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Protein

Maintenance of mitochondrial morphology protein 1

Gene

MMM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.UniRule annotation7 Publications

Miscellaneous

Normal levels of MMM1 require MDM34.
Present with 2490 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • aminophospholipid transport Source: SGD
  • mitochondrial genome maintenance Source: SGD
  • mitochondrial outer membrane translocase complex assembly Source: SGD
  • mitochondrion-endoplasmic reticulum membrane tethering Source: SGD
  • mitochondrion organization Source: SGD
  • phospholipid transport Source: SGD
  • protein import into mitochondrial outer membrane Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-32111-MONOMER.

Protein family/group databases

TCDBi9.A.58.1.1. the maintenance of mitochondrial morphology (mmm) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Maintenance of mitochondrial morphology protein 1UniRule annotation
Alternative name(s):
Mitochondrial outer membrane protein MMM1UniRule annotation
Yeast mitochondrial escape protein 6UniRule annotation
Gene namesi
Name:MMM1UniRule annotation
Synonyms:YME6
Ordered Locus Names:YLL006W
ORF Names:L1357
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL006W.
SGDiS000003929. MMM1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 100LumenalAdd BLAST100
Transmembranei101 – 121HelicalUniRule annotationAdd BLAST21
Topological domaini122 – 426CytoplasmicAdd BLAST305

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi215E → K in MMM1-6; impairs both mtDNA maintenance and mitochondrial morpholgy. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000965061 – 426Maintenance of mitochondrial morphology protein 1Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineUniRule annotation1
Glycosylationi50N-linked (GlcNAc...) asparagineUniRule annotation1
Glycosylationi55N-linked (GlcNAc...) asparagineUniRule annotation1
Glycosylationi59N-linked (GlcNAc...) asparagineUniRule annotation1

Post-translational modificationi

Glycosylated.UniRule annotation1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP41800.
PRIDEiP41800.

Interactioni

Subunit structurei

Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.UniRule annotation3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MDM12Q923285EBI-11029,EBI-10584

Protein-protein interaction databases

BioGridi31245. 633 interactors.
DIPiDIP-4150N.
IntActiP41800. 24 interactors.
MINTiMINT-495281.
STRINGi4932.YLL006W.

Structurei

3D structure databases

ProteinModelPortaliP41800.
SMRiP41800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MMM1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000201075.
InParanoidiP41800.
KOiK17764.
OMAiERCVEPR.
OrthoDBiEOG092C2Z53.

Family and domain databases

HAMAPiMF_03103. Mmm1. 1 hit.
InterProiView protein in InterPro
IPR027537. Mmm1.
IPR019411. MMM1_dom.
PfamiView protein in Pfam
PF10296. MMM1. 1 hit.

Sequencei

Sequence statusi: Complete.

P41800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDSENESTE TDSLMTFDDY ISKELPEHLQ RLIMENLKGS TTNDLKQTSN
60 70 80 90 100
NSEFNVSKNG SFKGLDDAIQ ALQMQSVLHP SSLGSLATSS KFSGWSFAQG
110 120 130 140 150
FFVGQLSIVL LFIFFLKFFI FSDEPSKSKN PKPAASRHRS KFKEYPFISR
160 170 180 190 200
EFLTSLVRKG AKQHYELNEE AENEHLQELA LILEKTYYNV DVHPAESLDW
210 220 230 240 250
FNVLVAQIIQ QFRSEAWHRD NILHSLNDFI GRKSPDLPEY LDTIKITELD
260 270 280 290 300
TGDDFPIFSN CRIQYSPNSG NKKLEAKIDI DLNDHLTLGV ETKLLLNYPK
310 320 330 340 350
PGIAALPINL VVSIVRFQAC LTVSLTNAEE FASTSNGSSS ENGMEGNSGY
360 370 380 390 400
FLMFSFSPEY RMEFEIKSLI GSRSKLENIP KIGSVIEYQI KKWFVERCVE
410 420
PRFQFVRLPS MWPRSKNTRE EKPTEL
Length:426
Mass (Da):48,660
Last modified:October 1, 1996 - v2
Checksum:i3610AEC2109355AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200W → S in AAA53581 (PubMed:8089172).Curated1
Sequence conflicti225S → W in AAA53581 (PubMed:8089172).Curated1
Sequence conflicti357S → A in AAA53581 (PubMed:8089172).Curated1
Sequence conflicti365E → Q in AAA53581 (PubMed:8089172).Curated1
Sequence conflicti368S → P in AAA53581 (PubMed:8089172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32793 Genomic DNA. Translation: AAA53581.1.
X91488 Genomic DNA. Translation: CAA62763.1.
Z73111 Genomic DNA. Translation: CAA97449.1.
BK006945 Genomic DNA. Translation: DAA09313.1.
PIRiS64748.
RefSeqiNP_013095.1. NM_001181826.1.

Genome annotation databases

EnsemblFungiiYLL006W; YLL006W; YLL006W.
GeneIDi850654.
KEGGisce:YLL006W.

Similar proteinsi

Entry informationi

Entry nameiMMM1_YEAST
AccessioniPrimary (citable) accession number: P41800
Secondary accession number(s): D6VXZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Was originally (PubMed:12972421 and PubMed:8089172) proposed to be inserted into either the outer or inner mitochondrial membrane, yet more recent data indicates that it is instead inserted into the ER.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names