAMsTIGR00279. L10e. 1 hit.
PROSITEPS01257. RIBOSOMAL_L10E. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP41805.
NextBio966921.

Entry information

Entry nameRL10_YEAST
AccessionPrimary (citable) accession number: P41805
Secondary accession number(s): D6VY76
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references